Missing links in cardiology: Long non-coding RNAs enter the arena

Pflugers Archiv European Journal of Physiology

Volumn 466, Issue 6, 2014, Pages 1177-1187

  Peters, Tim ^a   Schroen, Blanche ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Cardiac development; Cardiac remodeling; Heart failure; LncRNA; Non coding RNA

Indexed keywords

LONG UNTRANSLATED RNA; STEROID RECEPTOR RNA ACTIVATOR 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; CARDIOVASCULAR DISEASE; CONGESTIVE CARDIOMYOPATHY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENOME; HEART DEVELOPMENT; HEART DISEASE; HEART FAILURE; HEART MUSCLE FIBROSIS; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART FAILURE; HUMANS; RNA, LONG NONCODING;

EID: 84901911389     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-014-1479-1     Document Type: Review

References (84)

1. Amaral PP, Clark MB, Gascoigne DK, Dinger ME, Mattick JS (2011) lncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res 39(Database issue):D146-D151. doi:10.1093/nar/gkq1138
2. Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM (2013) MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Ther 20(3):274-282. doi:10.1038/gt.2012.38
3. Bhartiya D, Pal K, Ghosh S, Kapoor S, Jalali S, Panwar B, Jain S, Sati S, Sengupta S, Sachidanandan C, Raghava GP, Sivasubbu S, Scaria V (2013) lncRNome: a comprehensive knowledgebase of human long noncoding RNAs. Database (Oxford). doi:10.1093/database/bat034
4. Bovolenta M, Erriquez D, Valli E, Brioschi S, Scotton C, Neri M, Falzarano MS, Gherardi S, Fabris M, Rimessi P, Gualandi F, Perini G, Ferlini A (2012) The DMD locus harbours multiple long noncoding RNAs which orchestrate and control transcription of muscle dystrophin mRNA isoforms. PLoS ONE 7(9):e45328. doi:10.1371/journal.pone.0045328
5. Brockdorff N, Ashworth A, Kay GF, McCabe VM, Norris DP, Cooper PJ, Swift S, Rastan S (1992) The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71(3):515-526
6. Brown CJ, Hendrich BD, Rupert JL, Lafreniere RG, Xing Y, Lawrence J, Willard HF (1992) The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71(3):527-542
7. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE (2010) Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet 6(12):e1001233. doi:10.1371/journal.pgen.1001233
8. Caley DP, Pink RC, Trujillano D, Carter DR (2010) Long noncoding RNAs, chromatin, and development. Sci World J 10:90-102. doi:10.1100/tsw.2010.7
9. Cao G, Zhang J, Wang M, Song X, Liu W, Mao C, Lv C (2013) Differential expression of long non-coding RNAs in bleomycin-induced lung fibrosis. Int J Mol Med 32(2):355-364. doi:10.3892/ijmm.2013.1404
10. Caretti G, Schiltz RL, Dilworth FJ, Di Padova M, Zhao P, Ogryzko V, Fuller-Pace FV, Hoffman EP, Tapscott SJ, Sartorelli V (2006) The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev Cell 11(4):547-560. doi:10.1016/j.devcel.2006.08.003 (Pubitemid 44467725)
11. Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA (2013) A long noncoding RNA mediates both activation and repression of immune response genes. Science 341(6147):789-792. doi:10.1126/science.1240925
12. Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I, Collavin L, Santoro C, Forrest AR, Carninci P, Biffo S, Stupka E, Gustincich S (2012) Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature 491(7424):454-457. doi:10.1038/nature11508
13. Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I (2011) A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 147(2):358-369. doi:10.1016/j.cell.2011.09.028
14. Chen LL, Carmichael GG (2009) Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. Mol Cell 35(4):467-478. doi:10.1016/j.molcel.2009.06.027
15. Chen J, Wang DZ (2012) microRNAs in cardiovascular development. J Mol Cell Cardiol 52(5):949-957. doi:10.1016/j.yjmcc.2012.01.012
16. Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E (2004) The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett 566(1-3):43-47. doi:10.1016/j.febslet.2004.03.104 (Pubitemid 38625930)
17. Consortium EP, Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414):57-74. doi:10.1038/nature11247
