Apoptosis induction by the total flavonoids from arachniodes exilis in HepG2 cells through reactive oxygen species-mediated mitochondrial dysfunction involving MAPK activation

Evidence-based Complementary and Alternative Medicine

Volumn 2014, Issue , 2014, Pages

  Li, Huimin ^a,b   Chen, Jing ^a   Xiong, Chaomei ^a   Wei, Han ^a   Yin, Changchang ^b   Ruan, Jinlan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JIUJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; ARACHNIODES EXILIS EXTRACT; CASPASE 3; CASPASE 9; CYTOCHROME C; FLAVONOID; HOE 33342; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARACHNIODES EXILIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE TIME EFFECT RELATION; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; HUMAN TISSUE; IC 50; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 84902130270     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2014/906941     Document Type: Article

References (40)

1. Bruix J., Boix L., Sala M., Llovet J. M., Focus on hepatocellular carcinoma. Cancer Cell 2004 5 3 215 219 2-s2.0-1642544603 10.1016/S1535-6108(04) 00058-3
2. Song P. P., Standardizing management of hepatocellular carcinoma in China: devising evidence-based clinical practice guidelines. BioScience Trends 2013 7 5 250 252
3. Zhang Z., Zhang C., Ding Y., The activation of p38 and JNK by ROS, contribute to OLO-2-mediated intrinsic apoptosis in human hepatocellular carcinoma cells. Food and Chemical Toxicology 2014 63 38 47 10.1016/j.fct.2013. 10.043
4. Jang S. I., Lee Y. W., Cho C. K., Yoo H. S., Jang J. H., Identification of target genes involved in the antiproliferative effect of enzyme-modified ginseng extract in HepG2 hepatocarcinoma cell. Evidence-Based Complementary and Alternative Medicine 2013 2013 8 502568 10.1155/2013/502568
5. Kim D. S., Jeon B. K., Lee Y. E., Woo W. H., Mun Y. J., Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway. Evidence-Based Complementary and Alternative Medicine 2012 2012 8 2-s2.0-84863639477 10.1155/2012/981675 981675
6. Flora of China Editorial Committee, Flora of China 2004 Beijing, China Science Press
7. Chinese Materia Medica Editorial Board, Chinese Materia Medica 1999 1st Shanghai, China Shanghai Scientific and Technical Press
8. Yang Y., Lee G. J., Yoon D. H., Yu T., Oh J., Jeong D., Lee J., Kim S. H., Kim T. W., Cho J. Y., ERK1- and TBK1-targeted anti-inflammatory activity of an ethanol extract of Dryopteris crassirhizoma. Journal of Ethnopharmacology 2013 145 2 499 508 2-s2.0-84872133935 10.1016/j.jep.2012.11.019
9. Xue W. J., Du X. Y., Li D. H., Anti tumor effect of dryocrassin and damage effect on DNA. Chinese Journal of Pharmacology and Toxicology 1988 2 2 150 151
10. Petrache I., Choi M. E., Otterbein L. E., Chin B. Y., Mantell L. L., Horowitz S., Choi A. M. K., Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. The American Journal of Physiology 1999 277 3, part 1 L589 L595 2-s2.0-0032886918
11. Okada H., Mak T. W., Pathways of apoptotic and non-apoptotic death in tumour cells. Nature Reviews Cancer 2004 4 8 592 603 2-s2.0-3543092021
12. Wang J., Yuan L., Xiao H., Xiao C., Wang Y., Liu X., Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways. Apoptosis 2013 18 6 751 765 2-s2.0-84880573563 10.1007/s10495-013-0820-z
13. 2-terminal kinase pathway. Bioorganic and Medicinal Chemistry Letters 2010 20 22 6447 6451 2-s2.0-77958029943 10.1016/j.bmcl.2010.09.078
14. Liu H. B., Xiao Y. L., Xiong C. M., Wei A. H., Ruan J. L., Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation. European Journal of Pharmacology 2011 654 3 209 216 2-s2.0-79951683260 10.1016/j.ejphar.2010.12.036
15. Zhou D. N., Ruan J. L., Cai Y. L., Rao Y. Q., Chen Q., Fang W., Three new polyphenols from the rhizomes of Arachniodes exilis. Journal of Asian Natural Products Research 2008 10 5-6 559 563 2-s2.0-45849122868 10.1080/ 10286020801966880
16. Zhou D. N., Ruan J. L., Cai Y. L., Flavonoids from aerial parts of Arachniodes exilis. Chinese Pharmaceutical Journal 2008 43 16 1218 1220 2-s2.0-53049098461
17. Kim W. K., Bang M. H., Kim E. S., Kang N. E., Jung K. C., Cho H. J., Park J. H. Y., Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. The Journal of Nutritional Biochemistry 2005 16 3 155 162 2-s2.0-14644404912 10.1016/j.jnutbio.2004.10.010
18. Ren W., Qiao Z., Wang H., Zhu L., Zhang L., Flavonoids: promising anticancer agents. Medicinal Research Reviews 2003 23 4 519 534 2-s2.0-0038807711 10.1002/med.10033
19. Kim H. S., Wannatung T., Lee S., Yang W. K., Chung S. H., Lim J. S., Choe W., Kang I., Kim S. S., Ha J., Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer. Apoptosis 2012 17 9 938 949 2-s2.0-84865114863 10.1007/s10495-012-0719-0
