Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 2815-2827

  Marzaioli, Viviana ^a   Aguilar Pimentel, Juan Antonio ^a   Weichenmeier, Ingrid ^a   Luxenhofer, Georg ^b   Wiemann, Martin ^c   Landsiedel, Robert ^d   Wohlleben, Wendel ^d   Eiden, Stefanie ^e   Mempel, Martin ^f   Behrendt, Heidrun ^a   Schmidt Weber, Carsten ^a   Gutermuth, Jan ^a,g   Alessandrini, Francesca ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c IBE R and D gGmbH   (Germany)

^d BASF SE   (Germany)

^e BAYER AG   (Germany)

^f UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^g VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Allergic inflammation; Health impact; Immunomodulation

Indexed keywords

ALUMINUM HYDROXIDE; CHEMOKINE; CYTOKINE; MACROGOL; NANOPARTICLE; OVALBUMIN; SILICON DIOXIDE; IMMUNOLOGIC FACTOR;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL INFILTRATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; EOSINOPHIL; FEMALE; GENE EXPRESSION; GOBLET CELL; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; LUNG COMPLIANCE; LUNG RESISTANCE; LYMPHOCYTE; MACROPHAGE; MOUSE; MUCUS SECRETION; NEUTROPHIL; NONHUMAN; SURFACE PROPERTY; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; IMMUNOLOGY; MATERIALS TESTING; PNEUMONIA; STRUCTURE ACTIVITY RELATION; TOXICITY;

ANIMALS; FEMALE; IMMUNOLOGIC FACTORS; MATERIALS TESTING; MICE; MICE, INBRED BALB C; NANOPARTICLES; PNEUMONIA; SILICON DIOXIDE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 84902001440     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S57396     Document Type: Article

References (45)

