The reactive adventitia: Fibroblast oxidase in vascular function

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 12, 2002, Pages 1962-1971

  Rey, Federico E ^a,b   Pagano, Patrick J ^a  

^a HENRY FORD HOSPITAL   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Adventitia; Fibroblast; NAD(P)H oxidase; NADPH oxidoreductase; Remodeling; Vascular smooth muscle

Indexed keywords

REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADVENTITIA; ATHEROSCLEROSIS; BLOOD VESSEL TONE; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; FIBROBLAST; HUMAN; HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD CIRCULATION; CONNECTIVE TISSUE CELLS; FIBROBLASTS; HUMANS; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE;

EID: 0036924243     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000043452.30772.18     Document Type: Short Survey

References (136)

1. Stedman TL. Stedman's Medical Dictionary. Baltimore: Williams & Wilkins; 1995.
2. Fawcett DW. Blood and lymph vascular systems. In: Bloom and Fawcett Textbook of Histology. New York: Chapman & Hall; 1994:368-409.
3. Kelly DE, Wood RL, Enders AC. The circulatory systems. In: Bailey's Textbook of Microscopic Anatomy. Baltimore: Williams & Wilkins; 1984:387-424.
4. Suh Y-A, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK, Lambeth JD. Cell transformation by the superoxide-generating oxidase Moxl. Nature 1999;401:79-82. Letter.
5. O'Brien T. Adenoviral vectors and gene transfer to the blood vessel wall. Arterioscler Thromb Vasc Biol. 2000;20:1414-1416.
6. Kullo IJ, Simari RD, Schwartz RS. Vascular gene transfer: From bench to bedside. Arterioscler Thromb Vasc Biol. 1999;19:196-207.
7. Rios CD, Ooboshi H, Piegors D, Davidson BL, Heistad DD. Adenovirus-mediated gene transfer to normal and atherosclerotic arteries: A novel approach. Arterioscler Thromb Vasc Biol. 1995;15:2241-2245.
8. Chen AFY, Jiang S-W, Crotty TB, Tsutsui M, Smith LA, O'Brien T, Katusic ZS. Effects of in vivo adventitial expression of recombinant endothelial nitric Proc Natl Acad Sci USA. 1997;94:12568-12573.
9. Shi Y, Niculescu R, Wang D, Patel S, Davenpeck KL, Zalewski A., Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arterioscler Thromb Vasc Biol. 2001;21:739-745.
10. Tamura K, Kanzaki T. Tashiro J, Yokote K, Mori S, Ueda S, Saito Y, Morisaki N. Increased atherogenesis in Otsuka Long-Evans Tokushima fatty rats before the onset of diabetes mellitus: Association with overex-pression of PDGF beta;-receptors in aortic smooth muscle cells. Atherosclerosis. 2000;149:351-358.
11. Capers Q IV, Alexander RW, Lou P, de Leon H, Wilcox JN, Ishizaka N, Howard AB. Taylor WR. Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats. Hypertension. 1997;30:1397-1402.
12. Allbutt C. Diseases of the Arteries Including Angina Pectoris. London: Macmillan and Co: 1915.
13. Schwartz CJ, Mitchell JRA. Cellular infiltration of the human arterial adventitia associated with atheromatous plaques. Circulation. 1962:26:73-78.
14. Cassis LA, Lynch KR, Peach MJ. Localization of angiotensinogen messenger RNA in rat aorta. Circ Res. 1988;62:1259-1262.
15. Guan S, Fox J, Mitchell KD, Navar LG. Angiotensin and angiotensin converting enzyme tissue levels in two-kidney, one clip hypertensive rats. Hypertension. 1992;20:763-767.
16. Meier B, Radeke HH,. Selle S, Younes M,. Sies H, Resch K, Habermehl GG. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha;. Biochem J. 1989;263:539-545.
17. Milligan SA, Owens MW, Grisham MB. Differential regulation of extracellular signal-regulated kinase and nuclear factor-KB signal transduction pathways by hydrogen peroxide and tumor necrosis factor. Arch Biochem Biophys. 1998;352:255-262.
18. Torrecillas G, Boyano-Adánez Md.C, Medina J, Parra T, Griera M, López-Ongil S, Arilla E, Rodríguez-Puyol M, Rodríguez-Puyol D. The role of hydrogen peroxide in the contractile response to angiotensin II. Mol Pharmacol. 2000;59:104-112.
19. Fukuishi N, Sakaguchi M, Matsuura S,. Nakagawa C, Akagi R, Akagi M. The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells., Biochem Mol Med. 1997;61:107-113.
