메뉴 건너뛰기




Volumn 44, Issue 2, 2014, Pages 328-338

Breaking bad: Manipulation of the host response by Porphyromonas gingivalis

Author keywords

Dysbiosis; Immune subversion; Inflammation; P. gingivalis; Periodontitis

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

EID: 84893587232     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344202     Document Type: Article
Times cited : (260)

References (107)
  • 1
    • 84873047994 scopus 로고    scopus 로고
    • The human microbiome: from symbiosis to pathogenesis
    • Eloe-Fadrosh, E. A. and Rasko, D. A., The human microbiome: from symbiosis to pathogenesis. Annu. Rev. Med. 2013. 64: 145-163.
    • (2013) Annu. Rev. Med. , vol.64 , pp. 145-163
    • Eloe-Fadrosh, E.A.1    Rasko, D.A.2
  • 2
    • 84869006781 scopus 로고    scopus 로고
    • Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology
    • Hajishengallis, G. and Lamont, R. J., Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol. Oral Microbiol. 2012. 27: 409-419.
    • (2012) Mol. Oral Microbiol. , vol.27 , pp. 409-419
    • Hajishengallis, G.1    Lamont, R.J.2
  • 3
    • 84893614670 scopus 로고    scopus 로고
    • Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation
    • Kurashima, Y., Goto, Y. and Kiyono, H., Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur. J. Immunol. 2013. 43: 3108-3115.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 3108-3115
    • Kurashima, Y.1    Goto, Y.2    Kiyono, H.3
  • 5
    • 84876408419 scopus 로고    scopus 로고
    • 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution
    • Stecher, B., Maier, L. and Hardt, W. D., 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution. Nat. Rev. Microbiol. 2013. 11: 277-284.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 277-284
    • Stecher, B.1    Maier, L.2    Hardt, W.D.3
  • 7
    • 77956022026 scopus 로고    scopus 로고
    • r{long leg}Gum bug leave my heart alone"-epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis
    • Kebschull, M., Demmer, R. T. and Papapanou, P. N., r{long leg}Gum bug leave my heart alone"-epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. J. Dent. Res. 2010. 89: 879-902.
    • (2010) J. Dent. Res. , vol.89 , pp. 879-902
    • Kebschull, M.1    Demmer, R.T.2    Papapanou, P.N.3
  • 8
    • 84876842615 scopus 로고    scopus 로고
    • The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
    • Abusleme, L., Dupuy, A. K., Dutzan, N., Silva, N., Burleson, J. A., Strausbaugh, L. D., Gamonal, J. and Diaz, P. I., The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 2013. 7: 1016-1025.
    • (2013) ISME J. , vol.7 , pp. 1016-1025
    • Abusleme, L.1    Dupuy, A.K.2    Dutzan, N.3    Silva, N.4    Burleson, J.A.5    Strausbaugh, L.D.6    Gamonal, J.7    Diaz, P.I.8
  • 9
    • 77953223051 scopus 로고    scopus 로고
    • Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis
    • Stabholz, A., Soskolne, W. A. and Shapira, L., Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. Periodontol.2000 2010. 53: 138-153.
    • (2010) Periodontol.2000 , vol.53 , pp. 138-153
    • Stabholz, A.1    Soskolne, W.A.2    Shapira, L.3
  • 12
    • 84865276077 scopus 로고    scopus 로고
    • Porphyromonas gingivalis as a potential community activist for disease
    • Darveau, R. P., Hajishengallis, G. and Curtis, M. A., Porphyromonas gingivalis as a potential community activist for disease. J. Dent. Res. 2012. 91: 816-820.
    • (2012) J. Dent. Res. , vol.91 , pp. 816-820
    • Darveau, R.P.1    Hajishengallis, G.2    Curtis, M.A.3
  • 13
    • 81755166205 scopus 로고    scopus 로고
    • Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
    • Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L. et al., Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe 2011. 10: 497-506.
    • (2011) Cell Host Microbe , vol.10 , pp. 497-506
    • Hajishengallis, G.1    Liang, S.2    Payne, M.A.3    Hashim, A.4    Jotwani, R.5    Eskan, M.A.6    McIntosh, M.L.7
  • 15
    • 70349761672 scopus 로고    scopus 로고
    • Pathway analysis for intracellular Porphyromonas gingivalis using a strain ATCC 33277 specific database
    • Hendrickson, E. L., Xia, Q., Wang, T., Lamont, R. J. and Hackett, M., Pathway analysis for intracellular Porphyromonas gingivalis using a strain ATCC 33277 specific database. BMC Microbiol. 2009. 9: 185.
    • (2009) BMC Microbiol. , vol.9 , pp. 185
    • Hendrickson, E.L.1    Xia, Q.2    Wang, T.3    Lamont, R.J.4    Hackett, M.5
  • 17
    • 72249085398 scopus 로고    scopus 로고
    • Bacterial invasion of epithelial cells and spreading in periodontal tissue
    • Tribble, G. D. and Lamont, R. J., Bacterial invasion of epithelial cells and spreading in periodontal tissue. Periodontol. 2000 2010. 52: 68-83.
    • (2010) Periodontol. 2000 , vol.52 , pp. 68-83
    • Tribble, G.D.1    Lamont, R.J.2
  • 18
    • 0036265107 scopus 로고    scopus 로고
    • Involvement of integrins in fimbriae-mediated binding and invasion by Porphyromonas gingivalis
    • Yilmaz, O., Watanabe, K. and Lamont, R. J., Involvement of integrins in fimbriae-mediated binding and invasion by Porphyromonas gingivalis. Cell. Microbiol. 2002. 4: 305-314.
