Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

Biochemical and Biophysical Research Communications

Volumn 437, Issue 1, 2013, Pages 87-93

  Liu, Ju Mei ^a   Pan, Feng ^a   Li, Li ^a   Liu, Qian Rong ^a   Chen, Yong ^a   Xiong, Xin Xin ^a   Cheng, Kejun ^b,c   Yu, Shang Bin ^a   Shi, Zhi ^d   Yu, Albert Cheung Hoi ^e   Chen, Xiao Qian ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Chemical Biology Center   (China)

^c Vatalis Tech   (United States)

^d JINAN UNIVERSITY   (China)

^e PEKING UNIVERSITY   (China)

Author keywords

Apoptosis; Brain tumor; Cancer therapy; Glioma; Oxidative stress; Piplartine

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ALKALOID; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PIPERLONGUMINE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WESTERN BLOTTING;

2′-,7′-DICHLOROFLUORESCIN DIACETATE; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; APOPTOSIS; BRAIN TUMOR; C-JUN N-TERMINAL KINASE; CANCER THERAPY; DCFH-DA; DIMETHYL SULFOXIDE; DMEM; DMSO; DULBECCO'S MODIFIED EAGLE'S MEDIUM; FBS; FCM; FETAL BOVINE SERUM; FLOW CYTOMETRY; GBM; GLIOBLASTOMA MULTIFORME; GLIOMA; GLUTATHIONE; GSH; JNK; MTT; N-ACETYL-L-CYSTEINE; NAC; OXIDATIVE STRESS; PBS; PHOSPHATE BUFFERED SALINE; PI; PIPERLONGUMINE; PIPLARTINE; PL; PROPIDIUM IODIDE; REACTIVE OXYGEN SPECIES; ROS;

ASTROCYTES; CELL DEATH; CELL LINE, TUMOR; DIOXOLANES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; GLIOBLASTOMA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

EID: 84880511948     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.042     Document Type: Article

References (22)

1. Stupp R., Mason W.P., van den Bent M.J., Weller M., Fisher B., Taphoorn M.J., Belanger K., Brandes A.A., Marosi C., Bogdahn U., Curschmann J., Janzer R.C., Ludwin S.K., Gorlia T., Allgeier A., Lacombe D., Cairncross J.G., Eisenhauer E., Mirimanoff R.O. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 2005, 352:987-996.
2. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068.
3. Evans S.M., Judy K.D., Dunphy I., Jenkins W.T., Hwang W.T., Nelson P.T., Lustig R.A., Jenkins K., Magarelli D.P., Hahn S.M., Collins R.A., Grady M.S., Koch C.J. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin. Cancer Res. 2004, 10:8177-8184.
4. Zhao S., Lin Y., Xu W., Jiang W., Zha Z., Wang P., Yu W., Li Z., Gong L., Peng Y., Ding J., Lei Q., Guan K.L., Xiong Y. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009, 324:261-265.
5. Trachootham D., Alexandre J., Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?. Nat. Rev. Drug Discov. 2009, 8:579-591.
6. Bezerra D.P., Pessoa C., de Moraes M.O., Saker-Neto N., Silveira E.R., Costa-Lotufo L.V. Overview of the therapeutic potential of piplartine Piperlongumine. Eur. J. Pharm. Sci. 2012, 48:453-463.
7. Raj L., Ide T., Gurkar A.U., Foley M., Schenone M., Li X., Tolliday N.J., Golub T.R., Carr S.A., Shamji A.F., Stern A.M., Mandinova A., Schreiber S.L., Lee S.W. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 2011, 475:231-234.
8. Adams D.J., Dai M., Pellegrino G., Wagner B.K., Stern A.M., Shamji A.F., Schreiber S.L. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proc. Natl. Acad. Sci. USA 2012, 109:15115-15120.
9. Liu H., Luo R., Chen X., Liu J., Bi Y., Zheng L., Wu X. Tissue distribution profiles of three antiparkinsonian alkaloids from Piper longum L. in rats determined by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2013, 928:78-82.
10. Chen X.Q., Chen J.G., Zhang Y., Hsiao W.W., Yu A.C. 14-3-3gamma is upregulated by in vitro ischemia and binds to protein kinase Raf in primary cultures of astrocytes. Glia 2003, 42:315-324.
11. Chen X.Q., Qin L.Y., Zhang C.G., Yang L.T., Gao Z., Liu S., Lau L.T., Fung Y.W., Greenberg D.A., Yu A.C. Presence of neuroglobin in cultured astrocytes. Glia 2005, 50:182-186.
12. Ye S.Q., Zhou X.Y., Lai X.J., Zheng L., Chen X.Q. Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol. Sin. 2009, 30:913-918.
13. Zhang J., Lan S.J., Liu Q.R., Liu J.M., Chen X.Q. Neuroglobin, a novel intracellular hexa-coordinated globin, functions as a tumor suppressor in hepatocellular carcinoma via Raf/MAPK/Erk. Mol. Pharmacol. 2013, 83:1109-1119.
14. Chen X.Q., Yu A.C. The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes. Biochem. Biophys. Res. Commun. 2002, 296:657-663.
15. Gomez-Lazaro M., Galindo M.F., Melero-Fernandez de Mera R.M., Fernandez-Gomez F.J., Concannon C.G., Segura M.F., Comella J.X., Prehn J.H., Jordan J. Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol. Pharmacol. 2007, 71:736-743.
16. Xiao D., Zeng Y., Prakash L., Badmaev V., Majeed M., Singh S.V. Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase. Mol. Pharmacol. 2011, 79:499-507.
17. Kumar S., Jiang M.S., Adams J.L., Lee J.C. Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 1999, 263:825-831.
18. Schwer C.I., Mutschler M., Stoll P., Goebel U., Humar M., Hoetzel A., Schmidt R. Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Mol. Pharmacol. 2010, 77:660-669.
19. Wang T., Arifoglu P., Ronai Z., Tew K.D. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J. Biol. Chem. 2001, 276:20999-21003.
20. Randhawa H., Kibble K., Zeng H., Moyer M.P., Reindl K.M. Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicol. In Vitro 2013, 27:1626-1633.
21. Son D.J., Kim S.Y., Han S.S., Kim C.W., Kumar S., Park B.S., Lee S.E., Yun Y.P., Jo H., Park Y.H. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem. Biophys. Res. Commun. 2012, 427:349-354.
22. Jarvius M., Fryknas M., D'Arcy P., Sun C., Rickardson L., Gullbo J., Haglund C., Nygren P., Linder S., Larsson R. Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem. Biophys. Res. Commun. 2013, 431:117-123.