20. Paisley K, Martin W. Blockade of nitrergic transmission by hydroquinone, hydroxocobalamin and carboxy-PTIO in bovine retractor penis: Role of superoxide anion. Br J Pharmacol. 1996;117:1633-1638.
21. Gryglewski RJ, Palmer RMJ, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 1986;320:454-456. Letter.
22. Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol. 1986;250:H822-H827.
23. Beckman JS, Beckman TW, Chen J,. Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620-1624.
24. Mugge A, Elwell JH, Peterson TE, Harrison DG. Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol. 1991;~260:C219-C225.
25. Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium-derived contracting factor. Am J Physiol. 1989;257:H33-H37.
26. Jones SA, O'Donnell VB, Wood JD, Broughton JP, Hughes EJ, Jones OTG. Expression of phagocyte NADPH oxidase components in human endothelial cells. Am J Physiol. 1996;271: H1626-H1634
27. Görlach, Brandes RP, Nguyen K, Amidi M, Dehghani F, Busse R.A. gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res. 2000;87:26-32.
28. Bayraktutan U, Blayney L, Shah AM. Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arterioscler Thromb Vasc Biol. 2000;20:1903-1911.
29. Mohazzab-H KM, Kaminski PM, Wolin MS. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium, Am J Physiol 1994;266:H2568-H2572.
30. Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II. Circ Res. 2002:90:1205-1213.
31. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994;74:1141-1148.
32. Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation. 1997;95:588-593.
33. Mollnau H, Wendt M, Szöcs K, Lassague B, Schulz E, Oelze M, Li H, Bodenschatz M, August M, Kleschyov AL. Tsilimingas N, Walter U, Förstermann U, Meinertz T, Griendling K, Münzel T. Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res. 2002;90:e58-e65.
34. Pagano PJ, Ito Y, Tornheirn K, Gallop PM, Tauber Al, Cohen RA. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am J Physiol. 1995;268:H2274-H2280.
35. Steinhom RH, Morin IFC, Russell JA. The adventitia may be a barrier specific to nitric oxide in rabbit pulmonary artery. J Clin Invest. 1994;94:1883-1888.
36. Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quinn MT, Brecher P, Cohen RA. Superoxide anion from the adventitia of the rat thoracic aorta-inactivates nitric oxide. Circ Res. 1998;82:810-818.
37. Wang HD, Hope S, Du Y, Quinn MT, Cayatte A, Pagano PJ, Cohen RA. Paracrine role of adventitial superoxide anion in mediating spontaneoustone of the isolated rat aorta in angiotensin II-induced hypertension. Hypertension 1999;33:1225-1232.
38. Walsh MF, Barazi M, Pete G, Muniyappa R, Dunbar JC, Sowers JR. Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: Role of vascular nitric oxide. Endocrinology. 1996;137:1798-1803.
39. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA. 1991;88:10045-10048.
40. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. J Clin Invest. 1996;97:1916-1923.
41. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am JPhysiol 1996;271:C1424-C1437.
42. Lancaster JR Jr. A tutorial on the diffusibility and reactivity of free nitricoxide. Nitric Oxide. 1997;1:18-30.
43. Jacobson GM, Carretero OA, Pagano PJ. A cell-permeant NAD(P)H oxidase inhibitor reduces balloon injury-induced neointimal proliferation in the rat carotid artery. Hypertension. 2001:38:472. Abstract.
44. phox Circulation. 2002;106:2497-2502.
45. Pomposiello S, Yang X-P, Liu Y-H, Surakanti M, Rhaleb N-E, Sevilla M, Carretero OA, Autacoids mediate coronary vasoconstriction induced by nitric oxide synthesis inhibition. J Cardiovasc Pharmacol. 1997;30:599-606.
46. Liao D-F, Jin Z-G, Baas AS, Daum G, Gygi SP, Aebersold R, Berk BC. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J Biol Chem. 2000;275:189-196.
47. Touyz RM, El Mabrouk M, He G, Wu X-H, Schiffrin EL, Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin Il-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circ Res. 1999;84:505-515.
48. MAPK phosphorylation and IκB degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts. J Biol Chem. 2000;275:33905-33910.
49. Xin X, Yang S, Ingle G, Zlot C, Rangell L, Kowalski J, Schwall R, Ferrara N, Gerritsen ME. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 2001:158:1111-1120.
50. Panizo A, Pardo Mindán FJ, Galindo MF, Cenarruzabeitia E, Hernandez M, Dfez J. Are mast cells involved in hypertensive heart disease? J Hypertens. 1995;13:1201-1208.