    • (2002) Cell. Microbiol. , vol.4 , pp. 305-314
    • Yilmaz, O.1    Watanabe, K.2    Lamont, R.J.3
  • 19
    • 84858297793 scopus 로고    scopus 로고
    • Porphyromonas gingivalis SerB-mediated dephosphorylation of host cell cofilin modulates invasion efficiency
    • Moffatt, C. E., Inaba, H., Hirano, T. and Lamont, R. J., Porphyromonas gingivalis SerB-mediated dephosphorylation of host cell cofilin modulates invasion efficiency. Cell. Microbiol. 2012. 14: 577-588.
    • (2012) Cell. Microbiol. , vol.14 , pp. 577-588
    • Moffatt, C.E.1    Inaba, H.2    Hirano, T.3    Lamont, R.J.4
  • 20
    • 33746653692 scopus 로고    scopus 로고
    • A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion
    • Tribble, G. D., Mao, S., James, C. E. and Lamont, R. J., A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion. Proc. Natl. Acad. Sci. USA 2006. 103: 11027-11032.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 11027-11032
    • Tribble, G.D.1    Mao, S.2    James, C.E.3    Lamont, R.J.4
  • 21
    • 0141814846 scopus 로고    scopus 로고
    • Gingival epithelial cell signalling and cytoskeletal responses to Porphyromonas gingivalis invasion
    • Yilmaz, O., Young, P. A., Lamont, R. J. and Kenny, G. E., Gingival epithelial cell signalling and cytoskeletal responses to Porphyromonas gingivalis invasion. Microbiology 2003. 149: 2417-2426.
    • (2003) Microbiology , vol.149 , pp. 2417-2426
    • Yilmaz, O.1    Young, P.A.2    Lamont, R.J.3    Kenny, G.E.4
  • 22
    • 66749163678 scopus 로고    scopus 로고
    • Disulfide formation in the ER and mitochondria: two solutions to a common process
    • Riemer, J., Bulleid, N. and Herrmann, J. M., Disulfide formation in the ER and mitochondria: two solutions to a common process. Science 2009. 324: 1284-1287.
    • (2009) Science , vol.324 , pp. 1284-1287
    • Riemer, J.1    Bulleid, N.2    Herrmann, J.M.3
  • 23
    • 29644435936 scopus 로고    scopus 로고
    • Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells
    • Yilmaz, O., Verbeke, P., Lamont, R. J. and Ojcius, D. M., Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells. Infect. Immun. 2006. 74: 703-710.
    • (2006) Infect. Immun. , vol.74 , pp. 703-710
    • Yilmaz, O.1    Verbeke, P.2    Lamont, R.J.3    Ojcius, D.M.4
  • 24
    • 79954611838 scopus 로고    scopus 로고
    • Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway
    • Takeuchi, H., Furuta, N., Morisaki, I. and Amano, A., Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway. Cell. Microbiol. 2011. 13: 677-691.
    • (2011) Cell. Microbiol. , vol.13 , pp. 677-691
    • Takeuchi, H.1    Furuta, N.2    Morisaki, I.3    Amano, A.4
  • 27
    • 77949376775 scopus 로고    scopus 로고
    • Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells
    • Yao, L., Jermanus, C., Barbetta, B., Choi, C., Verbeke, P., Ojcius, D. M. and Yilmaz, O., Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells. Mol. Oral Microbiol. 2010. 25: 89-101.
    • (2010) Mol. Oral Microbiol. , vol.25 , pp. 89-101
    • Yao, L.1    Jermanus, C.2    Barbetta, B.3    Choi, C.4    Verbeke, P.5    Ojcius, D.M.6    Yilmaz, O.7
  • 28
    • 40749157178 scopus 로고    scopus 로고
    • ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2×7-mediated host-cell apoptosis
    • Yilmaz, O., Yao, L., Maeda, K., Rose, T. M., Lewis, E. L., Duman, M., Lamont, R. J. et al., ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2×7-mediated host-cell apoptosis. Cell. Microbiol. 2008. 10: 863-875.
    • (2008) Cell. Microbiol. , vol.10 , pp. 863-875
    • Yilmaz, O.1    Yao, L.2    Maeda, K.3    Rose, T.M.4    Lewis, E.L.5    Duman, M.6    Lamont, R.J.7
  • 29
    • 84877832916 scopus 로고    scopus 로고
    • Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2×7 receptor/NADPH-oxidase signalling and contributes to persistence
    • Choi, C. H., Spooner, R., DeGuzman, J., Koutouzis, T., Ojcius, D. M. and Yilmaz, O., Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2×7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell. Microbiol. 2013. 15: 961-976.
    • (2013) Cell. Microbiol. , vol.15 , pp. 961-976
    • Choi, C.H.1    Spooner, R.2    DeGuzman, J.3    Koutouzis, T.4    Ojcius, D.M.5    Yilmaz, O.6
  • 31
    • 79959448568 scopus 로고    scopus 로고
    • Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells
    • Moffatt, C. E. and Lamont, R. J., Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells. Infect. Immun. 2011. 79: 2632-2637.
