Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells

Biochemical and Biophysical Research Communications

Volumn 418, Issue 2, 2012, Pages 336-341

  Lefevre, Sophie ^a,b   Sliwa, Dominika ^a   Rustin, Pierre ^c,d   Camadro, Jean Michel ^a   Santos, Renata ^a  

^a INSTITUT JACQUES MONOD   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Frataxin; Friedreich ataxia; Mitochondrial dynamics; Oxidative stress

Indexed keywords

FRATAXIN;

ARTICLE; CONTROLLED STUDY; FIBROBLAST; FRAGMENTATION REACTION; FRIEDREICH ATAXIA; HUMAN; HUMAN CELL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

FRIEDREICH ATAXIA; GENE DELETION; GTP PHOSPHOHYDROLASES; HUMANS; IRON-BINDING PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84856687068     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.022     Document Type: Article

References (31)

1. Pandolfo M. Friedreich ataxia: the clinical picture. J. Neurol. 2009, 256(Suppl. 1):3-8.
2. Campuzano V., Montermini L., Molto M.D., et al. Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science 1996, 271:1423-1427.
3. Santos R., Lefevre S., Sliwa D., Seguin A., Camadro J.M., Lesuisse E. Friedreich ataxia: molecular mechanisms, redox considerations and therapeutic opportunities. Antioxid. Redox Signal. 2010, 13:651-690.
4. Bayot A., Santos R., Camadro J.M., Rustin P. Friedreich ataxia: the vicious circle hypothesis revisited. BMC Med. 2011, 9:112.
5. Westermann B. Mitochondrial fusion and fission in cell life and death. Nat. Rev. Mol. Cell Biol. 2010, 11:872-884.
6. Chen H., Chan D.C. Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum. Mol. Genet. 2009, 18:R169-76.
7. Campello S., Scorrano L. Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep. 2010, 11:678-684.
8. Schon E.A., Przedborski S. Mitochondria: the next (neurode) generation. Neuron 2011, 70:1033-1053.
9. Shidara Y., Hollenbeck P.J. Defects in mitochondrial axonal transport and membrane potential without increased reactive oxygen species production in a Drosophila model of Friedreich ataxia. J. Neurosci. 2010, 30:11369-11378.
10. Zhang Y., Lyver E.R., Knight S.A., Lesuisse E., Dancis A. Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis. J. Biol. Chem. 2005, 280:19794-19807.
11. Longtine M.S., McKenzie A.3rd., Demarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998, 14:953-961.
12. Paupe V., Dassa E., Goncalves S., Auchère F., Lönn M., Holmgren A., Rustin P. Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. PLoS One 2009, 4:e4253.
13. Sliwa D., Dairou J., Camadro J.M., Santos R. Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells. Biochem. J. 2012, 10.1042/BJ20111574.
14. Seguin A., Bayot A., Dancis A., Rogowska-Wrzesinska A., Auchère F., Camadro J.M., Bulteau A.L., Lesuisse E. Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress. Mitochondrion 2009, 9:130-138.
15. Santos R., Buisson N., Knight S.A., Dancis A., Camadro J.M., Lesuisse E. Candida albicans lacking the frataxin homologue: a relevant yeast model for studying the role of frataxin. Mol. Microbiol. 2004, 54:507-519.
16. Auchère F., Santos R., Planamente S., Lesuisse E., Camadro J.M. Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia. Hum. Mol. Genet. 2008, 17:2790-2802.
17. Scott S.V., Cassidy-Stone A., Meeusen S., Nunnari J. Staying in aerobic shape: how the structural integrity of mitochondria and mitochondrial DNA is maintained. Curr. Opin. Cell Biol. 2003, 15:482-488.
18. Sauvanet C., Duvezin-Caubet S., di Rago J.P., Rojo M. Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics. Semin. Cell Dev. Biol. 2010, 21:558-565.
19. Gakh O., Bedekovics T., Duncan S.F., Smith D.Y.4th., Berkholz D.S., Isaya G. Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assembly. J. Biol. Chem. 2010, 285:38486-38501.
20. Schmucker S., Martelli A., Colin F., Page A., Wattenhofer-Donzé M., Reutenauer L., Puccio H. Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex. PLoS One 2011, 6:e16199.
21. Koeppen A.H., Morral J.A., Davis A.N., Qian J., Petrocine S.V., Knutson M.D., Gibson W.M., Cusack M.J., Li D. The dorsal root ganglion in Friedreich's ataxia. Acta Neuropathol. 2009, 118:763-776.
22. Lu C., Schoenfeld R., Shan Y., Tsai H.J., Hammock B., Cortopassi G. Frataxin deficiency induces schwann cell inflammation and death. Biochim. Biophys. Acta 2009, 1792:1052-1061.
23. Morral J.A., Davis A.N., Qian J., Gelman B.B., Koeppen A.H. Pathology and pathogenesis of sensory neuropathy in Friedreich's ataxia. Acta Neuropathol. 2010, 120:97-108.
24. Puccio H., Simon D., Cossée M., Criqui-Filipe P., Tiziano F., Melki J., Hindelang C., Matyas R., Rustin P., Koenig M. Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat. Genet. 2001, 27:181-186.
25. Simon D., Seznec H., Gansmuller A., Carelle N., Weber P., Metzger D., Rustin P., Koenig M., Puccio H. Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J. Neurosci. 2004, 24:1987-1995.
26. Al-Mahdawi S., Pinto R.M., Varshney D., Lawrence L., Lowrie M.B., Hughes S., Webster Z., Blake J., Cooper J.M., King R., Pook M.A. GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology. Genomics 2006, 88:580-590.
27. Bulteau A.L., Dancis A., Gareil M., Montagne J.J., Camadro J.M., Lesuisse E. Oxidative stress and protease dysfunction in the yeast model of Friedreich ataxia. Free Radic. Biol. Med. 2007, 42:1561-1570.
28. Rötig A., de Lonlay P., Chretien D., Foury F., Koenig M., Sidi D., Munnich A., Rustin P. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat. Genet. 1997, 17:215-217.
29. Cho D.H., Nakamura T., Lipton S.A. Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol. Life Sci. 2010, 67:3435-3447.
30. Züchner S., Mersiyanova I.V., Muglia M., et al. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat. Genet. 2004, 36:449-451.
31. Jahani-Asl A., Cheung E.C., Neuspiel M., MacLaurin J.G., Fortin A., Park D.S., McBride H.M., Slack R.S. Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. J. Biol. Chem. 2007, 282:23788-23798.