메뉴 건너뛰기




Volumn 190, Issue 8, 2013, Pages 3839-3847

Complement in immune and inflammatory disorders: Therapeutic interventions

Author keywords

[No Author keywords available]

Indexed keywords

ADC 1004; AL 78898A; AMY 101; AMY 201; AMY 301; APL 1; ARC 1905; BIKACIOMAB; CACP 29; CCX 168; CETOR; COMPLEMENT; COMPLEMENT COMPONENT C1; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C5; COMPLEMENT INHIBITOR; ECULIZUMAB; HC 3 1496; IFX 1; IMMUNOMODULATING AGENT; LECTIN PATHWAY INHIBITOR; LFG 316; MEDI 7814; NAFAMSTAT; NAFAMSTAT MESILATE; NM 9308; NM 9401; NN 8209; NOX D 19; OMS 721; TA 106; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84875990477     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1203200     Document Type: Review
Times cited : (193)

References (91)
  • 1
    • 4544327145 scopus 로고    scopus 로고
    • Paul ehrlich: Magister mundi
    • Drews, J. 2004. Paul Ehrlich: magister mundi. Nat. Rev. Drug Discov. 3: 797-801.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 797-801
    • Drews, J.1
  • 2
    • 84858232815 scopus 로고    scopus 로고
    • Immune modulatory strategies: A playground with a swing and a seesaw
    • Hussell, T. 2012. Immune modulatory strategies: a playground with a swing and a seesaw. Expert Rev. Anti Infect. Ther. 10: 249-251.
    • (2012) Expert Rev. Anti Infect. Ther. , vol.10 , pp. 249-251
    • Hussell, T.1
  • 3
    • 84875968524 scopus 로고    scopus 로고
    • Complement in immune and inflammatory disorders: Pathophysiological mechanisms
    • Ricklin, D., and J. D. Lambris. 2013. Complement in immune and inflammatory disorders: pathophysiological mechanisms. J. Immunol. 190: 3831-3838.
    • (2013) J. Immunol. , vol.190 , pp. 3831-3838
    • Ricklin, D.1    Lambris, J.D.2
  • 4
    • 34548849117 scopus 로고    scopus 로고
    • The role of complement in inflammatory diseases from behind the scenes into the spotlight
    • Markiewski, M. M., and J. D. Lambris. 2007. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am. J. Pathol. 171: 715-727.
    • (2007) Am. J. Pathol. , vol.171 , pp. 715-727
    • Markiewski, M.M.1    Lambris, J.D.2
  • 5
    • 79961061340 scopus 로고    scopus 로고
    • C1-inhibitor: More than a serine protease inhibitor
    • Zeerleder, S. 2011. C1-inhibitor: more than a serine protease inhibitor. Semin. Thromb. Hemost. 37: 362-374.
    • (2011) Semin. Thromb. Hemost. , vol.37 , pp. 362-374
    • Zeerleder, S.1
  • 6
    • 84870890596 scopus 로고    scopus 로고
    • The effect of C1 inhibitor on myocardial ischemia and reperfusion injury
    • Lu, F., S. M. Fernandes, and A. E. Davis, III. 2013. The effect of C1 inhibitor on myocardial ischemia and reperfusion injury. Cardiovasc. Pathol. 22: 75-80.
    • (2013) Cardiovasc. Pathol. , vol.22 , pp. 75-80
    • Lu, F.1    Fernandes, S.M.2    Davis III, A.E.3
  • 8
    • 84875969071 scopus 로고    scopus 로고
    • C1 esterase inhibitor reverses invasive insulitis and hyperglycemia in a model of type 1 diabetes
    • October 10 - 15, 2012. Aegean Conferences, Chania, Greece
    • Koulmanda, M., M. E. Uknis, and T. B. Strom. 2012. C1 esterase inhibitor reverses invasive insulitis and hyperglycemia in a model of type 1 diabetes. In XXIV International Complement Workshop, October 10 - 15, 2012. Aegean Conferences, Chania, Greece.
