메뉴 건너뛰기




Volumn 16, Issue 6, 2014, Pages

Angiotensin II and vascular injury

Author keywords

Angiotensin receptors; Atherosclerosis; Calcification; Inflammation; Oxidative stress; Signal transduction; Vascular remodelling

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84901736495     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-014-0431-2     Document Type: Review
Times cited : (342)

References (154)
  • 1
    • 3242718855 scopus 로고    scopus 로고
    • From bedside to bench to bedside: Role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension
    • DOI 10.1152/ajpheart.00262.2004
    • Schiffrin EL, Touyz RM. From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension. Am J Physiol Heart Circ Physiol. 2004;287(2):H435-46. (Pubitemid 38960790)
    • (2004) American Journal of Physiology - Heart and Circulatory Physiology , vol.287 , Issue.2
    • Schiffrin, E.L.1    Touyz, R.M.2
  • 2
    • 0037675052 scopus 로고    scopus 로고
    • The role of angiotensin II in regulating vascular structural and functional changes in hypertension
    • Touyz RM. The role of angiotensin II in regulating vascular structural and functional changes in hypertension. Curr Hypertens Rep. 2003;5(2):155-64. (Pubitemid 38898946)
    • (2003) Current Hypertension Reports , vol.5 , Issue.2 , pp. 155-164
    • Touyz, R.M.1
  • 3
    • 84898005689 scopus 로고    scopus 로고
    • The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness
    • Aroor AR, Demarco VG, Jia G, Sun Z, Nistala R, Meininger GA, et al. The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front Endocrinol. 2013;4:161-8.
    • (2013) Front Endocrinol , vol.4 , pp. 161-168
    • Aroor, A.R.1    Demarco, V.G.2    Jia, G.3    Sun, Z.4    Nistala, R.5    Meininger, G.A.6
  • 4
    • 74949092226 scopus 로고    scopus 로고
    • New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism
    • Ferrario CM. New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension. 2010;55(2):445-52.
    • (2010) Hypertension , vol.55 , Issue.2 , pp. 445-452
    • Ferrario, C.M.1
  • 6
    • 77949536656 scopus 로고    scopus 로고
    • Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
    • Bader M. Tissue renin-angiotensin-aldosterone systems: targets for pharmacological therapy. Annu Rev Pharmacol Toxicol. 2010;50:439-65.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 439-465
    • Bader, M.1
  • 7
    • 0028300301 scopus 로고
    • The emerging concept of vascular remodeling
    • DOI 10.1056/NEJM199405193302008
    • Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med. 1994;330:1431-8. (Pubitemid 24139238)
    • (1994) New England Journal of Medicine , vol.330 , Issue.20 , pp. 1431-1438
    • Gibbons, G.H.1    Dzau, V.J.2
  • 8
    • 0035463112 scopus 로고    scopus 로고
    • Vascular remodeling in hypertension: Roles of apoptosis, inflammation, and fibrosis
    • Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension. 2001;38:581-7.
    • (2001) Hypertension , vol.38 , pp. 581-587
    • Intengan, H.D.1    Schiffrin, E.L.2
  • 9
    • 59849126798 scopus 로고    scopus 로고
    • The plastic nature of the vascular wall: A continuum of remodeling events contributing to control of arteriolar diameter and structure
    • Martinez-Lemus LA, Hill MA, Meininger GA. The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure. Physiology. 2009;24:45-57.
    • (2009) Physiology , vol.24 , pp. 45-57
    • Martinez-Lemus, L.A.1    Hill, M.A.2    Meininger, G.A.3
  • 11
    • 62949144844 scopus 로고    scopus 로고
    • The adipose renin-angiotensin system: Role in cardiovascular disease
    • Thatcher S. The adipose renin-angiotensin system: role in cardiovascular disease. Mol Cell Endocrinol. 2009;302(2):111-7.
    • (2009) Mol Cell Endocrinol , vol.302 , Issue.2 , pp. 111-117
    • Thatcher, S.1
  • 13
    • 84873057372 scopus 로고    scopus 로고
    • Evolving concepts on regulation and function of renin in distal nephron
    • Prieto MC, Gonzalez AA, Navar LG. Evolving concepts on regulation and function of renin in distal nephron. Pflugers Arch. 2013;465(1):121-32.
    • (2013) Pflugers Arch , vol.465 , Issue.1 , pp. 121-132
    • Prieto, M.C.1    Gonzalez, A.A.2    Navar, L.G.3
  • 14
    • 52049090409 scopus 로고    scopus 로고
    • Local adipose tissue renin-angiotensin system
    • Cassis LA. Local adipose tissue renin-angiotensin system. Curr Hypertens Rep. 2008;10(2):93-8.
    • (2008) Curr Hypertens Rep , vol.10 , Issue.2 , pp. 93-98
    • Cassis, L.A.1
  • 15
    • 33747588568 scopus 로고    scopus 로고
    • Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase
    • DOI 10.1254/jphs.CPJ06008X
    • Miyazaki M, Takai S. Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase. J Pharmacol Sci. 2006;100(5):391-7. (Pubitemid 44609530)
    • (2006) Journal of Pharmacological Sciences , vol.100 , Issue.5 , pp. 391-397
    • Miyazaki, M.1    Takai, S.2
  • 16
    • 77951499583 scopus 로고    scopus 로고
    • Prorenin, Renin, and their receptor: Moving targets
    • Reudelhuber TL. Prorenin, Renin, and their receptor: moving targets. Hypertension. 2010;55(5):1071-107.
    • (2010) Hypertension , vol.55 , Issue.5 , pp. 1071-1107
    • Reudelhuber, T.L.1
  • 18
    • 75149152420 scopus 로고    scopus 로고
    • The biology of the (pro)renin receptor
    • Nguyen G, Muller DN. The biology of the (pro)renin receptor. J Am Soc Nephrol. 2010;21(1):8-23.
    • (2010) J Am Soc Nephrol , vol.21 , Issue.1 , pp. 8-23
    • Nguyen, G.1    Muller, D.N.2
  • 19
    • 75149122361 scopus 로고    scopus 로고
    • The (pro)renin receptor in health and disease
    • Nguyen G. The (pro)renin receptor in health and disease. Ann Med. 2010;42(1):13-8.
    • (2010) Ann Med , vol.42 , Issue.1 , pp. 13-18
    • Nguyen, G.1
  • 20
    • 77957334373 scopus 로고    scopus 로고
    • Role of (pro)renin receptor in cardiovascular cells from the aspect of signaling
    • Hitom H, Liu G, Nishiyama A. Role of (pro)renin receptor in cardiovascular cells from the aspect of signaling. Front Biosci. 2010;2:1246-9.
    • (2010) Front Biosci , vol.2 , pp. 1246-1249
    • Hitom, H.1    Liu, G.2    Nishiyama, A.3
  • 21
    • 68549111147 scopus 로고    scopus 로고
    • The (pro)renin receptor: Site-specific and functional linkage to the vacuolar H+ -ATPase in the kidney
    • Advani A, Kelly DJ, Cox AJ,White KE, Advani SL, Thai K, et al. The (pro)renin receptor: site-specific and functional linkage to the vacuolar H+ -ATPase in the kidney. Hypertension. 2009;54:261-9.
    • (2009) Hypertension , vol.54 , pp. 261-269
    • Advani, A.1    Kelly, D.J.2    Cox, A.J.3    White, K.E.4    Advani, S.L.5    Thai, K.6
  • 22
    • 78049423569 scopus 로고    scopus 로고
    • Potential role of the (pro)renin receptor in cardiovascular and kidney diseases
    • Cousin C, Bracquart D, Contrepas A, Nguyen G. Potential role of the (pro)renin receptor in cardiovascular and kidney diseases. J Nephrol. 2010;23:508-13.
