Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose

European Journal of Pharmacology

Volumn 627, Issue 1-3, 2010, Pages 42-48

  Taye, Ashraf ^a   Saad, Adel H ^b   Kumar, Arun HS ^c   Morawietz, Henning ^d  

^a Minia University   (Egypt)

^b Minia University   (Egypt)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

eNOS; LOX 1 High glucose; NADPH oxidase; Oxidative stress

Indexed keywords

APOCYNIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; MESSENGER RNA; NITRITE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL LABELING; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; OXIDATIVE STRESS; PRIORITY JOURNAL; UMBILICAL ARTERY;

ACETOPHENONES; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; HUMANS; LIPOPROTEINS, LDL; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; OXIDATIVE STRESS; PROTEIN SUBUNITS; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 73449147620     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.10.045     Document Type: Article

References (46)

1. Abid M.R., Spokes K.C., Shih S.C., and Aird W.C. NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. The Journal of Biological Chemistry 282 (2007) 35373-35385
2. Al-Shabrawey M., Rojas M., Sanders T., Behzadian A., El-Remessy A., Bartoli M., Parpia A.K., Liou G., and Caldwell R.B. Role of NADPH oxidase in retinal vascular inflammation. Investigative Ophthalmology & Visual Science 49 (2008) 3239-3244
3. Archer S.L., Reeve H.L., Michelakis E., Puttagunta L., Waite R., Nelson D.P., Dinauer M.C., and Weir E.K. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 7944-7949
4. Balligand J.L., Ungureanu-Longrois D., Simmons W.W., Kobzik L., Lowenstein C.J., Lamas S., Kelly R.A., Smith T.W., and Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. American Journal of Physiology 268 (1995) H1293-1303
5. Bayraktutan U., Blayney L., and Shah A.M. Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular biology 20 (2000) 1903-1911
6. Bedard K., and Krause K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiological Reviews 87 (2007) 245-313
7. Bedard K., Lardy B., and Krause K.H. NOX family NADPH oxidases: not just in mammals. Biochimie 89 (2007) 1107-1112
8. Booth G., Stalker T.J., Lefer A.M., and Scalia R. Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes 51 (2002) 1556-1564
9. Calles-Escandon J., and Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocrine Updates 22 (2001) 36-52
10. Cave A.C., Brewer A.C., Narayanapanicker A., Ray R., Grieve D.J., Walker S., and Shah A.M. NADPH oxidases in cardiovascular health and disease. Antioxidants & Redox Signalling 8 (2006) 691-728
11. Cayatte A.J., Palacino J.J., Horten K., and Cohen R.A. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arteriosclerosis and Thrombosis 14 (1994) 753-759
12. Chung H.K., Lee I.K., Kang H., Suh J.M., Kim H., Park K.C., Kim D.W., Kim Y.K., Ro H.K., and Shong M. Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells. Experimental & Molecular Medicine 34 (2002) 451-461
13. Cosentino F., Hishikawa K., Katusic Z.S., and Luscher T.F. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 96 (1997) 25-28
14. Downs S.M., Humpherson P.G., and Leese H.J. Meiotic induction in cumulus cell-enclosed mouse oocytes: involvement of the pentose phosphate pathway. Biology of Reproduction 58 (1998) 1084-1094
15. Du X., Stocklauser-Farber K., and Rosen P. Generation of reactive oxygen intermediates, activation of NF-kappaB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?. Free Radical Biology & Medicine 27 (1999) 752-763
16. Figueroa-Romero C., Sadidi M., and Feldman E.L. Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Reviews in Endocrine & Metabolic Disorders 9 (2008) 301-314
17. Gorlach A., Brandes R.P., Bassus S., Kronemann N., Kirchmaier C.M., Busse R., and Schini-Kerth V.B. Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets. FASEB Journal 14 (2000) 1518-1528
18. Gupte S.A., Kaminski P.M., Floyd B., Agarwal R., Ali N., Ahmad M., Edwards J., and Wolin M.S. Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries. American Journal of Physiology 288 (2005) H13-21
19. Hayashida K., Kume N., Minami M., and Kita T. Lectin-like oxidized LDL receptor-1 (LOX-1) supports adhesion of mononuclear leukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions. FEBS Letters 511 (2002) 133-138
20. Heinloth A., Heermeier K., Raff U., Wanner C., and Galle J. Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells. Journal of the American Society of Nephrology 11 (2000) 1819-1825
