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Volumn 192, Issue 12, 2014, Pages 6020-6027

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT INHIBITOR; CP40; INTERLEUKIN 17; OSTEOCLAST DIFFERENTIATION FACTOR; UNCLASSIFIED DRUG;

EID: 84902180107     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400569     Document Type: Article
Times cited : (95)

References (75)
  • 1
    • 84866507629 scopus 로고    scopus 로고
    • Prevalence of periodontitis in adults in the United States: 2009 and 2010
    • Eke, P. I., B. A. Dye, L. Wei, G. O. Thornton-Evans, and R. J. Genco. 2012. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J. Dent. Res. 91:914-920.
    • (2012) J. Dent. Res. , vol.91 , pp. 914-920
    • Eke, P.I.1    Dye, B.A.2    Wei, L.3    Thornton-Evans, G.O.4    Genco, R.J.5
  • 3
    • 84891372427 scopus 로고    scopus 로고
    • Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response
    • Hajishengallis, G. 2014. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol. 35:3-11.
    • (2014) Trends Immunol. , vol.35 , pp. 3-11
    • Hajishengallis, G.1
  • 6
    • 82155185364 scopus 로고    scopus 로고
    • Diabetes mellitus and periodontitis: A tale of two common interrelated diseases
    • Lalla, E., and P. N. Papapanou. 2011. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat. Rev. Endocrinol. 7:738-748.
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 738-748
    • Lalla, E.1    Papapanou, P.N.2
  • 7
    • 84893200159 scopus 로고    scopus 로고
    • Adverse pregnancy outcomes (APOs) and periodontal disease: Pathogenic mechanisms
    • Madianos, P. N., Y. A. Bobetsis, and S. Offenbacher. 2013. Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms. J. Clin. Periodontol. 40(Suppl 14):S170-S180.
    • (2013) J. Clin. Periodontol. , vol.40 , Issue.SUPPL. 14
    • Madianos, P.N.1    Bobetsis, Y.A.2    Offenbacher, S.3
  • 8
    • 0036044319 scopus 로고    scopus 로고
    • The economics of periodontal diseases
    • Brown, L. J., B. A. Johns, and T. P. Wall. 2002. The economics of periodontal diseases. Periodontol. 2000 29:223-234.
    • (2002) Periodontol. 2000 , vol.29 , pp. 223-234
    • Brown, L.J.1    Johns, B.A.2    Wall, T.P.3
  • 9
    • 78650062475 scopus 로고    scopus 로고
    • Oral biofilm-associated diseases: Trends and implications for quality of life, systemic health and expenditures
    • Beikler, T., and T. F. Flemmig. 2011. Oral biofilm-associated diseases: trends and implications for quality of life, systemic health and expenditures. Periodontol. 2000 55:87-103.
    • (2011) Periodontol. 2000 , vol.55 , pp. 87-103
    • Beikler, T.1    Flemmig, T.F.2
  • 10
    • 0036370385 scopus 로고    scopus 로고
    • Classifying periodontal diseases-a long-standing dilemma
    • Armitage, G. C. 2002. Classifying periodontal diseases-a long-standing dilemma. Periodontol. 2000 30:9-23.
    • (2002) Periodontol. 2000 , vol.30 , pp. 9-23
    • Armitage, G.C.1
  • 12
    • 84855560497 scopus 로고    scopus 로고
    • Paradigm shift in the pharmacological management of periodontal diseases
    • Hasturk, H., A. Kantarci, and T. E. Van Dyke. 2012. Paradigm shift in the pharmacological management of periodontal diseases. Front. Oral Biol. 15:160-176.
    • (2012) Front. Oral Biol. , vol.15 , pp. 160-176
    • Hasturk, H.1    Kantarci, A.2    Van Dyke, T.E.3
  • 13
    • 84934434579 scopus 로고    scopus 로고
    • Complement-targeted therapeutics in periodontitis
    • Hajishengallis, G., and J. D. Lambris. 2013. Complement-targeted therapeutics in periodontitis. Adv. Exp. Med. Biol. 735:197-206.