    • (2010) J Nephrol , vol.23 , pp. 508-513
    • Cousin, C.1    Bracquart, D.2    Contrepas, A.3    Nguyen, G.4
  • 23
    • 77956392838 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2: Central regulator for cardiovascular function
    • Xia H, Lazartigues E. Angiotensin-converting enzyme 2: central regulator for cardiovascular function. Curr Hypertens Rep. 2010;12(3):170-5.
    • (2010) Curr Hypertens Rep , vol.12 , Issue.3 , pp. 170-175
    • Xia, H.1    Lazartigues, E.2
  • 24
    • 84873033171 scopus 로고    scopus 로고
    • ACE2, angiotensin-(1-7), andMas: The other side of the coin
    • Bader M. ACE2, angiotensin-(1-7), andMas: the other side of the coin. Pflugers Arch. 2013;465(1):79-85.
    • (2013) Pflugers Arch , vol.465 , Issue.1 , pp. 79-85
    • Bader, M.1
  • 25
    • 59849118931 scopus 로고    scopus 로고
    • Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension
    • Shaltout HA. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009;53(2):404-8.
    • (2009) Hypertension , vol.53 , Issue.2 , pp. 404-408
    • Shaltout, H.A.1
  • 27
    • 77649222347 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis
    • Imai Y. Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 2010;74(3):405-10.
    • (2010) Circ J , vol.74 , Issue.3 , pp. 405-410
    • Imai, Y.1
  • 28
    • 0032583129 scopus 로고    scopus 로고
    • Angiotensin-(1-7): A bioactive fragment of the renin-angiotensin system
    • DOI 10.1016/S0167-0115(98)00134-7, PII S0167011598001347
    • Ferrario CM, Iyer SN. Angiotensin-(1-7): a bioactive fragment of the renin-angiotensin system. Regul Pept. 1998;78(1-3):13-8. (Pubitemid 28561512)
    • (1998) Regulatory Peptides , vol.78 , Issue.1-3 , pp. 13-18
    • Ferrario, C.M.1    Iyer, S.N.2
  • 29
    • 77950505611 scopus 로고    scopus 로고
    • Lifetime overproduction of circulating Angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling
    • Santiago NM. Lifetime overproduction of circulating Angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling. Hypertension. 2010;55(4):889-96.
    • (2010) Hypertension , vol.55 , Issue.4 , pp. 889-896
    • Santiago, N.M.1
  • 30
    • 70349325847 scopus 로고    scopus 로고
    • Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia
    • Cangussu LM. Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides. 2009;30(10):1921-7.
    • (2009) Peptides , vol.30 , Issue.10 , pp. 1921-1927
    • Cangussu, L.M.1
  • 32
    • 42649115768 scopus 로고    scopus 로고
    • Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)- Mas axis
    • DOI 10.1113/expphysiol.2008.042002
    • Santos RA, Ferreira AJ, Simões E, Silva AC. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol. 2008;93(5):519-27. (Pubitemid 351595060)
    • (2008) Experimental Physiology , vol.93 , Issue.5 , pp. 519-527
    • Santos, R.A.S.1    Ferreira, A.J.2    Simoes E, S.A.C.3
  • 33
    • 36448975192 scopus 로고    scopus 로고
    • Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells
    • DOI 10.1161/HYPERTENSIONAHA.106.084848
    • Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM. Angiotensin-(1-7) counter-regulates angiotensin II signaling in human endothelial cells. Hypertension. 2007;50(6):1093-8. (Pubitemid 350172931)
    • (2007) Hypertension , vol.50 , Issue.6 , pp. 1093-1098
    • Sampaio, W.O.1    De Castro, C.H.2    Santos, R.A.S.3    Schiffrin, E.L.4    Touyz, R.M.5
  • 34
    • 73849117533 scopus 로고    scopus 로고
    • Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus
    • Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010;55(1):66-171.
    • (2010) Hypertension , vol.55 , Issue.1 , pp. 66-171
    • Gwathmey, T.M.1    Pendergrass, K.D.2    Reid, S.D.3    Rose, J.C.4    Diz, D.I.5    Chappell, M.C.6
  • 36
  • 37
    • 77149161422 scopus 로고    scopus 로고
    • Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated
    • Yang R, Walther T, Gembardt F, Smolders I, Vanderheyden P, Albiston AL, et al. Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated. J Hypertens. 2010;28(3):487-94.
    • (2010) J Hypertens , vol.28 , Issue.3 , pp. 487-494
    • Yang, R.1    Walther, T.2    Gembardt, F.3    Smolders, I.4    Vanderheyden, P.5    Albiston, A.L.6
  • 38
    • 33947591091 scopus 로고    scopus 로고
    • Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla
    • DOI 10.1016/j.regpep.2006.12.031, PII S016701150700002X
    • Ferreira PM, Souza Dos Santos RA, Campagnole-Santos MJ. Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla. Regul Pept. 2007;141(1-3):168-74. (Pubitemid 46482697)
    • (2007) Regulatory Peptides , vol.141 , Issue.1-3 , pp. 168-174
    • Ferreira, P.M.1    Souza Dos, S.R.A.2    Campagnole-Santos, M.J.3
  • 39
    • 84868271237 scopus 로고    scopus 로고
    • Protective role of the ACE2/Ang-(1-9) axis in cardiovascular remodeling
    • OcaranzaMP, Jalil JE. Protective role of the ACE2/Ang-(1-9) axis in cardiovascular remodeling. Int J Hypertens. 2012;2012:594-361.
    • (2012) Int J Hypertens , vol.2012 , pp. 594-1361
    • Ocaranza, M.P.1    Jalil, J.E.2
  • 41
    • 50649094200 scopus 로고    scopus 로고
    • Does the renin-angiotensin system also regulate intra-ocular pressure?
    • Vaajanen A, Luhtala S, Oksala O, Vapaatalo H. Does the renin-angiotensin system also regulate intra-ocular pressure? Ann Med. 2008;40(6):418-27.
    • (2008) Ann Med , vol.40 , Issue.6 , pp. 418-427
    • Vaajanen, A.1    Luhtala, S.2    Oksala, O.3    Vapaatalo, H.4
  • 42
    • 84862149818 scopus 로고    scopus 로고
    • The retinal renin-angiotensin system: Roles of angiotensin II and aldosterone
    • Wilkinson-Berka JL, Agrotis A, Deliyanti D. The retinal renin-angiotensin system: roles of angiotensin II and aldosterone. Peptides. 2012;36(1):142-50.
    • (2012) Peptides , vol.36 , Issue.1 , pp. 142-150
    • Wilkinson-Berka, J.L.1    Agrotis, A.2    Deliyanti, D.3
  • 43
    • 62549157381 scopus 로고    scopus 로고
    • The intracellular renin-angiotensin system in the heart
    • Kumar R, Singh VP, Baker KM. The intracellular renin-angiotensin system in the heart. Curr Hypertens Rep. 2009;11(2):104-10.
    • (2009) Curr Hypertens Rep , vol.11 , Issue.2 , pp. 104-110
    • Kumar, R.1    Singh, V.P.2    Baker, K.M.3
  • 44
    • 0033824138 scopus 로고    scopus 로고
    • International union of pharmacology XXII. The angiotension II receptors
    • deGasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology XXII. The angiotension II receptors. Pharmacol Rev. 2000;52:415-72.
    • (2000) Pharmacol Rev , vol.52 , pp. 415-472
    • DeGasparo, M.1    Catt, K.J.2    Inagami, T.3    Wright, J.W.4    Unger, T.5
  • 46
    • 84881001924 scopus 로고    scopus 로고
    • Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential
    • Carey RM, Padia SH. Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential. Clin Exp Pharmacol Physiol. 2013;40(8):527-34.
    • (2013) Clin Exp Pharmacol Physiol , vol.40 , Issue.8 , pp. 527-534
    • Carey, R.M.1    Padia, S.H.2
  • 47
    • 23944519605 scopus 로고    scopus 로고
    • How to explain the differences between renin angiotensin system modulators
    • DOI 10.1016/j.amjhyper.2005.05.005, PII S0895706105010174
    • Levy BI. How to explain the differences between renin-angiotensin system modulators. Am J Hypertens. 2005;18:134S-41S. (Pubitemid 41206570)
    • (2005) American Journal of Hypertension , vol.18 , Issue.9 SUPPL.
