Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α

Genes to Cells

Volumn 6, Issue 11, 2001, Pages 1003-1015

  Minami, Taichi ^a   Hara, Kenta ^a   Oshiro, Noriko ^a   Ueoku, Sachiko ^a   Yoshino, Ken Ichi ^a   Tokunaga, Chiharu ^a   Shirai, Yasuhito ^a   Saito, Naoaki ^a   Gout, Ivan ^b,c,d   Yonezawa, Kazuyoshi ^a  

^a KOBE UNIVERSITY   (Japan)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLYCINE; ISOPROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN P85; RAPAMYCIN; S6 KINASE; SERINE; THREONINE; WORTMANNIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DEPHOSPHORYLATION; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAMMAL; MUTANT; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TARGETING; RAT; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANDROSTADIENES; BLOTTING, WESTERN; ENZYME ACTIVATION; ENZYME INHIBITORS; ISOENZYMES; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS;

ANIMALIA; MAMMALIA;

EID: 0035188415     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2001.00479.x     Document Type: Article

References (38)

1. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
2. Insulin signal transduction through protein kinase cascades
3. Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase
4. Control of p70S6 kinase by kinase activity of FRAP in vivo
5. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
6. PDGF- and insulin-dependent p70S6k activation mediated by phosphatidylinositol-3-OH kinase
7. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
8. Differential subcellular localisation of two isoforms of p70 S6 protein kinase
9. Activation of p70S6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs
10. Molecular cloning and characterization of a novel p70 S6 kinase β containing a proline-rich region
11. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
12. Regulation of eIF-4E BP1 phosphorylation by mTOR
13. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
14. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
15. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70S6k
16. Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of Akt
17. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily
18. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
19. Characterization of S6K2, a novel kinase homologous to S6K1
20. Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway
21. Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
22. Drosophila S6 kinase: A regulator of cell size
23. Dual requirement for a newly identified phosphorylation site in p70S6k
24. Bidirectional modulation of insulin action by amino acids
25. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
26. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein
27. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
28. Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase
29. Phosphorylation and activation of p70s6k by PDK1
30. Nuclear localization of p85s6k: Functional requirement for entry into S phase
31. Cloning and characterization of p70 (S6K beta) defines a novel family of p70 S6 kinases
32. TOR, A central controller of cell growth
33. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells
34. Disruption of the p70(S6k)/p85(S6k) gene reveals a small mouse phenotype and a new functional S6 kinase
35. Cross-talk between the Erk and p70 S6K signaling pathways: MEK-dependent activation of S6K2 in cardiomyocytes
36. Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation
37. Multiple independent inputs are required for activation of the p70 S6 kinase
38. Regulation of the p70 S6 kinase by phosphorylation in vivo - Analysis using site-specific anti-phosphopeptide antibodies