    • (2013) Adv. Exp. Med. Biol. , vol.735 , pp. 197-206
    • Hajishengallis, G.1    Lambris, J.D.2
  • 14
    • 78049417345 scopus 로고    scopus 로고
    • Complement and periodontitis
    • Hajishengallis, G. 2010. Complement and periodontitis. Biochem. Pharmacol. 80:1992-2001.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1992-2001
    • Hajishengallis, G.1
  • 16
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • Ricklin, D., G. Hajishengallis, K. Yang, and J. D. Lambris. 2010. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11:785-797.
    • (2010) Nat. Immunol. , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 17
    • 0024528560 scopus 로고
    • Assessment of complement cleavage in gingival fluid during experimental gingivitis in man
    • Patters, M. R., C. E. Niekrash, and N. P. Lang. 1989. Assessment of complement cleavage in gingival fluid during experimental gingivitis in man. J. Clin. Periodontol. 16:33-37.
    • (1989) J. Clin. Periodontol. , vol.16 , pp. 33-37
    • Patters, M.R.1    Niekrash, C.E.2    Lang, N.P.3
  • 19
    • 0017398665 scopus 로고
    • Detection of functional complement components in gingival crevicular fluid from humans with periodontal diseases
    • Courts, F. J., R. J. Boackle, H. H. Fudenberg, and M. S. Silverman. 1977. Detection of functional complement components in gingival crevicular fluid from humans with periodontal diseases. J. Dent. Res. 56:327-331.
    • (1977) J. Dent. Res. , vol.56 , pp. 327-331
    • Courts, F.J.1    Boackle, R.J.2    Fudenberg, H.H.3    Silverman, M.S.4
  • 20
    • 0017605530 scopus 로고
    • Gingival fluid and serum in periodontal diseases. II. Evidence for cleavage of complement components C3, C3 proactivator (factor B) and C4 in gingival fluid
    • Schenkein, H. A., and R. J. Genco. 1977. Gingival fluid and serum in periodontal diseases. II. Evidence for cleavage of complement components C3, C3 proactivator (factor B) and C4 in gingival fluid. J. Periodontol. 48:778-784.
    • (1977) J. Periodontol. , vol.48 , pp. 778-784
    • Schenkein, H.A.1    Genco, R.J.2
  • 21
    • 0022710062 scopus 로고
    • Assessment of complement cleavage in gingival fluid in humans with and without periodontal disease
    • Niekrash, C. E., and M. R. Patters. 1986. Assessment of complement cleavage in gingival fluid in humans with and without periodontal disease. J. Periodontal Res. 21:233-242.
    • (1986) J. Periodontal Res. , vol.21 , pp. 233-242
    • Niekrash, C.E.1    Patters, M.R.2
  • 24
    • 84869761067 scopus 로고    scopus 로고
    • Local complement-targeted intervention in periodontitis: Proof-of-concept using a C5a receptor (CD88) antagonist
    • Abe, T., K. B. Hosur, E. Hajishengallis, E. S. Reis, D. Ricklin, J. D. Lambris, and G. Hajishengallis. 2012. Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J. Immunol. 189:5442-5448.
    • (2012) J. Immunol. , vol.189 , pp. 5442-5448
    • Abe, T.1    Hosur, K.B.2    Hajishengallis, E.3    Reis, E.S.4    Ricklin, D.5    Lambris, J.D.6    Hajishengallis, G.7
  • 29
    • 84861342868 scopus 로고    scopus 로고
    • Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing
    • Griffen, A. L., C. J. Beall, J. H. Campbell, N. D. Firestone, P. S. Kumar, Z. K. Yang, M. Podar, and E. J. Leys. 2012. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing. ISME J. 6:1176-1185.
    • (2012) ISME J. , vol.6 , pp. 1176-1185
    • Griffen, A.L.1    Beall, C.J.2    Campbell, J.H.3    Firestone, N.D.4    Kumar, P.S.5    Yang, Z.K.6    Podar, M.7    Leys, E.J.8
  • 30
    • 84876842615 scopus 로고    scopus 로고
    • The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
    • Abusleme, L., A. K. Dupuy, N. Dutzan, N. Silva, J. A. Burleson, L. D. Strausbaugh, J. Gamonal, and P. I. Diaz. 2013. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 7:1016-1025.