    • Levy, B.I.1
  • 48
    • 34247113814 scopus 로고    scopus 로고
    • 1 receptor: Novel insights into mechanisms and pathophysiology
    • DOI 10.1042/CS20060342
    • Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal transduction through theAT1 receptor: novel insights into mechanisms and pathophysiology. Clin Sci (Lond). 2007;112(8):417-28. (Pubitemid 46587457)
    • (2007) Clinical Science , vol.112 , Issue.7-8 , pp. 417-428
    • Higuchi, S.1    Ohtsu, H.2    Suzuki, H.3    Shirai, H.4    Frank, G.D.5    Eguchi, S.6
  • 49
    • 0032576551 scopus 로고    scopus 로고
    • Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases
    • Matsubara H. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal disease. Circ Res. 1998;83:1182-91. (Pubitemid 29006033)
    • (1998) Circulation Research , vol.83 , Issue.12 , pp. 1182-1191
    • Matsubara, H.1
  • 50
    • 22544448655 scopus 로고    scopus 로고
    • The AT2 receptor - A matter of love and hate
    • DOI 10.1016/j.peptides.2005.03.010, PII S0196978105001257, International Symposium on Peptides Receptors, from Gene to Therapy
    • Steckelings UM, Kaschina E, Unger. The AT2 receptor-A matter of love or hate. Peptides. 2005;26:1401-9. (Pubitemid 41021474)
    • (2005) Peptides , vol.26 , Issue.8 , pp. 1401-1409
    • Steckelings, U.M.1    Kaschina, E.2    Unger, T..3
  • 51
    • 84878627128 scopus 로고    scopus 로고
    • The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap
    • Tamura K, Wakui H, Maeda A, Dejima T, Ohsawa M, Azushima K, et al. The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap. Curr Pharm Des. 2013;19(17):3043-8.
    • (2013) Curr Pharm des , vol.19 , Issue.17 , pp. 3043-3048
    • Tamura, K.1    Wakui, H.2    Maeda, A.3    Dejima, T.4    Ohsawa, M.5    Azushima, K.6
  • 52
    • 84887986619 scopus 로고    scopus 로고
    • Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension
    • Wakui H, Dejima T, Tamura K, Uneda K, Azuma K, Maeda A, et al. Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension. Cardiovasc Res. 2013;100(3):511-9.
    • (2013) Cardiovasc Res , vol.100 , Issue.3 , pp. 511-519
    • Wakui, H.1    Dejima, T.2    Tamura, K.3    Uneda, K.4    Azuma, K.5    Maeda, A.6
  • 53
    • 77949889272 scopus 로고    scopus 로고
    • Atrap deficiency increases arterial blood pressure and plasma volume
    • Oppermann M, Gess B, Schweda F, Castrop H. Atrap deficiency increases arterial blood pressure and plasma volume. J Am Soc Nephrol. 2010;21(3):468-77.
    • (2010) J Am Soc Nephrol , vol.21 , Issue.3 , pp. 468-477
    • Oppermann, M.1    Gess, B.2    Schweda, F.3    Castrop, H.4
  • 54
    • 36348982705 scopus 로고    scopus 로고
    • Emerging concepts of regulation of angiotensin II receptors: New players and targets for traditional receptors
    • DOI 10.1161/ATVBAHA.107.144154
    • Mogi M, Iwai M, Horiuchi M. Emerging concepts of regulation of angiotensin II receptors: new players and targets for traditional receptors. Arterioscler Thromb Vasc Biol. 2007;27(12):2532-9. (Pubitemid 350158902)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.12 , pp. 2532-2539
    • Mogi, M.1    Iwai, M.2    Horiuchi, M.3
  • 57
    • 0035725997 scopus 로고    scopus 로고
    • 2 subtype receptor of angiotensin II from large arteries to the microcirculation
    • Henrion D, Kubis N, Lévy BI. Physiological and pathophysiological functions of the AT2 subtype receptor of angiotensin II - From large arteries to the microcirculation. Hypertension. 2001;38:1150-7. (Pubitemid 34252821)
    • (2001) Hypertension , vol.38 , Issue.5 , pp. 1150-1157
    • Henrion, D.1    Kubis, N.2    Levy, B.I.3
  • 58
    • 0034707501 scopus 로고    scopus 로고
    • Inflammation influences vascular remodeling through AT2 receptor expression and signaling
    • Akishita M. Inflammation influences vascular remodeling through AT2 receptor expression and signaling. Physiol Genomics. 2000;2:13-20.
    • (2000) Physiol Genomics , vol.2 , pp. 13-20
    • Akishita, M.1
  • 59
    • 0032890562 scopus 로고    scopus 로고
    • Role of extracellular signal-regulated kinases in angiotensin II- stimulated contraction of smooth muscle cells from human resistance arteries
    • Touyz RM, He G, Deng LY, Schiffrin EL. Role of extracellular signal-regulated kinases in angiotensin II-Stimulated contraction of smooth muscle cells from human resistance arteries. Circulation. 1999;99:392-9. (Pubitemid 29051265)
    • (1999) Circulation , vol.99 , Issue.3 , pp. 392-399
    • Touyz, R.M.1    He, G.2    Deng, L.-Y.3    Schiffrin, E.L.4
  • 60
    • 0032920339 scopus 로고    scopus 로고
    • Central role of the MAPK pathway in Ang II-mediated DNA synthesis and migration in rat vascular smooth muscle cells
    • Xi XP. Central role of the MAPK pathway in Ang II-mediated DNA synthesis and migration in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1999;19:73-82.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 73-82
    • Xi, X.P.1
  • 61
    • 0034725603 scopus 로고    scopus 로고
    • Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase
    • Eguchi S, Inagami T. Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept. 2000;91:13-20.
    • (2000) Regul Pept , vol.91 , pp. 13-20
    • Eguchi, S.1    Inagami, T.2
  • 62
    • 52449122086 scopus 로고    scopus 로고
    • Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways
    • Montezano AC, Callera GE, Yogi A, He Y, Tostes RC, He G, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008;28(8):1511-8.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.8 , pp. 1511-1518
    • Montezano, A.C.1    Callera, G.E.2    Yogi, A.3    He, Y.4    Tostes, R.C.5    He, G.6
  • 63
    • 0031460570 scopus 로고    scopus 로고
    • Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats
    • DOI 10.1097/00004872-199715120-00010
    • Touyz RM, Schiffrin EL. Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats. J Hypertens. 1997;15:1431-9. (Pubitemid 28039571)
    • (1997) Journal of Hypertension , vol.15 , Issue.12 I , pp. 1431-1439
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 64
    • 0037783377 scopus 로고    scopus 로고
    • c-Src induces phosphorylation and translocation of p47phox: Role in superoxide generation by angiotensin II in human vascular smooth muscle cells
    • DOI 10.1161/01.ATV.0000069236.27911.68
    • Touyz RM, Yao G, Schiffrin EL. c-Src induces phosphorylation and translocation of p47phox - Role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2003;23:981-7. (Pubitemid 36717143)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.6 , pp. 981-987
    • Touyz, R.M.1    Yao, G.2    Schiffrin, E.L.3
  • 65
    • 80051964047 scopus 로고    scopus 로고
    • Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: Role of PDGFR
    • Callera GE, Yogi A, Briones AM, Montezano AC, He Y, Tostes RC, et al. Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovasc Res. 2011;91(4):720-31.
