Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the process

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 6755-6764

  Brufatto, Nicole ^a   Nesheim, Michael E ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; ENZYMES;

PROTHROMBIN ACTIVATION;

BIOCHEMISTRY;

ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CYSTEINE; FLUORESCEIN; MEIZOTHROMBIN; PRETHROMBIN 2; PROTHROMBIN; UNCLASSIFIED DRUG; DNA; ENZYME PRECURSOR; RECOMBINANT PROTEIN; THROMBIN; THROMBOPLASTIN;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; BINDING COMPETITION; BINDING SITE; BIOLOGICAL MODEL; CHEMISTRY; DOSE RESPONSE; HUMAN; KINETICS; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; SITE DIRECTED MUTAGENESIS; THEORETICAL MODEL; TIME;

ARGININE; BINDING SITES; BINDING, COMPETITIVE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME PRECURSORS; FACTOR VA; FLUORESCEIN; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; MUTAGENESIS, SITE-DIRECTED; PROTHROMBIN; RECOMBINANT PROTEINS; THROMBIN; THROMBOPLASTIN; TIME FACTORS;

EID: 0037470249     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206413200     Document Type: Article

References (41)

1. Tracy, P. B., Eide, L. L., and Mann, K. G. (1985) J. Biol. Chem. 260, 2119-2124
2. Tracy, P. B., Nesheim, M. E., and Mann, K. G. (1981) J. Biol. Chem. 256, 743-751
3. Mann, K. G., Jenny, R. J., and Krishnaswamy, S. (1988) Ann. Rev. Biochem. 57, 915-956
4. Mann, K. G. (1987) Trends Biochem. Sci. 12, 229-233
5. Nesheim, M. E., Taswell, J. B., and Mann, K. G. (1979) J. Biol. Chem. 254, 10952-10962
6. Heldebrant, C. M., and Mann, K. G. (1973) J. Biol. Chem. 248, 3642-3652
7. Heldebrant, C. M., Butkowski, R. J., Bajaj, S. P., and Mann, K. G. (1973) J. Biol. Chem. 248, 7149-7163
8. Esmon, C. T., Owen, W. G., and Jackson, C. M. (1974) J. Biol. Chem. 249, 8045-8047
9. Krishnaswamy, S., Mann, K. G., and Nesheim, M. E. (1986) J. Biol. Chem. 261, 8977-8984
10. Cote, H. C. F., Stevens, W. K., Bajzar, L., Banfield, D. K., Nesheim, M. E., and MacGillivray, R. T. A. (1994) J. Biol. Chem. 269, 11374-11380
11. Brufatto, N., and Nesheim, M. E. (2001) J. Biol. Chem. 276, 17663-17671
12. Palmiter, R. D., Behringer, R. R., Quaife, C. J., Maxwell, F., Maxwell, I. H., and Brinster, R. L. (1987) Cell 50, 435-443
13. Bell, R. (2000) Spectral and Functional Properties of Single Tryptophan-to-Phenylalanine Mutants of Prothrombin and Thrombin. M.Sc. Thesis, Queen's University, Kingston, Ontario, Canada
14. Nesheim, M. E., Prendergast, F. G., and Mann, K. G. (1979) Biochemistry 18, 996-1003
15. Bloom, J. W., Nesheim, M. E., and Mann, K. G. (1979) Biochemistry 18, 4419-4425
16. Bajzar, L., Fredenburgh, J. C., and Nesheim, M. E. (1990) J. Biol. Chem. 265, 16948-16954
17. Walker, J. B., and Nesheim, M. E. (1999) J. Biol. Chem. 274, 5201-5212
18. Nesheim, M. E., Katzmann, J. A., Tracy, P. B., and Mann, K. G. (1981) Methods Enzymol. 80, 249-274
19. Boskovic, D. S., Bajzar, L. S., and Nesheim, M. E. (2001) J. Biol. Chem. 276, 28686-28693
20. Neville, D. M. (1971) J. Biol. Chem. 246, 6328-6334
21. Krishnaswamy, S., Church, W. R., Nesheim, M. E., and Mann, K. G. (1987) J. Biol. Chem. 262, 3291-3299
22. Coulombe, R., Yue, K. Q., Ghisla, S., and Vrielink, A. (2001) J. Biol. Chem. 276, 30435-30441
23. Leichus, B. N., and Blanchard, J. S. (1992) Biochemistry 31, 3065-3072
24. Sem, D. S., and Kasper, C. B. (1994) Biochemistry 33, 12012-12021
25. Martin, P. D., Malkowski, M. G., Box, J., Esmon, C. T., and Edwards, B. F. P. (1997) Structure 5, 1681-1693
26. Vijayalakshmi, J., Padmanabhan, K. P., Mann, K. G., and Tulinsky, A. (1994) Protein Sci. 3, 2254-2271
27. Walker, R. K., and Krishnaswamy, S. (1994) J. Biol. Chem. 269, 27441-27450
28. Rezaie, A. R. (2001) Blood 97, 2308-2313
29. Rezaie, A. R. (1998) J. Biol. Chem. 273, 16824-16827
30. Speijer, H., Billy, D., Willems, G., Hemker, H. C., and Lindhout, T. (1995) Thromb. Haemostasis 73, 648-653
31. Eisenburg, P. R., Siegel, J. E., Abendschein, D. R., and Miletich, J. P. (1993) J. Clin. Invest. 91, 1877-1883
32. Schoen, P., and Lindhout, T. (1991) Blood 78, 118-124
33. Schoen, P., Lindhout, T., Willems, G., and Hemker, H. C. (1989) J. Biol. Chem. 264, 10002-10007
34. Lindhout, T., Baruch, D., Schoen, P., Franssen, J., and Hemker, H. C. (1986) Biochemistry 25, 5962-5969
35. Ellis, V., Scully, M. F., and Kakkar, V. V. (1984) Biochemistry 23, 5882-5887
36. Walker, F. J., and Esmon, C. T. (1979) Biochem. Biophys. Res. Commun. 90, 641-647
37. Anderson, P. J., Nesset, A., Dharinawardana, K. R., and Bock, P. E. (2000) J. Biol. Chem. 275, 16435-16442
38. Krishnaswamy, S., and Betz, A. (1997) Biochemistry 36, 12080-12086
39. Kotkow, K. J., Deitcher, S. R., Furie, B., and Furie, B. C. (1995) J. Biol. Chem. 270, 4551-4557
40. Church, W. R., Quellette, L. A., and Messier, T. L. (1991) J. Biol. Chem. 266, 8384-8391
41. Esmon, C. T., and Jackson, C. M. (1974) J. Biol. Chem. 249, 7791-7797