Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage

Journal of Biological Chemistry

Volumn 288, Issue 39, 2013, Pages 27789-27800

  Bradford, Harlan N ^a   Orcutt, Steven J ^a,b   Krishnaswamy, Sriram ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b API Large Molecule Pharmaceutical Development and Manufacturing Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE BINDING; PROTHROMBINASE;

GLYCOPROTEINS;

MEMBRANES;

4 CARBOXYGLUTAMIC ACID; ARGININE; BLOOD CLOTTING FACTOR 10A; PROTEIN VARIANT; PROTHROMBIN; THROMBIN;

ARTICLE; BIOACCUMULATION; CARBOXYLATION; CATALYSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MEMBRANE BINDING; MEMBRANE BIOLOGY; MEMBRANE STRUCTURE; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; THROMBOCYTE;

BLOOD COAGULATION FACTORS; ENZYME KINETICS; MEMBRANE ENZYMES; PROTHROMBIN; PROTHROMBINASE; SERINE PROTEASE; ZYMOGEN ACTIVATION;

BLOOD COAGULATION; BLOOD PLATELETS; CELL MEMBRANE; FACTOR V; FACTOR VA; FACTOR XA; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PROTEIN BINDING; PROTHROMBIN; SUBSTRATE SPECIFICITY; THROMBOPLASTIN;

EID: 84884738672     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.502005     Document Type: Article

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