Culture duration-, donor-, and medium-dependent changes in OATP1B3-mediated telmisartan uptake in human hepatocytes

Drug Metabolism Letters

Volumn 7, Issue 2, 2013, Pages 117-125

  Zhu, Qing ^a   Xia, Haiyan ^a   Xia, Cindy Q ^a   Yang, Qian ^b   Doshi, Utkarsh ^b   Li, Albert P ^b   Liao, Mingxiang ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Vitro ADMET Laboratories   (United States)

Author keywords

Donor dependent; Human hepatocytes; Medium dependent; Oatp1b3; Telmisartan uptake; Time dependent; Uptake transporter

Indexed keywords

MESSENGER RNA; RIFAMPICIN; ROSUVASTATIN; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; TELMISARTAN; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; CULTURE MEDIUM; FLUOROBENZENE; ORGANIC ANION TRANSPORTER; PYRIMIDINE DERIVATIVE; SLCO1B3 PROTEIN, HUMAN; SULFONAMIDE;

ARTICLE; CULTURE MEDIUM; DONOR; DRUG ACTIVITY; DRUG EFFECT; DRUG UPTAKE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMIT OF QUANTITATION; LIVER CELL; LIVER CELL CULTURE; MALE; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; AGED; COMPARATIVE STUDY; CULTURE TECHNIQUE; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM; MIDDLE AGED; TIME; TRANSPORT AT THE CELLULAR LEVEL; YOUNG ADULT;

AGED; BENZIMIDAZOLES; BENZOATES; BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CULTURE MEDIA; FEMALE; FLUOROBENZENES; HEK293 CELLS; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PYRIMIDINES; RNA, MESSENGER; SULFONAMIDES; TIME FACTORS; TISSUE DONORS; TRANSFECTION; YOUNG ADULT;

EID: 84901759080     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1872312808666140317153311     Document Type: Article

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