Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice

Particle and Fibre Toxicology

Volumn 10, Issue 1, 2013, Pages

  Brandenberger, Christina ^a   Rowley, Nicole L ^a   Jackson Humbles, Daven N ^a   Zhang, Quanxuan ^a   Bramble, Lori A ^a   Lewandowski, Ryan P ^a   Wagner, James G ^a   Chen, Weimin ^a,b   Kaplan, Barbara L ^a,c   Kaminski, Norbert E ^a,c   Baker, Gregory L ^a   Worden, Robert M ^d   Harkema, Jack R ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b NONE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d Michigan State University   (United States)

Author keywords

Adjuvant potential; Allergic airway disease; Murine ovalbumin model; Silica nanoparticles; Th2 Th17 response

Indexed keywords

CD11B ANTIGEN; CD69 ANTIGEN; CXCL1 CHEMOKINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROGOL; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; MUCIN 5AC; NANOPARTICLE; OVALBUMIN; SILICA NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; SILICON DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; BIOENGINEERING; BLOOD SAMPLING; CELL INFILTRATION; CELL TRANSPORT; CELLULAR DISTRIBUTION; CHLORIDE CHANNEL CALCIUM ACTIVATED 3 GENE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE EXACERBATION; ENVIRONMENTAL EXPOSURE; EOSINOPHIL; FEMALE; GENE; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNORESPONSIVE GENE 1; INFLAMMATORY CELL; INNATE IMMUNITY; INTELECTIN 1 GENE; KERATINOCYTE CHEMOATTRACTANT GENE; LUNG LAVAGE; LYMPHOCYTE ACTIVATION; MACROPHAGE INFLAMMATORY PROTEIN 1 ALPHA GENE; MACROPHAGE INFLAMMATORY PROTEIN 2 GENE; MATERIAL COATING; METAPLASIA; MOUSE; MUCIN 5 AC GENE; MUCOUS CELL; NEUTROPHIL COUNT; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; TH17 CELL; TH2 CELL; ADVERSE EFFECTS; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; GENETICS; IMMUNOLOGY; LOEFFLER PNEUMONIA; LUNG; LYMPH NODE; METABOLISM; NEUTROPHIL CHEMOTAXIS; RESPIRATORY TRACT ALLERGY; RISK ASSESSMENT; TIME;

ANIMALIA; MURINAE; MUS;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMMUNOGLOBULIN E; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; LUNG; LYMPH NODES; MICE, INBRED BALB C; NANOPARTICLES; NEUTROPHIL INFILTRATION; OVALBUMIN; PARTICLE SIZE; PULMONARY EOSINOPHILIA; RESPIRATORY HYPERSENSITIVITY; RISK ASSESSMENT; SILICON DIOXIDE; TH17 CELLS; TH2 CELLS; TIME FACTORS;

EID: 84879491061     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-10-26     Document Type: Article

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