    • (2012) XXIV International Complement Workshop
    • Koulmanda, M.1    Uknis, M.E.2    Strom, T.B.3
  • 9
    • 84872336333 scopus 로고    scopus 로고
    • Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: A focus on eculizumab
    • Schmidtko, J., S. Peine, Y. El-Housseini, M. Pascual, and P. Meier. 2013. Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: a focus on eculizumab. Am. J. Kidney Dis. 61: 289-299.
    • (2013) Am. J. Kidney Dis. , vol.61 , pp. 289-299
    • Schmidtko, J.1    Peine, S.2    El-Housseini, Y.3    Pascual, M.4    Meier, P.5
  • 10
    • 80155167232 scopus 로고    scopus 로고
    • Inhibition of terminal complement activation in severe shiga toxin-associated HUS - Perfect example for a fast track from bench to bedside
    • Orth-Höller, D., M. Riedl, and R. Würzner. 2011. Inhibition of terminal complement activation in severe Shiga toxin-associated HUS - perfect example for a fast track from bench to bedside. EMBO Mol Med 3: 617-619.
    • (2011) EMBO Mol Med , vol.3 , pp. 617-619
    • Orth-Höller, D.1    Riedl, M.2    Würzner, R.3
  • 11
    • 70450224874 scopus 로고    scopus 로고
    • Recent developments in low molecular weight complement inhibitors
    • Qu, H., D. Ricklin, and J. D. Lambris. 2009. Recent developments in low molecular weight complement inhibitors. Mol. Immunol. 47: 185-195.
    • (2009) Mol. Immunol. , vol.47 , pp. 185-195
    • Qu, H.1    Ricklin, D.2    Lambris, J.D.3
  • 14
    • 77950925961 scopus 로고    scopus 로고
    • Specific inhibition of the classical complement pathway with an engineered single-chain fv to C1q globular heads decreases complement activation by apoptotic cells
    • Duvall, M. R., H. Y. Hwang, and R. J. Boackle. 2010. Specific inhibition of the classical complement pathway with an engineered single-chain Fv to C1q globular heads decreases complement activation by apoptotic cells. Immunobiology 215: 395-405.
    • (2010) Immunobiology , vol.215 , pp. 395-405
    • Duvall, M.R.1    Hwang, H.Y.2    Boackle, R.J.3
  • 17
    • 84862023318 scopus 로고    scopus 로고
    • Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2
    • Héja, D., V. Harmat, K. Fodor, M. Wilmanns, J. Dobó, K. A. Kékesi, P. Závodszky, P. Gál, and G. Pál. 2012. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J. Biol. Chem. 287: 20290-20300.
    • (2012) J. Biol. Chem. , vol.287 , pp. 20290-20300
    • Héja, D.1    Harmat, V.2    Fodor, K.3    Wilmanns, M.4    Dobó, J.5    Kékesi, K.A.6    Závodszky, P.7    Gál, P.8    Pál, G.9
  • 18
    • 84868201188 scopus 로고    scopus 로고
    • Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis
    • Pavlov, V. I., M. O. Skjoedt, Y. Siow Tan, A. Rosbjerg, P. Garred, and G. L. Stahl. 2012. Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis. Circulation 126: 2227-2235.
    • (2012) Circulation , vol.126 , pp. 2227-2235
    • Pavlov, V.I.1    Skjoedt, M.O.2    Siow Tan, Y.3    Rosbjerg, A.4    Garred, P.5    Stahl, G.L.6
  • 19
    • 9644280856 scopus 로고    scopus 로고
    • The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
    • Harboe, M., G. Ulvund, L. Vien, M. Fung, and T. E. Mollnes. 2004. The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin. Exp. Immunol. 138: 439-446.
    • (2004) Clin. Exp. Immunol. , vol.138 , pp. 439-446
    • Harboe, M.1    Ulvund, G.2    Vien, L.3    Fung, M.4    Mollnes, T.E.5
  • 20
    • 84934440020 scopus 로고    scopus 로고
    • Progress and trends in complement therapeutics
    • Ricklin, D., and J. D. Lambris. 2013. Progress and trends in complement therapeutics. Adv. Exp. Med. Biol. 734: 1-22.
