A novel non-aromatic b-ring flavonoid: Isolation, structure elucidation and its induction of apoptosis in human colon ht-29 tumor cell via the reactive oxygen species-mitochondrial dysfunction and mapk activation

Food and Chemical Toxicology

Volumn 49, Issue 9, 2011, Pages 2445-2452

  Wei, Anhua ^a   Zhou, Daonian ^a,b   Xiong, Chaomei ^a   Cai, Yaling ^a   Ruan, Jinlan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Mayinglong Pharmaceutical Group Co Ltd   (China)

Author keywords

Apoptosis; HT 29 cell; Macrothelypteris viridifrons; MAPK; Mitochondrial; Reactive oxygen species

Indexed keywords

2 (1,2 DIHYDROXY 4 OXO CYCLOHEX 5 ENYL) 5 HYDROXY 7 ETHOXY CHROMONE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; COLON CANCER; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFRARED RADIATION; MACROTHELYPTERIS VIRIDIFRONS; MASS SPECTROMETRY; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEAR MAGNETIC RESONANCE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ACETYLCYSTEINE; APOPTOSIS; BLOTTING, WESTERN; ENZYME ACTIVATION; FLAVONOIDS; HT29 CELLS; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

MACROTHELYPTERIS;

EID: 79960844000     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.067     Document Type: Article

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