    • (2011) Infect. Immun. , vol.79 , pp. 2632-2637
    • Moffatt, C.E.1    Lamont, R.J.2
  • 32
    • 16644369965 scopus 로고    scopus 로고
    • Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis are components of a polymicrobial intracellular flora within human buccal cells
    • Rudney, J. D., Chen, R. and Sedgewick, G. J., Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis are components of a polymicrobial intracellular flora within human buccal cells. J. Dent. Res. 2005. 84: 59-63.
    • (2005) J. Dent. Res. , vol.84 , pp. 59-63
    • Rudney, J.D.1    Chen, R.2    Sedgewick, G.J.3
  • 33
    • 72249100413 scopus 로고    scopus 로고
    • Subgingival biofilm formation
    • Kuboniwa, M. and Lamont, R. J., Subgingival biofilm formation. Periodontol. 2000 2010. 52: 38-52.
    • (2010) Periodontol. 2000 , vol.52 , pp. 38-52
    • Kuboniwa, M.1    Lamont, R.J.2
  • 34
    • 79960169778 scopus 로고    scopus 로고
    • The pathogenic persona of community-associated oral streptococci
    • Whitmore, S. E. and Lamont, R. J., The pathogenic persona of community-associated oral streptococci. Mol. Microbiol. 2011. 81: 305-314.
    • (2011) Mol. Microbiol. , vol.81 , pp. 305-314
    • Whitmore, S.E.1    Lamont, R.J.2
  • 36
    • 84864271151 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and bacterial virulence
    • Whitmore, S. E. and Lamont, R. J., Tyrosine phosphorylation and bacterial virulence. Int. J. Oral Sci. 2012. 4: 1-6.
    • (2012) Int. J. Oral Sci. , vol.4 , pp. 1-6
    • Whitmore, S.E.1    Lamont, R.J.2
  • 37
    • 49249093047 scopus 로고    scopus 로고
    • A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes
    • Maeda, K., Tribble, G. D., Tucker, C. M., Anaya, C., Shizukuishi, S., Lewis, J. P., Demuth, D. R. et al., A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes. Mol. Microbiol. 2008. 69: 1153-1164.
    • (2008) Mol. Microbiol. , vol.69 , pp. 1153-1164
    • Maeda, K.1    Tribble, G.D.2    Tucker, C.M.3    Anaya, C.4    Shizukuishi, S.5    Lewis, J.P.6    Demuth, D.R.7
  • 38
    • 78650892286 scopus 로고    scopus 로고
    • Structural dissection and in vivo effectiveness of a peptide inhibitor of Porphyromonas gingivalis adherence to Streptococcus gordonii
    • Daep, C. A., Novak, E. A., Lamont, R. J. and Demuth, D. R., Structural dissection and in vivo effectiveness of a peptide inhibitor of Porphyromonas gingivalis adherence to Streptococcus gordonii. Infect. Immun. 2011. 79: 67-74.
    • (2011) Infect. Immun. , vol.79 , pp. 67-74
    • Daep, C.A.1    Novak, E.A.2    Lamont, R.J.3    Demuth, D.R.4
  • 39
    • 44949084624 scopus 로고    scopus 로고
    • Role of differential expression of streptococcal arginine deiminase in inhibition of fimA expression in Porphyromonas gingivalis
    • Lin, X., Lamont, R. J., Wu, J. and Xie, H., Role of differential expression of streptococcal arginine deiminase in inhibition of fimA expression in Porphyromonas gingivalis. J. Bacteriol. 2008. 190: 4367-4371.
    • (2008) J. Bacteriol. , vol.190 , pp. 4367-4371
    • Lin, X.1    Lamont, R.J.2    Wu, J.3    Xie, H.4
  • 40
    • 71549142866 scopus 로고    scopus 로고
    • Negative correlation of distributions of Streptococcus cristatus and Porphyromonas gingivalis in subgingival plaque
    • Wang, B. Y., Wu, J., Lamont, R. J., Lin, X. and Xie, H., Negative correlation of distributions of Streptococcus cristatus and Porphyromonas gingivalis in subgingival plaque. J. Clin. Microbiol. 2009. 47: 3902-3906.
    • (2009) J. Clin. Microbiol. , vol.47 , pp. 3902-3906
    • Wang, B.Y.1    Wu, J.2    Lamont, R.J.3    Lin, X.4    Xie, H.5
  • 41
    • 84865559445 scopus 로고    scopus 로고
    • Streptococcus cristatus ArcA interferes with Porphyromonas gingivalis pathogenicity in mice
    • Xie, H., Hong, J., Sharma, A. and Wang, B. Y., Streptococcus cristatus ArcA interferes with Porphyromonas gingivalis pathogenicity in mice. J. Periodontal Res. 2012. 47: 578-583.
    • (2012) J. Periodontal Res. , vol.47 , pp. 578-583
    • Xie, H.1    Hong, J.2    Sharma, A.3    Wang, B.Y.4
  • 42
    • 77953209789 scopus 로고    scopus 로고
    • Comparison of neutrophil functions in aggressive and chronic periodontitis
    • Ryder, M. I., Comparison of neutrophil functions in aggressive and chronic periodontitis. Periodontol. 2000 2010. 53: 124-137.
    • (2010) Periodontol. 2000 , vol.53 , pp. 124-137
    • Ryder, M.I.1
  • 43
    • 0037264098 scopus 로고    scopus 로고
    • Origin and function of the cellular components in gingival crevice fluid
    • Delima, A. J. and Van Dyke, T. E., Origin and function of the cellular components in gingival crevice fluid. Periodontol. 2000 2003. 31: 55-76.