    • (2013) Adv. Exp. Med. Biol. , vol.734 , pp. 1-22
    • Ricklin, D.1    Lambris, J.D.2
  • 22
    • 77955901581 scopus 로고    scopus 로고
    • Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of escherichia coli sepsis
    • Silasi-Mansat, R., H. Zhu, N. I. Popescu, G. Peer, G. Sfyroera, P. Magotti, L. Ivanciu, C. Lupu, T. E. Mollnes, F. B. Taylor, et al. 2010. Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood 116: 1002-1010.
    • (2010) Blood , vol.116 , pp. 1002-1010
    • Silasi-Mansat, R.1    Zhu, H.2    Popescu, N.I.3    Peer, G.4    Sfyroera, G.5    Magotti, P.6    Ivanciu, L.7    Lupu, C.8    Mollnes, T.E.9    Taylor, F.B.10
  • 23
    • 79952118241 scopus 로고    scopus 로고
    • Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration
    • Chi, Z. L., T. Yoshida, J. D. Lambris, and T. Iwata. 2010. Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration. Adv. Exp. Med. Biol. 703: 127-135.
    • (2010) Adv. Exp. Med. Biol. , vol.703 , pp. 127-135
    • Chi, Z.L.1    Yoshida, T.2    Lambris, J.D.3    Iwata, T.4
  • 25
    • 67449093446 scopus 로고    scopus 로고
    • Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
    • Katschke, K. J., Jr., S. Stawicki, J. Yin, M. Steffek, H. Xi, L. Sturgeon, P. E. Hass, K. M. Loyet, L. Deforge, Y. Wu, et al. 2009. Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement. J. Biol. Chem. 284: 10473-10479.
    • (2009) J. Biol. Chem. , vol.284 , pp. 10473-10479
    • Katschke Jr., K.J.1    Stawicki, S.2    Yin, J.3    Steffek, M.4    Xi, H.5    Sturgeon, L.6    Hass, P.E.7    Loyet, K.M.8    Deforge, L.9    Wu, Y.10
  • 26
    • 77950380221 scopus 로고    scopus 로고
    • A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: Both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement
    • Lindorfer, M. A., A. W. Pawluczkowycz, E. M. Peek, K. Hickman, R. P. Taylor, and C. J. Parker. 2010. A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement. Blood 115: 2283-2291.
    • (2010) Blood , vol.115 , pp. 2283-2291
    • Lindorfer, M.A.1    Pawluczkowycz, A.W.2    Peek, E.M.3    Hickman, K.4    Taylor, R.P.5    Parker, C.J.6
  • 29
    • 77957840856 scopus 로고    scopus 로고
    • Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury
    • Kimura, Y., L. Zhou, T. Miwa, and W. C. Song. 2010. Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J. Clin. Invest. 120: 3545-3554.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3545-3554
    • Kimura, Y.1    Zhou, L.2    Miwa, T.3    Song, W.C.4
  • 31
    • 77957916119 scopus 로고    scopus 로고
    • Cobra venom factor: Structure, function, and humanization for therapeutic complement depletion
    • Vogel, C. W., and D. C. Fritzinger. 2010. Cobra venom factor: structure, function, and humanization for therapeutic complement depletion. Toxicon 56: 1198-1222.
    • (2010) Toxicon , vol.56 , pp. 1198-1222
    • Vogel, C.W.1    Fritzinger, D.C.2
  • 34
    • 84866011957 scopus 로고    scopus 로고
    • Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy
    • Ricklin, D. 2012. Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy. Immunobiology 217: 1057-1066.
    • (2012) Immunobiology , vol.217 , pp. 1057-1066
    • Ricklin, D.1
  • 35
    • 33750935095 scopus 로고    scopus 로고
    • The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass
    • Li, J. S., J. Jaggers, and P. A. Anderson. 2006. The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. Expert Rev. Cardiovasc. Ther. 4: 649-654.
