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Volumn 2012, Issue , 2012, Pages

Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACETYLCYSTEINE; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DIOSGENIN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

EID: 84863639477     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/981675     Document Type: Article
Times cited : (76)

References (37)
  • 1
    • 58149154359 scopus 로고    scopus 로고
    • Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin
    • Raju J., Mehta R., Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin Nutrition and Cancer 2009 61 1 27 35
    • (2009) Nutrition and Cancer , vol.61 , Issue.1 , pp. 27-35
    • Raju, J.1    Mehta, R.2
  • 2
    • 0031836072 scopus 로고    scopus 로고
    • Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat
    • DOI 10.1002/hep.510280118
    • Accatino L., Pizarro M., Sols N., Koenig C. S., Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat Hepatology 1998 28 1 129 140 (Pubitemid 28299994)
    • (1998) Hepatology , vol.28 , Issue.1 , pp. 129-140
    • Accatino, L.1    Pizarro, M.2    Solis, N.3    Koenig, C.S.4
  • 4
    • 0642348024 scopus 로고    scopus 로고
    • Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells
    • Corbiere C., Liagre B., Bianchi A., Bordji K., Daua M., Netter P., Beneytout J. L., Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells International Journal of Oncology 2003 22 4 899 905
    • (2003) International Journal of Oncology , vol.22 , Issue.4 , pp. 899-905
    • Corbiere, C.1    Liagre, B.2    Bianchi, A.3    Bordji, K.4    Daua, M.5    Netter, P.6    Beneytout, J.L.7
  • 5
    • 0842268520 scopus 로고    scopus 로고
    • Diosgenin-3-O-α-L-rhamnopyranosyl-(1→4)-β -D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway
    • DOI 10.1080/1028602031000147357
    • Wang S. L., Cai B., Cui C. B., Liu H. W., Wu C. F., Yao X. S., Diosgenin-3-O- -L-rhamnopyranosyl-(1→4)- -D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway Journal of Asian Natural Products Research 2004 6 2 115 125 (Pubitemid 38173849)
    • (2004) Journal of Asian Natural Products Research , vol.6 , Issue.2 , pp. 115-125
    • Wang, S.-L.1    Cai, B.2    Cui, C.-B.3    Liu, H.-W.4    Wu, C.-F.5    Yao, X.-S.6
  • 6
    • 11244325805 scopus 로고    scopus 로고
    • 2+ homeostasis
    • DOI 10.1007/s00280-004-0849-3
    • Liu M. J., Wang Z., Ju Y., Wong R. N. S., Wu Q. Y., Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca 2+ homeostasis Cancer Chemotherapy and Pharmacology 2005 55 1 79 90 (Pubitemid 40064499)
    • (2005) Cancer Chemotherapy and Pharmacology , vol.55 , Issue.1 , pp. 79-90
    • Liu, M.-J.1    Wang, Z.2    Ju, Y.3    Wong, R.N.-S.4    Wu, Q.-Y.5
  • 8
    • 8844280276 scopus 로고    scopus 로고
    • Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells
    • DOI 10.1038/sj.cr.7290219, PII 7290219
    • Corbiere C., Liagre B., Terro F., Beneytout J. L., Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells Cell Research 2004 14 3 188 196 (Pubitemid 43231816)
    • (2004) Cell Research , vol.14 , Issue.3 , pp. 188-196
    • Corbiere, C.1    Liagre, B.2    Terro, F.3    Beneytout, J.-L.4
  • 9
    • 12844273499 scopus 로고    scopus 로고
    • Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression
    • Liagre B., Vergne-Salle P., Corbiere C., Charissoux J. L., Beneytout J. L., Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression Arthritis Research Therapy 2004 6 4 R373 R383
    • (2004) Arthritis Research Therapy , vol.6 , Issue.4
    • Liagre, B.1    Vergne-Salle, P.2    Corbiere, C.3    Charissoux, J.L.4    Beneytout, J.L.5
  • 10
    • 78651461704 scopus 로고    scopus 로고
    • Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells
    • Lepage C., Léger D. Y., Bertrand J., Martin F., Beneytout J. L., Liagre B., Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells Cancer Letters 2011 301 2 193 202
    • (2011) Cancer Letters , vol.301 , Issue.2 , pp. 193-202
    • Lepage, C.1    Léger, D.Y.2    Bertrand, J.3    Martin, F.4    Beneytout, J.L.5    Liagre, B.6
  • 11
    • 77951908366 scopus 로고    scopus 로고
    • Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
    • Li F., Fernandez P. P., Rajendran P., Hui K. M., Sethi G., Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells Cancer Letters 2010 292 2 197 207
    • (2010) Cancer Letters , vol.292 , Issue.2 , pp. 197-207
