Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation

Journal of Biological Chemistry

Volumn 288, Issue 31, 2013, Pages 22734-22744

  Pozzi, Nicola ^a   Chen, Zhiwei ^a   Gohara, David W ^a   Niu, Weiling ^a   Heyduk, Tomasz ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOACTIVATION; CONFORMATIONAL FLEXIBILITY; PROTHROMBIN ACTIVATION; PROTHROMBINASE; SOLUTION STUDY; SOLVENT ACCESSIBILITY; STRUCTURE-BASED; X-RAY STRUCTURE;

BIOCHEMISTRY; BIOLOGY;

GLYCOPROTEINS;

ALANINE; ARGININE; ASPARTIC ACID; BLOOD CLOTTING FACTOR 10A; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; ISOLEUCINE; LEUCINE; PRETHROMBIN 1; PRETHROMBIN 2; PROTHROMBIN; SERINE; THREONINE; THROMBIN; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; KRINGLE DOMAIN; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

COAGULATION FACTORS; ENZYME MUTATION; ENZYME STRUCTURE; STRUCTURAL BIOLOGY; THROMBIN; ZYMOGEN;

CRYSTALLOGRAPHY, X-RAY; ENERGY TRANSFER; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTHROMBIN; STATIC ELECTRICITY;

EID: 84881227791     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.466946     Document Type: Article

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