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Volumn 20, Issue 2, 2000, Pages 385-391

Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-α-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells

Author keywords

Cytokines; Monocyte chemoattractant protein 1; Reactive oxygen species; Smooth muscle cells; Tyrosine kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; ANTIOXIDANT; CATALASE; CYTOKINE; DIMETHYLTHIOUREA; DIPHENYLIODONIUM SALT; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033972465     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.2.385     Document Type: Article
Times cited : (90)

References (50)
  • 2
    • 0030797134 scopus 로고    scopus 로고
    • Effect of probucol treatment on gene expression of VCAM-1, MCP-1, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis
    • Fruebis J, Gonzalez V, Silvestre M, Palinski W. Effect of probucol treatment on gene expression of VCAM-1, MCP-1, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis. Arterioscler Thromb Vasc Biol. 1997;17:1289-1302.
    • (1997) Arterioscler Thromb Vasc Biol. , vol.17 , pp. 1289-1302
    • Fruebis, J.1    Gonzalez, V.2    Silvestre, M.3    Palinski, W.4
  • 3
    • 0028901870 scopus 로고
    • Cytokines regulate genes involved in atherogenesis
    • Libby P, Galis ZS. Cytokines regulate genes involved in atherogenesis. Ann N Y Acad Sci. 1995;748:158-170.
    • (1995) Ann N Y Acad Sci. , vol.748 , pp. 158-170
    • Libby, P.1    Galis, Z.S.2
  • 4
    • 0030368532 scopus 로고    scopus 로고
    • Role of tumor necrosis factor-alpha on mesangial cell MCP-1 expression and monocyte migration: Mechanisms mediated by signal transduction
    • Pai R, Ha H, Kirschenbaum MA, Kamanna VS. Role of tumor necrosis factor-alpha on mesangial cell MCP-1 expression and monocyte migration: mechanisms mediated by signal transduction. J Am Soc Nephrol. 1996;7:914-923.
    • (1996) J Am Soc Nephrol. , vol.7 , pp. 914-923
    • Pai, R.1    Ha, H.2    Kirschenbaum, M.A.3    Kamanna, V.S.4
  • 6
    • 0030996930 scopus 로고    scopus 로고
    • Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1
    • Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ Res. 1997;81:1-7.
    • (1997) Circ Res. , vol.81 , pp. 1-7
    • Wung, B.S.1    Cheng, J.J.2    Hsieh, H.J.3    Shyy, Y.J.4    Wang, D.L.5
  • 7
    • 0031106325 scopus 로고    scopus 로고
    • Modulation of IL-1-induced chemokine expression in human mesangial cells through alterations in redox status
    • Rovin BH, Dickerson JA, Tan LC, Fassler J. Modulation of IL-1-induced chemokine expression in human mesangial cells through alterations in redox status. Cytokine. 1997;9:178-186.
    • (1997) Cytokine. , vol.9 , pp. 178-186
    • Rovin, B.H.1    Dickerson, J.A.2    Tan, L.C.3    Fassler, J.4
  • 8
    • 0029890554 scopus 로고    scopus 로고
    • Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells
    • Xu Y, Rojkind M, Czaja MJ. Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells. Gastroenterology. 1996;110:1870-1877.
    • (1996) Gastroenterology. , vol.110 , pp. 1870-1877
    • Xu, Y.1    Rojkind, M.2    Czaja, M.J.3
  • 9
    • 0030827057 scopus 로고    scopus 로고
    • Tumor necrosis factor α and interleukin-1 signaling: Do MAPKK kinases connect it all?
    • Eder J. Tumor necrosis factor α and interleukin-1 signaling: do MAPKK kinases connect it all? Trends Pharmacol Sci. 1997;18:319-322.
    • (1997) Trends Pharmacol Sci. , vol.18 , pp. 319-322
    • Eder, J.1
  • 10
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian MAPKs
    • Cano E, Mahadevan LC. Parallel signal processing among mammalian MAPKs. Trends Biochem Sci. 1995;20:117-122.
    • (1995) Trends Biochem Sci. , vol.20 , pp. 117-122
    • Cano, E.1    Mahadevan, L.C.2
  • 11
    • 0028073283 scopus 로고
    • MAPKs: New JNK expands the group
    • Davis RJ. MAPKs: new JNK expands the group. Trends Biochem Sci. 1994;19:470-473.
    • (1994) Trends Biochem Sci. , vol.19 , pp. 470-473
    • Davis, R.J.1
  • 12
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb MH, Goldsmith EJ. How MAP kinases are regulated. J Biol Chem. 1995;25:14843-14846.