    • Li, F.1    Fernandez, P.P.2    Rajendran, P.3    Hui, K.M.4    Sethi, G.5
  • 13
    • 0842281645 scopus 로고    scopus 로고
    • Cell Death: Critical Control Points
    • DOI 10.1016/S0092-8674(04)00046-7
    • Danial N. N., Korsmeyer S. J., Cell death: critical control points Cell 2004 116 2 205 219 (Pubitemid 38167313)
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 14
    • 0027161158 scopus 로고
    • Effect of bcl-2 on fas antigen-mediated cell death
    • Itoh N., Tsujimoto Y., Nagata S., Effect of bcl-2 on fas antigen-mediated cell death Journal of Immunology 1993 151 2 621 627 (Pubitemid 23215727)
    • (1993) Journal of Immunology , vol.151 , Issue.2 , pp. 621-627
    • Itoh, N.1    Tsujimoto, Y.2    Nagata, S.3
  • 15
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl- 2 regulation of apoptosis
    • DOI 10.1126/science.275.5303.1132
    • Kluck R. M., Bossy-Wetzel E., Green D. R., Newmeyer D. D., The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis Science 1997 275 5303 1132 1136 (Pubitemid 27097313)
    • (1997) Science , vol.275 , Issue.5303 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 17
    • 0025201693 scopus 로고
    • Cytotoxic mechanism of tumor necrosis factor-α
    • Larrick J. W., Wright S. C., Cytotoxic mechanism of tumor necrosis factor- The FASEB Journal 1990 4 14 3215 3223 (Pubitemid 120012567)
    • (1990) FASEB Journal , vol.4 , Issue.14 , pp. 3215-3223
    • Larrick, J.W.1    Wright, S.C.2
  • 18
    • 0032500543 scopus 로고    scopus 로고
    • Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs
    • DOI 10.1074/jbc.273.41.26900
    • Simizu S., Takada M., Umezawa K., Imoto M., Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs The Journal of Biological Chemistry 1998 273 41 26900 26907 (Pubitemid 28471710)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.41 , pp. 26900-26907
    • Simizu, S.1    Takada, M.2    Umezawa, K.3    Imoto, M.4
  • 19
    • 33747080587 scopus 로고    scopus 로고
    • 2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells
    • DOI 10.1016/j.cellsig.2006.02.001, PII S0898656806000350
    • Aggeli I. K. S., Gaitanaki C., Beis I., Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells Cellular Signalling 2006 18 10 1801 1812 (Pubitemid 44216133)
    • (2006) Cellular Signalling , vol.18 , Issue.10 , pp. 1801-1812
    • Aggeli, I.-K.S.1    Gaitanaki, C.2    Beis, I.3
  • 21
    • 49349083531 scopus 로고    scopus 로고
    • Redox control of cell fate by MAP kinase: Physiological roles of ASK1-MAP kinase pathway in stress signaling
    • Matsuzawa A., Ichijo H., Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling Biochimica et Biophysica Acta 2008 1780 11 1325 1336
    • (2008) Biochimica et Biophysica Acta , vol.1780 , Issue.11 , pp. 1325-1336
    • Matsuzawa, A.1    Ichijo, H.2
  • 22
    • 14444281569 scopus 로고    scopus 로고
    • Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
    • DOI 10.1126/science.275.5296.90
    • Ichijo H., Nishida E., Irie K., Ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y., Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways Science 1997 275 5296 90 94 (Pubitemid 27020316)
    • (1997) Science , vol.275 , Issue.5296 , pp. 90-94
    • Ichijo, H.1    Nishida, E.2    Irie, K.3    Ten Dijke, P.4    Saitoh, M.5    Moriguchi, T.6    Takagi, M.7    Matsumoto, K.8    Miyazono, K.9    Gotoh, Y.10
  • 24
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry N. A., Lazebnik Y., Caspases: enemies within Science 1998 281 5381 1312 1316 (Pubitemid 28406817)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 25
    • 27544446991 scopus 로고    scopus 로고
    • Life in the balance: How BH3-only proteins induce apoptosis
    • DOI 10.1016/j.ceb.2005.10.001, PII S095506740500150X
    • Willis S. N., Adams J. M., Life in the balance: how BH3-only proteins induce apoptosis Current Opinion in Cell Biology 2005 17 6 617 625 (Pubitemid 41540411)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.6 , pp. 617-625
    • Willis, S.N.1    Adams, J.M.2
  • 27
    • 68149154728 scopus 로고    scopus 로고
    • BH3-only proteins and their roles in programmed cell death
    • Giam M., Huang D. C. S., Bouillet P., BH3-only proteins and their roles in programmed cell death Oncogene 2008 27 1 S128 S136
    • (2008) Oncogene , vol.27 , Issue.1
    • Giam, M.1    Huang, D.C.S.2    Bouillet, P.3
  • 28
    • 33644524120 scopus 로고    scopus 로고
    • Apoptosis and necrosis in the liver: A tale of two deaths?