    • (2006) Expert Rev. Cardiovasc. Ther. , vol.4 , pp. 649-654
    • Li, J.S.1    Jaggers, J.2    Anderson, P.A.3
  • 36
    • 0035064642 scopus 로고    scopus 로고
    • TP-10 (AVANT immunotherapeutics)
    • Rioux, P. 2001. TP-10 (AVANT Immunotherapeutics). Curr. Opin. Investig. Drugs 2: 364-371.
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , pp. 364-371
    • Rioux, P.1
  • 37
    • 0036864134 scopus 로고    scopus 로고
    • Targeting anticomplement agents
    • Smith, R. A. 2002. Targeting anticomplement agents. Biochem. Soc. Trans. 30: 1037-1041.
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 1037-1041
    • Smith, R.A.1
  • 39
    • 84934442096 scopus 로고    scopus 로고
    • CR2-mediated targeting of complement inhibitors: Bench-to-bedside using a novel strategy for site-specific complement modulation
    • Holers, V. M., B. Rohrer, and S. Tomlinson. 2013. CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Adv. Exp. Med. Biol. 734: 137-154.
    • (2013) Adv. Exp. Med. Biol. , vol.734 , pp. 137-154
    • Holers, V.M.1    Rohrer, B.2    Tomlinson, S.3
  • 40
    • 80055082640 scopus 로고    scopus 로고
    • Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases
    • Fridkis-Hareli, M., M. Storek, I. Mazsaroff, A. M. Risitano, A. S. Lundberg, C. J. Horvath, and V. M. Holers. 2011. Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Blood 118: 4705-4713.
    • (2011) Blood , vol.118 , pp. 4705-4713
    • Fridkis-Hareli, M.1    Storek, M.2    Mazsaroff, I.3    Risitano, A.M.4    Lundberg, A.S.5    Horvath, C.J.6    Holers, V.M.7
  • 41
    • 84863504959 scopus 로고    scopus 로고
    • The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment
    • Risitano, A. M., R. Notaro, C. Pascariello, M. Sica, L. del Vecchio, C. J. Horvath, M. Fridkis-Hareli, C. Selleri, M. A. Lindorfer, R. P. Taylor, et al. 2012. The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. Blood 119: 6307-6316.
    • (2012) Blood , vol.119 , pp. 6307-6316
    • Risitano, A.M.1    Notaro, R.2    Pascariello, C.3    Sica, M.4    Del Vecchio, L.5    Horvath, C.J.6    Fridkis-Hareli, M.7    Selleri, C.8    Lindorfer, M.A.9    Taylor, R.P.10
  • 42
    • 84864605570 scopus 로고    scopus 로고
    • Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization
    • Rohrer, B., B. Coughlin, M. Bandyopadhyay, and V. M. Holers. 2012. Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. J. Ocul. Pharmacol. Ther. 28: 402-409.
    • (2012) J. Ocul. Pharmacol. Ther. , vol.28 , pp. 402-409
    • Rohrer, B.1    Coughlin, B.2    Bandyopadhyay, M.3    Holers, V.M.4
  • 43
    • 84875977072 scopus 로고    scopus 로고
    • The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer models and acts by CR2-dependent targeting of CR1 regulatory activity
    • Holers, M., N. Banda, G. Mehta, M. Fridkis-Hareli, E. Or, M. Storek, R. Altman, K. Johnson, and S. Katti. 2012. The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer models and acts by CR2-dependent targeting of CR1 regulatory activity. Immunobiology 217: 1210.
    • (2012) Immunobiology , vol.217 , pp. 1210
    • Holers, M.1    Banda, N.2    Mehta, G.3    Fridkis-Hareli, M.4    Or, E.5    Storek, M.6    Altman, R.7    Johnson, K.8    Katti, S.9
  • 44
    • 84875974452 scopus 로고    scopus 로고
    • Rational engineering of a novel complement regulator-based therapeutic affords triple targeting of host surfaces and pathway-specific inhibition of complement activation
    • Schmidt, C. Q., H. Bai, Z. Lin, A. M. Risitano, P. N. Barlow, D. Ricklin, and J. D. Lambris. 2012. Rational engineering of a novel complement regulator-based therapeutic affords triple targeting of host surfaces and pathway-specific inhibition of complement activation. Immunobiology 217: 1197.
