Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats

Kidney International

Volumn 74, Issue 6, 2008, Pages 823-824

  Krebs, Christian ^a   Weber, Matthias ^a   Steinmetz, Oliver ^a   Meyer Schwesinger, Catherine ^a   Stahl, Rolf ^a   Danser, A H Jan ^b   Garrelds, Ingrid ^b   Van Goor, Harry ^c   Nguyen, Genevieve ^d   Müller, Dominik ^e   Wenzel, Ulrich ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d INSERM   (France)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 50849087977     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.315     Document Type: Letter

References (5)

1. Nguyen G, Delarue F, Burckle C et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109: 1417-1427.
2. Ichihara A, Hayashi M, Kaneshiro Y et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin. J Clin Invest 2004; 114: 1128-1135.
3. Uddin MN, Nabi AH, Nakagawa T et al. Non-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, 'decoy peptide'. Front Biosci 2008; 13: 745-753.
4. Krebs C, Hamming I, Sadaghiani S et al. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int 2007; 72: 725-730.
5. Batenburg WW, Krop M, Garrelds IM et al. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens 2007; 12: 2441-2453.