    • Malhi H., Gores G. J., Lemasters J. J., Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 2006 43 2, supplement 1 S31 S44
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Malhi, H.1    Gores, G.J.2    Lemasters, J.J.3
  • 30
    • 0030175485 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase cascades and regulation of gene expression
    • DOI 10.1016/S0952-7915(96)80131-2
    • Su B., Karin M., Mitogen-activated protein kinase cascades and regulation of gene expression Current Opinion in Immunology 1996 8 3 402 411 (Pubitemid 26229663)
    • (1996) Current Opinion in Immunology , vol.8 , Issue.3 , pp. 402-411
    • Su, B.1    Karin, M.2
  • 32
    • 0033583321 scopus 로고    scopus 로고
    • Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
    • Wang T. H., Popp D. M., Wang H. S., Saitoh M., Mural J. G., Henley D. C., Ichijo H., Wimalasena J., Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells The Journal of Biological Chemistry 1999 274 12 8208 8216
    • (1999) The Journal of Biological Chemistry , vol.274 , Issue.12 , pp. 8208-8216
    • Wang, T.H.1    Popp, D.M.2    Wang, H.S.3    Saitoh, M.4    Mural, J.G.5    Henley, D.C.6    Ichijo, H.7    Wimalasena, J.8
  • 33
    • 0033554554 scopus 로고    scopus 로고
    • Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
    • DOI 10.1038/sj.onc.1202975
    • Hoeflich K. P., Yeh W. C., Yao Z., Mak T. W., Woodgett J. R., Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1) Oncogene 1999 18 42 5814 5820 (Pubitemid 29507435)
    • (1999) Oncogene , vol.18 , Issue.42 , pp. 5814-5820
    • Hoeflich, K.P.1    Yeh, W.-C.2    Yao, Z.3    Mak, T.W.4    Woodgett, J.R.5
  • 34
    • 34548067718 scopus 로고    scopus 로고
    • Thioredoxin signaling as a target for cancer therapy
    • DOI 10.1016/j.coph.2007.04.003, PII S1471489207000914, Cancer/Immunomodulation
    • Powis G., Kirkpatrick D. L., Thioredoxin signaling as a target for cancer therapy Current Opinion in Pharmacology 2007 7 4 392 397 (Pubitemid 47289261)
    • (2007) Current Opinion in Pharmacology , vol.7 , Issue.4 , pp. 392-397
    • Powis, G.1    Kirkpatrick, D.L.2
  • 35
    • 0037115761 scopus 로고    scopus 로고
    • Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): A distinct pathway from those of chemically induced and receptor-mediated apoptosis
    • DOI 10.1042/BJ20020101
    • Saeki K., Kobayashi N., Inazawa Y., Zhang H., Nishitoh H., Ichijo H., Saeki K., Isemura M., Yuo A., Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis Biochemical Journal 2002 368 3 705 720 (Pubitemid 36042672)
    • (2002) Biochemical Journal , vol.368 , Issue.3 , pp. 705-720
    • Saeki, K.1    Kobayashi, N.2    Inazawa, Y.3    Zhang, H.4    Nishitoh, H.5    Ichijo, H.6    Saeki, K.7    Isemura, M.8    Yuo, A.9
  • 36
    • 34848844388 scopus 로고    scopus 로고
    • Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL
    • Hsu W. H., Hsieh Y. S., Kuo H. C., Teng C. Y., Huang H. I., Wang C. J., Yang S. F., Liou Y. S., Kuo W. H., Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL Archives of Toxicology 2007 81 10 719 728
    • (2007) Archives of Toxicology , vol.81 , Issue.10 , pp. 719-728
    • Hsu, W.H.1    Hsieh, Y.S.2    Kuo, H.C.3    Teng, C.Y.4    Huang, H.I.5    Wang, C.J.6    Yang, S.F.7    Liou, Y.S.8    Kuo, W.H.9
  • 37
    • 74949087380 scopus 로고    scopus 로고
    • BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROS-p38MAPKS- linked cascade
    • Hyun M. S., Hur J. M., Mun Y. J., Kim D., Woo W. H., BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROS-p38MAPKS-linked cascade Journal of Cellular Biochemistry 2010 109 2 329 338
    • (2010) Journal of Cellular Biochemistry , vol.109 , Issue.2 , pp. 329-338
    • Hyun, M.S.1    Hur, J.M.2    Mun, Y.J.3    Kim, D.4    Woo, W.H.5


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