    • (2003) Periodontol. 2000 , vol.31 , pp. 55-76
    • Delima, A.J.1    Van Dyke, T.E.2
  • 44
    • 0031061830 scopus 로고    scopus 로고
    • The gingival tissues: the architecture of periodontal protection
    • Schroeder, H. E. and Listgarten, M. A., The gingival tissues: the architecture of periodontal protection. Periodontol. 2000 1997. 13: 91-120.
    • (1997) Periodontol. 2000 , vol.13 , pp. 91-120
    • Schroeder, H.E.1    Listgarten, M.A.2
  • 46
    • 78049467465 scopus 로고    scopus 로고
    • Destruction of bacterial biofilms by polymorphonuclear neutrophils: relative contribution of phagocytosis, DNA release, and degranulation
    • Meyle, E., Stroh, P., Gunther, F., Hoppy-Tichy, T., Wagner, C. and Hansch, G. M., Destruction of bacterial biofilms by polymorphonuclear neutrophils: relative contribution of phagocytosis, DNA release, and degranulation. Int. J. Artif. Organs 2010. 33: 608-620.
    • (2010) Int. J. Artif. Organs , vol.33 , pp. 608-620
    • Meyle, E.1    Stroh, P.2    Gunther, F.3    Hoppy-Tichy, T.4    Wagner, C.5    Hansch, G.M.6
  • 47
    • 33846091738 scopus 로고    scopus 로고
    • The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN)
    • Wagner, C., Zimmermann, S., Brenner-Weiss, G., Hug, F., Prior, B., Obst, U. and Hansch, G. M., The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN). Anal. Bioanal. Chem. 2007. 387: 481-487.
    • (2007) Anal. Bioanal. Chem. , vol.387 , pp. 481-487
    • Wagner, C.1    Zimmermann, S.2    Brenner-Weiss, G.3    Hug, F.4    Prior, B.5    Obst, U.6    Hansch, G.M.7
  • 48
    • 84870560296 scopus 로고    scopus 로고
    • Immune defense against S. epidermidis biofilms: components of the extracellular polymeric substance activate distinct bactericidal mechanisms of phagocytic cells
    • Meyle, E., Brenner-Weiss, G., Obst, U., Prior, B. and Hansch, G. M., Immune defense against S. epidermidis biofilms: components of the extracellular polymeric substance activate distinct bactericidal mechanisms of phagocytic cells. Int. J. Artif. Organs 2012. 35: 700-712.
    • (2012) Int. J. Artif. Organs , vol.35 , pp. 700-712
    • Meyle, E.1    Brenner-Weiss, G.2    Obst, U.3    Prior, B.4    Hansch, G.M.5
  • 49
    • 70549087775 scopus 로고    scopus 로고
    • Phagocytosis of staphylococci biofilms by polymorphonuclear neutrophils: S. aureus and S. epidermidis differ with regard to their susceptibility towards the host defense
    • Guenther, F., Stroh, P., Wagner, C., Obst, U. and Hansch, G. M., Phagocytosis of staphylococci biofilms by polymorphonuclear neutrophils: S. aureus and S. epidermidis differ with regard to their susceptibility towards the host defense. Int. J. Artif. Organs 2009. 32: 565-573.
    • (2009) Int. J. Artif. Organs , vol.32 , pp. 565-573
    • Guenther, F.1    Stroh, P.2    Wagner, C.3    Obst, U.4    Hansch, G.M.5
  • 50
    • 64549083243 scopus 로고    scopus 로고
    • Host defence against Staphylococcus aureus biofilms infection: phagocytosis of biofilms by polymorphonuclear neutrophils (PMN)
    • Gunther, F., Wabnitz, G. H., Stroh, P., Prior, B., Obst, U., Samstag, Y., Wagner, C. et al., Host defence against Staphylococcus aureus biofilms infection: phagocytosis of biofilms by polymorphonuclear neutrophils (PMN). Mol. Immunol. 2009. 46: 1805-1813.
    • (2009) Mol. Immunol. , vol.46 , pp. 1805-1813
    • Gunther, F.1    Wabnitz, G.H.2    Stroh, P.3    Prior, B.4    Obst, U.5    Samstag, Y.6    Wagner, C.7
  • 51
    • 33746619299 scopus 로고    scopus 로고
    • Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection
    • Mydel, P., Takahashi, Y., Yumoto, H., Sztukowska, M., Kubica, M., Gibson, F. C., 3rd, Kurtz, D. M., Jr. et al., Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog. 2006. 2: e76.
    • (2006) PLoS Pathog. , vol.2
    • Mydel, P.1    Takahashi, Y.2    Yumoto, H.3    Sztukowska, M.4    Kubica, M.5    Gibson III, F.C.6    Kurtz Jr, D.M.7
  • 52
    • 56149086187 scopus 로고    scopus 로고
    • Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice
    • Hajishengallis, G., Wang, M., Bagby, G. J. and Nelson, S., Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J. Immunol. 2008. 181: 4141-4149.
    • (2008) J. Immunol. , vol.181 , pp. 4141-4149
    • Hajishengallis, G.1    Wang, M.2    Bagby, G.J.3    Nelson, S.4
  • 53
    • 42949165456 scopus 로고    scopus 로고
    • Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis
    • Sheets, S. M., Robles-Price, A. G., McKenzie, R. M., Casiano, C. A. and Fletcher, H. M., Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis. Front. Biosci. 2008. 13: 3215-3238.