    • (2011) Cardiovasc Res , vol.91 , Issue.4 , pp. 720-731
    • Callera, G.E.1    Yogi, A.2    Briones, A.M.3    Montezano, A.C.4    He, Y.5    Tostes, R.C.6
  • 66
    • 0036179708 scopus 로고    scopus 로고
    • Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats
    • DOI 10.1161/hy02t2.102909
    • Touyz RM. Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased c-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension. 2002;39:479-85. (Pubitemid 34165169)
    • (2002) Hypertension , vol.39 , Issue.2 II , pp. 479-485
    • Touyz, R.M.1    Wu, X.-H.2    He, G.3    Salomon, S.4    Schiffrin, E.L.5
  • 67
    • 0035569024 scopus 로고    scopus 로고
    • Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients
    • Touyz RM. Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension. 2001;38:56-64. (Pubitemid 34224771)
    • (2001) Hypertension , vol.38 , Issue.1 , pp. 56-64
    • Touyz, R.M.1    He, G.2    Wu, X.-H.3    Park, J.B.4    El, M.M.5    Schiffrin, E.L.6
  • 68
    • 0035146135 scopus 로고    scopus 로고
    • Transactivation: A novel signaling pathway from angiotensin II to tyrosine kinase receptors
    • DOI 10.1006/jmcc.2000.1272
    • Saito Y, Berk BC. Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors. J Mol Cell Cardiol. 2001;33:3-7. (Pubitemid 32127779)
    • (2001) Journal of Molecular and Cellular Cardiology , vol.33 , Issue.1 , pp. 3-7
    • Saito, Y.1    Berk, B.C.2
  • 69
    • 80051545455 scopus 로고    scopus 로고
    • Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts
    • Burger D, Montezano AC, Nishigaki N, He Y, Carter A, Touyz RM. Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts. Arterioscler Thromb Vasc Biol. 2011;31(8):1898-907.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.8 , pp. 1898-1907
    • Burger, D.1    Montezano, A.C.2    Nishigaki, N.3    He, Y.4    Carter, A.5    Touyz, R.M.6
  • 71
    • 78049274198 scopus 로고    scopus 로고
    • The role of Rho protein signaling in hypertension
    • Loirand G, Pacaud P. The role of Rho protein signaling in hypertension. Nat Rev Cardiol. 2010;7(11):637-47.
    • (2010) Nat Rev Cardiol , vol.7 , Issue.11 , pp. 637-647
    • Loirand, G.1    Pacaud, P.2
  • 73
    • 76249134110 scopus 로고    scopus 로고
    • The Rho exchange factor Arhgef1mediates the effects of angiotensin II on vascular tone and blood pressure
    • Guilluy C, Bregeon J, Tourmaniantz G. The Rho exchange factor Arhgef1mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010;16:183-90.
    • (2010) Nat Med , vol.16 , pp. 183-190
    • Guilluy, C.1    Bregeon, J.2    Tourmaniantz, G.3
  • 74
    • 70449638109 scopus 로고    scopus 로고
    • Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells
    • Bregeon J, Loirand G, Pacaud P. Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2009;297(5):C1062-70.
    • (2009) Am J Physiol Cell Physiol , vol.297 , Issue.5
    • Bregeon, J.1    Loirand, G.2    Pacaud, P.3
  • 75
    • 84860647033 scopus 로고    scopus 로고
    • RhoA guanine exchange factor expression profile in arteries: Evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension
    • Cario-Toumaniantz C, Ferland-McCollough D, Chadeuf G, Toumaniantz G, Rodriguez M, Galizzi JP, et al. RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension. Am J Physiol Cell Physiol. 2012;302:C1394-404.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Cario-Toumaniantz, C.1    Ferland-McCollough, D.2    Chadeuf, G.3    Toumaniantz, G.4    Rodriguez, M.5    Galizzi, J.P.6
  • 76
    • 0036226356 scopus 로고    scopus 로고
    • Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats
    • DOI 10.1124/jpet.301.2.459
    • Kobayashi N, Nakano S, Mita S, Kobayashi T, Honda T, Tsubokou Y, et al. Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. J Pharmacol Exp Ther. 2002;301:459-66. (Pubitemid 34429955)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.301 , Issue.2 , pp. 459-466
    • Kobayashi, N.1    Nakano, S.2    Mita, S.-I.3    Kobayashi, T.4    Honda, T.5    Tsubokou, Y.6    Matsuoka, H.7
  • 77
    • 4444333896 scopus 로고    scopus 로고
    • Reactive oxygen species and angiotensin II signaling in vascular cells - Implications in cardiovascular disease
    • Touyz RM. Reactive oxygen species and angiotensin II signaling in vascular cells - implications in cardiovascular disease. Braz J Med Biol Res. 2004;37(8):1263-73. (Pubitemid 39172561)
    • (2004) Brazilian Journal of Medical and Biological Research , vol.37 , Issue.8 , pp. 1263-1273
    • Touyz, R.M.1
  • 78
    • 0348109425 scopus 로고    scopus 로고
    • Reactive Oxygen Species in the Vasculature: Molecular and Cellular Mechanisms
    • DOI 10.1161/01.HYP.0000100443.09293.4F
    • Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension. 2003;42:1075-81. (Pubitemid 37549058)
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1075-1081
    • Taniyama, Y.1    Griendling, K.K.2
  • 81
    • 0036924243 scopus 로고    scopus 로고
    • The reactive adventitia: Fibroblast oxidase in vascular function
    • DOI 10.1161/01.ATV.0000043452.30772.18
    • Rey FE, Pagano PJ. The reactive adventitia: fibroblast oxidase in vascular function. Arterioscler Thromb Vasc Biol. 2002;22(12):1962-71. (Pubitemid 36025200)
    • (2002) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.22 , Issue.12 , pp. 1962-1971
    • Rey, F.E.1    Pagano, P.J.2
  • 82
    • 84860918905 scopus 로고    scopus 로고
    • Molecular mechanisms of hypertension-reactive oxygen species and antioxidants: A basic science update for the clinician
    • Montezano AC, Touyz RM. Molecular mechanisms of hypertension-reactive oxygen species and antioxidants: a basic science update for the clinician. Can J Cardiol. 2012;28(3):288-95.
    • (2012) Can J Cardiol , vol.28 , Issue.3 , pp. 288-295
    • Montezano, A.C.1    Touyz, R.M.2
  • 83
    • 1942468123 scopus 로고    scopus 로고
    • Novel NAD(P)H oxidases in the cardiovascular system
    • Griendling KK. Novel NAD(P)H oxidases in the cardiovascular system. Heart. 2004;90(5):491-3. (Pubitemid 38530160)
    • (2004) Heart , vol.90 , Issue.5 , pp. 491-493
    • Griendling, K.K.1
  • 84
    • 77953535497 scopus 로고    scopus 로고
    • Oxidative stress and hypertension: Current concepts
    • Briones AM, Touyz RM. Oxidative stress and hypertension: current concepts. Curr Hypertens Rep. 2010;12(2):135-42.
    • (2010) Curr Hypertens Rep , vol.12 , Issue.2 , pp. 135-142
    • Briones, A.M.1    Touyz, R.M.2
  • 85
    • 84877270825 scopus 로고    scopus 로고
    • NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis
    • Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, et al. NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation. 2013;127(18):1888-902.
    • (2013) Circulation , vol.127 , Issue.18 , pp. 1888-1902
    • Gray, S.P.1    Di Marco, E.2    Okabe, J.3    Szyndralewiez, C.4    Heitz, F.5    Montezano, A.C.6
  • 87
    • 84866183230 scopus 로고    scopus 로고
    • Targeting NADPH oxidases in vascular pharmacology
    • Schramm A, Matusik P, Osmenda G, Guzik TJ. Targeting NADPH oxidases in vascular pharmacology. Vasc Pharmacol. 2012;56(5-6):216-31.
    • (2012) Vasc Pharmacol , vol.56 , Issue.5-6 , pp. 216-231
    • Schramm, A.1    Matusik, P.2    Osmenda, G.3    Guzik, T.J.4
  • 88
    • 77952489013 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells
    • Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, AlmasriM, et al. Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells. Circ Res. 2010;106(8):1363-73.
