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1
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35548953077
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Some uses of transition metal complexes as anti-cancer and anti-HIV agents
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This review focuses the uses of metal-based drugs as anticancer and anti-HIV agents.
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Sun R.W.Y., Ma D.L., Wong E.L.M., and Che C.M. Some uses of transition metal complexes as anti-cancer and anti-HIV agents. Dalton Trans (2007) 4884-4892. This review focuses the uses of metal-based drugs as anticancer and anti-HIV agents.
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Dalton Trans
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Sun, R.W.Y.1
Ma, D.L.2
Wong, E.L.M.3
Che, C.M.4
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2
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64549106469
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Metal complexes, their cellular targets and potential for cancer therapy
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This review focuses on the development of non-platinum metal complexes as anticancer drugs.
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Chen D., Milacic V., Frezza M., and Dou Q.P. Metal complexes, their cellular targets and potential for cancer therapy. Curr Pharm Des 15 (2009) 777-791. This review focuses on the development of non-platinum metal complexes as anticancer drugs.
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Curr Pharm Des
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Chen, D.1
Milacic, V.2
Frezza, M.3
Dou, Q.P.4
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3
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43049147578
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New trends for metal complexes with anticancer activity
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The use of metal as scaffold rather than reactive center and the departure from cisplatin paradigm of activity toward a more targeted, cancer cell-specific approach were discussed in this review.
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Bruijnincx P.C.A., and Sadler P.J. New trends for metal complexes with anticancer activity. Curr Opin Chem Biol 12 (2008) 197-206. The use of metal as scaffold rather than reactive center and the departure from cisplatin paradigm of activity toward a more targeted, cancer cell-specific approach were discussed in this review.
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Curr Opin Chem Biol
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Bruijnincx, P.C.A.1
Sadler, P.J.2
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4
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Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
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Van Rijt S.H., and Sadler P.J. Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov Today 14 (2009) 1089-1097
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Drug Discov Today
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Van Rijt, S.H.1
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70350351432
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Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: structural and kinetic aspects
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Angelucci F., Sayed A.A., Williams D.L., Boumis G., Brunori M., Dimastrogiovanni D., Miele A.E., Pauly F., and Bellelli A. Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem 284 (2009) 28977-28985
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Angelucci, F.1
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Brunori, M.5
Dimastrogiovanni, D.6
Miele, A.E.7
Pauly, F.8
Bellelli, A.9
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6
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0021970996
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Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models
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Mirabelli C.K., Johnson R.K., Sung C.M., Faucette L., Muirhead K., and Crooke S.T. Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models. Cancer Res 45 (1985) 32-39
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Mirabelli, C.K.1
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Muirhead, K.5
Crooke, S.T.6
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7
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61449155600
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A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor
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Ott I., Qian X., Xu Y., Vlecken D.H., Marques I.J., Kubutat D., Will J., Sheldrick W.S., Jesse P., Prokop A., et al. A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor. J Med Chem 52 (2009) 763-770
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Ott, I.1
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Will, J.7
Sheldrick, W.S.8
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Prokop, A.10
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8
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33751275548
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A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts
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An in vivo study revealed that gold(III) dithiocarbamate compound is a promising anticancer agent that inhibits the activity of 20S proteasome and 26S proteasome.
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Milacic V., Chen D., Ronconi L., Landis-Piwowar K.R., Fregona D., and Dou Q.P. A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts. Cancer Res 66 (2006) 10478-10486. An in vivo study revealed that gold(III) dithiocarbamate compound is a promising anticancer agent that inhibits the activity of 20S proteasome and 26S proteasome.
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Milacic, V.1
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Dou, Q.P.6
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9
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0035899183
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Human thioredoxin reductase is efficiently inhibited by (2,2′:6′,2″-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy
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Becker K., Herold-Mende C., Park J.J., Lowe G., and Schirmer R.H. Human thioredoxin reductase is efficiently inhibited by (2,2′:6′,2″-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy. J Med Chem 44 (2001) 2784-2792
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Becker, K.1
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10
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67449132090
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Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1
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Lo Y.C., Ko T.P., Su W.C., Su T.L., and Wang A.H.J. Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1. J Inorg Biochem 103 (2009) 1082-1092
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Lo, Y.C.1
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11
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Mechanistic insight into the inhibition of matrix metalloproteinases by platinum substrates
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in press
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Arnesano F, Boccarelli A, Cornacchia D, Nushi F, Sasanelli R, Coluccia M, Natile G: Mechanistic insight into the inhibition of matrix metalloproteinases by platinum substrates. J Med Chem 2009, in press.