    • (1995) J Biol Chem. , vol.25 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 13
    • 0029896250 scopus 로고    scopus 로고
    • Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase
    • Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee J-D. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem. 1996;271:16586-16590.
    • (1996) J Biol Chem. , vol.271 , pp. 16586-16590
    • Abe, J.1    Kusuhara, M.2    Ulevitch, R.J.3    Berk, B.C.4    Lee, J.-D.5
  • 15
    • 0032488837 scopus 로고    scopus 로고
    • P38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor
    • Berghe WV, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, Haegeman G. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J Biol Chem. 1998; 273:3285-3290.
    • (1998) J Biol Chem. , vol.273 , pp. 3285-3290
    • Berghe, W.V.1    Plaisance, S.2    Boone, E.3    De Bosscher, K.4    Schmitz, M.L.5    Fiers, W.6    Haegeman, G.7
  • 16
    • 0030152161 scopus 로고    scopus 로고
    • TNF regulates the in vivo occupancy of both distal and proximal regulatory regions of the MCP-1/JE gene
    • Ping D, Jones PL, Boss JM. TNF regulates the in vivo occupancy of both distal and proximal regulatory regions of the MCP-1/JE gene. Immunity. 1996;4:455-469.
    • (1996) Immunity. , vol.4 , pp. 455-469
    • Ping, D.1    Jones, P.L.2    Boss, J.M.3
  • 17
  • 18
    • 0027301258 scopus 로고
    • Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G: Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase
    • Satriano JA, Shuldiner M, Hora K, Xing Y, Shan Z, Schlondorff D. Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G: evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase. J Clin Invest. 1993;92:1564-1571.
    • (1993) J Clin Invest. , vol.92 , pp. 1564-1571
    • Satriano, J.A.1    Shuldiner, M.2    Hora, K.3    Xing, Y.4    Shan, Z.5    Schlondorff, D.6
  • 19
    • 0025881171 scopus 로고
    • Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells
    • Griendling KK, Taubman MB, Akers M, Mendlowitz M, Alexander RW. Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells. J Biol Chem. 1991;266: 15498-15504.
    • (1991) J Biol Chem. , vol.266 , pp. 15498-15504
    • Griendling, K.K.1    Taubman, M.B.2    Akers, M.3    Mendlowitz, M.4    Alexander, R.W.5
  • 20
    • 0029661428 scopus 로고    scopus 로고
    • P22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells
    • Ushio Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem. 1996;271: 23317-23321.
    • (1996) J Biol Chem. , vol.271 , pp. 23317-23321
    • Ushio Fukai, M.1    Zafari, A.M.2    Fukui, T.3    Ishizaka, N.4    Griendling, K.K.5
  • 22
    • 0030951146 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta
    • Guan Z, Baier LD, Morrison AR. p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta. J Biol Chem. 1997;272: 8083-8089.
    • (1997) J Biol Chem. , vol.272 , pp. 8083-8089
    • Guan, Z.1    Baier, L.D.2    Morrison, A.R.3
  • 23
    • 0028920561 scopus 로고
    • Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells
    • Duff JL, Monia BP, Berk BC. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. J Biol Chem. 1995;270:7161-7166.
    • (1995) J Biol Chem. , vol.270 , pp. 7161-7166
    • Duff, J.L.1    Monia, B.P.2    Berk, B.C.3
  • 24
    • 0030886770 scopus 로고    scopus 로고
    • Oxidative stress activates extracellular signal-regulated kinases through src and ras in cultured cardiac myocytes of neonatal rats
    • Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y, Yazaki Y. Oxidative stress activates extracellular signal-regulated kinases through src and ras in cultured cardiac myocytes of neonatal rats. J Clin Invest. 1997;100:1813-1821.
    • (1997) J Clin Invest. , vol.100 , pp. 1813-1821
    • Aikawa, R.1    Komuro, I.2    Yamazaki, T.3    Zou, Y.4    Kudoh, S.5    Tanaka, M.6    Shiojima, I.7    Hiroi, Y.8    Yazaki, Y.9
  • 25
    • 0028365310 scopus 로고
    • Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
    • Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994;74:1141-1148.
    • (1994) Circ Res. , vol.74 , pp. 1141-1148
    • Griendling, K.K.1    Minieri, C.A.2    Ollerenshaw, J.D.3    Alexander, R.W.4
  • 26
    • 0032493829 scopus 로고    scopus 로고
    • Cytokine-mediated induction of ceramide production is redox-sensitive: Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases
    • Singh I, Pahan K, Khan M, Singh AK. Cytokine-mediated induction of ceramide production is redox-sensitive: implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases. J Biol Chem. 1998;273:20354-20362.