    • (2010) Circ Res , vol.106 , Issue.8 , pp. 1363-1373
    • Montezano, A.C.1    Burger, D.2    Paravicini, T.M.3    Chignalia, A.Z.4    Yusuf, H.5    Almasri, M.6
  • 90
    • 84880030138 scopus 로고    scopus 로고
    • Reactive oxygen species, vascular Noxs, and hypertension: Focus on translational and clinical research
    • Montezano AC, Touyz RM. Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research. Antioxid Redox Signal. 2014;20(1):164-82.
    • (2014) Antioxid Redox Signal , vol.20 , Issue.1 , pp. 164-182
    • Montezano, A.C.1    Touyz, R.M.2
  • 91
    • 79956093997 scopus 로고    scopus 로고
    • Expression of a gp91phox-containing leukocyte-type NADPH oxidase in human vascular smooth muscle cells - modulation by Ang II
    • Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, et al. Expression of a gp91phox-containing leukocyte-type NADPH oxidase in human vascular smooth muscle cells - modulation by Ang II. Circ Res. 2006;90:1205-13.
    • (2006) Circ Res , vol.90 , pp. 1205-1213
    • Touyz, R.M.1    Chen, X.2    Tabet, F.3    Yao, G.4    He, G.5    Quinn, M.T.6
  • 92
    • 84859997420 scopus 로고    scopus 로고
    • Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: Influence of hypertension and angiotensin II
    • This study clearly identifies differential mechanisms whereby Ang II and blood pressure influence mechanosensitive signaling in vascular smooth muscle cells
    • .• Paravicini TM, Montezano AC, Yusuf H. Touyz RM activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II. J Am Soc Hypertens. 2012;6(3):169-78. This study clearly identifies differential mechanisms whereby Ang II and blood pressure influence mechanosensitive signaling in vascular smooth muscle cells.
    • (2012) J Am Soc Hypertens , vol.6 , Issue.3 , pp. 169-178
    • Paravicini, T.M.1    Montezano, A.C.2    Yusuf, H.3    Touyz, R.M.4
  • 93
    • 0032737361 scopus 로고    scopus 로고
    • Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells
    • Touyz RM, Schiffrin EL. Ang II-stimulated superoxide production is mediated via phospholipase D in human vascular smooth muscle cells. Hypertension. 1999;34(4):976-82. (Pubitemid 29501333)
    • (1999) Hypertension , vol.34 , Issue.4 II , pp. 976-982
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 94
    • 0034948793 scopus 로고    scopus 로고
    • Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: Role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways
    • DOI 10.1097/00004872-200107000-00009
    • Touyz RM, Schiffrin EL. Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. J Hypertens. 2001;19:1245-54. (Pubitemid 32595280)
    • (2001) Journal of Hypertension , vol.19 , Issue.7 , pp. 1245-1254
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 95
    • 0034137152 scopus 로고    scopus 로고
    • Oxidative stress and vascular damage in hypertension
    • Touyz RM. Oxidative stress and vascular damage in hypertension. Curr Hypertens Rep. 2001;2:98-105.
    • (2001) Curr Hypertens Rep , vol.2 , pp. 98-105
    • Touyz, R.M.1
  • 96
    • 84892600240 scopus 로고    scopus 로고
    • Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2
    • Petrovič D. Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2. Clin Exp Hypertens. 2014;36(1):36-40.
    • (2014) Clin Exp Hypertens , vol.36 , Issue.1 , pp. 36-40
    • Petrovič, D.1
  • 97
    • 1642276271 scopus 로고    scopus 로고
    • Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    • DOI 10.1097/00004872-200403000-00016
    • Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL. Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. J Hypertens. 2004;22(3):535-42. (Pubitemid 38368487)
    • (2004) Journal of Hypertension , vol.22 , Issue.3 , pp. 535-542
    • Virdis, A.1    Neves, M.F.2    Amiri, F.3    Touyz, R.M.4    Schiffrin, E.L.5
  • 98
    • 0642276003 scopus 로고    scopus 로고
    • Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction
    • DOI 10.1016/S0968-0004(03)00174-9, PII S0968000403001749
    • Chiarugi P, Cirri P. Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction. Trends Biochem Sci. 2003;28:509-14. (Pubitemid 38340416)
    • (2003) Trends in Biochemical Sciences , vol.28 , Issue.9 , pp. 509-514
    • Chiarugi, P.1    Cirri, P.2
  • 99
    • 0037365968 scopus 로고    scopus 로고
    • Specificity of a third kind: Reactive oxygen and nitrogen intermediates in cell signaling
    • DOI 10.1172/JCI200318174
    • Nathan C. Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J Clin Invest. 2003;111:769-78. (Pubitemid 37074948)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.6 , pp. 769-778
    • Nathan, C.1
  • 100
    • 0142043984 scopus 로고    scopus 로고
    • Redox signaling and the MAP kinase pathways
    • Torres M, Forman HJ. Redox signaling and the MAP kinase pathways. Biofactors. 2003;17:287-96. (Pubitemid 37267162)
    • (2003) BioFactors , vol.17 , Issue.1-4 , pp. 287-296
    • Torres, M.1    Forman, H.J.2
  • 101
    • 48849104298 scopus 로고    scopus 로고
    • Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR
    • Tabet F, Schiffrin EL, Callera GE, He Y, Yao G, Ostman A, et al. Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR. Circ Res. 2008;103(2):149-58.
    • (2008) Circ Res , vol.103 , Issue.2 , pp. 149-158
    • Tabet, F.1    Schiffrin, E.L.2    Callera, G.E.3    He, Y.4    Yao, G.5    Ostman, A.6
  • 102
    • 84871819023 scopus 로고    scopus 로고
    • Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
    • An in vivo study demonstrating that an orally active inhibitor of Nox1 and Nox4 ameliorates development of nephropathy in a model of diabetes, indicating a role for Nox1/4-derived reactive oxygen in diabetic nephropathy
    • .• SedeekM, Gutsol A,Montezano AC, Burger D, Nguyen Dinh Cat A, Kennedy CR, et al. Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clin Sci (Lond). 2013;124(3):191-202. An in vivo study demonstrating that an orally active inhibitor of Nox1 and Nox4 ameliorates development of nephropathy in a model of diabetes, indicating a role for Nox1/4-derived reactive oxygen in diabetic nephropathy.
    • (2013) Clin Sci (Lond) , vol.124 , Issue.3 , pp. 191-202
    • Sedeek, M.1    Gutsol, A.2    Montezano, A.C.3    Burger, D.4    Nguyen Dinh Cat, A.5    Kennedy, C.R.6
  • 103
    • 0141961908 scopus 로고    scopus 로고
    • Candesartan reduces oxidative stress and inflammation in patients with essential hypertension
    • DOI 10.1291/hypres.26.691
    • Dohi Y. Candesartan reduces oxidative stress and inflammation in patients with essential hypertension. Hypertens Res. 2003;26:691-7. (Pubitemid 37258655)
    • (2003) Hypertension Research , vol.26 , Issue.9 , pp. 691-697
    • Dohi, Y.1    Ohashi, M.2    Sugiyama, M.3    Takase, H.4    Sato, K.5    Ueda, R.6
  • 104
    • 84888179267 scopus 로고    scopus 로고
    • Oxidative stress/angiotensinogen/reninangiotensin systemaxis in patients with diabetic nephropathy
    • Kamiyama M, Urushihara M, Morikawa T, Konishi Y, Imanishi M, Nishiyama A, et al. Oxidative stress/angiotensinogen/reninangiotensin systemaxis in patients with diabetic nephropathy. Int J Mol Sci. 2013;14(11):23045-62.
    • (2013) Int J Mol Sci , vol.14 , Issue.11 , pp. 23045-23062
    • Kamiyama, M.1    Urushihara, M.2    Morikawa, T.3    Konishi, Y.4    Imanishi, M.5    Nishiyama, A.6
  • 105
    • 84862903745 scopus 로고    scopus 로고
    • The vascular smooth muscle cell in arterial pathology: A cell that can take on multiple roles
    • Lacolley P, Regnault V, Nicoletti A, Li Z, Michel JB. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res. 2012;95(2):194-204.