1. Arora S, Rajwade JM, Paknikar KM. Nanotoxicology and in vitro studies: the need of the hour. Toxicol Appl Pharmacol. 2012;258:151-165.
2. Napierska D, Thomassen LC, Lison D, Martens JA, Hoet PH. The nanosilica hazard: another variable entity. Part FibreToxicol. 2010;7:39.
3. Hansen SF, Michelson ES, Kamper A, Borling P, StuerLauridsen F, Baun A. Categorization framework to aid exposure assessment of nanomaterials in consumer products. Ecotoxicology. 2008;17:438-447.
4. Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311:622-627.
5. Fröhlich E, Roblegg E. Models for oral uptake of nanoparticles in consumer products. Toxicology. 2012;291:10-17.
6. Mortensen LJ, Oberdörster G, Pentland AP, Delouise LA. In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett. 2008;8:2779-2787.
7. Yu KO, Grabinski CM, Schrand AM, etal. Toxicity of amorphous silica nanoparticles in mouse keratinocytes. J Nanopart Res. 2009;11:15-24.
8. Kreyling WG, SemmlerBehnke M, Seitz J, etal. Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol. 2009;21 Suppl 1:55-60.
9. Ho M, Wu KY, Chein HM, Chen LC, Cheng TJ. Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric. Inhal Toxicol. 2011;23:947-956.
10. Gustafsson Å, Lindstedt E, Elfsmark LS, Bucht A. Lung exposure of titanium dioxide nanoparticles induces innate immune activation and longlasting lymphocyte response in the Dark Agouti rat. J Immunotoxicol. 2011;8:111-121.
11. Lipka J, SemmlerBehnke M, Sperling RA, etal. Biodistribution of PEGmodified gold nanoparticles following intratracheal instillation and intravenous injection. Biomaterials. 2010;31: 6574-6581.
12. 2. Toxicol In Vitro. 2013;27:24-33.
13. Lin W, Huang YW, Zhou XD, Ma Y. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol. 2006;217:252-259.
14. Farcal LR, Uboldi C, Mehn D, etal. Mechanisms of toxicity induced by SiO2 nanoparticles of in vitro human alveolar barrier: effects on cytokine production, oxidative stress induction, surfactant proteins A mRNA expression and nanoparticles uptake. Nanotoxicology. 2013;7(6):1095-1110.
15. Park MDZ, Lynch I, RamírezGarcía S, etal. In vitro evaluation of cytotoxic and inflammatory properties of silica nanoparticles of different sizes in murine RAW 264.7 macrophages. J Nanopart Res. 2011;13: 6775-6787.
16. Cho WS, Choi M, Han BS, etal. Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles. Toxicol Lett. 2007;175:24-33.
17. Klein CL, Wiench K, Wiemann M, MaHock L, van Ravenzwaay B, Landsiedel R. Hazard identification of inhaled nanomaterials: making use of shortterm inhalation studies. Arch Toxicol. 2012;86: 1137-1151.
18. Landsiedel R, MaHock L, Kroll A, etal. Testing metaloxide nanomaterials for human safety. Adv Mater. 2010;22:2601-2627.
19. Han B, Guo J, Abrahaley T, etal. Adverse effect of nanosilicon dioxide on lung function of rats with or without ovalbumin immunization. PLoS One. 2011;6:e17236.
20. Brandenberger C, Rowley NL, JacksonHumbles DN, etal. Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice. PartFibreToxicol. 2013;10:26.
21. Lankoff A, Arabski M, WegierekCiuk A, etal. Effect of surface modification of silica nanoparticles on toxicity and cellular uptake by human peripheral blood lymphocytes in vitro. Nanotoxicology. 2013;7(3): 235-250.
22. Morishige T, Yoshioka Y, Inakura H, etal. The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture. Biomaterials. 2010;31:6833-6842.
23. Alessandrini F, Schulz H, Takenaka S, etal. Effects of ultrafine carbon particle inhalation on allergic inflammation of the lung. J Allergy Clin Immunol. 2006;117:824-830.
24. Bedoret D, Wallemacq H, Marichal T, etal. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest. 2009;119:3723-3738.
25. Alessandrini F, Weichenmeier I, van Miert E, etal. Effects of ultrafine particlesinduced oxidative stress on Clara cells in allergic lung inflammation. PartFibreToxicol. 2010;7:11.
26. Hussain S, Vanoirbeek JA, Luyts K, etal. Lung exposure to nanoparticles modulates an asthmatic response in a mouse model. Eur Respir J. 2011;37:299-309.
27. Alessandrini F, BeckSpeier I, Krappmann D, etal. Role of oxidative stress in ultrafine particleinduced exacerbation of allergic lung inflammation. Am J Respir CritCareMed. 2009;179:984-991.
28. Alessandrini F, SemmlerBehnke M, Jakob T, Schulz H, Behrendt H, Kreyling W. Total and regional deposition of ultrafine particles in a mouse model of allergic inflammation of the lung. Inhal Toxicol. 2008;20:585-593.
29. 2 in rats: fractions of particle diameter below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy. Inhal Toxicol. 2012;24:939-951.
30. Alexis NE, Soukup J, Nierkens S, Becker S. Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma. Am J PhysiolLungCell Mol Physiol. 2001;280:L369-L375.
31. Moreira AP, Hogaboam CM. Macrophages in allergic asthma: finetuning their proand antiinflammatory actions for disease resolution. J Interferon Cytokine Res. 2011;31:485-491.
32. Yamashita K, Yoshioka Y, Higashisaka K, etal. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol. 2011;6:321-328.
33. Yoshida T, Yoshioka Y, Matsuyama K, etal. Surface modification of amorphous nanosilica particles suppresses nanosilicainduced cytotoxicity, ROS generation, and DNA damage in various mammalian cells. Biochem Biophys Res Commun. 2012;427:748-752.
34. Ahamed M. Silica nanoparticlesinduced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells. Hum Exp Toxicol. 2013;32:186-195.
35. He Q, Zhang J, Shi J, etal. The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses. Biomaterials. 2010;31:1085-1092.
36. Monopoli MP, Aberg C, Salvati A, Dawson KA. Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol. 2012;7(12):779-786.
37. Guzmán E, Ferrari M, Santini E, Liggieri L, Ravera F. Influence of silica nanoparticles on phase behavior and structural properties of DPPC-Palmitic acid Langmuir monolayers. Colloids Surf A Physicochem Eng Asp. 2012;413:280-287.
38. Guzmán E, Liggieri L, Santini E, Ferrari M, Ravera F. Mixed DPPC-cholesterolLangmuir monolayers in presence of hydrophilic silica nanoparticles. Colloids Surf B Biointerfaces. 2013;105:284-293.
39. Nabeshi H, Yoshikawa T, Arimori A, etal. Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages. Nanoscale Res Lett. 2011;6:93.
40. Palmqvist C, Wardlaw AJ, Bradding P. Chemokines and their receptors as potential targets for the treatment of asthma. Br J Pharmacol. 2007;151:725-736.
41. Cormier SA, Yuan S, Crosby JR, etal. T(H)2mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages. Am J Respir Cell Mol Biol. 2002;27: 678-687.
42. Zhang Q, Hitchins VM, Schrand AM, Hussain SM, Goering PL. Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of proinflammatory mediators. Nanotoxicology. 2011;5:284-295.
43. Stütz AM, Pickart LA, Trifilieff A, Baumruker T, PrieschlStrassmayr E, Woisetschläger M. The Th2 cell cytokines IL4 and IL13 regulate found in inflammatory zone 1/resistinlike molecule alpha gene expression by a STAT6 and CCAAT/enhancerbinding proteindependent mechanism. J Immunol. 2003;170:1789-1796.
44. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev. 2006;86:245-278.
45. Kanoh S, Tanabe T, Rubin BK. IL13induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells. Clin Exp Allergy. 2011;41:1747-1756.