    • (2008) Front. Biosci. , vol.13 , pp. 3215-3238
    • Sheets, S.M.1    Robles-Price, A.G.2    McKenzie, R.M.3    Casiano, C.A.4    Fletcher, H.M.5
  • 54
    • 84894443827 scopus 로고    scopus 로고
    • Neutrophil homeostasis and periodontal health in children and adults
    • DOI: 10.1177/0022034513507956.
    • Hajishengallis, E. and Hajishengallis, G., Neutrophil homeostasis and periodontal health in children and adults. J. Dent. Res. 2013. 92. DOI: 10.1177/0022034513507956.
    • (2013) J. Dent. Res. , vol.92
    • Hajishengallis, E.1    Hajishengallis, G.2
  • 55
    • 77953616099 scopus 로고    scopus 로고
    • Periodontitis: a polymicrobial disruption of host homeostasis
    • Darveau, R. P., Periodontitis: a polymicrobial disruption of host homeostasis. Nat. Rev. Microbiol. 2010. 8: 481-490.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 481-490
    • Darveau, R.P.1
  • 56
    • 0032036517 scopus 로고    scopus 로고
    • Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis
    • Darveau, R. P., Belton, C. M., Reife, R. A. and Lamont, R. J., Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis. Infect. Immun. 1998. 66: 1660-1665.
    • (1998) Infect. Immun. , vol.66 , pp. 1660-1665
    • Darveau, R.P.1    Belton, C.M.2    Reife, R.A.3    Lamont, R.J.4
  • 57
    • 84876829405 scopus 로고    scopus 로고
    • The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-κB RelA/p65
    • Takeuchi, H., Hirano, T., Whitmore, S. E., Morisaki, I., Amano, A. and Lamont, R. J., The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-κB RelA/p65. PLoS Pathog. 2013. 9: e1003326.
    • (2013) PLoS Pathog. , vol.9
    • Takeuchi, H.1    Hirano, T.2    Whitmore, S.E.3    Morisaki, I.4    Amano, A.5    Lamont, R.J.6
  • 58
    • 0028902201 scopus 로고
    • Ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and promote neutrophil adhesion
    • Darveau, R. P., Cunningham, M. D., Bailey, T., Seachord, C., Ratcliffe, K., Bainbridge, B., Dietsch, M. et al., Ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and promote neutrophil adhesion. Infect. Immun. 1995. 63: 1311-1317.
    • (1995) Infect. Immun. , vol.63 , pp. 1311-1317
    • Darveau, R.P.1    Cunningham, M.D.2    Bailey, T.3    Seachord, C.4    Ratcliffe, K.5    Bainbridge, B.6    Dietsch, M.7
  • 59
    • 78049449136 scopus 로고    scopus 로고
    • Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats
    • Bainbridge, B., Verma, R. K., Eastman, C., Yehia, B., Rivera, M., Moffatt, C., Bhattacharyya, I. et al., Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats. Infect. Immun. 2010. 78: 4560-4569.
    • (2010) Infect. Immun. , vol.78 , pp. 4560-4569
    • Bainbridge, B.1    Verma, R.K.2    Eastman, C.3    Yehia, B.4    Rivera, M.5    Moffatt, C.6    Bhattacharyya, I.7
  • 60
    • 79952123931 scopus 로고    scopus 로고
    • Microbial manipulation of receptor crosstalk in innate immunity
    • Hajishengallis, G. and Lambris, J. D., Microbial manipulation of receptor crosstalk in innate immunity. Nat. Rev. Immunol. 2011. 11: 187-200.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 187-200
    • Hajishengallis, G.1    Lambris, J.D.2
  • 61
    • 77955760680 scopus 로고    scopus 로고
    • Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins
    • Guo, Y., Nguyen, K. A. and Potempa, J., Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol. 2000 2010. 54: 15-44.
    • (2010) Periodontol. 2000 , vol.54 , pp. 15-44
    • Guo, Y.1    Nguyen, K.A.2    Potempa, J.3
  • 62
    • 84863826834 scopus 로고    scopus 로고
    • Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen
    • Bostanci, N. and Belibasakis, G. N., Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiol. Lett. 2012. 333: 1-9.
    • (2012) FEMS Microbiol. Lett. , vol.333 , pp. 1-9
    • Bostanci, N.1    Belibasakis, G.N.2
  • 63
    • 84869761067 scopus 로고    scopus 로고
    • Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist
    • Abe, T., Hosur, K. B., Hajishengallis, E., Reis, E. S., Ricklin, D., Lambris, J. D. and Hajishengallis, G., Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J. Immunol. 2012. 189: 5442-5448.
    • (2012) J. Immunol. , vol.189 , pp. 5442-5448
    • Abe, T.1    Hosur, K.B.2    Hajishengallis, E.3    Reis, E.S.4    Ricklin, D.5    Lambris, J.D.6    Hajishengallis, G.7
  • 65
    • 79251544574 scopus 로고    scopus 로고
    • The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss
    • Liang, S., Krauss, J. L., Domon, H., McIntosh, M. L., Hosur, K. B., Qu, H., Li, F. et al., The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J. Immunol. 2011. 186: 869-877.