    • (2012) Cardiovasc Res , vol.95 , Issue.2 , pp. 194-204
    • Lacolley, P.1    Regnault, V.2    Nicoletti, A.3    Li, Z.4    Michel, J.B.5
  • 107
    • 79957655520 scopus 로고    scopus 로고
    • Can microRNAs control vascular smooth muscle phenotypicmodulation and the response to injury?
    • Albinsson S, SessaWC. Can microRNAs control vascular smooth muscle phenotypicmodulation and the response to injury? Physiol Genomics. 2011;43(10):529-33.
    • (2011) Physiol Genomics , vol.43 , Issue.10 , pp. 529-533
    • Albinsson, S.1    Sessa, W.C.2
  • 108
    • 1442299090 scopus 로고    scopus 로고
    • Extracellular matrix biology: A new frontier in linking the pathology and therapy of hypertension?
    • DOI 10.1097/00004872-200312000-00002
    • Tayebjee MH, MacFadyen RJ, Lip GY. Extracellular matrix biology: a new frontier in linking the pathology and therapy of hypertension? J Hypertens. 2003;21:2211-8. (Pubitemid 38293553)
    • (2003) Journal of Hypertension , vol.21 , Issue.12 , pp. 2211-2218
    • Tayebjee, M.H.1    MacFadyen, R.J.2    Lip, G.Y.H.3
  • 110
    • 77950864155 scopus 로고    scopus 로고
    • Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling
    • Castro MM, Rizzi E, Prado CM, Rossi MA, Tanus-Santos JE, Gerlach RF. Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling. Matrix Biol. 2010;29(3):194-201.
    • (2010) Matrix Biol , vol.29 , Issue.3 , pp. 194-201
    • Castro, M.M.1    Rizzi, E.2    Prado, C.M.3    Rossi, M.A.4    Tanus-Santos, J.E.5    Gerlach, R.F.6
  • 111
    • 0035177661 scopus 로고    scopus 로고
    • Role of endogenous angiotensin II in the increased expression of growth factors in vascular smooth muscle cells from spontaneously hypertensive rats
    • DOI 10.1097/00005344-200101000-00013
    • Satoh C. Role of endogenous angiotensin II in the increased expression of growth factors in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Pharmacol. 2001;37(1):108-18. (Pubitemid 32012937)
    • (2001) Journal of Cardiovascular Pharmacology , vol.37 , Issue.1 , pp. 108-118
    • Satoh, C.1    Fukuda, N.2    Hu, W.-Y.3    Nakayama, M.4    Kishioka, H.5    Kanmatsuse, K.6
  • 112
    • 3042754866 scopus 로고    scopus 로고
    • Hypertension, transforming growth factor-β, angiotensin II and kidney disease
    • DOI 10.1097/01.hjh.0000125468.35523.7b
    • Bobik A. Hypertension, transforming growth factor-β, angiotensin II and kidney disease. J Hypertens. 2004;22(7):1265-7. (Pubitemid 38888070)
    • (2004) Journal of Hypertension , vol.22 , Issue.7 , pp. 1265-1267
    • Bobik, A.1
  • 113
    • 84888224333 scopus 로고    scopus 로고
    • Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation
    • Bruder-Nascimento T, Chinnasamy P, Riascos-Bernal DF, Cau SB, Callera GE, Touyz RM, et al. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. J Mol Cell Cardiol. 2014;66:18-26.
    • (2014) J Mol Cell Cardiol , vol.66 , pp. 18-26
    • Bruder-Nascimento, T.1    Chinnasamy, P.2    Riascos-Bernal, D.F.3    Cau, S.B.4    Callera, G.E.5    Touyz, R.M.6
  • 115
    • 4444238183 scopus 로고    scopus 로고
    • Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling
    • DOI 10.1161/01.HYP.0000138688.78906.6b
    • Zhao Q, Ishibashi M, Hiasa K, Tan C, Takeshita A, Egashira K. Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling. Hypertension. 2004;44(3):264-70. (Pubitemid 39172204)
    • (2004) Hypertension , vol.44 , Issue.3 , pp. 264-270
    • Zhao, Q.1    Ishibashi, M.2    Hiasa, K.-I.3    Tan, C.4    Takeshita, A.5    Egashira, K.6
  • 116
    • 84856120511 scopus 로고    scopus 로고
    • T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury
    • An elegant study showing that adoptive transfer of T regulatory lymphocytes ameliorates vascular injury in mice infused with aldosterone, supporting a role for innate and adaptive immunity in vascular damage associated with activation of the renin angiotensin aldosterone system
    • .• Kasal DA, Barhoumi T, Li MW, Yamamoto N, Zdanovich E, Rehman A, et al. T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury. Hypertension. 2012;59:324-30. An elegant study showing that adoptive transfer of T regulatory lymphocytes ameliorates vascular injury in mice infused with aldosterone, supporting a role for innate and adaptive immunity in vascular damage associated with activation of the renin angiotensin aldosterone system.
    • (2012) Hypertension , vol.59 , pp. 324-330
    • Kasal, D.A.1    Barhoumi, T.2    Li, M.W.3    Yamamoto, N.4    Zdanovich, E.5    Rehman, A.6
  • 117
    • 77955171998 scopus 로고    scopus 로고
    • Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension
    • Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, et al. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res. 2010;107(2):263-70.
    • (2010) Circ Res , vol.107 , Issue.2 , pp. 263-270
    • Marvar, P.J.1    Thabet, S.R.2    Guzik, T.J.3    Lob, H.E.4    McCann, L.A.5    Weyand, C.6
  • 119
    • 0038893696 scopus 로고    scopus 로고
    • The inflammatory aspect of the microcirculation in hypertension: Oxidative stress, leukocytes/endothelial interaction, apoptosis
    • DOI 10.1038/sj.mn.7800141
    • Suematsu M. The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes/endothelial interaction, apoptosis. Microcirculation. 2002;9:259-76. (Pubitemid 135685862)
    • (2002) Microcirculation , vol.9 , Issue.4 , pp. 259-276
    • Suematsu, M.1    Suzuki, H.2    Delano, F.A.3    Schmid-Schonbein, G.W.4
  • 120
    • 0035960634 scopus 로고    scopus 로고
    • Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury
    • Wu L, Iwai M, Nakagami H. Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury. Circulation. 2001;104:2716-21. (Pubitemid 33108140)
    • (2001) Circulation , vol.104 , Issue.22 , pp. 2716-2721
    • Wu, L.1    Iwai, M.2    Nakagami, H.3    Li, Z.4    Chen, R.5    Suzuki, J.6    Akishita, M.7    De Gasparo, M.8    Horiuchi, M.9
  • 121
    • 0036882119 scopus 로고    scopus 로고
    • PPARa activator effects on Ang II-induced vascular oxidative stress and inflammation
    • DOI 10.1161/01.HYP.0000037969.41360.CC
    • Diep QN, Amiri F, Touyz RM, Cohn JS, Endemann D, Neves MF, et al. PPARa activator effects on Ang II-induced vascular oxidative stress and inflammation. Hypertension. 2002;40:866-71. (Pubitemid 35434908)
    • (2002) Hypertension , vol.40 , Issue.6 , pp. 866-871
    • Diep, Q.N.1    Amiri, F.2    Touyz, R.M.3    Cohn, J.S.4    Endemann, D.5    Neves, M.F.6    Schiffrin, E.L.7
  • 122
    • 74949126382 scopus 로고    scopus 로고
    • Endothelial and vascular muscle PPARgamma in arterial pressure regulation: Lessons from genetic interference and deficiency
    • Sigmund CD. Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension. 2010;55(2):437-44.
