Protective effects of rutin on liver injury induced by biliary obstruction in rats

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 106-116

  Pan, Pin Ho ^a   Lin, Shih Yi ^b   Wang, Ya Yu ^b   Chen, Wen Ying ^c   Chuang, Yu Han ^b   Wu, Chih Cheng ^b   Chen, Chun Jung ^b,c,d,e  

^a TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d TUNGHAI UNIVERSITY   (Taiwan)

^e HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Cholestasis; Fibrosis; Flavonoids; Free radicals; Inflammation; Oxidative stress; Rutin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; RUTOSIDE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1; ACTIN; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; GLUTATHIONE; MADH2 PROTEIN, RAT; MADH3 PROTEIN, RAT; NFE2L2 PROTEIN, RAT; PEROXIDASE; SMOOTH MUSCLE ACTIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVATION; EXPERIMENTAL LIVER INJURY; EXTRACELLULAR MATRIX; HEPATITIS; INTRACELLULAR SIGNALING; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER HOMOGENATE; LIVER PROTECTION; MALE; MORNING DOSAGE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BILIARY TRACT SURGERY; BIOSYNTHESIS; DRUG EFFECTS; HEPATOBILIARY SYSTEM; INFLAMMATION; INJURIES; LIVER; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ACTINS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BILIARY TRACT; BILIARY TRACT SURGICAL PROCEDURES; CHOLESTASIS; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE; HEME OXYGENASE-1; INFLAMMATION; INTERLEUKIN-1BETA; LIVER; LIVER CIRRHOSIS; MALE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RUTIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84901979303     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.05.001     Document Type: Article

References (44)