    • (1998) J Biol Chem. , vol.273 , pp. 20354-20362
    • Singh, I.1    Pahan, K.2    Khan, M.3    Singh, A.K.4
  • 27
    • 0021795717 scopus 로고
    • Modulation of oxidant lung injury by using liposome-entrapped superoxide dismutase and catalase
    • Freeman BA, Turrens JF, Mirza Z, Crapo JD, Young SL. Modulation of oxidant lung injury by using liposome-entrapped superoxide dismutase and catalase. Fed Proc. 1985;44:2591-2595.
    • (1985) Fed Proc. , vol.44 , pp. 2591-2595
    • Freeman, B.A.1    Turrens, J.F.2    Mirza, Z.3    Crapo, J.D.4    Young, S.L.5
  • 29
    • 0027365599 scopus 로고
    • Vascular cell-adhesion molecule-1 (VCAM-1) gene-transcription and expression are regulated through an antioxidant sensitive mechanism in human vascular endothelial cells
    • Marui N, Offerman M, Swcrlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. Vascular cell-adhesion molecule-1 (VCAM-1) gene-transcription and expression are regulated through an antioxidant sensitive mechanism in human vascular endothelial cells. J Clin Invest. 1993;92:1866-1874.
    • (1993) J Clin Invest. , vol.92 , pp. 1866-1874
    • Marui, N.1    Offerman, M.2    Swcrlick, R.3    Kunsch, C.4    Rosen, C.A.5    Ahmad, M.6    Alexander, R.W.7    Medford, R.M.8
  • 31
    • 0032510977 scopus 로고    scopus 로고
    • P38 MAP kinase is a critical component of the redox-sensitive signaling pathways by angiotensin II: Role in vascular smooth muscle cell hypertrophy
    • Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. p38 MAP kinase is a critical component of the redox-sensitive signaling pathways by angiotensin II: role in vascular smooth muscle cell hypertrophy. J Biol Chem. 1998;273:15022-15029.
    • (1998) J Biol Chem. , vol.273 , pp. 15022-15029
    • Ushio-Fukai, M.1    Alexander, R.W.2    Akers, M.3    Griendling, K.K.4
  • 32
    • 0030808984 scopus 로고    scopus 로고
    • Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
    • Kummer JL, Rao PK, Heidenreich KA. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997;272:20490-20494.
    • (1997) J Biol Chem. , vol.272 , pp. 20490-20494
    • Kummer, J.L.1    Rao, P.K.2    Heidenreich, K.A.3
  • 34
    • 0029880123 scopus 로고    scopus 로고
    • Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1. And collagenase expression in cultured human synovial cells
    • Sato M, Miyazaki T, Nagaya T, Murata Y, Ida N, Maeda K, Seo H. Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1. and collagenase expression in cultured human synovial cells. J Rheumatol. 1996;23: 432-438.
    • (1996) J Rheumatol. , vol.23 , pp. 432-438
    • Sato, M.1    Miyazaki, T.2    Nagaya, T.3    Murata, Y.4    Ida, N.5    Maeda, K.6    Seo, H.7
  • 35
    • 0030849255 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in the induction of chemokine JE/MCP-1 gene by phorbol-12-myristate-13-acetate in Balb 3T3 cells
    • Murata M, Arata S, Nose K. Involvement of reactive oxygen species in the induction of chemokine JE/MCP-1 gene by phorbol-12-myristate-13-acetate in Balb 3T3 cells. Cell Struct Funct. 1997;22:231-238.
    • (1997) Cell Struct Funct. , vol.22 , pp. 231-238
    • Murata, M.1    Arata, S.2    Nose, K.3
  • 38
    • 0032556924 scopus 로고    scopus 로고
    • Ararchidonic acid activates Jun N-terminal kinase in vascular smooth muscle cells
    • Madamanchi NR, Bukoski RD, Runge MS, Rao GN. Ararchidonic acid activates Jun N-terminal kinase in vascular smooth muscle cells. Oncogene. 1998;16:417-422.
    • (1998) Oncogene. , vol.16 , pp. 417-422
    • Madamanchi, N.R.1    Bukoski, R.D.2    Runge, M.S.3    Rao, G.N.4
  • 39
    • 0032476632 scopus 로고    scopus 로고
    • Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells
    • Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM. Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Circ Res. 1998;83: 952-959.
    • (1998) Circ Res. , vol.83 , pp. 952-959
    • Chen, X.L.1    Tummala, P.E.2    Olbrych, M.T.3    Alexander, R.W.4    Medford, R.M.5
  • 40
    • 0032936517 scopus 로고    scopus 로고
    • The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells
    • Goebeler M, Kilian K, Gillitzer R, Kunz M, Yoshimura T, Brocker EB, Rapp UR, Ludwig S. The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells. Blood. 1999;93:857-865.