18. Cordes KR, Srivastava D (2009) MicroRNA regulation of cardiovascular development. Circ Res 104(6):724-732. doi:10.1161/CIRCRESAHA.108.192872
19. Da Costa Martins PA, De Windt LJ (2012) MicroRNAs in control of cardiac hypertrophy. Cardiovasc Res 93(4):563-572. doi:10.1093/cvr/cvs013
20. Dinger ME, Pang KC, Mercer TR, Mattick JS (2008) Differentiating protein-coding and noncoding RNA: challenges and ambiguities. PLoS Comput Biol 4(11):e1000176. doi:10.1371/journal.pcbi.1000176
21. Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C et al (2012) Landscape of transcription in human cells. Nature 489(7414):101-108. doi:10.1038/nature11233
22. Duan M, Yao H, Hu G, Chen X, Lund AK, Buch S (2013) HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy. PloS ONE 8(3):e60170. doi:10.1371/journal.pone.0060170
23. Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12(12):861-874. doi:10.1038/nrg3074
24. Frenquelli M, Muzio M, Scielzo C, Fazi C, Scarfo L, Rossi C, Ferrari G, Ghia P, Caligaris-Cappio F (2010) MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27. Blood 115(19):3949-3959. doi:10.1182/blood-2009-11-254656
25. Friedrichs F, Zugck C, Rauch GJ, Ivandic B, Weichenhan D, Muller-Bardorff M, Meder B, El Mokhtari NE, Regitz-Zagrosek V, Hetzer R, Schafer A, Schreiber S, Chen J, Neuhaus I, Ji R, Siemers NO, Frey N, Rottbauer W, Katus HA, Stoll M (2009) HBEGF, SRA1, and IK: three cosegregating genes as determinants of cardiomyopathy. Genome Res 19(3):395-403. doi:10.1101/gr.076653.108
26. Gedicke-Hornung C, Behrens-Gawlik V, Reischmann S, Geertz B, Stimpel D, Weinberger F, Schlossarek S, Precigout G, Braren I, Eschenhagen T, Mearini G, Lorain S, Voit T, Dreyfus PA, Garcia L, Carrier L (2013) Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice. EMBO Mol Med 5(7):1060-1077. doi:10.1002/emmm.201202168
27. Graff JW, Dickson AM, Clay G, McCaffrey AP, Wilson ME (2012) Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem 287(26):21816-21825. doi:10.1074/jbc.M111.327031
28. Grote P, Wittler L, Hendrix D, Koch F, Wahrisch S, Beisaw A, Macura K, Blass G, Kellis M, Werber M, Herrmann BG (2013) The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell 24(2):206-214. doi:10.1016/j.devcel.2012.12.012
29. Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, Bernstein BE, Kellis M, Regev A, Rinn JL, Lander ES (2009) Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458(7235):223-227. doi:10.1038/nature07672
30. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D (2011) STAT3 and cardiac remodeling. Heart Fail Rev 16(1):35-47. doi:10.1007/s10741-010-9170-x
31. Hangauer MJ, Vaughn IW, McManus MT (2013) Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet 9(6):e1003569. doi:10.1371/journal.pgen.1003569
32. Howard PL, Dally GY, Ditta SD, Austin RC, Worton RG, Klamut HJ, Ray PN (1999) Dystrophin isoforms DP71 and DP427 have distinct roles in myogenic cells. Muscle Nerve 22(1):16-27 (Pubitemid 28564033)
33. Hube F, Guo J, Chooniedass-Kothari S, Cooper C, Hamedani MK, Dibrov AA, Blanchard AA, Wang X, Deng G, Myal Y, Leygue E (2006) Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines. DNA Cell Biol 25(7):418-428. doi:10.1089/dna.2006.25.418 (Pubitemid 44175334)
34. Hube F, Velasco G, Rollin J, Furling D, Francastel C (2011) Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation. Nucleic Acids Res 39(2):513-525. doi:10.1093/nar/gkq833
35. Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT (2007) Altered microRNA expression in human heart disease. Physiol Genomics 31(3):367-373. doi:10.1152/physiolgenomics.00144.2007 (Pubitemid 350127777)
36. Ip JY, Nakagawa S (2012) Long non-coding RNAs in nuclear bodies. Develop Growth Differ 54(1):44-54. doi:10.1111/j.1440-169X.2011.01303.x
37. Ishii N, Ozaki K, Sato H, Mizuno H, Saito S, Takahashi A, Miyamoto Y, Ikegawa S, Kamatani N, Hori M, Saito S, Nakamura Y, Tanaka T (2006) Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. J Hum Genet 51(12):1087-1099. doi:10.1007/s10038-006-0070-9 (Pubitemid 44800728)
38. Kapranov P, St Laurent G, Raz T, Ozsolak F, Reynolds CP, Sorensen PH, Reaman G, Milos P, Arceci RJ, Thompson JF, Triche TJ (2010) The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol 8:149. doi:10.1186/1741-7007-8-149
39. Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K et al (2001) Functional annotation of a full-length mouse cDNA collection. Nature 409(6821):685-690. doi:10.1038/35055500
40. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA (2013) Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell 152(3):570-583. doi:10.1016/j.cell.2013. 01.003
41. Knoll M, Simmons S, Bouquet C, Grun JR, Melchers F (2013) miR-221 redirects precursor B cells to the BM and regulates their residence. Eur J Immunol 43(9):2497-2506. doi:10.1002/eji.201343367
42. Kong SW, Hu YW, Ho JW, Ikeda S, Polster S, John R, Hall JL, Bisping E, Pieske B, dos Remedios CG, Pu WT (2010) Heart failure-associated changes in RNA splicing of sarcomere genes. Circ Cardiovasc Genet 3(2):138-146. doi:10.1161/CIRCGENETICS.109.904698
43. Kornienko AE, Guenzl PM, Barlow DP, Pauler FM (2013) Gene regulation by the act of long non-coding RNA transcription. BMC Biol 11:59. doi:10.1186/1741-7007-11-59
44. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J et al (2001) Initial sequencing and analysis of the human genome. Nature 409(6822):860-921. doi:10.1038/35057062
45. Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW (1999) A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell 97(1):17-27 (Pubitemid 29165886)
46. Latronico MV, Condorelli G (2009) MicroRNAs and cardiac pathology. Nat Rev Cardiol 6(6):419-429. doi:10.1038/nrcardio.2009.56
47. Leung A, Trac C, Jin W, Lanting L, Akbany A, Saetrom P, Schones DE, Natarajan R (2013) Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells. Circ Res 113(3):266-278. doi:10.1161/CIRCRESAHA. 112.300849
48. Lin Q, Schwarz J, Bucana C, Olson EN (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276(5317):1404-1407 (Pubitemid 27235406)
49. Liu N, Olson EN (2010) MicroRNA regulatory networks in cardiovascular development. Dev Cell 18(4):510-525. doi:10.1016/j.devcel.2010.03.010
50. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, del Monte F, Hajjar RJ, Linke WA (2004) Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res 95(7):708-716. doi:10.1161/01.RES.0000143901.37063.2f (Pubitemid 39331931)
51. Mann DL (2002) Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res 91(11):988-998
52. Nakagawa S, Ip JY, Shioi G, Tripathi V, Zong X, Hirose T, Prasanth KV (2012) Malat1 is not an essential component of nuclear speckles in mice. Rna 18(8):1487-1499. doi:10.1261/rna.033217.112
53. Nakagawa S, Naganuma T, Shioi G, Hirose T (2011) Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol 193(1):31-39. doi:10.1083/jcb.201011110
54. Ohno S (1972) So much "junk" DNA in our genome. Brookhaven Symp Biol 23:366-370
55. Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y et al (2002) Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420(6915):563-573. doi:10.1038/nature01266 (Pubitemid 35477049)
56. Pang KC, Frith MC, Mattick JS (2006) Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function. Trends in genetics : TIG 22(1):1-5. doi:10.1016/j.tig.2005.10.003 (Pubitemid 43011990)
57. Quiat D, Olson EN (2013) MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment. J Clin Invest 123(1):11-18. doi:10.1172/JCI62876
58. Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H (2007) Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev 12(3-4):331-343. doi:10.1007/s10741-007-9034-1 (Pubitemid 350176706)
59. Rapicavoli NA, Qu K, Zhang J, Mikhail M, Laberge RM, Chang HY (2013) A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. eLife 2:e00762. doi:10.7554/eLife.00762
60. Ravasi T, Suzuki H, Pang KC, Katayama S, Furuno M, Okunishi R, Fukuda S, Ru K, Frith MC, Gongora MM, Grimmond SM, Hume DA, Hayashizaki Y, Mattick JS (2006) Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res 16(1):11-19. doi:10.1101/gr.4200206 (Pubitemid 43048929)
61. Ritter O, Haase H, Schulte HD, Lange PE, Morano I (1999) Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors. J Cell Biochem 74(4):551-561 (Pubitemid 29372495)
62. Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL (2013) Multiple knockout mouse models reveal lincRNAs are required for life and brain development. eLife 2:e01749. doi:10.7554/eLife.01749