20. Piret J. P., Minet E., Cosse J. P., Ninane N., Debacq C., Raes M., Michiels C., Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis. The Journal of Biological Chemistry 2005 280 10 9336 9344 2-s2.0-15744369062 10.1074/jbc.M411858200
21. Fujita M., Yasuda M., Kitatani K., Miyazawa M., Hirabayashi K., Takekoshi S., Iida T., Hirasawa T., Murakami M., Mikami M., Ishiwata I., Shimizu M., Osamura R. Y., An up-to-date anti-cancer treatment strategy focusing on HIF-1alpha suppression: its application for refractory ovarian cancer. Acta Histochemica et Cytochemica 2007 40 5 139 142 2-s2.0-37549042410 10.1267/ahc.07024
22. Wei A. H., Zhou D. N., Xiong C. M., Cai Y. L., Ruan J. L., A novel non-aromatic B-ring flavonoid: isolation, structure elucidation and its induction of apoptosis in human colon HT-29 tumor cell via the reactive oxygen species-mitochondrial dysfunction and MAPK activation. Food and Chemical Toxicology 2011 49 9 2445 2452 2-s2.0-79960844000 10.1016/j.fct.2011.06.067
23. Shi L., Yu X., Yang H., Wu X., Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactive oxygen species and activation of JNK and p38 MAPK pathways. PLoS ONE 2013 8 6 2-s2.0-84878919999 10.1371/journal.pone.0066781 e66781
24. Karawajew L., Rhein P., Czerwony G., Ludwig W. D., Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood 2005 105 12 4767 4775 2-s2.0-20444427605 10.1182/blood-2004-09-3428
25. Knoblach S. M., Nikolaeva M., Huang X., Fan L., Krajewski S., Reed J. C., Faden A. I., Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome. Journal of Neurotrauma 2002 19 10 1155 1170 2-s2.0-0036799487
26. del Poeta G., Venditti A., del Principe M. I., Maurillo L., Buccisano F., Tamburini A., Cox M. C., Franchi A., Bruno A., Mazzone C., Panetta P., Suppo G., Masi M., Amadori S., Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML). Blood 2003 101 6 2125 2131 2-s2.0-0037443479 10.1182/blood-2002-06-1714
27. Huang X. F., Luo S. K., Xu J., Li J., Xu D. R., Wang L. H., Yan M., Wang X. R., Wan X. B., Zheng F. M., Zeng Y. X., Liu Q., Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood 2008 111 5 2854 2865 2-s2.0-41949102523 10.1182/blood-2007-07-099325
28. Goping I. S., Sawchuk T., Rieger A., Shostak I., Bleackley R. C., Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise. Blood 2008 111 4 2142 2151 2-s2.0-41349121168 10.1182/blood-2007-08-105221
29. Chen J., Li H. M., Zhang X. N., Xiong C. M., Ruan J. L., Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. Journal of Huazhong University of Science and Technology (Medical Sciences) 2014 34 1 125 130 10.1007/s11596-014-1243-y
30. Budihardjo I., Oliver H., Lutter M., Luo X., Wang X. D., Biochemical pathways of caspase activation during apoptosis. Annual Review of Cell and Developmental Biology 1999 15 269 290 2-s2.0-0033280669 10.1146/annurev.cellbio. 15.1.269
31. Ola M. S., Nawaz M., Ahsan H., Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Molecular and Cellular Biochemistry 2011 351 1-2 41 58 2-s2.0-79953719964 10.1007/s11010-010-0709-x
32. Porter A. G., Jänicke R. U., Emerging roles of caspase-3 in apoptosis. Cell Death and Differentiation 1999 6 2 99 104 2-s2.0-0344142396
33. Ashe P. C., Berry M. D., Apoptotic signaling cascades. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2003 27 2 199 214 2-s2.0-0037376285 10.1016/S0278-5846(03)00016-2
34. Chang L., Karin M., Mammalian MAP kinase signalling cascades. Nature 2001 410 6824 37 40 2-s2.0-0035282334 10.1038/35065000
35. Xia Z., Dickens M., Raingeaud J., Davis R. J., Greenberg M. E., Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995 270 5240 1326 1331 2-s2.0-0028880006
36. Ichijo H., Nishida E., Irie K., Ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y., Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997 275 5296 90 94 2-s2.0-14444281569 10.1126/science.275.5296.90
37. Min L., He B., Hui L., Mitogen-activated protein kinases in hepatocellular carcinoma development. Seminars in Cancer Biology 2011 21 1 10 20 2-s2.0-79952036568 10.1016/j.semcancer.2010.10.011
38. Circu M. L., Aw T. Y., Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Biology and Medicine 2010 48 6 749 762 2-s2.0-76049083966 10.1016/j.freeradbiomed.2009.12.022
39. Ito K., Hirao A., Arai F., Takubo K., Matsuoka S., Miyamoto K., Ohmura M., Naka K., Hosokawa K., Ikeda Y., Suda T., Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nature Medicine 2006 12 4 446 451 2-s2.0-33645730667 10.1038/nm1388
40. Sahu R. P., Zhang R., Batra S., Shi Y., Srivastava S. K., Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. Carcinogenesis 2009 30 10 1744 1753 2-s2.0-70349989502 10.1093/carcin/bgp157