A binuclear gold(I) complex with mixed bridging diphosphine and bis(N-heterocyclic carbene) ligands shows favorable thiol reactivity and inhibits tumor growth and angiogenesis in vivo

Angewandte Chemie - International Edition

Volumn 53, Issue 23, 2014, Pages 5810-5814

  Zou, Taotao ^a   Lum, Ching Tung ^a   Lok, Chun Nam ^a   To, Wai Pong ^a   Low, Kam Hung ^a   Che, Chi Ming ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (China)

Author keywords

antitumor agents; gold(I); N heterocyclic carbenes; thiol reactivity; thioredoxin reductase (TrxR)

Indexed keywords

BIOLOGICAL MATERIALS; BLOOD; DERMATOLOGY; GOLD; MAMMALS; ONCOLOGY; ORGANIC COMPOUNDS; STEM CELLS; TUMORS;

ANTI-TUMOR AGENTS; CANCER STEM CELLS; DIPHOSPHINE LIGAND; GOLD COMPLEXES; INHIBITION OF TUMOR GROWTH; N-HETEROCYCLIC CARBENES; THIOL REACTIVITY; THIOREDOXIN REDUCTASE;

LIGANDS;

CARBENE; GOLD; LIGAND; METHANE; THIOL DERIVATIVE; THIOREDOXIN REDUCTASE;

ANALOGS AND DERIVATIVES; ANIMAL; CELL PROLIFERATION; CHEMISTRY; HELA CELL LINE; HUMAN; METABOLISM; MOUSE; NEOVASCULARIZATION (PATHOLOGY); RABBIT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GOLD; HELA CELLS; HUMANS; LIGANDS; METHANE; MICE; NEOVASCULARIZATION, PATHOLOGIC; RABBITS; SULFHYDRYL COMPOUNDS; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84901770059     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201400142     Document Type: Article

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