    • (2012) Immunobiology , vol.217 , pp. 1197
    • Schmidt, C.Q.1    Bai, H.2    Lin, Z.3    Risitano, A.M.4    Barlow, P.N.5    Ricklin, D.6    Lambris, J.D.7
  • 46
    • 79954997898 scopus 로고    scopus 로고
    • Protection of nonself surfaces from complement attack by factor H-binding peptides: Implications for therapeutic medicine
    • Wu, Y. Q., H. Qu, G. Sfyroera, A. Tzekou, B. K. Kay, B. Nilsson, K. Nilsson Ekdahl, D. Ricklin, and J. D. Lambris. 2011. Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine. J. Immunol. 186: 4269-4277.
    • (2011) J. Immunol. , vol.186 , pp. 4269-4277
    • Wu, Y.Q.1    Qu, H.2    Sfyroera, G.3    Tzekou, A.4    Kay, B.K.5    Nilsson, B.6    Nilsson Ekdahl, K.7    Ricklin, D.8    Lambris, J.D.9
  • 49
    • 0023357139 scopus 로고
    • Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-C5 antibodies
    • Frei, Y., J. D. Lambris, and B. Stockinger. 1987. Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-C5 antibodies. Mol. Cell. Probes 1: 141-149.
    • (1987) Mol. Cell. Probes , vol.1 , pp. 141-149
    • Frei, Y.1    Lambris, J.D.2    Stockinger, B.3
  • 52
    • 0029114993 scopus 로고
    • Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease
    • Wang, Y., S. A. Rollins, J. A. Madri, and L. A. Matis. 1995. Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proc. Natl. Acad. Sci. USA 92: 8955-8959.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8955-8959
    • Wang, Y.1    Rollins, S.A.2    Madri, J.A.3    Matis, L.A.4
  • 54
    • 79959361476 scopus 로고    scopus 로고
    • Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: Combined results from the PRIMO-CABG I and II trials
    • PRIMO-CABG II Investigators
    • Smith, P. K., S. K. Shernan, J. C. Chen, M. Carrier, E. D. Verrier, P. X. Adams, T. G. Todaro, L. H. Muhlbaier, and J. H. Levy; PRIMO-CABG II Investigators. 2011. Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials. J. Thorac. Cardiovasc. Surg. 142: 89-98.
    • (2011) J. Thorac. Cardiovasc. Surg. , vol.142 , pp. 89-98
    • Smith, P.K.1    Shernan, S.K.2    Chen, J.C.3    Carrier, M.4    Verrier, E.D.5    Adams, P.X.6    Todaro, T.G.7    Muhlbaier, L.H.8    Levy, J.H.9
  • 56
    • 2442613898 scopus 로고    scopus 로고
    • Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: A randomized trial
    • PRIMO-CABG Investigators
    • Verrier, E. D., S. K. Shernan, K. M. Taylor, F. Van de Werf, M. F. Newman, J. C. Chen, M. Carrier, A. Haverich, K. J. Malloy, P. X. Adams, et al; PRIMO-CABG Investigators. 2004. Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial. JAMA 291: 2319-2327.
    • (2004) JAMA , vol.291 , pp. 2319-2327
    • Verrier, E.D.1    Shernan, S.K.2    Taylor, K.M.3    Van De Werf, F.4    Newman, M.F.5    Chen, J.C.6    Carrier, M.7    Haverich, A.8    Malloy, K.J.9    Adams, P.X.10
  • 59
    • 84863210085 scopus 로고    scopus 로고
    • Targeting complement factor 5 in combination with vascular endothelial growth factor (VEGF) inhibition for neo-vascular age related macular degeneration (AMD): Results of a phase 1 study
    • Ophthotech Study Group (Abstr.)