    • (2013) ISME J. , vol.7 , pp. 1016-1025
    • Abusleme, L.1    Dupuy, A.K.2    Dutzan, N.3    Silva, N.4    Burleson, J.A.5    Strausbaugh, L.D.6    Gamonal, J.7    Diaz, P.I.8
  • 31
    • 84875990477 scopus 로고    scopus 로고
    • Complement in immune and inflammatory disorders: Therapeutic interventions
    • Ricklin, D., and J. D. Lambris. 2013. Complement in immune and inflammatory disorders: therapeutic interventions. J. Immunol. 190:3839-3847.
    • (2013) J. Immunol. , vol.190 , pp. 3839-3847
    • Ricklin, D.1    Lambris, J.D.2
  • 32
    • 0021949676 scopus 로고
    • Morphological studies on periodontal disease in the cynomolgus monkey. II. Light microscopic observations on ligature-induced periodontitis
    • Brecx, M. C., J. Nalbandian, K. Ooya, K. S. Kornman, and P. B. Robertson. 1985. Morphological studies on periodontal disease in the cynomolgus monkey. II. Light microscopic observations on ligature-induced periodontitis. J. Periodontal Res. 20:165-175.
    • (1985) J. Periodontal Res. , vol.20 , pp. 165-175
    • Brecx, M.C.1    Nalbandian, J.2    Ooya, K.3    Kornman, K.S.4    Robertson, P.B.5
  • 34
    • 0019443764 scopus 로고
    • The microbiology of ligature-induced periodontitis in the cynomolgus monkey
    • Kornman, K. S., S. C. Holt, and P. B. Robertson. 1981. The microbiology of ligature-induced periodontitis in the cynomolgus monkey. J. Periodontal Res. 16:363-371.
    • (1981) J. Periodontal Res. , vol.16 , pp. 363-371
    • Kornman, K.S.1    Holt, S.C.2    Robertson, P.B.3
  • 35
    • 0031908674 scopus 로고    scopus 로고
    • IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis
    • Assuma, R., T. Oates, D. Cochran, S. Amar, and D. T. Graves. 1998. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J. Immunol. 160:403-409.
    • (1998) J. Immunol. , vol.160 , pp. 403-409
    • Assuma, R.1    Oates, T.2    Cochran, D.3    Amar, S.4    Graves, D.T.5
  • 38
    • 0029795542 scopus 로고    scopus 로고
    • The C5a chemoattractant receptor mediates mucosal defence to infection
    • Höpken, U. E., B. Lu, N. P. Gerard, and C. Gerard. 1996. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 383:86-89.
    • (1996) Nature , vol.383 , pp. 86-89
    • Höpken, U.E.1    Lu, B.2    Gerard, N.P.3    Gerard, C.4
  • 39
    • 0033801979 scopus 로고    scopus 로고
    • Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice
    • Baker, P. J., M. Dixon, and D. C. Roopenian. 2000. Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect. Immun. 68:5864-5868.
    • (2000) Infect. Immun. , vol.68 , pp. 5864-5868
    • Baker, P.J.1    Dixon, M.2    Roopenian, D.C.3
  • 40
    • 84869029797 scopus 로고    scopus 로고
    • Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment
    • McIntosh, M. L., and G. Hajishengallis. 2012. Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment. Mol. Oral Microbiol. 27:449-457.
    • (2012) Mol. Oral Microbiol. , vol.27 , pp. 449-457
    • McIntosh, M.L.1    Hajishengallis, G.2
  • 41
    • 38149006156 scopus 로고    scopus 로고
    • The use of rodent models to investigate host-bacteria interactions related to periodontal diseases
    • Graves, D. T., D. Fine, Y. T. Teng, T. E. Van Dyke, and G. Hajishengallis. 2008. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J. Clin. Periodontol. 35:89-105.