51. Daugherty A, Manning MW, Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest. 2000;105:1605-1612.
52. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, Sundaresan M, Finkel T, Goldschmidt-Clermont PJ. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science. 1997;275:1649-1652.
53. Chatelain RE, Dardik B. Increased DNA replication in the arterial adventitia after aortic ligation. Hypertension. 1988;11: I-130-I-134.
54. Zalewski A, Shi Y. Vascular myofibroblasts: Lessons from coronary repair and remodeling. Arterioscler Thromb Vosc Biol. 1997;17:417-422.
55. Owens GK, Rabinovitch PS, Schwartz SM. Smooth muscle cell hypertrophy versus hyperplasia in hypertension. Proc Natl Acad Sci USA. 1981;78:7759-7763.
56. Griffin SA, Brown WCB, MacPherson F, McGrath JC, Wilson VG, Korsgaard N, Mulvany MJ, Lever AF. Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism. Hypertension. 1991;17:626-635.
57. Schiffers PMH. van der Heijden HAMD, Fazzi GE, Struijker Boudier HAJ, De Mey JGR. Tonic tone in arteries exposed continuously to angiotensin II in vitro. J Pharniacol E-vp Tlier. 1993;266:1520-1527.
58. Plunkett WC, Overbeck HW. Increased arteriolar wall-to-lumen ratio in a normotensive vascular bed in coarctation hypertension. Am J Physiol. 1985;249:H859-H866.
59. Parker SB, Wade SS, Prewitt RL. 'Pressure, mediates angiotensin II-induced arterial hypertrophy and PDGF-A expression. Hypertension. 1998;32:452-458.
60. Berk BC, Vekshtein V, Gordon HM,. Tsuda T. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension. 1989;13:305-314.
61. Rao GN, Berk BC. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res. 1992;70:593-599.
62. phox mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblasts. Hypertension. 1998;32:331-337.
63. Fukai T, Siegfried MR, Ushio-Fukai M, Griendling KK, Harrison DG. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circ Res. 1999;85:23-28.
64. Wang HD, Xu S, Johns DG, Du Y, Quinn MT, Cayatte AJ, Cohen RA. Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice. Circ Res. 2001;88:947-953.
65. Sappino AP, Schürch W, Gabbiani G. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest. 1990;63:144-161.
66. Weber KT, Sun Y, Katwa LC. Myofibroblasts and local angiotensin II in rat cardiac tissue repair, Int J Biochem Cell Biol., 1997:29:31-42.
67. Powell JS, Clozel J-P. Muller RKM, Kuhn H, Hefti F. Hosang M, Baumgartner HR. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science. 1989;245:186-188.,
68. Farhy RD, Carretero OA, Ho K-L, Scicli AG. Role of kinins and nitric oxide in the effects of angiotensin converting enzyme inhibitors on neointima formation. Circ Res. 1993;72:1202-1210.
69. Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanisms of vascular renin-angiotensin system in myointimaI hyperplasia. Hypertension. 1991;18(suppl II):II-100-II-105.
70. Geisterfer AAT, Peach MJ, Owens GK, Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 1988;62:749-756.
71. Patel S, Shi Y, Niculescu R, Chung EH, Martin JL, Zalewski A. Characteristics of coronary smooth muscle cells and adventitial fibroblasts. Circulation. 2000;101:524-532.
72. Shi Y, Pieniek M, Fard A, O'Brien J, Mannion JD, Zalewski A. Adventitial remodeling after coronary arterial injury. Circulation. 1996;93:340-348.
73. Barker SGE, Talbert A, Cottam S, Baskerville PA, Martin JF. Arterial intimal hyperplasia after occlusion of the adventitiaI adventitial vasa vasorum in the pig. Arterioscler Thromb. 1993;13:70-77.
74. Shi Y, O'Brien JE Jr, Mannion JD, Morrison RC, Chung W, Fard A, Zalewski A. Remodeling of autologous saphenous vein grafts: The role of perivascular myofibroblasts. Circulation. 1997;95:2684-2693.
75. Holifield B, Helgason T, Jemelka S, Taylor A, Navran S, Allen J, Seidel C. Differentiated vascular myocytes: Are they involved in neointimal formation? J Clin Invest. 1996;97:814-825.
76. Li G, Chen Y-F, Greene GL, Oparil S, Thompson JA. Estrogen inhibits vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro. Circulation. 1999;100:1639-1645.
77. West NEJ, Guzik TJ, Black E, Channon KM. Enhanced superoxide production in experimental venous bypass graft intimaI intimal hyperplasia: Role of NAD(P)H oxidase. Arterioscler Thromb Vasc Biol. 2001;21:189-194.
