FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage

Journal of Neuroscience

Volumn 34, Issue 23, 2014, Pages 7802-7813

  Deng, Qiudong ^a   Holler, Christopher J ^a   Taylor, Georgia ^a   Hudson, Kathryn F ^a   Watkins, William ^a   Gearing, Marla ^a   Ito, Daisuke ^b   Murray, Melissa E ^c   Dickson, Dennis W ^c   Seyfried, Nicholas T ^a   Kukar, Thomas ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KEIO UNIVERSITY   (Japan)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Amyotrophic lateral sclerosis (ALS); Cytoplasmic translocation; DNA damage; Frontotemporal lobar degeneration (FTLD); Fused in Sarcoma (FUS); Phosphorylation

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; FUSED IN SARCOMA PROTEIN; TATA BINDING PROTEIN ASSOCIATED FACTOR; TRANSPORTIN 1; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL CULTURE; CELL FRACTIONATION; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NERVE CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTON TRANSPORT; QUANTITATIVE ANALYSIS; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

AMYOTROPHIC LATERAL SCLEROSIS (ALS); CYTOPLASMIC TRANSLOCATION; DNA DAMAGE; FRONTOTEMPORAL LOBAR DEGENERATION (FTLD); FUSED IN SARCOMA (FUS); PHOSPHORYLATION;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; ASTROCYTES; CELLS, CULTURED; CYTOPLASM; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; ENEDIYNES; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; IMMUNOPRECIPITATION; MUTAGENS; MUTATION; NEURONS; NUCLEAR PROTEINS; PHOSPHORYLATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA-BINDING PROTEIN EWS; RNA-BINDING PROTEIN FUS; TATA-BINDING PROTEIN ASSOCIATED FACTORS;

EID: 84901785917     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0172-14.2014     Document Type: Article

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