    • (2008) J. Clin. Periodontol. , vol.35 , pp. 89-105
    • Graves, D.T.1    Fine, D.2    Teng, Y.T.3    Van Dyke, T.E.4    Hajishengallis, G.5
  • 42
    • 84880046627 scopus 로고    scopus 로고
    • Optimization of the ligature-induced periodontitis model in mice
    • Abe, T., and G. Hajishengallis. 2013. Optimization of the ligature-induced periodontitis model in mice. J. Immunol. Methods 394:49-54.
    • (2013) J. Immunol. Methods , vol.394 , pp. 49-54
    • Abe, T.1    Hajishengallis, G.2
  • 44
    • 1542507065 scopus 로고    scopus 로고
    • Periodontal diagnoses and classification of periodontal diseases
    • Armitage, G. C. 2004. Periodontal diagnoses and classification of periodontal diseases. Periodontol. 2000 34:9-21.
    • (2004) Periodontol. 2000 , vol.34 , pp. 9-21
    • Armitage, G.C.1
  • 45
    • 79251502922 scopus 로고    scopus 로고
    • Antibody to receptor activator of NF-κB ligand ameliorates T cell-mediated periodontal bone resorption
    • Lin, X., X. Han, T. Kawai, and M. A. Taubman. 2011. Antibody to receptor activator of NF-κB ligand ameliorates T cell-mediated periodontal bone resorption. Infect. Immun. 79:911-917.
    • (2011) Infect. Immun. , vol.79 , pp. 911-917
    • Lin, X.1    Han, X.2    Kawai, T.3    Taubman, M.A.4
  • 47
    • 79251544574 scopus 로고    scopus 로고
    • The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss
    • Liang, S., J. L. Krauss, H. Domon, M. L. McIntosh, K. B. Hosur, H. Qu, F. Li, A. Tzekou, J. D. Lambris, and G. Hajishengallis. 2011. The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J. Immunol. 186:869-877.
    • (2011) J. Immunol. , vol.186 , pp. 869-877
    • Liang, S.1    Krauss, J.L.2    Domon, H.3    McIntosh, M.L.4    Hosur, K.B.5    Qu, H.6    Li, F.7    Tzekou, A.8    Lambris, J.D.9    Hajishengallis, G.10
  • 48
    • 0026725842 scopus 로고
    • Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis
    • Wingrove, J. A., R. G. Di Scipio, Z. Chen, J. Potempa, J. Travis, and T. E. Hugli. 1992. Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. J. Biol. Chem. 267:18902-18907.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18902-18907
    • Wingrove, J.A.1    Di Scipio, R.G.2    Chen, Z.3    Potempa, J.4    Travis, J.5    Hugli, T.E.6
  • 49
    • 38049148318 scopus 로고    scopus 로고
    • Dietinduced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge
    • Amar, S., Q. Zhou, Y. Shaik-Dasthagirisaheb, and S. Leeman. 2007. Dietinduced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge. Proc. Natl. Acad. Sci. USA 104:20466-20471.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 20466-20471
    • Amar, S.1    Zhou, Q.2    Shaik-Dasthagirisaheb, Y.3    Leeman, S.4
  • 50
    • 84901611214 scopus 로고    scopus 로고
    • Aging and its impact on innate immunity and inflammation: Implications for periodontitis
    • Hajishengallis, G. 2014. Aging and its impact on innate immunity and inflammation: Implications for periodontitis. J. Oral Biosci. 56:30-37.
    • (2014) J. Oral Biosci. , vol.56 , pp. 30-37
    • Hajishengallis, G.1
  • 52
    • 84866934694 scopus 로고    scopus 로고
    • Targeting IL-17 and TH17 cells in chronic inflammation
    • Miossec, P., and J. K. Kolls. 2012. Targeting IL-17 and TH17 cells in chronic inflammation. Nat. Rev. Drug Discov. 11:763-776.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 763-776
    • Miossec, P.1    Kolls, J.K.2
  • 54
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Inflammation and Host Response to Injury, Large Scale Collaborative Research Program
    • Inflammation and Host Response to Injury, Large Scale Collaborative Research Program. 2013. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 110:3507-3512.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 3507-3512
  • 55
    • 77950187449 scopus 로고    scopus 로고
    • Crosstalk pathways between Tolllike receptors and the complement system
    • Hajishengallis, G., and J. D. Lambris. 2010. Crosstalk pathways between Tolllike receptors and the complement system. Trends Immunol. 31:154-163.
