Binding of prorenin to (pro)renin receptor induces the proliferation of human umbilical artery smooth muscle cells via ROS generation and ERK1/2 activation

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 15, Issue 2, 2014, Pages 99-108

  Liu, Feng Y ^a   Liu, Xiao Y ^a   Zhang, Li J ^a   Cheng, Yun P ^a   Jiang, Yi N ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

(pro)renin receptor; apoptosis; atherosclerosis; proliferation; ROS

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; MITOGEN ACTIVATED PROTEIN KINASE 1; PRORENIN; PRORENIN RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ATP6AP2 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RENIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN UMBILICAL ARTERY SMOOTH MUSCLE CELL; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SMOOTH MUSCLE FIBER; UMBILICAL ARTERY; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PREGNANCY; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOTENSIN II; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; NADPH OXIDASE; PHOSPHORYLATION; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTORS, CELL SURFACE; RENIN; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84902191009     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320314525215     Document Type: Article

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