    • (2010) Hypertension , vol.55 , Issue.2 , pp. 437-444
    • Sigmund, C.D.1
  • 124
    • 34347350171 scopus 로고    scopus 로고
    • Chronic kidney disease: Effects on the cardiovascular system
    • DOI 10.1161/CIRCULATIONAHA.106.678342, PII 0000301720070703000015
    • Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116(1):85-97. (Pubitemid 47016250)
    • (2007) Circulation , vol.116 , Issue.1 , pp. 85-97
    • Schiffrin, E.L.1    Lipman, M.L.2    Mann, J.F.E.3
  • 125
    • 36448960501 scopus 로고    scopus 로고
    • Determinants of Progression of Coronary Artery Calcification in Type 2 Diabetes. Role of Glycemic Control and Inflammatory/Vascular Calcification Markers
    • DOI 10.1016/j.jacc.2007.08.032, PII S0735109707029026
    • Anand DV, Lim E, Darko D, Bassett P, Hopkins D, Lipkin D, et al. Determinants of progression of coronary artery calcification in type 2 diabetes role of glycemic control and inflammatory/vascular calcification markers. J Am Coll Cardiol. 2007;50(23):2218-25. (Pubitemid 350166815)
    • (2007) Journal of the American College of Cardiology , vol.50 , Issue.23 , pp. 2218-2225
    • Anand, D.V.1    Lim, E.2    Darko, D.3    Bassett, P.4    Hopkins, D.5    Lipkin, D.6    Corder, R.7    Lahiri, A.8
  • 126
    • 80055085689 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor limits pulse-wave velocity and aortic calcification in a rat model of cystic renal disease
    • Ng K, Hildreth CM, Avolio AP, Phillips JK. Angiotensin-converting enzyme inhibitor limits pulse-wave velocity and aortic calcification in a rat model of cystic renal disease. Am J Physiol Renal Physiol. 2011;301(5):F959-66.
    • (2011) Am J Physiol Renal Physiol , vol.301 , Issue.5
    • Ng, K.1    Hildreth, C.M.2    Avolio, A.P.3    Phillips, J.K.4
  • 127
    • 84855274336 scopus 로고    scopus 로고
    • Szczepański M. Myśliwiec The mechanism of vascular calcification - A systematic review
    • Karwowski W, Naumnik B, Szczepański M. Myśliwiec The mechanism of vascular calcification - a systematic review. Med Sci Monit. 2012;18:1-11.
    • (2012) Med Sci Monit , vol.18 , pp. 1-11
    • Karwowski, W.1    Naumnik, B.2
  • 128
    • 0037341318 scopus 로고    scopus 로고
    • Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification
    • DOI 10.1161/01.ATV.0000059406.92165.31
    • Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol. 2003;23:489-94. (Pubitemid 36337227)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.3 , pp. 489-494
    • Tyson, K.L.1    Reynolds, J.L.2    McNair, R.3    Zhang, Q.4    Weissberg, P.L.5    Shanahan, C.M.6
  • 129
    • 34548475293 scopus 로고    scopus 로고
    • Vascular calcification in chronic kidney disease: New developments in drug therapy
    • DOI 10.1038/sj.ki.5002477, PII 5002477
    • Huybers S, Bindels RJ. Vascular calcification in chronic kidney disease: new developments in drug therapy. Kidney Int. 2007;72:663-5. (Pubitemid 47373798)
    • (2007) Kidney International , vol.72 , Issue.6 , pp. 663-665
    • Huybers, S.1    Bindels, R.J.M.2
  • 130
    • 34250613172 scopus 로고    scopus 로고
    • Sodium-dependent phosphate cotransporters and vascular calcification
    • DOI 10.1097/MNH.0b013e3281c55ef1, PII 0004155220070700000007
    • Li X, Giachelli CM. Sodium-dependent phosphate cotransporters and vascular calcification. Curr Opin Nephrol Hypertens. 2007;16:325-8. (Pubitemid 46944330)
    • (2007) Current Opinion in Nephrology and Hypertension , vol.16 , Issue.4 , pp. 325-328
    • Li, X.1    Giachelli, C.M.2
  • 131
    • 40949158527 scopus 로고    scopus 로고
    • BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells
    • Li X, Yang HY, Giachelli CM. BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis. 2008;199:271-7.
    • (2008) Atherosclerosis , vol.199 , pp. 271-277
    • Li, X.1    Yang, H.Y.2    Giachelli, C.M.3
  • 132
    • 70349913584 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: The Diabetes Heart Study
    • Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, et al. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24:1719-27.
    • (2009) J Bone Miner Res , vol.24 , pp. 1719-1727
    • Freedman, B.I.1    Bowden, D.W.2    Ziegler, J.T.3    Langefeld, C.D.4    Lehtinen, A.B.5    Rudock, M.E.6
  • 133
    • 36048959129 scopus 로고    scopus 로고
    • Osteopontin: A multifunctional molecule regulating chronic inflammation and vascular disease
    • DOI 10.1161/ATVBAHA.107.144824, PII 0004360520071100000006
    • ScatenaM, Liaw L, Giachelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol. 2007;27:2302-9. (Pubitemid 350203943)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.11 , pp. 2302-2309
    • Scatena, M.1    Liaw, L.2    Giachelli, C.M.3
  • 134
    • 84879115100 scopus 로고    scopus 로고
    • Cross-Talk of receptor activator of nuclear factor-κB ligand signaling with renin-angiotensin system in vascular calcification
    • In vitro and in vivo studies demonstrate that Ang II induces vascular calcification through pathways that involve receptor activator of nuclear factor-κB ligand (RANKL) and that RANKL itself influences the RAS. These data indicate a circuitous interaction between these systems that amplifies atherogenesis and vascular calcification
    • .• Osako MK, Nakagami H, Shimamura M, Koriyama H, Nakagami F, Shimizu H, et al. Cross-Talk of receptor activator of nuclear factor-κB ligand signaling with renin-angiotensin system in vascular calcification. Arterioscler Thromb Vasc Biol. 2013;33:1287-96. In vitro and in vivo studies demonstrate that Ang II induces vascular calcification through pathways that involve receptor activator of nuclear factor-κB ligand (RANKL) and that RANKL itself influences the RAS. These data indicate a circuitous interaction between these systems that amplifies atherogenesis and vascular calcification.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1287-1296
    • Osako, M.K.1    Nakagami, H.2    Shimamura, M.3    Koriyama, H.4    Nakagami, F.5    Shimizu, H.6
  • 135
    • 77955964632 scopus 로고    scopus 로고
    • Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium
    • Montezano AC, Zimmerman D, Yusuf H, Burger D, Chignalia AZ, Wadhera V, et al. Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension. 2010;56(3):453-62.
    • (2010) Hypertension , vol.56 , Issue.3 , pp. 453-462
    • Montezano, A.C.1    Zimmerman, D.2    Yusuf, H.3    Burger, D.4    Chignalia, A.Z.5    Wadhera, V.6
  • 136
    • 13444267278 scopus 로고    scopus 로고
    • Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: Role of angiotensin II
    • DOI 10.1161/01.RES.0000152967.88472.3e
    • He Y, Yao G, Savoia C, Touyz RM. Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. Circ Res. 2005;96(2):207-15. (Pubitemid 40209368)
    • (2005) Circulation Research , vol.96 , Issue.2 , pp. 207-215
    • He, Y.1    Yao, G.2    Savoia, C.3    Touyz, R.M.4
  • 137
    • 84865800113 scopus 로고    scopus 로고
    • Role of matrix Gla protein in angiotensin II-induced exacerbation of vascular calcification
    • Demonstration that Ang II influences vascular calcification through processes that interfere with the natural calcification inhibitor, matrix Gla protein and activation of the transcription factors, runt-related transcription factor 2 and NF-κB
    • .• Jia G, Stormont RM, Gangahar DM, Agrawal DK. Role of matrix Gla protein in angiotensin II-induced exacerbation of vascular calcification. Am J Physiol Heart Circ Physiol. 2012;303(5):H523-32. Demonstration that Ang II influences vascular calcification through processes that interfere with the natural calcification inhibitor, matrix Gla protein and activation of the transcription factors, runt-related transcription factor 2 and NF-κB.
