Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway

Journal of Hypertension

Volumn 29, Issue 4, 2011, Pages 696-705

  Liu, Gang ^a,b   Hitomi, Hirofumi ^a   Hosomi, Naohisa ^a   Shibayama, Yuki ^a   Nakano, Daisuke ^a   Kiyomoto, Hideyasu ^a   Ma, Hong ^b   Yamaji, Yasuyoshi ^c   Kohno, Masakazu ^a   Ichihara, Atsuhiro ^d   Itoh, Hiroshi ^d   Nishiyama, Akira ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c Saitama Social Insurance Hospital   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

(pro)renin receptor; epidermal growth factor receptor; prorenin; vascular smooth muscle cell

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PRORENIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 79952759673     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328343c62b     Document Type: Article

References (33)

1. Nguyen G, Delarue F, Berrou J, Rondeau E, Sraer JD. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int 1996; 50:1897-1903. (Pubitemid 26417532)
2. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109:1417-1427. (Pubitemid 34596167)
3. Nguyen G. Renin/prorenin receptors. Kidney Int 2006; 69:1503-1506.
4. Schefe JH, MenkM, Reinemund J, Effertz K, Hobbs RM, Pandolfi PP, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 2006; 99:1355-1366. (Pubitemid 44949671)
5. SakodaM, Ichihara A, Kaneshiro Y, Takemitsu T, Nakazato Y, Nabi AH, et al. (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hypertens Res 2007; 30:1139-1146.
6. Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000; 52:639-672.
7. Min LJ, Mogi M, Li JM, Iwanami J, Iwai M, Horiuchi M. Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells. Circ Res 2005; 97:434-442. (Pubitemid 41298173)
8. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, et al. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 2006; 47:894-900. (Pubitemid 44297561)
9. Susic D, Zhou X, Frohlich ED, Lippton H, Knight M. Cardiovascular effects of prorenin blockade in genetically spontaneously hypertensive rats on normal and high-salt diet. Am J Physiol Heart Circ Physiol 2008; 295:H1117-H1121.
10. Eguchi S, Numaguchi K, Iwasaki H, Matsumoto T, Yamakawa T, Utsunomiya H, et al. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem 1998; 273:8890-8896. (Pubitemid 28176171)
11. Yamauchi T, Suzuki F, Takahashi A, Tsutsumi I, Hori H, Watanabe T, et al. Expression of rat renin in mammalian cells and its purification. Clin Exp Hypertens A 1992; 14:377-392.
12. Hitomi H, Fukui T, Moriwaki K, Matsubara K, Sun GP, Rahman M, et al. Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells. J Hypertens 2006; 24:1089-1095. (Pubitemid 43772317)
13. Nishiyama A, Yao L, Fan Y, Kyaw M, Kataoka N, Hashimoto K, et al. Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension 2005; 45:710-716. (Pubitemid 40418370)
14. Moriwaki K, Kiyomoto H, Hitomi H, Ihara G, Kaifu K, Matsubara K, et al. Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway. Kidney Int 2006; 70:788-793. (Pubitemid 44215356)
15. Huang Y, Noble NA, Zhang J, Xu C, Border WA. Renin-stimulated TGFbeta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int 2007; 72:45-52. (Pubitemid 47014443)
16. Zhang J, Noble NA, Border WA, Owens RT, Huang Y. Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells. Am J Physiol Endocrinol Metab 2008; 295:E810-E819.
17. Eguchi S, Dempsey PJ, Frank GD, Motley ED, Inagami T. Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloproteasedependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK. J Biol Chem 2001; 276:7957-7962.
18. Ushio-Fukai M, Griendling KK, Becker PL, Hilenski L, Halleran S, Alexander RW. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2001; 21:489-495. (Pubitemid 32323378)
19. Feldt S, Maschke U, Dechend R, Luft FC, Muller DN. The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol 2008; 19:743-748.
20. Catanzaro DF. Physiological relevance of renin/prorenin binding and uptake. Hypertens Res 2005; 28:97-105. (Pubitemid 40663059)
21. Uraoka M, Ikeda K, Nakagawa Y, Koide M, Akakabe Y, Nakano-Kurimoto R, et al. Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system. Biochem Biophys Res Commun 2009; 390:1202-1207.
22. Feldt S, Batenburg WW, Mazak I, Maschke U, Wellner M, Kvakan H, et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 2008; 51:682-688. (Pubitemid 351301521)
23. Kaneshiro Y, Ichihara A, Sakoda M, Takemitsu T, Nabi AH, Uddin MN, et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. J Am Soc Nephrol 2007; 18:1789-1795. (Pubitemid 46870315)
24. De Paolis P, Porcellini A, Savoia C, Lombardi A, Gigante B, Frati G, et al. Functional cross-talk between angiotensin II and epidermal growth factor receptors in NIH3T3 fibroblasts. J Hypertens 2002; 20:693-699. (Pubitemid 34913713)
25. Cheng J, Du J. Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. Arterioscler Thromb Vasc Biol 2007; 27:1744-1751. (Pubitemid 47207169)
26. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655-1657. (Pubitemid 34579158)
27. Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, et al. Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. Am J Physiol Cell Physiol 2004; 287:C494-C499. (Pubitemid 38955241)
28. Schefe JH, Neumann C, Goebel M, Danser J, Kirsch S, Gust R, et al. Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren. J Hypertens 2008; 26:1787-1794.
29. Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR. Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells. J Biol Chem 2008; 283:16320-16331.
30. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensinconverting- enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 1993; 329:1456-1462. (Pubitemid 23335891)
31. Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345:861-869.
32. Wilson DM, Luetscher JA. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N Engl J Med 1990; 323:1101-1106. (Pubitemid 20370731)
33. Luetscher JA, Kraemer FB, Wilson DM, Schwartz HC, Bryer-Ash M. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N Engl J Med 1985; 312:1412-1417. (Pubitemid 15083658)