Regulation of insulin secretion by geniposide: Possible involvement of phosphatidylinositol 3-phosphate kinase

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 9, 2014, Pages 1287-1294

  Guo, L X ^a   Liu, J H ^a   Yin, F ^a  

^a CHONGQING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

Author keywords

Geniposide; Insulin secretion; Phosphatidylinositol 3 phosphate kinase (PI3K); Type 2 diabetes mellitus (T2DM)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GENIPOSIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE TRANSPORTER 2; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; ANTIDIABETIC AGENT; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN; IRIDOID; PDPK1 PROTEIN, RAT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SLC2A2 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; INS 1 CELL LINE; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TIME; UPREGULATION;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ANIMALS; CELL LINE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; GLYCOGEN SYNTHASE KINASE 3; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; IRIDOIDS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 84902179399     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. KAHN SE, HULL RL, UTZSCHNEIDER KM Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840-846. (Pubitemid 46024990)
2. KUMAR H, MISHRA M, BAJPAI S, POKHRIA D, ARYA AK, SINGH R.K., TRIPATHI K. Correlation of insulin resistance, beta cell function and insulin sensitivity with serum sFas and sFasL in newly diagnosed type 2 diabetes. Acta Diabetol 2011: June 22. [Epub ahead of print]
3. BELL GI, POLONSKY KS Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 2001; 414: 788-791. (Pubitemid 34000781)
4. WARD WK, BEARD JC, HALTER JB, PFEIFER MA, PORTE D, JR. Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care 1984; 7: 491-502. (Pubitemid 14048622)
5. PORKSEN N, HOLLINGDAL M, JUHL C, BUTLER P, VELDHUIS JD, SCHMITZ O. Pulsatile insulin secretion: detection, regulation, and role in diabetes. Diabetes 2002; 51(SUPPL. 1): S245-254. (Pubitemid 34761523)
6. KAHN SE, HALBAN PA Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 1997; 46: 1725-1732. (Pubitemid 27456403)
7. BERNAL-MIZRACHI E, WEN W, STAHLHUT S, WELLING CM, PERMUTT MA Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001; 108: 1631-1638. (Pubitemid 33144873)
8. HASHIMOTO N, KIDO Y, UCHIDA T, ASAHARA S, SHIGEYAMA Y, MATSUDA T, TAKEDA A, TSUCHIHASHI D, NISHIZAWA A, OGAWA W, FUJIMOTO Y, OKAMURA H, ARDEN KC, HERRERA PL, NODA T, KASUGA M. Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet 2006; 38: 589-593.
9. TUTTLE RL, GILL NS, PUGH W, LEE J P, KOEBERLEIN B, FURTH EE, POLONSKY KS, NAJI A, BIRNBAUM MJ. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med 2001; 7: 1133-1137. (Pubitemid 33010022)
10. ALESSI DR, CAUDWELL FB, ANDJELKOVIC M, HEMMINGS BA, COHEN P. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 1996; 399: 333-338. (Pubitemid 26426877)
11. ALESSI DR, JAMES SR, DOWNES C P, HOLMES AB, GAFFNEY PR, REESE CB, COHEN P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997; 7: 261-269. (Pubitemid 27176852)
12. BIONDI RM, KIELOCH A, CURRIE RA, DEAK M, ALESSI DR The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EM-BO J 2001; 20: 4380-4390. (Pubitemid 32772032)
13. ARAKAWA M, EBATO C, MITA T, HIROSE T, KAWAMORI R, FUJITANI Y, WATADA H. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem Biophys Res Commun 2009; 390: 809-814.
14. BURMEISTER MA, FERRE T, AYALA JE, KING EM, HOLT RM, AYALA JE Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice. Am J Physiol Endocrinol Metab 2012; 302: E334-343.
15. SHAO S, LIU Z, YANG Y, ZHANG M, YU X. SREBP-1c, Pdx-1, and GLP-1R involved in palmitate-EPA regulated glucose-stimulated insulin secretion in INS-1 cells. J Cell Biochem 2010; 111: 634-642.
16. FAVARO E, GRANATA R, MICELI I, BARAGLI A, SETTANNI F, CAVALLO PERIN P, GHIGO E, CAMUSSI G, ZANONE MM. The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways. Diabetologia 2012; 55: 1058-1070.