    • Cousins, S. W.; Ophthotech Study Group. 2010. Targeting complement factor 5 in combination with vascular endothelial growth factor (VEGF) inhibition for neo-vascular age related macular degeneration (AMD): results of a phase 1 study. Invest. Ophthalmol. Vis. Sci. 51: 1251 (Abstr.).
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 1251
    • Cousins, S.W.1
  • 62
    • 34247263765 scopus 로고    scopus 로고
    • In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick ornithodoros moubata
    • Hepburn, N. J., A. S. Williams, M. A. Nunn, J. C. Chamberlain-Banoub, J. Hamer, B. P. Morgan, and C. L. Harris. 2007. In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata. J. Biol. Chem. 282: 8292-8299.
    • (2007) J. Biol. Chem. , vol.282 , pp. 8292-8299
    • Hepburn, N.J.1    Williams, A.S.2    Nunn, M.A.3    Chamberlain-Banoub, J.C.4    Hamer, J.5    Morgan, B.P.6    Harris, C.L.7
  • 63
    • 33846507393 scopus 로고    scopus 로고
    • CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration
    • Bora, N. S., S. Kaliappan, P. Jha, Q. Xu, B. Sivasankar, C. L. Harris, B. P. Morgan, and P. S. Bora. 2007. CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration. J. Immunol. 178: 1783-1790.
    • (2007) J. Immunol. , vol.178 , pp. 1783-1790
    • Bora, N.S.1    Kaliappan, S.2    Jha, P.3    Xu, Q.4    Sivasankar, B.5    Harris, C.L.6    Morgan, B.P.7    Bora, P.S.8
  • 64
    • 79955721853 scopus 로고    scopus 로고
    • A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration
    • Cashman, S. M., K. Ramo, and R. Kumar-Singh. 2011. A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration. PLoS ONE 6: e19078.
    • (2011) PLoS ONE , vol.6
    • Cashman, S.M.1    Ramo, K.2    Kumar-Singh, R.3
  • 66
    • 84875991689 scopus 로고    scopus 로고
    • HMGB1 release by C5a anaphylatoxin is an effective target for sepsis treatment
    • Okada, N., M. Imai, A. Okada, F. Ono, and H. Okada. 2012. HMGB1 release by C5a anaphylatoxin is an effective target for sepsis treatment. Clin. Exp. Pharmacol. 2: 1000114.
    • (2012) Clin. Exp. Pharmacol. , vol.2 , pp. 1000114
    • Okada, N.1    Imai, M.2    Okada, A.3    Ono, F.4    Okada, H.5
  • 67
    • 78650806319 scopus 로고    scopus 로고
    • Attenuation of crosstalk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation
    • Tokodai, K., M. Goto, A. Inagaki, W. Nakanishi, N. Ogawa, K. Satoh, N. Kawagishi, S. Sekiguchi, B. Nilsson, N. Okada, et al. 2010. Attenuation of crosstalk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation. Transplantation 90: 1358-1365.
    • (2010) Transplantation , vol.90 , pp. 1358-1365
    • Tokodai, K.1    Goto, M.2    Inagaki, A.3    Nakanishi, W.4    Ogawa, N.5    Satoh, K.6    Kawagishi, N.7    Sekiguchi, S.8    Nilsson, B.9    Okada, N.10
  • 68
    • 33845514506 scopus 로고    scopus 로고
    • Drug evaluation: The C5a receptor antagonist PMX-53
    • Köhl, J. 2006. Drug evaluation: the C5a receptor antagonist PMX-53. Curr. Opin. Mol. Ther. 8: 529-538.
    • (2006) Curr. Opin. Mol. Ther. , vol.8 , pp. 529-538
    • Köhl, J.1
  • 70
    • 69249152289 scopus 로고    scopus 로고
    • Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of alzheimer's disease
    • Fonseca, M. I., R. R. Ager, S. H. Chu, O. Yazan, S. D. Sanderson, F. M. LaFerla, S. M. Taylor, T. M. Woodruff, and A. J. Tenner. 2009. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J. Immunol. 183: 1375-1383.
