Current concepts of immune dysregulation in cystic fibrosis

International Journal of Biochemistry and Cell Biology

Volumn 52, Issue , 2014, Pages 108-112

  Rieber, N ^a   Hector, A ^a   Carevic, M ^a   Hartl, D ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cystic fibrosis; Immunity; Innate; Neutrophils; Toll like receptors

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; TOLL LIKE RECEPTOR;

ARTICLE; BONE MARROW CELL; CYSTIC FIBROSIS; DIAGNOSTIC APPROACH ROUTE; HUMAN; IMMUNE DYSREGULATION; INFLAMMATION; INNATE IMMUNITY; LUNG FIBROSIS; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; SPECIES DIFFERENCE; SUPPRESSOR CELL; ANIMAL; IMMUNOLOGY; NEUTROPHIL;

BACTERIA (MICROORGANISMS);

ANIMALS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; IMMUNITY, INNATE; NEUTROPHILS;

EID: 84901631277     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.01.017     Document Type: Article

References (41)

1. C.J. Blohmke, J. Park, A.F. Hirschfeld, R.E. Victor, J. Schneiderman, and D. Stefanowicz et al. TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis Journal of Immunology 185 2010 7731 7738
2. C.J. Blohmke, R.E. Victor, A.F. Hirschfeld, I.M. Elias, D.G. Hancock, and C.R. Lane et al. Innate immunity mediated by TLR5 as a novel anti-inflammatory target for cystic fibrosis lung disease Journal of Immunology 180 2008 7764 7773
3. T.L. Bonfield, C.A. Hodges, C.U. Cotton, and M.L. Drumm Absence of the cystic fibrosis transmembrane regulator (Cftr) from myeloid-derived cells slows resolution of inflammation and infection Journal of Leukocyte Biology 92 2012 1111 1122
4. R.W. Bonvillain, R.G. Painter, D.E. Adams, A. Viswanathan, N.A. Lanson Jr., and G. Wang RNA interference against CFTR affects HL60-derived neutrophil microbicidal function Free Radical Biology & Medicine 49 2010 1872 1880
5. N. Borregaard Neutrophils, from marrow to microbes Immunity 33 2010 657 670
6. E.M. Bruscia, P.X. Zhang, A. Satoh, C. Caputo, R. Medzhitov, and A. Shenoy et al. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis Journal of Immunology 186 2011 6990 6998
7. S. de Bentzmann, P. Roger, F. Dupuit, O. Bajolet-Laudinat, C. Fuchey, and M.C. Plotkowski et al. Asialo GM1 is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelial cells Infection and Immunity 64 1996 1582 1588 (Pubitemid 26129819)
8. D. Descamps, M. Le Gars, V. Balloy, D. Barbier, S. Maschalidi, and M. Tohme et al. Toll-like receptor 5 (TLR5), IL-1 beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing Proceedings of the National Academy of Sciences of the United States of America 109 2012 1619 1624
9. P.J. Dubin, and J.K. Kolls IL-17 in cystic fibrosis: more than just Th17 cells American Journal of Respiratory and Critical Care Medicine 184 2011 155 157
10. P.J. Dubin, F. McAllister, and J.K. Kolls Is cystic fibrosis a TH17 disease? Inflammation Research 56 2007 221 227
11. D.I. Gabrilovich, and S. Nagaraj Myeloid-derived suppressor cells as regulators of the immune system Nature Reviews Immunology 9 2009 162 174
12. A. Gaggar, A. Hector, P.E. Bratcher, M.A. Mall, M. Griese, and D. Hartl The role of matrix metalloproteinases in cystic fibrosis lung disease The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology 38 2011 721 727
13. M. Griese, M. Kappler, C. Eismann, M. Ballmann, S. Junge, and E. Rietschel et al. Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial American Journal of Respiratory and Critical Care Medicine 188 2013 83 89
14. M. Griese, M. Kappler, A. Gaggar, and D. Hartl Inhibition of airway proteases in cystic fibrosis lung disease The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology 32 2008 783 795
15. M.B. Hampton, A.J. Kettle, and C.C. Winterbourn Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing Blood 92 1998 3007 3017 (Pubitemid 28492304)
16. D. Hartl, A. Gaggar, E. Bruscia, A. Hector, V. Marcos, and A. Jung et al. Innate immunity in cystic fibrosis lung disease Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society 11 2012 363 382
17. L.R. Hoffman, and B.W. Ramsey Cystic fibrosis therapeutics: the road ahead Chest 143 2013 207 213
18. H. Husebye, O. Halaas, H. Stenmark, G. Tunheim, O. Sandanger, and B. Bogen et al. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity Embo Journal 25 2006 683 692 (Pubitemid 43292431)