    • (2010) Trends Immunol. , vol.31 , pp. 154-163
    • Hajishengallis, G.1    Lambris, J.D.2
  • 57
    • 33947629255 scopus 로고    scopus 로고
    • Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
    • Miyake, K. 2007. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 19:3-10.
    • (2007) Semin. Immunol. , vol.19 , pp. 3-10
    • Miyake, K.1
  • 58
    • 77949683133 scopus 로고    scopus 로고
    • Extracellular matrix molecules: Endogenous danger signals as new drug targets in kidney diseases
    • Schaefer, L. 2010. Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases. Curr. Opin. Pharmacol. 10:185-190.
    • (2010) Curr. Opin. Pharmacol. , vol.10 , pp. 185-190
    • Schaefer, L.1
  • 59
    • 84866050890 scopus 로고    scopus 로고
    • Complement and dysbiosis in periodontal disease
    • Hajishengallis, G., and J. D. Lambris. 2012. Complement and dysbiosis in periodontal disease. Immunobiology 217:1111-1116.
    • (2012) Immunobiology , vol.217 , pp. 1111-1116
    • Hajishengallis, G.1    Lambris, J.D.2
  • 60
    • 84862081068 scopus 로고    scopus 로고
    • Complement C3ainduced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice
    • Mizutani, N., H. Goshima, T. Nabe, and S. Yoshino. 2012. Complement C3ainduced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice. J. Immunol. 188:5694-5705.
    • (2012) J. Immunol. , vol.188 , pp. 5694-5705
    • Mizutani, N.1    Goshima, H.2    Nabe, T.3    Yoshino, S.4
  • 61
    • 79960559299 scopus 로고    scopus 로고
    • Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in agerelated macular degeneration
    • Liu, B., L. Wei, C. Meyerle, J. Tuo, H. N. Sen, Z. Li, S. Chakrabarty, E. Agron, C. C. Chan, M. L. Klein, et al. 2011. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in agerelated macular degeneration. J. Transl. Med. 9:1-12.
    • (2011) J. Transl. Med. , vol.9 , pp. 1-12
    • Liu, B.1    Wei, L.2    Meyerle, C.3    Tuo, J.4    Sen, H.N.5    Li, Z.6    Chakrabarty, S.7    Agron, E.8    Chan, C.C.9    Klein, M.L.10
  • 62
    • 77951028450 scopus 로고    scopus 로고
    • Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis
    • Xu, R., R. Wang, G. Han, J. Wang, G. Chen, L. Wang, X. Li, R. Guo, B. Shen, and Y. Li. 2010. Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis. Eur. J. Immunol. 40:1079-1088.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1079-1088
    • Xu, R.1    Wang, R.2    Han, G.3    Wang, J.4    Chen, G.5    Wang, L.6    Li, X.7    Guo, R.8    Shen, B.9    Li, Y.10
  • 63
    • 77956955243 scopus 로고    scopus 로고
    • Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    • Lajoie, S., I. P. Lewkowich, Y. Suzuki, J. R. Clark, A. A. Sproles, K. Dienger, A. L. Budelsky, and M. Wills-Karp. 2010. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat. Immunol. 11:928-935.
    • (2010) Nat. Immunol. , vol.11 , pp. 928-935
    • Lajoie, S.1    Lewkowich, I.P.2    Suzuki, Y.3    Clark, J.R.4    Sproles, A.A.5    Dienger, K.6    Budelsky, A.L.7    Wills-Karp, M.8
  • 64
    • 84860902599 scopus 로고    scopus 로고
    • Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis
    • Bosmann, M., J. V. Sarma, G. Atefi, F. S. Zetoune, and P. A. Ward. 2012. Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J. 26:1640-1651.