    • (2012) Am J Physiol Heart Circ Physiol , vol.303 , Issue.5
    • Jia, G.1    Stormont, R.M.2    Gangahar, D.M.3    Agrawal, D.K.4
  • 141
    • 37349021003 scopus 로고    scopus 로고
    • Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
    • DOI 10.1161/CIRCULATIONAHA.106.676890, PII 0000301720071016000013
    • Tabas I, Williams KJ, Borén J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation. 2007;16:1832-44. (Pubitemid 350287108)
    • (2007) Circulation , vol.116 , Issue.16 , pp. 1832-1844
    • Tabas, I.1    Williams, K.J.2    Boren, J.3
  • 142
    • 0028963942 scopus 로고
    • Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site
    • Nicholson AC, Frieda S, Pearce A, Silverstein RL. Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site. Arterioscler Thromb Vasc Biol. 1995;15(2):269-75.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , Issue.2 , pp. 269-275
    • Nicholson, A.C.1    Frieda, S.2    Pearce, A.3    Silverstein, R.L.4
  • 143
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • DOI 10.1016/S0092-8674(00)81574-3
    • Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 1998;93(2):229-40. (Pubitemid 28180856)
    • (1998) Cell , vol.93 , Issue.2 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 144
    • 84885139155 scopus 로고    scopus 로고
    • Uptake of oxLDL and IL-10 production bymacrophages requires PAFR and CD36 recruitment into the same lipid rafts
    • Rios FJ, Ferracini M, Pecenin M, Koga MM, Wang Y, Ketelhuth DF, et al. Uptake of oxLDL and IL-10 production bymacrophages requires PAFR and CD36 recruitment into the same lipid rafts. PLoS ONE. 2013;8(10):e76893.
    • (2013) PLoS ONE , vol.8 , Issue.10
    • Rios, F.J.1    Ferracini, M.2    Pecenin, M.3    Koga, M.M.4    Wang, Y.5    Ketelhuth, D.F.6
  • 145
    • 84884241196 scopus 로고    scopus 로고
    • Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR
    • Rios FJ, Koga MM, Pecenin M, Ferracini M, Gidlund M, Jancar S. Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR. Mediat Inflamm. 2013;2013:198 - 3.
    • (2013) Mediat Inflamm , vol.2013 , pp. 198-203
    • Rios, F.J.1    Koga, M.M.2    Pecenin, M.3    Ferracini, M.4    Gidlund, M.5    Jancar, S.6
  • 146
    • 84879569545 scopus 로고    scopus 로고
    • Immune effector mechanisms implicated in atherosclerosis: From mice to humans
    • Libby P, Lichtman AH, Hansson GK. Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity. 2013;38(6):1092-104.
    • (2013) Immunity , vol.38 , Issue.6 , pp. 1092-1104
    • Libby, P.1    Lichtman, A.H.2    Hansson, G.K.3
  • 147
    • 84888990675 scopus 로고    scopus 로고
    • oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4
    • This study elucidates a novel mechanism contributing to vascular inflammation through the urokinase receptor, which responds to endogenous atherogenic ligands, such as oxLDL, impacting on CD36 and TLR4 function
    • .• Kiyan Y, Tkachuk S, Hilfiker-Kleiner D, Haller H, Fuhrman B, Dumler I. oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4. J Mol Cell Cardiol. 2014;66:72-82. This study elucidates a novel mechanism contributing to vascular inflammation through the urokinase receptor, which responds to endogenous atherogenic ligands, such as oxLDL, impacting on CD36 and TLR4 function.
    • (2014) J Mol Cell Cardiol , vol.66 , pp. 72-82
    • Kiyan, Y.1    Tkachuk, S.2    Hilfiker-Kleiner, D.3    Haller, H.4    Fuhrman, B.5    Dumler, I.6
  • 148
    • 84865253634 scopus 로고    scopus 로고
    • MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation
    • This interesting study demonstrates that in vascular smooth muscle cells, microRNA-195 reduces proliferation, migration, and synthesis of IL-1β, IL-6, and IL-8. These findings were extended to a rat model where the microRNA-195 gene was introduced by adenovirus, and showed reduced neointimal formation in balloon-injured carotid arteries. Taken together, these data suggest that microRNA-195 may be vasculo-protective
    • .• Wang YS, Wang HY, Liao YC, Tsai PC, Chen KC, Cheng HY, et al. MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation. Cardiovasc Res. 2012;95(4):517-26. This interesting study demonstrates that in vascular smooth muscle cells, microRNA-195 reduces proliferation, migration, and synthesis of IL-1β, IL-6, and IL-8. These findings were extended to a rat model where the microRNA-195 gene was introduced by adenovirus, and showed reduced neointimal formation in balloon-injured carotid arteries. Taken together, these data suggest that microRNA-195 may be vasculo-protective.
    • (2012) Cardiovasc Res , vol.95 , Issue.4 , pp. 517-526
    • Wang, Y.S.1    Wang, H.Y.2    Liao, Y.C.3    Tsai, P.C.4    Chen, K.C.5    Cheng, H.Y.6
  • 149
    • 35848937965 scopus 로고    scopus 로고
    • Angiotensin II induces capillary formation from endothelial cells via the LOX-1-dependent redox-sensitive pathway
    • DOI 10.1161/HYPERTENSIONAHA.107.096446
    • Hu C, Dandapat A, Mehta JL. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
    • (2007) Hypertension , vol.50 , Issue.5 , pp. 952-957
    • Hu, C.1    Dandapat, A.2    Mehta, J.L.3
  • 150
    • 0034724687 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species
    • DOI 10.1074/jbc.275.17.12633
    • Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, Campagnola M, et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem. 2000;275(17):12633-8. (Pubitemid 30241412)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.17 , pp. 12633-12638
    • Cominacini, L.1    Fratta, P.A.2    Garbin, U.3    Davoli, A.4    Tosetti, M.L.5    Campagnola, M.6    Rigoni, A.7    Pastorino, A.M.8    Lo, C.V.9    Sawamura, T.10
  • 151
    • 73449147620 scopus 로고    scopus 로고
    • Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose
    • Taye A, Saad AH, Kumar AH, Morawietz H. Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose. Eur J Pharmacol. 2010;627:42-8.
    • (2010) Eur J Pharmacol , vol.627 , pp. 42-48
    • Taye, A.1    Saad, A.H.2    Kumar, A.H.3    Morawietz, H.4
  • 152
    • 80053260510 scopus 로고    scopus 로고
    • Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway
    • Tsai KL, Chen LH, Chiou SH, Chiou GY, Chen YC, Chou HY, et al. Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway. Mol Nutr Food Res. 2011;55:S227-40.
    • (2011) Mol Nutr Food Res , vol.55
    • Tsai, K.L.1    Chen, L.H.2    Chiou, S.H.3    Chiou, G.Y.4    Chen, Y.C.5    Chou, H.Y.6
  • 153
    • 47649128227 scopus 로고    scopus 로고
    • Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression
    • Hu C, Dandapat A, Chen J, Liu Y, Hermonat PL, Carey RM, et al. Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression. Atherosclerosis. 2008;199:284-94.
    • (2008) Atherosclerosis , vol.199 , pp. 284-294
    • Hu, C.1    Dandapat, A.2    Chen, J.3    Liu, Y.4    Hermonat, P.L.5    Carey, R.M.6
  • 154
    • 78649867655 scopus 로고    scopus 로고
    • The angiotensin receptor blocker, telmisartan, reduces and stabilizes atherosclerosis in ApoE and AT1aR double deficient mice
    • Fukuda D, Enomoto S, Hirata Y, Nagai R, Sata M. The angiotensin receptor blocker, telmisartan, reduces and stabilizes atherosclerosis in ApoE and AT1aR double deficient mice. Biomed Pharmacother. 2010;64(10):712-7.
    • (2010) Biomed Pharmacother , vol.64 , Issue.10 , pp. 712-717
    • Fukuda, D.1    Enomoto, S.2    Hirata, Y.3    Nagai, R.4    Sata, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.