19. G. John, A.O. Yildirim, B.K. Rubin, D.C. Gruenert, and M.O. Henke TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells American Journal of Respiratory Cell and Molecular Biology 42 2010 424 431
20. C. Kelly, P. Canning, P.J. Buchanan, M.T. Williams, V. Brown, and D.C. Gruenert et al. Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells American Journal of Physiology. Lung Cellular and Molecular Physiology 304 2013 L371 L382
21. E. Kolaczkowska, and P. Kubes Neutrophil recruitment and function in health and inflammation Nature Reviews Immunology 13 2013 159 175
22. B. Koller, M. Kappler, P. Latzin, A. Gaggar, M. Schreiner, and S. Takyar et al. TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease Journal of Immunology 181 2008 2753 2763
23. M. Le Gars, D. Descamps, D. Roussel, E. Saussereau, L. Guillot, and M. Ruffin et al. Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo American Journal of Respiratory and Critical Care Medicine 187 2013 170 179
24. F. McAllister, A. Henry, J.L. Kreindler, P.J. Dubin, L. Ulrich, and C. Steele et al. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis Journal of Immunology 175 2005 404 412 (Pubitemid 40884344)
25. R.B. Moss, S.J. Mistry, M.W. Konstan, J.M. Pilewski, E. Kerem, and R. Tal-Singer et al. Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society 12 2013 241 248
26. L. Nahrlich, J.G. Mainz, C. Adams, C. Engel, G. Herrmann, and V. Icheva et al. Therapy of CF-patients with amitriptyline and placebo - a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study Cellular Physiology and Biochemistry 31 2013 505 512
27. W.M. Nauseef How human neutrophils kill and degrade microbes: an integrated view Immunological Reviews 219 2007 88 102 (Pubitemid 47390004)
28. D. Oceandy, B.J. McMorran, S.N. Smith, R. Schreiber, K. Kunzelmann, and E.W.F.W. Alton et al. Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities Human Molecular Genetics 11 2002 1059 1067 (Pubitemid 34521087)
29. R.G. Painter, L. Marrero, G.A. Lombard, V.G. Valentine, W.M. Nauseef, and G. Wang CFTR-mediated halide transport in phagosomes of human neutrophils Journal of Leukocyte Biology 87 2010 933 942
30. R.G. Painter, V.G. Valentine, N.A. Lanson Jr., K. Leidal, Q. Zhang, and G. Lombard et al. CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis Biochemistry 45 2006 10260 10269 (Pubitemid 44384801)
31. H.R. Rabin, and M.G. Surette The cystic fibrosis airway microbiome Current Opinion in Pulmonary Medicine 18 2012 622 627
32. N. Rieber, A. Brand, A. Hector, U. Graepler-Mainka, M. Ost, and I. Schafer et al. Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease Journal of Immunology 190 2013 1276 1284
33. C.S. Rogers, D.A. Stoltz, D.K. Meyerholz, L.S. Ostedgaard, T. Rokhlina, and P.J. Taft et al. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs Science 321 2008 1837 1841
34. P.D. Sly, C.L. Gangell, L. Chen, R.S. Ware, S. Ranganathan, and L.S. Mott et al. Risk factors for bronchiectasis in children with cystic fibrosis The New England Journal of Medicine 368 2013 1963 1970
35. X. Su, M.R. Looney, H.E. Su, J.W. Lee, Y. Song, and M.A. Matthay Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice Inflammation Research 60 2011 619 632
36. F.S. Sutterwala, L.A. Mijares, L. Li, Y. Ogura, B.I. Kazmierczak, and R.A. Flavell Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome Journal of Experimental Medicine 204 2007 3235 3245
37. H.L. Tan, N. Regamey, S. Brown, A. Bush, C.M. Lloyd, and J.C. Davies The Th17 pathway in cystic fibrosis lung disease American Journal of Respiratory and Critical Care Medicine 184 2011 252 258
38. R.W. Vandivier, T.R. Richens, S.A. Horstmann, A.M. deCathelineau, M. Ghosh, and S.D. Reynolds et al. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences American Journal of Physiology. Lung Cellular and Molecular Physiology 297 2009 L677 L686
39. M.C. Wolfgang, J. Jyot, A.L. Goodman, R. Ramphal, and S. Lory Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients Proceedings of the National Academy of Sciences of the United States of America 101 2004 6664 6668 (Pubitemid 38586031)
40. P.X. Zhang, T.S. Murray, V.R. Villella, E. Ferrari, S. Esposito, and A. D'Souza et al. Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator Journal of Immunology 190 2013 5196 5206
41. Y. Zhou, K. Song, R.G. Painter, M. Aiken, J. Reiser, and B.A. Stanton et al. Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils Journal of Innate Immunity 5 2013 219 230