    • (2009) J. Immunol. , vol.183 , pp. 1375-1383
    • Fonseca, M.I.1    Ager, R.R.2    Chu, S.H.3    Yazan, O.4    Sanderson, S.D.5    LaFerla, F.M.6    Taylor, S.M.7    Woodruff, T.M.8    Tenner, A.J.9
  • 71
    • 80054953020 scopus 로고    scopus 로고
    • Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats
    • Breivik, T., Y. Gundersen, P. Gjermo, S. M. Taylor, T. M. Woodruff, and P. K. Opstad. 2011. Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats. J. Periodontal Res. 46: 643-647.
    • (2011) J. Periodontal Res. , vol.46 , pp. 643-647
    • Breivik, T.1    Gundersen, Y.2    Gjermo, P.3    Taylor, S.M.4    Woodruff, T.M.5    Opstad, P.K.6
  • 72
    • 84871575617 scopus 로고    scopus 로고
    • The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10
    • Jain, U., T. M. Woodruff, and A. W. Stadnyk. 2013. The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br. J. Pharmacol. 168: 488-501.
    • (2013) Br. J. Pharmacol. , vol.168 , pp. 488-501
    • Jain, U.1    Woodruff, T.M.2    Stadnyk, A.W.3
  • 76
    • 84873472582 scopus 로고    scopus 로고
    • C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
    • Lim, J., A. Iyer, J. Y. Suen, V. Seow, R. C. Reid, L. Brown, and D. P. Fairlie. 2013. C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J. 27: 822-831.
    • (2013) FASEB J. , vol.27 , pp. 822-831
    • Lim, J.1    Iyer, A.2    Suen, J.Y.3    Seow, V.4    Reid, R.C.5    Brown, L.6    Fairlie, D.P.7
  • 77
    • 84866027849 scopus 로고    scopus 로고
    • Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders
    • Risitano, A. M. 2012. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders. Immunobiology 217: 1080-1087.
    • (2012) Immunobiology , vol.217 , pp. 1080-1087
    • Risitano, A.M.1
  • 79
    • 27144440502 scopus 로고    scopus 로고
    • Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria
    • Hill, A., P. Hillmen, S. J. Richards, D. Elebute, J. C. Marsh, J. Chan, C. F. Mojcik, and R. P. Rother. 2005. Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria. Blood 106: 2559-2565.
    • (2005) Blood , vol.106 , pp. 2559-2565
    • Hill, A.1    Hillmen, P.2    Richards, S.J.3    Elebute, D.4    Marsh, J.C.5    Chan, J.6    Mojcik, C.F.7    Rother, R.P.8
  • 80
    • 79960076285 scopus 로고    scopus 로고
    • Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: Safety, efficacy, and unexpected laboratory phenomena
    • Röth, A., C. Hock, A. Konik, S. Christoph, and U. Dührsen. 2011. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena. Int. J. Hematol. 93: 704-714.
    • (2011) Int. J. Hematol. , vol.93 , pp. 704-714
    • Röth, A.1    Hock, C.2    Konik, A.3    Christoph, S.4    Dührsen, U.5
  • 81
    • 33644830187 scopus 로고    scopus 로고
    • Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H
    • S Reis, E., D. A. Falcão, and L. Isaac. 2006. Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H. Scand. J. Immunol. 63: 155-168.
    • (2006) Scand. J. Immunol. , vol.63 , pp. 155-168
    • Reis, E.S.1    Falcão, D.A.2    Isaac, L.3
  • 83
    • 77953431167 scopus 로고    scopus 로고
    • Protective role of complement C5a in an experimental model of staphylo-coccus aureus bacteremia
    • von Köckritz-Blickwede, M., S. Konrad, S. Foster, J. E. Gessner, and E. Medina. 2010. Protective role of complement C5a in an experimental model of Staphylo-coccus aureus bacteremia. J. Innate Immun. 2: 87-92.