63. Sayed D, Abdellatif M (2011) MicroRNAs in development and disease. Physiol Rev 91(3):827-887. doi:10.1152/physrev.00006.2010
64. Schroen B, Heymans S (2009) MicroRNAs and beyond: the heart reveals its treasures. Hypertension 54(6):1189-1194. doi:10.1161/HYPERTENSIONAHA.109.133942
65. Schroen B, Heymans S (2012) Small but smart-microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing. Cardiovasc Res 93(4):605-613. doi:10.1093/cvr/cvr268
66. Shi X, Sun M, Liu H, Yao Y, Song Y (2013) Long non-codingRNAs: a new frontier in the study of human diseases. Cancer Lett 339(2):159-166. doi:10.1016/j.canlet.2013.06.013
67. Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE, Lee JT (2013) High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. doi:10.1038/nature12719
68. Sone M, Hayashi T, Tarui H, Agata K, Takeichi M, Nakagawa S (2007) The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. J Cell Sci 120(Pt 15):2498-2506. doi:10.1242/jcs.009357 (Pubitemid 47323859)
69. Song HK, Hong SE, Kim T, Kimdo H (2012) Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy. PloS ONE 7(4):e35552. doi:10.1371/journal.pone.0035552
70. Sucharov C, Bristow MR, Port JD (2008) miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol 45(2):185-192. doi:10.1016/j.yjmcc.2008.04.014
71. Suter D, Tomasini R, Reber U, Gorman L, Kole R, Schumperli D (1999) Double-target antisense U7 snRNAs promote efficient skipping of an aberrant exon in three human beta-thalassemic mutations. Hum Mol Genet 8(13):2415-2423
72. Taft RJ, Pheasant M, Mattick JS (2007) The relationship between non-protein-coding DNA and eukaryotic complexity. BioEssays 29(3):288-299. doi:10.1002/bies.20544 (Pubitemid 46384167)
73. Tijsen AJ, Pinto YM, Creemers EE (2012) Non-cardiomyocyte microRNAs in heart failure. Cardiovasc Res 93(4):573-582. doi:10.1093/cvr/cvr344
74. Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, Freier SM, Bennett CF, Sharma A, Bubulya PA, Blencowe BJ, Prasanth SG, Prasanth KV (2010) The nuclear-retained noncoding RNAMALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39(6):925-938. doi:10.1016/j.molcel.2010.08.011
75. Tsuiji H, Yoshimoto R, Hasegawa Y, Furuno M, Yoshida M, Nakagawa S (2011) Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes Cells 16(5):479-490. doi:10.1111/j.1365-2443.2011.01502.x
76. Ulitsky I, Shkumatava A, Jan CH, Sive H, Bartel DP (2011) Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell 147(7):1537-1550. doi:10.1016/j.cell.2011.11.055
77. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR et al (2001) The sequence of the human genome. Science 291(5507):1304-1351. doi:10.1126/science.1058040 (Pubitemid 32173090)
78. Volders PJ, Helsens K, Wang X, Menten B, Martens L, Gevaert K, Vandesompele J, Mestdagh P (2013) LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Res 41(Database issue):D246-D251. doi:10.1093/nar/gks915
79. Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43(6):904-914. doi:10.1016/j.molcel.2011.08.018
80. Wang J, Zhang J, Zheng H, Li J, Liu D, Li H, Samudrala R, Yu J, Wong GK (2004) Mouse transcriptome: neutral evolution of 'noncoding' complementary DNAs. Nature 431 (7010):1 p following 757; discussion following 757
81. Wheeler TM, Leger AJ, Pandey SK, MacLeod AR, Nakamori M, Cheng SH, Wentworth BM, Bennett CF, Thornton CA (2012) Targeting nuclear RNA for in vivo correction of myotonic dystrophy. Nature 488(7409):111-115. doi:10.1038/ nature11362
82. Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG (2005) A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science 309(5740):1570-1573. doi:10.1126/science.1115901 (Pubitemid 41266484)
83. Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR Jr, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J Jr, Chen J, Xiao RP, Cheng H, Fu XD (2005) ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 120(1):59-72. doi:10.1016/j.cell.2004.11.036 (Pubitemid 40094603)
84. Zhou Q, Chung AC, Huang XR, Dong Y, Yu X, Lan HY (2013) Identification of novel long noncoding RNAs associated with TGF-beta/Smad3-mediated renal inflammation and fibrosis by RNA sequencing. Am J Pathol. doi:10.1016/j.ajpath. 2013.10.007