    • (1999) Blood. , vol.93 , pp. 857-865
    • Goebeler, M.1    Kilian, K.2    Gillitzer, R.3    Kunz, M.4    Yoshimura, T.5    Brocker, E.B.6    Rapp, U.R.7    Ludwig, S.8
  • 41
    • 0033083043 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase p38 is necessary for interleukin-1β-induced monocyte chemoattractant protein-1 expression by human mesangial cells
    • Rovin BH, Wilmer WA, Danne M, Dickerson JA, Dixon CL, Lu L. The mitogen-activated protein kinase p38 is necessary for interleukin-1β-induced monocyte chemoattractant protein-1 expression by human mesangial cells. Cytokine. 1999;11:118-126.
    • (1999) Cytokine. , vol.11 , pp. 118-126
    • Rovin, B.H.1    Wilmer, W.A.2    Danne, M.3    Dickerson, J.A.4    Dixon, C.L.5    Lu, L.6
  • 42
    • 0032213909 scopus 로고    scopus 로고
    • Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: A brief overview
    • Chakraborti S, Chakraborti T. Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: a brief overview. Cell Signal. 1998;10:675-683.
    • (1998) Cell Signal. , vol.10 , pp. 675-683
    • Chakraborti, S.1    Chakraborti, T.2
  • 43
    • 0030770395 scopus 로고    scopus 로고
    • Platelet-derived growth factor stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein-1 in human aortic smooth muscle cells
    • Marumo T, Schini-Kerth VB, Fisslthaler B, Busse R. Platelet-derived growth factor stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein-1 in human aortic smooth muscle cells. Circulation. 1997;96:2361-2367.
    • (1997) Circulation. , vol.96 , pp. 2361-2367
    • Marumo, T.1    Schini-Kerth, V.B.2    Fisslthaler, B.3    Busse, R.4
  • 44
    • 0032491398 scopus 로고    scopus 로고
    • A redox-triggered ras-effector interaction: Recruitment of phosphatidylinositol 3′-kinase to Ras by redox stress
    • Deora AA, Win T, Vanhaesebroeck B, Lander HM. A redox-triggered ras-effector interaction: recruitment of phosphatidylinositol 3′-kinase to Ras by redox stress. J Biol Chem. 1998;273:29923-29928.
    • (1998) J Biol Chem. , vol.273 , pp. 29923-29928
    • Deora, A.A.1    Win, T.2    Vanhaesebroeck, B.3    Lander, H.M.4
  • 45
    • 0029130785 scopus 로고
    • Activation of nuclear factor-kappa B correlates with MCP-1 expression by human mesangial cells
    • Rovin BH, Dickerson JA, Tan LC, Hebert CA. Activation of nuclear factor-kappa B correlates with MCP-1 expression by human mesangial cells. Kidney Int. 1995;48:1263-1271.
    • (1995) Kidney Int. , vol.48 , pp. 1263-1271
    • Rovin, B.H.1    Dickerson, J.A.2    Tan, L.C.3    Hebert, C.A.4
  • 46
    • 0033555787 scopus 로고    scopus 로고
    • Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene
    • Ping D, Boekhoudt GH, Rogers EM, Boss JM. Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene. J Immunol. 1999;162: 727-734.
    • (1999) J Immunol. , vol.162 , pp. 727-734
    • Ping, D.1    Boekhoudt, G.H.2    Rogers, E.M.3    Boss, J.M.4
  • 47
    • 0032548944 scopus 로고    scopus 로고
    • Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha
    • Ahmad M, Theofanidis P, Medford RM. Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha. J Biol Chem. 1998;273:4616-4621.
    • (1998) J Biol Chem. , vol.273 , pp. 4616-4621
    • Ahmad, M.1    Theofanidis, P.2    Medford, R.M.3
  • 48
    • 0028907394 scopus 로고
    • Endothelin-mediated positive inotropic effect induced by free radicals in isolated cardiac muscle
    • De Keulenaer GW, Andries LA, Sys SU, Brutsaert DL. Endothelin-mediated positive inotropic effect induced by free radicals in isolated cardiac muscle. Circ Res. 1995;76:878-884.
    • (1995) Circ Res. , vol.76 , pp. 878-884
    • De Keulenaer, G.W.1    Andries, L.A.2    Sys, S.U.3    Brutsaert, D.L.4
  • 49
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524-526.
    • (1987) Nature. , vol.327 , pp. 524-526
    • Palmer, R.M.J.1    Ferrige, A.G.2    Moncada, S.3


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