21. Ho F.M., Liu S.H., Liau C.S., Huang P.J., Shiah S.G., and Lin-Shiau S.Y. Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage. Journal of Cellular Biochemistry 75 (1999) 258-263
22. Huang P.L., Huang Z., Mashimo H., Bloch K.D., Moskowitz M.A., Bevan J.A., and Fishman M.C. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377 (1995) 239-242
23. Jin L., Lagoda G., Leite R., Webb R.C., and Burnett A.L. NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction. The Journal of Sexual Medicine 5 (2008) 544-551
24. Kitiyakara C., Chabrashvili T., Chen Y., Blau J., Karber A., Aslam S., Welch W.J., and Wilcox C.S. Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. Journal of the American Society of Nephrology 14 (2003) 2775-2782
25. Li H., and Forstermann U. Nitric oxide in the pathogenesis of vascular disease. Journal of Pathology 190 (2000) 244-254
26. Li J.M., Gall N.P., Grieve D.J., Chen M., and Shah A.M. Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension 40 (2002) 477-484
27. Li J.M., and Shah A.M. Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit. The Journal of Biological Chemistry 278 (2003) 12094-12100
28. Li L., Sawamura T., and Renier G. Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium. Diabetes 52 (2003) 1843-1850
29. Liu S., Ma X., Gong M., Shi L., Lincoln T., and Wang S. Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species. Free Radical Biology & Medicine 42 (2007) 852-863
30. Mazzone T., Chait A., and Plutzky J. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet 371 (2008) 1800-1809
31. Meyer J.W., and Schmitt M.E. A central role for the endothelial NADPH oxidase in atherosclerosis. FEBS Letters 472 (2000) 1-4
32. Mollnau H., Wendt M., Szocs K., Lassegue B., Schulz E., Oelze M., Li H., Bodenschatz M., August M., Kleschyov A.L., Tsilimingas N., Walter U., Forstermann U., Meinertz T., Griendling K., and Munzel T. Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circulation Research 90 (2002) E58-65
33. Morawietz H., Rueckschloss U., Niemann B., Duerrschmidt N., Galle J., Hakim K., Zerkowski H.R., Sawamura T., and Holtz J. Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein. Circulation 100 (1999) 899-902
34. Quagliaro L., Piconi L., Assaloni R., Martinelli L., Motz E., and Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 52 (2003) 2795-2804
35. Salt I.P., Morrow V.A., Brandie F.M., Connell J.M., and Petrie J.R. High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells. The Journal of Biological Chemistry 278 (2003) 18791-18797
36. Sawamura T., Kume N., Aoyama T., Moriwaki H., Hoshikawa H., Aiba Y., Tanaka T., Miwa S., Katsura Y., Kita T., and Masaki T. An endothelial receptor for oxidized low-density lipoprotein. Nature 386 (1997) 73-77
37. Schulz E., Anter E., and Keaney Jr. J.F. Oxidative stress, antioxidants, and endothelial function. Current Medicinal Chemistry 11 (2004) 1093-1104
38. Sonta T., Inoguchi T., Tsubouchi H., Sekiguchi N., Kobayashi K., Matsumoto S., Utsumi H., and Nawata H. Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity. Free Radical Biology & Medicine 37 (2004) 115-123
39. Srinivasan S., Hatley M.E., Bolick D.T., Palmer L.A., Edelstein D., Brownlee M., and Hedrick C.C. Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. Diabetologia 47 (2004) 1727-1734
40. Stehouwer C.D., Lambert J., Donker A.J., and van Hinsbergh V.W. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovascular Research 34 (1997) 55-68
41. Tian N., Moore R.S., Phillips W.E., Lin L., Braddy S., Pryor J.S., Stockstill R.L., Hughson M.D., and Manning Jr. R.D. NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension. American Journal of Physiology 295 (2008) R1858-R1865
42. Ungvari Z., Csiszar A., Edwards J.G., Kaminski P.M., Wolin M.S., Kaley G., and Koller A. Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arteriosclerosis, Thrombosis, and Vascular Biology 23 (2003) 418-424
43. Wang L.J., Yu Y.H., Zhang L.G., Wang Y., Niu N., Li Q., and Guo L.M. Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. European Journal of Pharmacology 597 (2008) 75-80
44. Weidig P., McMaster D., and Bayraktutan U. High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells. Diabetes, Obesity & Metabolism 6 (2004) 432-441
45. Wendt M.C., Daiber A., Kleschyov A.L., Mulsch A., Sydow K., Schulz E., Chen K., Keaney Jr. J.F., Lassegue B., Walter U., Griendling K.K., and Munzel T. Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radical Biology & Medicine 39 (2005) 381-391
46. Xu M., Dai D.Z., and Dai Y. Normalizing NADPH oxidase contributes to attenuating diabetic nephropathy by the dual endothelin receptor antagonist CPU0213 in rats. American Journal of Nephrology 29 (2009) 252-256