    • (2010) J. Innate Immun. , vol.2 , pp. 87-92
    • Von Köckritz-Blickwede, M.1    Konrad, S.2    Foster, S.3    Gessner, J.E.4    Medina, E.5
  • 84
    • 65349094547 scopus 로고    scopus 로고
    • Taking complement to the clinic: Has the time finally come?
    • Lachmann, P. J., and R. A. Smith. 2009. Taking complement to the clinic: has the time finally come? Scand. J. Immunol. 69: 471-478.
    • (2009) Scand. J. Immunol. , vol.69 , pp. 471-478
    • Lachmann, P.J.1    Smith, R.A.2
  • 85
    • 24644487357 scopus 로고    scopus 로고
    • Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection
    • Atkinson, C., H. Song, B. Lu, F. Qiao, T. A. Burns, V. M. Holers, G. C. Tsokos, and S. Tomlinson. 2005. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J. Clin. Invest. 115: 2444-2453.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2444-2453
    • Atkinson, C.1    Song, H.2    Lu, B.3    Qiao, F.4    Burns, T.A.5    Holers, V.M.6    Tsokos, G.C.7    Tomlinson, S.8
  • 87
    • 84934438226 scopus 로고    scopus 로고
    • The effects of selective complement and CD14 inhibition on the E. Coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood
    • Brekke, O. L., C. Waage, D. Christiansen, H. Fure, H. Qu, J. D. Lambris, B. Osterud, E. W. Nielsen, and T. E. Mollnes. 2013. The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood. Adv. Exp. Med. Biol. 734: 123-136.
    • (2013) Adv. Exp. Med. Biol. , vol.734 , pp. 123-136
    • Brekke, O.L.1    Waage, C.2    Christiansen, D.3    Fure, H.4    Qu, H.5    Lambris, J.D.6    Osterud, B.7    Nielsen, E.W.8    Mollnes, T.E.9
  • 89
    • 84868661963 scopus 로고    scopus 로고
    • A sweet spot to control complement-induced inflammation
    • Ricklin, D., E. S. Reis, and J. D. Lambris. 2012. A sweet spot to control complement-induced inflammation. Nat. Med. 18: 1340-1341.
    • (2012) Nat. Med. , vol.18 , pp. 1340-1341
    • Ricklin, D.1    Reis, E.S.2    Lambris, J.D.3
  • 90
    • 84858600671 scopus 로고    scopus 로고
    • Control of methicillin resistant staphylococcus aureus infection utilizing a novel immunostimulatory peptide
    • Sheen, T. R., C. K. Cavaco, C. M. Ebrahimi, M. L. Thoman, S. D. Sanderson, E. L. Morgan, and K. S. Doran. 2011. Control of methicillin resistant Staphylococcus aureus infection utilizing a novel immunostimulatory peptide. Vaccine 30: 9-13.
    • (2011) Vaccine , vol.30 , pp. 9-13
    • Sheen, T.R.1    Cavaco, C.K.2    Ebrahimi, C.M.3    Thoman, M.L.4    Sanderson, S.D.5    Morgan, E.L.6    Doran, K.S.7
  • 91
    • 70649089218 scopus 로고    scopus 로고
    • Enhancement of in vivo and in vitro immune functions by a conformationally biased, response-selective agonist of human C5a: Implications for a novel adjuvant in vaccine design
    • Morgan, E. L., B. N. Morgan, E. A. Stein, E. L. Vitrs, M. L. Thoman, S. D. Sanderson, and J. A. Phillips. 2009. Enhancement of in vivo and in vitro immune functions by a conformationally biased, response-selective agonist of human C5a: implications for a novel adjuvant in vaccine design. Vaccine 28: 463-469.
    • (2009) Vaccine , vol.28 , pp. 463-469
    • Morgan, E.L.1    Morgan, B.N.2    Stein, E.A.3    Vitrs, E.L.4    Thoman, M.L.5    Sanderson, S.D.6    Phillips, J.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.