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Arnesano, F.1
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Sasanelli, R.5
Coluccia, M.6
Natile, G.7
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12
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70349976185
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Rational design of an organometallic glutathione transferase inhibitor
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Ang W.H., Parker L.J., De Luca A., Juillerat-Jeanneret L., Morton C.J., Lo Bello M., Parker M.W., and Dyson P.J. Rational design of an organometallic glutathione transferase inhibitor. Angew Chem Int Ed Engl 48 (2009) 3854-3857
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Ang, W.H.1
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Morton, C.J.5
Lo Bello, M.6
Parker, M.W.7
Dyson, P.J.8
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13
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52449114832
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Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols
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Hickey J.L., Ruhayel R.A., Barnard P.J., Baker M.V., Berners-Price S.J., and Filipovska A. Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols. J Am Chem Soc 130 (2008) 12570-12571
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The rational design of anticancer platinum complexes: the importance of the structure-activity relationship
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Montana A.M., and Batalla C. The rational design of anticancer platinum complexes: the importance of the structure-activity relationship. Curr Med Chem 16 (2009) 2235-2260
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Montana, A.M.1
Batalla, C.2
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Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity. DNA binding and induction of apoptosis in human cervix epitheloid cancer cells
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A substitution-inert gold(III) porphyrin complex (gold-1a) is found to be stable against GSH reduction.
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Che C.M., Sun R.W.Y., Yu W.Y., Ko C.B., Zhu N., and Sun H. Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity. DNA binding and induction of apoptosis in human cervix epitheloid cancer cells. Chem Commun (Camb) (2003) 1718-1719. A substitution-inert gold(III) porphyrin complex (gold-1a) is found to be stable against GSH reduction.
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Che, C.M.1
Sun, R.W.Y.2
Yu, W.Y.3
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Zhu, N.5
Sun, H.6
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Gold(III) porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species
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Wang Y., He Q.Y., Sun R.W.Y., Che C.M., and Chiu J.F. Gold(III) porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species. Cancer Res 65 (2005) 11553-11564
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Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways
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Wang Y., He Q.Y., Che C.M., Tsao S.W., Sun R.W.Y., and Chiu J.F. Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways. Biochem Pharmacol 75 (2008) 1282-1291
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Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma
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Lum C.T., Yang Z.F., Li H.Y., Sun R.W.Y., Fan S.T., Poon R.T.P., Lin M.C.M., Che C.M., and Kung H.F. Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma. Int J Cancer 118 (2006) 1527-1538
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Lin, M.C.M.7
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Kung, H.F.9
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Gold (III) porphyrin complexes induce apoptosis and cell cycle arrest and inhibit tumor growth in colon cancer
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Tu S., Sun R.W.Y., Lin M.C.M., Cui J.T., Zou B., Gu Q., Kung H.F., Che C.M., and Wong B.C.Y. Gold (III) porphyrin complexes induce apoptosis and cell cycle arrest and inhibit tumor growth in colon cancer. Cancer 115 (2009) 4459-4469
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Anti-cancer complex gold(III) porphyrin 2a as a novel histone deacetylase inhibitor targeting Wnt/β-catenin pathway
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An in vivo study revealed that gold(III) porphyrin complex (gold-2a) is a potent anticancer agent and a novel histone deacetylase inhibitor, in press
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Chow KHM, Sun RWY, Lam JBB, Li CKL, Xu A, MA DL, Abagyan R, Wang Y, Che CM: Anti-cancer complex gold(III) porphyrin 2a as a novel histone deacetylase inhibitor targeting Wnt/β-catenin pathway. Cancer Res 2009, in press. An in vivo study revealed that gold(III) porphyrin complex (gold-2a) is a potent anticancer agent and a novel histone deacetylase inhibitor.
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Chow, K.H.M.1
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MA, D.L.6
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Che, C.M.9
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Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA
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Ma D.L., Che C.M., and Yan S.C. Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA. J Am Chem Soc 131 (2009) 1835-1846
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Stabilization of G-Quadruplex DNA with platinum(II) Schiff-base complexes: luminescent probe and down regulation of c-myc oncogene expression
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A series of platinum(II) complexes, mimic organic stabilizers, were found to stabilize c-myc G-quadruplex DNA.
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Wu P., Ma D.L., Leung C.H., Yan C.H., Zhu N., Abagyan R., and Che C.M. Stabilization of G-Quadruplex DNA with platinum(II) Schiff-base complexes: luminescent probe and down regulation of c-myc oncogene expression. Chemistry 15 (2009) 13008-13021. A series of platinum(II) complexes, mimic organic stabilizers, were found to stabilize c-myc G-quadruplex DNA.
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Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor
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A series of organoruthenium complexes, mimic staurosporine, were found to be potent protein kinase inhibitors.
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Anand R., Maksimoska J., Pagano N., Wong E.Y., Gimotty P.A., Diamond S.L., Meggers E., and Marmorstein R. Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. J Med Chem 52 (2009) 1602-1611. A series of organoruthenium complexes, mimic staurosporine, were found to be potent protein kinase inhibitors.
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24
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Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3
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Atilla-Gokcumen G.E., Pagano N., Streu C., Maksimoska J., Filippakopoulos P., Knapp S., and Meggers E. Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3. Chembiochem 9 (2008) 2933-2936
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Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes
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67049154293
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The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase
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Xie P., Streu C., Qin J., Bregman H., Pagano N., Meggers E., and Marmorstein R. The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry 48 (2009) 5187-5198
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Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity
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Xie P., Williams D.S., Atilla-Gokcumen G.E., Milk L., Xiao M., Smalley K.S.M., Herlyn M., Meggers E., and Marmorstein R. Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. ACS Chem Biol 3 (2008) 305-316
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