Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression

Journal of the American College of Cardiology

Volumn 63, Issue 23, 2014, Pages 2549-2557

  Kamal, Fadia A ^a   Mickelsen, Deanne M ^b   Wegman, Katherine M ^a   Travers, Joshua G ^a   Moalem, Jacob ^b   Hammes, Stephen R ^b   Smrcka, Alan V ^b   Blaxall, Burns C ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

catecholamines; fibrosis; heart failure; hypertrophy; sympathetic nervous system

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CHROMOGRANIN A; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 2 PHOSPHOINOSITIDE 3 KINASE GAMMA; GALLEIN; GLYCOGEN SYNTHASE KINASE 3; PROTEIN KINASE B; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE; CARDIOVASCULAR AGENT; G PROTEIN COUPLED RECEPTOR GBETAGAMMA; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA;

ADRENAL GLAND; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CATECHOLAMINE RELEASE; CONTROLLED STUDY; DESENSITIZATION; DISEASE COURSE; EX VIVO STUDY; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; IN VITRO STUDY; MOUSE; NONHUMAN; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HEART; HEART CONTRACTION; HEART MUSCLE; HEART STROKE VOLUME; HUMAN; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TREATMENT OUTCOME; ANIMAL TISSUE; CATECHOLAMINE SYNTHESIS; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME PHOSPHORYLATION; HEART VENTRICLE HYPERTROPHY; HUMAN TISSUE; PROTEIN TRANSPORT; SURVIVAL RATE;

ADRENAL GLANDS; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEART; HEART FAILURE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDIUM; STROKE VOLUME; TREATMENT OUTCOME; XANTHENES;

EID: 84902134191     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.02.587     Document Type: Article

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