A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor

Journal of Medicinal Chemistry

Volumn 52, Issue 3, 2009, Pages 763-770

  Ott, Ingo ^a,b   Qian, Xuhong ^b   Xu, Yufang ^b   Vlecken, Danielle H W ^c   Marques, Ines J ^c   Kubutat, Dominic ^d   Will, Joanna ^d   Sheldrick, William S ^d   Jesse, Patrick ^e   Prokop, Aram ^e   Bagowski, Christoph P ^c  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c LEIDEN UNIVERSITY   (Netherlands)

^d RUHR UNIVERSITY BOCHUM   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

[N (N',N' DIMETHYLAMINOETHYL) 1,8 NAPHTHALIMIDE 4 SULFIDE]TRIETHYLPHOSPHINE GOLD COMPLEX; ANGIOGENESIS INHIBITOR; GOLD COMPLEX; NAPHTHALIMIDE DERIVATIVE; PHOSPHINE DERIVATIVE; THIOREDOXIN REDUCTASE; TRIETHYLPHOSPHINE GOLD; UNCLASSIFIED DRUG; (N (N',N' DIMETHYLAMINOETHYL) 1,8 NAPHTHALIMIDE 4 SULFIDE)(TRIETHYLPHOSPHINE)GOLD(I); (N-(N',N'-DIMETHYLAMINOETHYL)-1,8-NAPHTHALIMIDE-4-SULFIDE)(TRIETHYLPHOSPHINE)GOLD(I); ANTINEOPLASTIC AGENT; ORGANOGOLD COMPOUND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CELL CULTURE; CELL NUCLEUS; CELL ORGANELLE; CELL PROLIFERATION; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DNA FRAGMENTATION; DRUG STRUCTURE; EMBRYO; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; FLUOROMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; MASS SPECTROMETRY; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; NONHUMAN; PHARMACODYNAMICS; TUMOR CELL; TUMOR VASCULARIZATION; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; CELL STRAIN HT29; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; DRUG EFFECT; MAXIMUM TOLERATED DOSE; SYNTHESIS; TANDEM MASS SPECTROMETRY;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; EMBRYO, NONMAMMALIAN; HT29 CELLS; HUMANS; MAXIMUM TOLERATED DOSE; MICROSCOPY, CONFOCAL; ORGANOGOLD COMPOUNDS; TANDEM MASS SPECTROMETRY; THIOREDOXIN-DISULFIDE REDUCTASE; ZEBRAFISH;

EID: 61449155600     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8012135     Document Type: Article

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