Inhibition of 1,4-β-D-xylan xylanohydrolase by the specific aspartic protease inhibitor pepstatin: Probing the two-step inhibition mechanism

Journal of Biological Chemistry

Volumn 279, Issue 45, 2004, Pages 47024-47033

  Vathipadiekal, Vinod ^a   Rao, Mala ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; DISSOCIATION; HYDROGEN BONDS; PROTEINS; REACTION KINETICS;

INHIBITION MECHANISM; XYLANASE;

ENZYME INHIBITION;

ASPARTIC PROTEINASE INHIBITOR; HISTIDINE; HYDROLASE; PEPSTATIN; XYLAN ENDO 1,3 BETA XYLOSIDASE;

ARTICLE; CATALYSIS; ENZYME BINDING; ENZYME INHIBITOR COMPLEX; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; ISOMERIZATION; KINETICS; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL;

ACTINOBACTERIA; ASPARTIC ENDOPEPTIDASES; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDO-1,4-BETA XYLANASES; ENZYME INHIBITORS; HISTIDINE; INHIBITORY CONCENTRATION 50; KINETICS; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; PEPSTATINS; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; TEMPERATURE; THERMODYNAMICS; TIME FACTORS;

THERMOMONOSPORA;

EID: 8744220600     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407866200     Document Type: Article

References (65)