    • (2011) J. Immunol. , vol.186 , pp. 869-877
    • Liang, S.1    Krauss, J.L.2    Domon, H.3    McIntosh, M.L.4    Hosur, K.B.5    Qu, H.6    Li, F.7
  • 66
    • 84875517343 scopus 로고    scopus 로고
    • A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis
    • Jain, S., Coats, S. R., Chang, A. M. and Darveau, R. P., A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis. Infect. Immun. 2013. 81: 1277-1286.
    • (2013) Infect. Immun. , vol.81 , pp. 1277-1286
    • Jain, S.1    Coats, S.R.2    Chang, A.M.3    Darveau, R.P.4
  • 68
    • 17444403917 scopus 로고    scopus 로고
    • C5a negatively regulates toll-like receptor 4-induced immune responses
    • Hawlisch, H., Belkaid, Y., Baelder, R., Hildeman, D., Gerard, C. and Kohl, J., C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity 2005. 22: 415-426.
    • (2005) Immunity , vol.22 , pp. 415-426
    • Hawlisch, H.1    Belkaid, Y.2    Baelder, R.3    Hildeman, D.4    Gerard, C.5    Kohl, J.6
  • 69
    • 33845462504 scopus 로고    scopus 로고
    • Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption
    • Burns, E., Bachrach, G., Shapira, L. and Nussbaum, G., Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J. Immunol. 2006. 177: 8296-8300.
    • (2006) J. Immunol. , vol.177 , pp. 8296-8300
    • Burns, E.1    Bachrach, G.2    Shapira, L.3    Nussbaum, G.4
  • 70
    • 34848855747 scopus 로고    scopus 로고
    • Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo
    • Hajishengallis, G., Shakhatreh, M. A., Wang, M. and Liang, S., Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J. Immunol. 2007. 179: 2359-2367.
    • (2007) J. Immunol. , vol.179 , pp. 2359-2367
    • Hajishengallis, G.1    Shakhatreh, M.A.2    Wang, M.3    Liang, S.4
  • 71
    • 77950187449 scopus 로고    scopus 로고
    • Crosstalk pathways between Toll-like receptors and the complement system
    • Hajishengallis, G. and Lambris, J. D., Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010. 31: 154-163.
    • (2010) Trends Immunol. , vol.31 , pp. 154-163
    • Hajishengallis, G.1    Lambris, J.D.2
  • 72
    • 17444394875 scopus 로고    scopus 로고
    • Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase
    • Harokopakis, E. and Hajishengallis, G., Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur. J. Immunol. 2005. 35: 1201-1210.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1201-1210
    • Harokopakis, E.1    Hajishengallis, G.2
  • 73
    • 33744903384 scopus 로고    scopus 로고
    • TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae
    • Harokopakis, E., Albzreh, M. H., Martin, M. H. and Hajishengallis, G., TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. J. Immunol. 2006. 176: 7645-7656.
    • (2006) J. Immunol. , vol.176 , pp. 7645-7656
    • Harokopakis, E.1    Albzreh, M.H.2    Martin, M.H.3    Hajishengallis, G.4
  • 74
    • 34848908962 scopus 로고    scopus 로고
    • Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages
    • Wang, M., Shakhatreh, M. A., James, D., Liang, S., Nishiyama, S., Yoshimura, F., Demuth, D. R. et al., Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J. Immunol. 2007. 179: 2349-2358.
    • (2007) J. Immunol. , vol.179 , pp. 2349-2358
    • Wang, M.1    Shakhatreh, M.A.2    James, D.3    Liang, S.4    Nishiyama, S.5    Yoshimura, F.6    Demuth, D.R.7
  • 75
    • 67649220664 scopus 로고    scopus 로고
    • Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?
    • Hajishengallis, G., Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics? Microbes Infect. 2009. 11: 637-645.
    • (2009) Microbes Infect. , vol.11 , pp. 637-645
    • Hajishengallis, G.1
  • 76
    • 34249799593 scopus 로고    scopus 로고
    • Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system
    • Popadiak, K., Potempa, J., Riesbeck, K. and Blom, A. M., Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J. Immunol. 2007. 178: 7242-7250.
    • (2007) J. Immunol. , vol.178 , pp. 7242-7250
    • Popadiak, K.1    Potempa, J.2    Riesbeck, K.3    Blom, A.M.4
  • 77
    • 61449163214 scopus 로고    scopus 로고
    • Corruption of innate immunity by bacterial proteases
    • Potempa, J. and Pike, R. N., Corruption of innate immunity by bacterial proteases. J. Innate Immun. 2009. 1: 70-87.
    • (2009) J. Innate Immun. , vol.1 , pp. 70-87
    • Potempa, J.1    Pike, R.N.2
  • 78
    • 33748078137 scopus 로고    scopus 로고
    • Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement
    • Slaney, J. M., Gallagher, A., Aduse-Opoku, J., Pell, K. and Curtis, M. A., Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement. Infect. Immun. 2006. 74: 5352-5361.
    • (2006) Infect. Immun. , vol.74 , pp. 5352-5361
    • Slaney, J.M.1    Gallagher, A.2    Aduse-Opoku, J.3    Pell, K.4    Curtis, M.A.5
  • 79
    • 0026202116 scopus 로고
    • Complement factor D-like activity of Porphyromonas gingivalis W83
    • Schenkein, H. A., Complement factor D-like activity of Porphyromonas gingivalis W83. Oral Microbiol. Immunol. 1991. 6: 216-220.