1. R. Bataller, and D.A. Brenner Liver fibrosis J. Clin. Invest. 115 2005 209 218 (Pubitemid 40385459)
2. V. Desmet, T. Roskams, and P. Van Eyken Ductular reaction in the liver Pathol. Res. Pract. 191 1995 513 524
3. T. Lamireau, M. Zoltowska, E. Levy, I. Yousef, J. Rosenbaum, B. Tuchweber, and A. Desmoulière Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion Life Sci. 72 2003 1401 1411 (Pubitemid 36090124)
4. T.Z. Liu, K.T. Lee, C.L. Chern, J.T. Cheng, A. Stern, and L.Y. Tsai Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB Ann. Clin. Lab. Sci. 31 2001 383 390 (Pubitemid 32988663)
5. J. González-Gallego, M.V. García-Mediavilla, S. Sánchez-Campos, and M.J. Tuñón Fruit polyphenols, immunity and inflammation Br. J. Nutr. 104 Suppl. 3 2010 15 27
6. R. Acquaviva, R. Lanteri, G.L. Destri, R. Caltabiano, L. Vanella, S. Lanzafame, A.D. Cataldo, G.L. Volti, and C.D. Giacomo Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G664 G670
7. M. Gao, Y. Ma, and D. Liu Rutin suppresses palmitic acids-triggered inflammation in macrophages and block high fat diet-induced obesity and fatty liver in mice Pharm. Res. 30 2013 2940 2950
8. 4-induced hepatotoxicity in rodents Fitoterapia 73 2002 557 563 (Pubitemid 35477750)
9. C.C. Lee, S.R. Shen, Y.J. Lai, and S.C. Wu Rutin and quercetin, bioactive components from tartary buckwheat, prevent liver inflammatory injury Food Funct 4 2013 794 802
10. W.Y. Chen, S.Y. Lin, H.C. Pan, S.L. Liao, Y.H. Chuang, Y.J. Yen, S.Y. Lin, and C.J. Chen Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats J. Nutr. Biochem. 23 2012 252 264
11. Y. Han, T. Haraguchi, S. Iwanaga, H. Tomotake, Y. Okazaki, S. Mineo, A. Moriyama, J. Inoue, and N. Kato Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer J. Agric. Food Chem. 57 2009 8587 8590
12. P.H. Pan, S.Y. Lin, Y.C. Ou, W.Y. Chen, Y.H. Chuang, Y.J. Yen, S.L. Liao, S.L. Raung, and C.J. Chen Stearic acid attenuates cholestasis-induced liver injury Biochem. Biophys. Res. Commun. 391 2010 1537 1542
13. H.C. Pan, T.K. Kao, Y.C. Ou, D.Y. Yang, Y.J. Yen, C.C. Wang, Y.H. Chuang, S.L. Liao, S.L. Raung, C.W. Wu, A.N. Chiang, and C.J. Chen Protective effect of docosahexaenoic acid against brain injury in ischemic rats J. Nutr. Biochem. 28 2009 715 725
14. H. Nagase, and J.F. Woessner Matrix metalloproteinases J. Biol. Chem. 274 1999 21491 21494 (Pubitemid 129519680)
15. M. Beaussier, D. Wendum, E. Schiffer, S. Dumont, C. Rev, A. Lienhart, and C. Housset Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries Lab. Invest. 87 2007 292 303 (Pubitemid 46353940)
16. A.M. Gressner, R. Weiskirchen, K. Breitkopf, and S. Dooley Roles of TGF-beta in hepatic fibrosis Front. Biosci. 7 2002 d793 d807
17. T. Kobayashi, T. Inoue, H. Okada, T. Kikuta, Y. Tanno, T. Nishida, M. Takigawa, T. Sugaya, and H. Suzuki Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose Clin. Exp. Nephrol. 9 2005 114 121 (Pubitemid 40875099)
18. E.S. Fox, J.C. Kim, and T.F. Tracy NF-kappaB activation and modulation in hepatic macrophages during cholestatic injury J. Surg. Res. 72 1997 129 134 (Pubitemid 27495583)
19. E. Gäbele, M. Froh, G.E. Arteel, T. Uesugi, C. Hellerbrand, J. Schölmerich, D.A. Brenner, R.G. Thurman, and R.A. Rippe TNFα is required for cholestasis-induced liver fibrosis in the mouse Biochem. Biophys. Res. Commun. 378 2009 348 353
20. A. Chen, and S. Zheng Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-κB and ERK signaling Br. J. Pharmacol. 153 2008 557 567 (Pubitemid 351199009)
21. C.H. Kang, Y.H. Choi, S.K. Moon, W.J. Kim, and G.Y. Kim Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway Int. Immunopharmacol. 17 2013 808 813
22. Y.W. Kim, S.M. Lee, S.M. Shin, S.J. Hwang, J.S. Brooks, H.E. Kang, M.G. Lee, S.C. Kim, and S.G. Kim Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury Free Radic. Biol. Med. 47 2009 1082 1092
23. G. Poli, and M. Parola Oxidative damage and fibrogenesis Free Radic. Biol. Med. 22 1997 287 305 (Pubitemid 26399335)
24. C. Le Jossic-Corcos, S. Duclos, L.C. Ramirez, I. Zaghini, G. Chevillard, P. Martin, T. Pineau, and P. Bournot Effects of peroxisome proliferator- activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes Biochim. Biophys. Acta 49-58 1683 2004
25. S.G. Parkar, D.E. Stevenson, and M.A. Skinner The potential influence of fruit polyphenols on colonic microflora and human gut health Int. J. Food Microbiol. 124 2008 295 298
26. E. Olaso, and S.L. Friedmann Molecular regulation of hepatic fibrogenesis J. Hepatol. 29 1998 836 847 (Pubitemid 28505945)
27. E.J. Williams, M.D. Gaca, D.R. Brigstock, M.J. Arthur, and R.C. Benyon Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells J. Hepatol. 32 2000 754 761 (Pubitemid 30262735)
28. K. Uchio, M. Graham, N.M. Dean, J. Rosenbaum, and A. Desmouliere Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis Wound Repair Regen. 12 2000 60 66
29. E.P. Cai, and J.K. Lin Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells J. Agric. Food Chem. 57 2009 9817 9827
30. Y. Cai, C. Fan, J. Yan, N. Tian, and X. Ma Effects of rutin on the expression of PPARγ in skeletal muscles of db/db mice Planta Med. 78 2012 861 865
31. S. Demirbilek, M. Akm, K. Gurunluoglu, N.E. Aydm, M.H. Emre, E. Tas, R.T. Aksoy, and S. Ay The NF-κB inhibitors attenuate hepatic injury in bile duct ligated rats Pediatr. Surg. Int 22 2006 655 663 (Pubitemid 44378710)
32. M. Fu, J. Zhang, X. Zhu, D.E. Myles, T.M. Willson, X. Liu, and Y.E. Chen Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3 J. Biol. Chem. 276 2001 45888 45894
33. R.A. Rippe, L.W. Schrum, B. Stefanovic, J.A. Solis-Herruzo, and D.A. Brenner NF-kappaB inhibits expression of the alpha1 (I) collagen gene DNA Cell Biol 18 1999 751 761 (Pubitemid 29504189)
34. L.Q. Yuan, Y. Lu, X.H. Luo, H. Xie, X.P. Wu, and E.Y. Liao Taurine promotes connective tissue growth factor (CTGF) expression in osteoblasts through the ERK signal pathway Amino Acids 32 2007 425 430 (Pubitemid 46559573)
35. M.K. Phanish, N.A. Wahab, B.M. Hendry, and M.E. Dockrell TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signaling Nephron Exp. Nephrol. 100 2005 E156 E165
36. G. Alpini, S. Glasser, D. Alvaro, Y. Ueno, M. Marzioni, H. Francis, L. Baiocchi, T. Stati, B. Barbaro, J.L. Phinizy, J. Mauldin, and G. Lesage Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol-3-kinase-dependent pathway in rats Gastroenterology 123 2002 1226 1237
37. E. Seki, S. De Minicis, C.H. Osterreicher, J. Kluwe, Y. Osawa, D.A. Brenner, and R.F. Schwabe TLR4 enhances TGF-beta signaling and hepatic fibrosis Nat. Med 13 2007 1324 1332 (Pubitemid 350073596)
38. A.I. Potapovich, D. Lulli, P. Fidanza, V.A. Kostyuk, C.D. Luca, S. Pastore, and L.G. Korkina Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathway Toxicol. Appl. Pharmacol. 255 2011 138 149
39. S. Reagan-Shaw, M. Nihal, and N. Ahmad Dose translation from animal to human studies revisited FASEB J. 22 2007 659 661
40. S.K. Panchal, H. Poudyal, T.V. Arumugam, and L. Brown Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats J. Nutr. 141 2011 1062 1069
41. A. Scalbert, and G. Williamson Dietary intake and bioavailability of polyphenols J. Nutr. 130 2000 S2073 S2085
42. S.P. Boyle, V.L. Dobson, S.J. Duthie, D.C. Hinselwood, J.A. M. Kyle, and A.R. Collins Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study Eur. J. Clin. Nutr. 54 2000 774 782
43. Y. Nakamura, S. Ishimitsu, and Y. Tonogai Effects of quercetin and rutin on serum and hepatic lipid concentrations, fecal steroid excretion and serum antioxidant properties J. Health Sci. 46 2000 229 240
44. C. Shackelford, G. Long, J. Wolf, C. Okerberg, and R. Herbert Qualitative and quantitative analysis of non-neoplastic lesions in toxicology studies Toxicol. Pathol. 30 2002 93 96 (Pubitemid 34194564)