78. Szöcs K, Lassègue B, Sorescu D, Hilenski LL, Valppu L, Couse TL, Wilcox JN, Quinn MT, Lambeth JD, Griendling KK. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol. 2002;22:21-27.
79. Ross R. Atherosclerosis: A defense mechanism gone awry (Rous-Whipple Award Lecture). Am J Pathol. 1993;143:987-1002.
80. Schwartz SM, Campbell GR, Campbell JH. Replication of smooth muscle cells in vascular disease. Circ Res. 1986;58:427-444.
81. de Leon H, Ollerenshaw JD, Griendling KK, Wilcox JN. Adventitial cells do not contribute to neointimal mass after balloon angioplasty of the rat common carotid artery. Circulation. 2001;104:1591-1593.
82. Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ. Angiotenst Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol. 1995;27:2347-2357.
83. Dourron HM, Jacobson GM, Reddy DJ, Pagano PJ, Adventitial gene transfer of NAD(P)H oxidase inhibitor suppresses increased superoxide following balloon angioplasty in the rat carotid artery. Hypertension. 2002;40:383. Abstract.
84. Wilcox JN, Scott NA. Potential role of the adventitia in artritis and atherosclerosis. Int J Cardiol. 1996;54(suppl):S21-S35.
85. van der Loo B, Martin JF, The adventitia, endothelium and atherosclerosis. Int J Microcirc. 1997;17:280-288.
86. Griendling KK, Alexander RW. Oxidative stress and cardiovascular disease. Circulation. 1997;96:3264-3265.
87. Berk BC, Haendeler J, Sottile J. Angiotensin II, atherosclerosis, and aortic aneurysms. J Clin Invest. 2000;105:1525-1526.
88. Hope S, Brecher P, Chobanian AV. Comparison of the effects of AT, receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis. Am J Hypertens. 1999;12:28-34.
89. Chobanian AV, Haudenschild CC, Nickerson C, Hope S. Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Hypertension. 1992;20:473-477.
90. Chobanian AV. The effects of ACE inhibitors and other antihypertensive drugs on cardiovascular risk factors and atherogenesis. Clin Cardiol 1990;13: VII-43-VII-48.
91. Heart Outcomes Prevention Evaluation (HOPE) Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the HOPE study and MICRO-HOPE substudy. Lancet. 2000;355:253-259.
92. Weiss D, Kools JJ, Taylor WR, Angiotensin II-induced hypertension accelerates the development of atherosclerosis in Apo E-deficient mice. Circulation. 2001;103:448-454.
93. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ. Res. 1998;82:1298-1305.
94. Shriver AE, Li W, Weintraub NL, Miller FJ, Superoxide levels and NADPH oxidase activity are increased in neointimal as compared with medial smooth muscle cells. J Invest Med. 2000;48:248A. Abstract.
95. phox in human coronary arteries. Circulation. 1999;100:1494-1498.
96. Kirk EA, Dinauer MC, Rosen H, Chait A, Heinecke JW, LeBoeuf RC. Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice. Arterioscler. Thromb Vasc Biol. 2000;20:1529-1535.
97. phox: An essential component of NADPH oxidase. Circulation. 2000;101:1234-1236.
98. Barry-Lane PA, Patterson C, van der Merwe M, Hu Z,. Holland SM, Yeh ETH, Runge MS. p47phox is required for atherosclerotic lesion progression in ApoE-1-mice. J Clin Invest. 2001;108:1513-1522.
99. DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: Molecular interaction of oxidase proteins. J Leukoc Biol. 1996;60:677-691.
100. Zhan S, Vazquez N, Zhan SH, Wientjes FB, Budarf ML, Schrock E, Ried T, Green ED, Chanock SJ, Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex. Blood. 1996;88:2714-2721.
101. 558. Biochem J. 2000;349:113-117.
102. Knaus UG, Morris S, Dong H-J, Chernoff J, Bokoch GM. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science. 1995;269:221-223
103. Mohazzab-H KM, Wolin MS. Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle. Am J Physiol. 1994;267:L815-L822.
104. Meier B, Cross AR, Hancock JT, Kaup FJ, Jones OTG. Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem J. 1991;275:241-245.
105. Pagano PJ, Clark JK, Cifuentes-Pagano ME, Clark SM, Callis GM, Quinn MT. Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II. Proc Natl Nati Acad Sci U S A. 1997;94:14483-14488.
106. Heyworth PG, Peveri P, Curnutte JT. Biological oxidant: generation and injurious consequences., In: Cochrane CC, Gimbrone MA Jr, eds. Cell and Molecular Mechanics of Inflammation. San Diego: Academic Press; 1992.