    • (1991) Oral Microbiol. Immunol. , vol.6 , pp. 216-220
    • Schenkein, H.A.1
  • 80
    • 0026725842 scopus 로고
    • Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis
    • Wingrove, J. A., DiScipio, R. G., Chen, Z., Potempa, J., Travis, J. and Hugli, T. E., Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. J. Biol. Chem. 1992. 267: 18902-18907.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18902-18907
    • Wingrove, J.A.1    DiScipio, R.G.2    Chen, Z.3    Potempa, J.4    Travis, J.5    Hugli, T.E.6
  • 81
    • 54049101495 scopus 로고    scopus 로고
    • Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis
    • Potempa, M., Potempa, J., Okroj, M., Popadiak, K., Eick, S., Nguyen, K. A., Riesbeck, K. et al., Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis. J. Immunol. 2008. 181: 5537-5544.
    • (2008) J. Immunol. , vol.181 , pp. 5537-5544
    • Potempa, M.1    Potempa, J.2    Okroj, M.3    Popadiak, K.4    Eick, S.5    Nguyen, K.A.6    Riesbeck, K.7
  • 83
    • 62449341627 scopus 로고    scopus 로고
    • Porphyromonas gingivalis RgpA-Kgp proteinase-adhesin complexes penetrate gingival tissue and induce proinflammatory cytokines or apoptosis in a concentration-dependent manner
    • O'Brien-Simpson, N. M., Pathirana, R. D., Walker, G. D. and Reynolds, E. C., Porphyromonas gingivalis RgpA-Kgp proteinase-adhesin complexes penetrate gingival tissue and induce proinflammatory cytokines or apoptosis in a concentration-dependent manner. Infect. Immun. 2009. 77: 1246-1261.
    • (2009) Infect. Immun. , vol.77 , pp. 1246-1261
    • O'Brien-Simpson, N.M.1    Pathirana, R.D.2    Walker, G.D.3    Reynolds, E.C.4
  • 84
    • 72249086451 scopus 로고    scopus 로고
    • Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'- phosphatase activities
    • Coats, S. R., Jones, J. W., Do, C. T., Braham, P. H., Bainbridge, B. W., To, T. T., Goodlett, D. R. et al., Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'- phosphatase activities. Cell. Microbiol. 2009. 11: 1587-1599.
    • (2009) Cell. Microbiol. , vol.11 , pp. 1587-1599
    • Coats, S.R.1    Jones, J.W.2    Do, C.T.3    Braham, P.H.4    Bainbridge, B.W.5    To, T.T.6    Goodlett, D.R.7
  • 85
    • 79952284296 scopus 로고    scopus 로고
    • Temperature dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defences
    • Curtis, M. A., Percival, R. S., Devine, D., Darveau, R. P., Coats, S. R., Rangarajan, M., Tarelli, E. et al., Temperature dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defences. Infect. Immun. 2011. 79: 1187-1193.
    • (2011) Infect. Immun. , vol.79 , pp. 1187-1193
    • Curtis, M.A.1    Percival, R.S.2    Devine, D.3    Darveau, R.P.4    Coats, S.R.5    Rangarajan, M.6    Tarelli, E.7
  • 86
    • 79953299900 scopus 로고    scopus 로고
    • The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes
    • Belstrom, D., Holmstrup, P., Damgaard, C., Borch, T. S., Skjodt, M. O., Bendtzen, K. and Nielsen, C. H., The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes. Infect. Immun. 2011. 79: 1559-1565.
    • (2011) Infect. Immun. , vol.79 , pp. 1559-1565
    • Belstrom, D.1    Holmstrup, P.2    Damgaard, C.3    Borch, T.S.4    Skjodt, M.O.5    Bendtzen, K.6    Nielsen, C.H.7
  • 87
    • 84866149963 scopus 로고    scopus 로고
    • Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential
    • Carrion, J., Scisci, E., Miles, B., Sabino, G. J., Zeituni, A. E., Gu, Y., Bear, A. et al., Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J. Immunol. 2012. 189: 3178-3187.
    • (2012) J. Immunol. , vol.189 , pp. 3178-3187
    • Carrion, J.1    Scisci, E.2    Miles, B.3    Sabino, G.J.4    Zeituni, A.E.5    Gu, Y.6    Bear, A.7
  • 88
    • 84864040160 scopus 로고    scopus 로고
    • Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells
    • Madrigal, A. G., Barth, K., Papadopoulos, G. and Genco, C. A., Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012. 8: e1002723.
    • (2012) PLoS Pathog. , vol.8
    • Madrigal, A.G.1    Barth, K.2    Papadopoulos, G.3    Genco, C.A.4
  • 89
    • 84884677299 scopus 로고    scopus 로고
    • Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)
    • Maresz, K. J., Hellvard, A., Sroka, A., Adamowicz, K., Bielecka, E., Koziel, J., Gawron, K. et al., Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog. 2013. 9: e1003627.
    • (2013) PLoS Pathog. , vol.9
    • Maresz, K.J.1    Hellvard, A.2    Sroka, A.3    Adamowicz, K.4    Bielecka, E.5    Koziel, J.6    Gawron, K.7
  • 90
    • 77956375710 scopus 로고    scopus 로고
    • Review: pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways
    • Hayashi, C., Gudino, C. V., Gibson, F. C., 3rd and Genco, C. A., Review: pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol. Oral Microbiol. 2010. 25: 305-316.