    • (2012) FASEB J. , vol.26 , pp. 1640-1651
    • Bosmann, M.1    Sarma, J.V.2    Atefi, G.3    Zetoune, F.S.4    Ward, P.A.5
  • 66
    • 84856591543 scopus 로고    scopus 로고
    • The RANKL-OPG system in clinical periodontology
    • Belibasakis, G. N., and N. Bostanci. 2012. The RANKL-OPG system in clinical periodontology. J. Clin. Periodontol. 39:239-248.
    • (2012) J. Clin. Periodontol. , vol.39 , pp. 239-248
    • Belibasakis, G.N.1    Bostanci, N.2
  • 67
    • 72249104320 scopus 로고    scopus 로고
    • Complementary Tolls in the periodontium: How periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host
    • Krauss, J. L., J. Potempa, J. D. Lambris, and G. Hajishengallis. 2010. Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol. 2000 52:141-162.
    • (2010) Periodontol. 2000 , vol.52 , pp. 141-162
    • Krauss, J.L.1    Potempa, J.2    Lambris, J.D.3    Hajishengallis, G.4
  • 68
    • 61449163214 scopus 로고    scopus 로고
    • Corruption of innate immunity by bacterial proteases
    • Potempa, J., and R. N. Pike. 2009. Corruption of innate immunity by bacterial proteases. J. Innate Immun. 1:70-87.
    • (2009) J. Innate Immun. , vol.1 , pp. 70-87
    • Potempa, J.1    Pike, R.N.2
  • 69
    • 63149173182 scopus 로고    scopus 로고
    • Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola
    • McDowell, J. V., B. Huang, J. C. Fenno, and R. T. Marconi. 2009. Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola. Infect. Immun. 77:1417-1425.
    • (2009) Infect. Immun. , vol.77 , pp. 1417-1425
    • McDowell, J.V.1    Huang, B.2    Fenno, J.C.3    Marconi, R.T.4
  • 70
    • 84857463226 scopus 로고    scopus 로고
    • A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system
    • Jusko, M., J. Potempa, A. Y. Karim, M. Ksiazek, K. Riesbeck, P. Garred, S. Eick, and A. M. Blom. 2012. A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system. J. Immunol. 188:2338-2349.
    • (2012) J. Immunol. , vol.188 , pp. 2338-2349
    • Jusko, M.1    Potempa, J.2    Karim, A.Y.3    Ksiazek, M.4    Riesbeck, K.5    Garred, P.6    Eick, S.7    Blom, A.M.8
  • 71
    • 34249799593 scopus 로고    scopus 로고
    • Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system
    • Popadiak, K., J. Potempa, K. Riesbeck, and A. M. Blom. 2007. Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J. Immunol. 178:7242-7250.
    • (2007) J. Immunol. , vol.178 , pp. 7242-7250
    • Popadiak, K.1    Potempa, J.2    Riesbeck, K.3    Blom, A.M.4
  • 73
    • 84893587232 scopus 로고    scopus 로고
    • Breaking bad: Manipulation of the host response by Porphyromonas gingivalis
    • Hajishengallis, G., and R. J. Lamont. 2014. Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur. J. Immunol. 44:328-338.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 328-338
    • Hajishengallis, G.1    Lamont, R.J.2
  • 74
    • 0037292394 scopus 로고    scopus 로고
    • Are dental diseases examples of ecological catastrophes?
    • Marsh, P. D. 2003. Are dental diseases examples of ecological catastrophes? Microbiology 149:279-294.
    • (2003) Microbiology , vol.149 , pp. 279-294
    • Marsh, P.D.1
  • 75
    • 84897542244 scopus 로고    scopus 로고
    • Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria
    • Risitano, A. M., D. Ricklin, Y. Huang, E. S. Reis, H. Chen, P. Ricci, Z. Lin, C. Pascariello, M. Raia, M. Sica, et al. 2014. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood 123:2094-2101
    • (2014) Blood , vol.123 , pp. 2094-2101
    • Risitano, A.M.1    Ricklin, D.2    Huang, Y.3    Reis, E.S.4    Chen, H.5    Ricci, P.6    Lin, Z.7    Pascariello, C.8    Raia, M.9    Sica, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.