1. Legler, G. (1990) Adv. Carbohydr. Chem. Biochem. 48, 319-385
2. Sinnot, M. L. (1990) Chem. Rev. 90, 1171-1202
3. Elbein, A. D., Legler, G., Trusty, A., McDowell, W., and Schwarz, R. (1984) Arch. Biochem. Biophys. 235, 579-588
4. Leroy, E., and Reymond, J.-L. (1999) Org. Lett. 1, 775-777
5. Truscheit, E., Frommer, W., Junge, B., Muller, L., Schimdt, D. D., and Wingender, W. (1981) Angew. Chem. Int. Ed. Engl. 20, 744-761
6. Fenton, R. J., Morley, P. J., Owens, I. J., Gower, D., Parry, S., Crossman, L., and Wong, T. (1999) Antimicrob. Agents Chemother.43, 2642-2647
7. Biely, P. (1985) Trends Biotechnol. 3, 286-290
8. Kulkarni, N., Shendye, A., and Rao, M. (1999) FEMS Microbiol. Rev. 23, 411-456
9. Tarvainen, K., and Keskinen, H. (1991) Clin. Exp. Allergy 21, 609-615
10. Harris, G. W., Jenkins, N. A., Connerton, I., Cummings, N., Lo Leggio, L., Scott, M., Hazlewood, G. P., Laurie, J. I., Gilbert, H. J., and Pickersgill, R. W. (1994) Structure 2, 1107-1116
11. White, A., Withers, S. G., Gilkes, N. R., and Rose, N. R. (1994) Biochemistry 33, 12546-12552
12. Davies, G. J., Wilson, K., and Henrissat, B. (1997) Biochem. J. 321, 557-559
13. Royers, J. C., and Nakas, J. P. (1989) Enzyme Microb. Technol. 11, 405-410
14. Ly, H. D., and Withers, S. G. (1999) Annu. Rev. Biochem. 316, 695-696
15. White, A., Tull, D., Johns, K., Withers, S. G., and Rose, D. R. (1996) Nat. Struct. Biol. 3, 149-154
16. Stutz, A. E. (1999) Immunosugars as Glycosidase Inhibitors: Nojirimycin and Beyond, pp. 95-120, Wiley-VCH, Weinheim, Germany
17. Umezawa, H., Aoyagi, T., Morishima, H., Hamed, M., and Takeuchi, T. (1970) J. Antibiot. (Tokyo) 23, 259-262
18. Sachdev, G. P., Brownstein, A. D., and Fruton, J. S. (1973) J. Biol. Chem. 248, 6292-6299
19. Barrett, A. J., and Dingle, J. T. (1972) Biochem. J. 127, 439-441
20. Murakami, K., Inagami, T., Michelakis, A. M., and Cohen, S. (1973) Biochem. Biophys. Res. Commun. 54, 482-487
21. Carvol, P., Devaux, C., and Menard, J. (1973) FEBS Lett. 34, 189-192
22. Umezawa, H. (1972) Enzyme Inhibitors of Microbial Origin, p. 31, University Park Press, Baltimore, MD
23. Miller, R. P., Poper, C. J., Wilson, C. W., and De Vito, E. (1972) Biochem. Pharmacol. 21, 2941-2944
24. Lazar, J., Orth, H., Mochring, J., and Gross, F. (1972) Naunyn Schmiededbergs Arch. Pharmacol. 275, 114-118
25. Von der Helm, K., Gurtler, L., Eberle, J., and Deinhardt, F. (1989) FEBS Lett. 247, 349-352
26. George, S. P., Ahmad, A., and Rao, M. (2001) Bioresour. Technol. 77, 171-175
27. George, S. P., Ahmad, A., and Rao, M. (2001) Biochem. Biophys. Res. Commun. 282, 48-54
28. Miller, G. L. (1959) Anal. Chem. 31, 426-428
29. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
30. Dixon, M. (1953) Biochem. J. 55, 170-171
31. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138
32. Beith, J. G. (1995) Methods Enzymol. 248, 59-84
33. Morrison, J. F., and Stone, S. R. (1985) Comments Mol. Cell. Biophys. 2, 347-368
34. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. 62, 201-302
35. Houtzager, V., Oullet, M., Falgueyret, J.-P., Passmore, L. A., Bayly, C., and Percival, M. D. (1996) Biochemistry 35, 10974-10984
36. Lakowicz, J. R. (1983) Principles of Fluorescence Spectrosmpy, pp. 180-195, Plenum Press, New York
37. Marciniszyn, J., Jr., Hartsuck, J. A., and Tang, J. (1976) J. Biol. Chem. 251, 7088-7094
38. McKown, M. M., Wrokman, R, J., and Gregerman, R. I. (1974) J. Biol. Chem. 249, 7770-7774
39. Knight, C. G., and Barrett, A. J. (1976), Biochem. J. 155, 117-125
40. George, S. P., and Rao, M. (2001) Eur. J. Biochem. 268, 2881-2888
41. Dash, C., Vinod, V. P., George, S. P., and Rao, M. (2002) J. Biol. Chem. 277, 17978-17986
42. Murao, S., and Miyata, S. (1980) Agric. Biol. Chem. 44, 219-221
43. Hohenschutz, L. D., Bell, E. A., Jewess, P. J., Leworthy, D. P., Pryce, R. J., Arnold, E., and Clardy, J. (1981) Phytochemistry 20, 811-814
44. Pan, Y. T., Hori, H., Saul, R., Sanford, B. A., Molyneux, R. J., and Elbein, A. D. (1983) Biochemistry 22, 3975-3984
45. Dorling, P. R., Huxtable, C. R., and Colegate, S. M. (1980) Biochem. J. 191, 649-651
46. Withers, S. G., and Aerbersold, R. (1995) Protein Sci. 4, 361-372
47. Leger, G. (1968) Hoppe-Seyler's Z. Physiol. Chem. 349, 767-774
48. Halazy, S., Berges, V., Ehrhard, E., and Danzin, C. (1990) Bioorg. Chem. 18, 330-334
49. Marshall, P. J., Sinnott, M. L., Smith, P. J., and Widdows, D. (1981) J. Chem. Soc. Perkin Trans. I, 366-376
50. Williams, J. W., and Morrison, J. F. (1979) Methods Enzymol. 63, 437-467
51. Wolfenden, R. (1976) Annu. Rev. Biophys. Bioeng. 5, 271-306
52. Szedlacsek, S., and Duggleby, R. G. (1995) Methods Enzymol. 249, 144-180
53. Sculley, M. J., Morrison, J. F., and Cleland, W. W. (1996) Biochim. Biophys. Acta 1298, 78-86
54. Morrison, J. F. (1982) Trends Biochem. Sci. 7, 102-105
55. Yiallouros, I., Vassiliou, S., Yiotakis, A., Zwilling, R., Stocker, W., and Dive, V. (1998) Biochem. J. 331, 375-379
56. Ploux, O., Breyne, O., Carillon, S., and Marquet, A. (1999) Eur. J. Biochem. 259, 63-70
57. Pegg, M. S., and Itzstein, M. v. (1994) Biochem. Mol. Biol. Int. 32, 851-858
58. Kati, W. M., Saldivar, A. S., Mohamadi, F., Sham, H. L., Laver, W. G., and Kohlbrenner, W. E. (1998) Biochem. Biophys. Res. Commun. 244, 408-413
59. Pawagi, A. B., and Deber, C. M. (1990) Biochemistry 20, 950-955
60. Cheung, H. C. (1991) in Topics in Fluorescence Spectroscopy (Lakowicz, J. R., ed) Vol. 2, pp127-176, Plenum Press, New York
61. Simons, S. S., Jr., Thompson, E. B., and Johnson, D. F. (1979) Biochemistry 18, 4915-4922
62. Palczewski, K., Hargrave, P. A., and Kochman, M. (1983) Eur. J. Biochem. 137, 429-435
63. Rao, M. B., Tanksale, A. M., Ghatge, M. S., and Deshpande, V. V. (1998) Microbiol. Mol. Biol. Rev. 62, 597-635
64. Natesh, R., Bhanumoorthy, P., Vithayathil, P. J., Sekar, K., Ramakumar, S., and Viswamitra, M. A. (1999) J. Mol. Biol. 288, 999-1012
65. Fujinaga, M., Chernaia, M. M., Tarasova, N. I., Mosinann, S. C., and James, M. N. G. (1995) Protein Sci. 4, 960-972