    • (2010) Mol. Oral Microbiol. , vol.25 , pp. 305-316
    • Hayashi, C.1    Gudino, C.V.2    Gibson III, F.C.3    Genco, C.A.4
  • 91
    • 77955744624 scopus 로고    scopus 로고
    • Periodontal innate immune mechanisms relevant to atherosclerosis and obesity
    • Zelkha, S. A., Freilich, R. W. and Amar, S., Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol. 2000 2010. 54: 207-221.
    • (2010) Periodontol. 2000 , vol.54 , pp. 207-221
    • Zelkha, S.A.1    Freilich, R.W.2    Amar, S.3
  • 94
    • 72549086297 scopus 로고    scopus 로고
    • Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species
    • Stathopoulou, P. G., Benakanakere, M. R., Galicia, J. C. and Kinane, D. F., Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J. Clin. Periodontol. 2010. 37: 24-29.
    • (2010) J. Clin. Periodontol. , vol.37 , pp. 24-29
    • Stathopoulou, P.G.1    Benakanakere, M.R.2    Galicia, J.C.3    Kinane, D.F.4
  • 95
    • 77649198160 scopus 로고    scopus 로고
    • ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis
    • Yilmaz, O., Sater, A. A., Yao, L., Koutouzis, T., Pettengill, M. and Ojcius, D. M., ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis. Cell. Microbiol. 2010. 12: 188-198.
    • (2010) Cell. Microbiol. , vol.12 , pp. 188-198
    • Yilmaz, O.1    Sater, A.A.2    Yao, L.3    Koutouzis, T.4    Pettengill, M.5    Ojcius, D.M.6
  • 97
    • 84872003451 scopus 로고    scopus 로고
    • Role of TLR2 dependent-IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis
    • Gaddis, D. E., Maynard, C. L., Weaver, C. T., Michalek, S. M. and Katz, J., Role of TLR2 dependent-IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis. J. Leukoc. Biol. 2012. 93: 21-31.
    • (2012) J. Leukoc. Biol. , vol.93 , pp. 21-31
    • Gaddis, D.E.1    Maynard, C.L.2    Weaver, C.T.3    Michalek, S.M.4    Katz, J.5
  • 98
    • 84866934694 scopus 로고    scopus 로고
    • Targeting IL-17 and TH17 cells in chronic inflammation
    • Miossec, P. and Kolls, J. K., Targeting IL-17 and TH17 cells in chronic inflammation. Nat. Rev. Drug Discov. 2012. 11: 763-776.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 763-776
    • Miossec, P.1    Kolls, J.K.2
  • 99
    • 52649128246 scopus 로고    scopus 로고
    • A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17
    • Gaffen, S. L. and Hajishengallis, G., A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. J. Dent. Res. 2008. 87: 817-828.
    • (2008) J. Dent. Res. , vol.87 , pp. 817-828
    • Gaffen, S.L.1    Hajishengallis, G.2
  • 100
    • 33846045743 scopus 로고    scopus 로고
    • The role of T cells in periodontal disease: homeostasis and autoimmunity
    • Gemmell, E., Yamazaki, K. and Seymour, G. J., The role of T cells in periodontal disease: homeostasis and autoimmunity. Periodontol. 2000 2007. 43: 14-40.
    • (2007) Periodontol. 2000 , vol.43 , pp. 14-40
    • Gemmell, E.1    Yamazaki, K.2    Seymour, G.J.3
  • 101
    • 78650083063 scopus 로고    scopus 로고
    • Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints
    • Garlet, G. P., Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J. Dent. Res. 2010. 89: 1349-1363.
    • (2010) J. Dent. Res. , vol.89 , pp. 1349-1363
    • Garlet, G.P.1
  • 104
    • 84861342868 scopus 로고    scopus 로고
    • Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing
    • Griffen, A. L., Beall, C. J., Campbell, J. H., Firestone, N. D., Kumar, P. S., Yang, Z. K., Podar, M. et al., Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing. ISME J. 2012. 6: 1176-1185.
    • (2012) ISME J. , vol.6 , pp. 1176-1185
    • Griffen, A.L.1    Beall, C.J.2    Campbell, J.H.3    Firestone, N.D.4    Kumar, P.S.5    Yang, Z.K.6    Podar, M.7
  • 105
    • 84863989927 scopus 로고    scopus 로고
    • Review of osteoimmunology and the host response in endodontic and periodontal lesions
    • DOI 10.3402/jom.v3403i3400.5304.
    • Graves, D. T., Oates, T. and Garlet, G. P., Review of osteoimmunology and the host response in endodontic and periodontal lesions. J. Oral Microbiol. 2011. 3. DOI 10.3402/jom.v3403i3400.5304.
    • (2011) J. Oral Microbiol. , vol.3
    • Graves, D.T.1    Oates, T.2    Garlet, G.P.3
  • 106
    • 57349119867 scopus 로고    scopus 로고
    • Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis
    • Johnson, J. D., Chen, R., Lenton, P. A., Zhang, G., Hinrichs, J. E. and Rudney, J. D., Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis. J. Periodontol. 2008. 79: 2305-2312.
    • (2008) J. Periodontol. , vol.79 , pp. 2305-2312
    • Johnson, J.D.1    Chen, R.2    Lenton, P.A.3    Zhang, G.4    Hinrichs, J.E.5    Rudney, J.D.6
  • 107
    • 8744259752 scopus 로고    scopus 로고
    • Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study
    • Eick, S. and Pfister, W., Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study. J. Periodontol. 2004. 75: 1327-1334.
    • (2004) J. Periodontol. , vol.75 , pp. 1327-1334
    • Eick, S.1    Pfister, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.