17. FU Y, LIU B, LIU J, LIU Z, LIANG D, LI F, LI D, CAO Y, ZHANG X, ZHANG N, YANG Z. Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Int Immunopharmacol 2012; 14: 792-798.
18. NI HY, ZHANG ZH, FU HZ Research and development of Fructus Gardeniae. Zhongguo Zhong Yao Za Zhi 2006; 31: 538-541.
19. DING Y, ZHANG T, TAO JS, ZHANG LY, SHI JR, JI G. Potential hepatotoxicity of geniposide, the major iridoid glycoside in dried ripe fruits of Gardenia jasminoides (Zhi-zi). Natural Prod Res 2012 Mar 29. [Epub ahead of print]
20. LIN YJ, LAI CC, LAI CH, SUE SC, LIN CW, HUNG CH, LIN TH, HSU WY, HUANG SM, HUNG YL, TIEN N, LIU X, CHEN CL, TSAI FJ. Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide. Eur J Med Chem 2012; 62C: 206-213.
21. LIU J, YIN F, ZHENG X, JING J, HU Y. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. Neurochem Int 2007; 51: 361-369. (Pubitemid 47503463)
22. LIU JH, YIN F, GUO LX, DENG XH, HU YH Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway. Acta Pharmacol Sini 2009; 30: 159-165.
23. WU SY, WANG G F, LIU ZQ, RAO JJ, LU L, XU W, WU SG, ZHANG JJ. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sini 2009; 30: 202-208.
24. GUO LX, XIA ZN, GAO X, YIN F, LIU JH Glucagonlike peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells. Acta Pharmacol Sini 2012; 33: 237-241.
25. LEIBIGER B, MOEDE T, UHLES S, BARKER CJ, CREVEAUX M, DOMIN J, BERGGREN PO, LEIBIGER IB. Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion. FASEB J 2010; 24: 1824-1837.
26. NOGUEIRA TC, ANHE GF CARVALHO CR, CURI R, BORDIN S, CARPINELLI AR. Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. Pancreas 2008; 37: 309-315.
27. PULLEN N, DENNIS PB, ANDJELKOVIC M, DUFNER A, KOZMA SC, HEMMINGS BA, THOMAS G. Phosphorylation and activation of p70s6k by PDK1. Science 1998; 279: 707-710.
28. MINAMI T, HARA K, OSHIRO N, UEOKU S, YOSHINO K, TOKUNAGA C, SHIRAI Y, SAITO N, GOUT I, YONEZAWA K. Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha. Genes Cells 2001; 6: 1003-1015. (Pubitemid 33100034)
29. LEE-FRUMAN KK, KUO CJ, LIPPINCOTT J, TERADA N, BLENIS J. Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene 1999; 18: 5108-5114. (Pubitemid 29443756)
30. KATSO R, OKKENHAUG K, AHMADI K, WHITE S, TIMMS J, WATERFIELD MD Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17: 615-675. (Pubitemid 33096187)
31. HIRSCH E, COSTA C, CIRAOLO E. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol 2007; 194: 243-256. (Pubitemid 47249663)
32. ROBERTSON DG, DATTA K, WELLS D, EGNASH L, ROBOSKY L, MANNING M, ROHDE C, REILY MD. Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase. Chem Res Toxicol 2007; 20: 1871-1877.
33. CHAUSSADE C, REWCASTLE GW, KENDALL JD, DENNY WA, CHO K, GRONNING LM, CHONG ML, ANAGNOSTOU SH, JACKSON S P, DANIELE N, SHEPHERD PR. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J 2007; 404: 449-458. (Pubitemid 46953919)
34. PARK JY, LIN PY, WEISS RH Targeting the PI3K-Akt pathway in kidney cancer. Expert Rev Anticancer Ther 2007; 7: 863-870. (Pubitemid 47007992)
35. PIQUER S, BARCELO-BATLLORI S, JULIA M, MARZO N, NADAL B, GUINOVART JJ, GOMIS R. Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta cells. Biochem Biophys Res Commun 2007; 358: 385-391. (Pubitemid 46778909)
36. BRAND C, CIPOK M, ATTALI V, BAK A, SAMPSON SR Protein kinase C delta participates in insulin-induced activation of PKB via PDK1. Biochem Biophys Res Commun 2006; 349: 954-962. (Pubitemid 44380192)
37. HUI H, TANG YG, ZHU L, KHOURY N, HUI Z, WANG KY, PERFETTI R, GO VL Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas 2010; 39: 315-322.
38. BANDYOPADHYAY GK, YU JG, OFRECIO J, OLEFSKY JM Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. Diabetes 2005; 54: 2351-2359. (Pubitemid 41134262)
39. WILKES JJ, NGUYEN MT, BANDYOPADHYAY GK, NELSON E, OLEFSKY JM Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. Am J Physiol Endocrinol Metab 2005; 289: E1015-1022. (Pubitemid 43671051)