107. Arroyo CM, Carmichael AJ, Bouscarel B, Liang JH, Weglicki WB. Endothelial cells as a source of oxygen-free radicals: An ESR study. Free Radic Res Commun. 1990;9:287-296.
108. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem. 1996;271:23317-23321.
109. Fukui T, Ishizaka N, Rajagopalan S,. Laursen JB, Capers Q IV, Taylor WR, Harrison DG, de Leon H, Wilcox JN, Griendling KK. p22phox mRNA niRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res. 1997;80:45-51
110. Meyer JW, Holland JA, Ziegler LM, Chang M-M, Beebe G, Schmitt ME. Identification of a functional leukocyte-type NADPH oxidase in human endothelial cells: A potential atherogenic source of reactive oxygen species. Endothelium. 1999;7:11-22.
111. phox: Beyond the endothelium. Circ Res. 2000;87:1-3.
112. phox is necessary for production of superoxide by NADPH oxidase in vascular fibroblasts but not smooth muscle cells. J Invest Med. 2000;48:247A. Abstract.
113. phox in aortas from angiotensin II-infused mice. Am J Physiol. 2000;279:H2234-H2240.
114. phox homologues in vascular smooth muscle cells. nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res. 2001;88:888-894.
115. phox: Cloning and tissue expression of Nox3,. Nox4, and Nox5. Gene. 2001;269:131-140.
116. Fukui T, Lassegue B, Kai H, Alexander RW, Griendling KK. Cytochrome b-558 a-subunit cloning and expression in rat aortic smooth muscle cells. Biochim Biophys Acta. 1995;1231:215-219.
117. phox may participate in forming this oxidase in vitro and in vivo. J Biol Chem. 1999;274:19814-19822.
118. Lavigne MC, Malech HL. Holland SM, Leto TL. Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells. Circulation. 2001;104:79-84.
119. Meier B, Jesaitis AJ, Emmendorffer A, Roesler J, Quinn MT. The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct. Biochem J. 1993;289:481-486.
120. phox-based NADH oxidase in vascular smooth muscle. Biochem J. 1998;329:653-657.
121. 2-generating NADH oxidase in human lung fibroblasts by transforming growth factorβ1. J Biol Chem. 1995;270:30334-30338.
122. Ushio-Fukai M, Griendling KK, Becker PL, Hilenski H, Halleran S, Alexander RW. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2001;21:489-495.
123. Laderoute KR, Webster KA. Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes. Circ Res. 1997;80:336-344.
124. Yoshizumi M, Abe J, Haendeler J, Huang Q, Berk BC. Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species. J Biol Chem.;2000;275:11706-11712.
125. Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee J-D. Big mitogen-activated protein kinase 1 (BMKI) is a redox-sensitive kinase. J Biol Chem. 1996;271:16586-16590.
126. Griendling KK, Sorescu D, Lassègue B, Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol. 2000;20:2175-2183
127. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. p38 mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II 11: Role in vascular smooth muscle cell hypertrophy. J Biol Chem. 1998;273:15022-15029.
128. Viedt C, Soto U, Krieger-Brauer HI, Fei J, Elsing C, Kübler W, Kreuzer J. Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin II: Involvement of p22phox and reactive oxygen species. Arterioscler Thromb Vasc Biol. 2000;20:940-948.
129. Jin Z-G, Melaragno MG, Liao D-F, Yan C, Haendeler J 3, Suh Y-A, Lambeth JD, Berk BC. Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res. 2000;87:789-796.
130. - in vascular smooth muscle cells. Circ Res. 1995;77:29-36.
131. de Wit R, Capello A, Boonstra J, Verkleu AJ, Post JA,. Hydrogen peroxide inhibits epidermal growth factor receptor internalization in human fibroblasts. Free Radic Biol Med, 2000;28:28-38.
132. Abe J, Berk BC, Fyn and JAK2 mediate Ras activation by reactive oxygen species. J Biol Chem. 1999;274:21003-21010.
133. Kessler DJ, Duyao MP, Spicer DB, Sonenshein GE. NF-kB-like factors mediate interleukin I induction of c-myc gene transcription in fibroblasts. J Exp Med. 1992;176:787-792.
134. kipI and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals. Kidney Int. 1998;54:1923-1933.
135. Sdi1/Cip1/Waf1 expression during the cell cycle in aortic adventitial fibroblasts. Arterioscler Thromb Vasc Biol. 2000;20:27-34.
136. Itahana K, Dimri GP, Hara E, Itahana Y, Zou Y, Desprez P-Y, Campisi J. A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem. 2002;277:18206-18214.