Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice

Molecular Nutrition and Food Research

Volumn 58, Issue 6, 2014, Pages 1309-1321

  Kamata, Shotaro ^a   Yamamoto, Junya ^a   Kamijo, Kenta ^a   Ochiai, Takahito ^a   Morita, Tamako ^a   Yoshitomi, Yurika ^a   Hagiya, Yoshifumi ^a   Kubota, Masashi ^a   Ohkubo, Rika ^a   Kawaguchi, Maiko ^b   Himi, Toshiyuki ^c   Kasahara, Tadashi ^a   Ishii, Isao ^a  

^a KEIO UNIVERSITY   (Japan)

^b MEIJI UNIVERSITY   (Japan)

^c MUSASHINO UNIVERSITY   (Japan)

Author keywords

Amino acid starvation; Autophagy; Computed tomography; Essential amino acid; Muscle atrophy

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATINE KINASE; ESSENTIAL AMINO ACID; FATTY ACID; GLUCOSE BLOOD LEVEL; INSULIN; SERUM ALBUMIN; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL; BLOOD; BODY WEIGHT; C57BL MOUSE; CALORIC INTAKE; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; DEFICIENCY; DIET; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; MOUSE; SKELETAL MUSCLE; UREA NITROGEN BLOOD LEVEL;

ADIPOSE TISSUE; ALANINE TRANSAMINASE; AMINO ACIDS, ESSENTIAL; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BODY WEIGHT; CHOLESTEROL; CREATINE KINASE; DIET; ENERGY INTAKE; FATTY ACIDS, NONESTERIFIED; INSULIN; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; SERUM ALBUMIN; TOMOGRAPHY, X-RAY COMPUTED; TRIGLYCERIDES;

EID: 84901941076     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300758     Document Type: Article

References (37)

1. Rose, W. C., Johnson, J. E., Haines, W. J., The amino acid requirements of man. I. The role of valine and methionine. J. Biol. Chem. 1950, 182, 541-556.
2. Rose, W. C., Haines, W. J., Warner, D. T., The amino acid requirements of man. III. The role of isoleucine additional evidence concerning histidine. J. Biol. Chem. 1951, 193, 605-612.
3. Rose, W. C., Haines, W. J., Warner, D. T., The amino acid requirements of man. V. The role of lysine, arginine, and tryptophan. J. Biol. Chem. 1954, 206, 421-430.
4. Gallinetti, J., Harputlugil, E., Mitchell, J. R., Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem. J. 2013, 449, 1-10.
5. Peng, W., Robertson, L., Gallinetti, J., Mejia, P. et al., Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice. Sci. Transl. Med. 2012, 4, 118ra111.
6. Jousse, C., Averous, J., Bruhat, A., Carraro, V. et al., Amino acids as regulators of gene expression: molecular mechanisms. Biochem. Biophys. Res. Commun. 2004, 313, 447-452.
7. Kilberg, M. S., Shan, J., Su, N., ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol. Metab. 2009, 20, 436-443.
8. Palii, S. S., Thiaville, M. M., Pan, Y. X., Zhong, C., Kilberg, M. S., Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) system A transporter gene. Biochem. J. 2006, 395, 517-527.
9. Leung, P. M., Rogers, Q. R., Importance of prepyriform cortex in food-intake response of rats to amino acids. Am. J. Physiol. 1971, 221, 929-935.
10. Rudell, J. B., Rechs, A. J., Kelman, T. J., Ross-Inta, C. M. et al., The anterior piriform cortex is sufficient for detecting depletion of an indispensable amino acid, showing independent cortical sensory function. J. Neurosci. 2011, 31, 1583-1590.
11. Anthony, T. G., Gietzen, D. W., Detection of amino acid deprivation in the central nervous system. Curr. Opin. Clin. Nutr. Metab. Care 2013, 16, 96-101.
12. Koehnle, T. J., Russell, M. C., Gietzen, D. W., Rats rapidly reject diets deficient in essential amino acids. J. Nutr. 2003, 133, 2331-2335.
13. Hao, S., Sharp, J. W., Ross-Inta, C. M., McDaniel, B. J. et al., Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 2005, 307, 1776-1778.
14. Laplante, M., Sabatini, D. M., mTOR signaling in growth control and disease. Cell 2012, 149, 274-293.
15. Avruch, J., Long, X., Ortiz-Vega, S., Rapley, J. et al., Amino acid regulation of TOR complex 1. Am. J. Physiol. Endocrinol. Metab. 2009, 296, E592-E602.
16. Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A. et al., The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008, 320, 1496-1501.
17. Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., Guan, K. L., Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 2008, 10, 935-945.
18. Efeyan, A., Zoncu, R., Chang, S., Gumper, I. et al., Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 2013, 493, 679-683.
19. Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S. et al., mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 2011, 334, 678-683.
20. Hara, K., Yonezawa, K., Weng, Q. P., Kozlowski, M. T. et al., Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 1998, 273, 14484-14494.
21. Han, J. M., Jeong, S. J., Park, M. C., Kim, G. et al., Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149, 410-424.
22. Akahoshi, N., Kobayashi, C., Ishizaki, Y., Izumi, T. et al., Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum. Mol. Genet. 2008, 17, 1994-2005.
23. Ishii, I., Akahoshi, N., Yamada, H., Nakano, S. et al., Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J. Biol. Chem. 2010, 285, 26358-26368.
24. Lubura, M., Hesse, D., Neumann, N., Scherneck, S. et al., Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice. PLoS One 2012, 7, e37026.
25. Hayasaka, N., Nagai, N., Kawao, N., Niwa, A. et al., In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke. PLoS One 2012, 7, e32342.
26. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., Ohsumi, Y., In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell. 2004, 15, 1101-1111.
27. Cao, P. R., Kim, H. J., Lecker, S. H., Ubiquitin-protein ligases in muscle wasting. Int. J. Biochem. Cell Biol. 2005, 37, 2088-2097.
28. Masiero, E., Agatea, L., Mammucari, C., Blaauw, B. et al., Autophagy is required to maintain muscle mass. Cell Metab. 2009, 10, 507-515.
29. Hundal, H. S., Taylor, P. M., Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am. J. Physiol. Endocrinol. Metab. 2009, 296, E603-E613.
30. Dodd, K. M., Tee, A. R., Leucine and mTORC1: a complex relationship. Am. J. Physiol. Endocrinol. Metab. 2012, 302, E1329-E1342.
31. Harvey, R. A., Ferrier, D. R., Lippincott's Illustrated Reviews: Biochemistry, 5th edn., Lippincott Williams & Wilkins, Philadelphia 2011.
32. Kouchiwa, T., Wada, K., Uchiyama, M., Kasezawa, N. et al., Age-related changes in serum amino acids concentrations in healthy individuals. Clin. Chem. Lab. Med. 2012, 50, 861-870.
33. Noguchi, Y., Zhang, Q. W., Sugimoto, T., Furuhata, Y. et al., Network analysis of plasma and tissue amino acids and the generation of an amino index for potential diagnostic use. Am. J. Clin. Nutr. 2006, 83, 513S-519S.
34. Kimura, T., Takahashi, M., Imaizumi, A., Noguchi, Y., Ando, T., in: D'Mello, J. P. F. (Ed.), Amino Acid Profiles for Diagnostic Applications, CAB International, Cambridge 2012, pp. 464-476.
35. Guo, F., Cavener, D. R., The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 2007, 5, 103-114.
36. Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. et al., Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 2012, 491, 458-462.
37. Maddocks, O. D., Berkers, C. R., Mason, S. M., Zheng, L. et al., Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 2012, 493, 542-546.