ROS-mediated EB1 phosphorylation through Akt/GSK3β pathway: Implication in cancer cell response to microtubule-targeting agents

Oncotarget

Volumn 5, Issue 10, 2014, Pages 3408-3423

  Grand, Marion Le ^a,b   Rovini, Amandine ^a,c   Bourgarel Rey, Veronique ^a,b   Honore, Stephane ^a,b   Bastonero, Sonia ^a   Braguer, Diane ^a   Carre, Manon ^a  

^a University of the Mediterranean Aix Marseille II   (France)

^b TIMONE HOSPITAL   (France)

^c MAYO CLINIC   (United States)

Author keywords

Akt GSK3 pathway; Chemotherapy; EB1 phosphorylation; Microtubule dynamics; Mitochondrial ROS

Indexed keywords

DIMETHYL SULFOXIDE; EPOTHILONE B; GLYCOGEN SYNTHASE KINASE 3BETA; ONCOPROTEIN; PACLITAXEL; POTASSIUM CYANIDE; PROTEIN EB1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; ROTENONE; SERINE; THREONINE; TIRON; UNCLASSIFIED DRUG; VINCRISTINE; ANTINEOPLASTIC AGENT; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MAPRE1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; TUBULIN MODULATOR;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER CELL LINE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MICROTUBULE; MITOCHONDRIAL DYNAMICS; NONHUMAN; OXIDATIVE STRESS; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CELL MOTION; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; LUNG TUMOR; METABOLISM; NON SMALL CELL LUNG CANCER; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOPRECIPITATION; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION; TUBULIN MODULATORS;

EID: 84902119951     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1982     Document Type: Article

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