A novel synthetic HTB derivative, BECT inhibits lipopolysaccharide-mediated inflammatory response by suppressing the p38 MAPK/JNK and NF-κB activation pathways

Pharmacological Reports

Volumn 66, Issue 3, 2014, Pages 471-479

  Kang, Seong Mook ^a   More, Sandeep Vasant ^a   Park, Ju Young ^b   Kim, Byung Wook ^a   In, Park Jeong ^a   Yoon, Sung Hwa ^b   Choi, Dong Kug ^a  

^a Konkuk University   (South Korea)

^b Ajou University   (South Korea)

Author keywords

HTB derivative; Lipopolysaccharide; Microglia; Neurodegenerative disease; Neuroinflammation

Indexed keywords

2 HYDROXY 4 TRIFUOROMETHYLBENZOIC ACID DERIVATIVE; ANTIINFLAMMATORY AGENT; BENZOIC ACID DERIVATIVE; BUT 2 ENEDIOIC ACID BIS(2 CARBOXY 5 TRIFLUOROMETHYLPHENYL)ESTER; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4-TRIFLUOROMETHYLSALICYLIC ACID; SALICYLIC ACID DERIVATIVE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; GENE EXPRESSION; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL LINE; DRUG EFFECTS; INFLAMMATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SALICYLATES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901474047     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2013.08.015     Document Type: Article

References (40)

1. E.C. Hirsch, S. Hunot, and Hartmann A: Neuroinflammatory processes in Parkinson's disease Parkinsonism Related Disorder 1 11 Suppl 2005 S9 S15
2. T. Arimoto, and Bing G: Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration Neurobiology of Disease 12 2003 35 45 (Pubitemid 36259966)
3. C. Knott, G. Stern, and 1. Wilkin GP: Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2 Molecular and Cellular Neurosciences 16 2000 724 739 (Pubitemid 32062060)
4. M. Mogi, M. Harada, P. Riederer, H. Narabayashi, K. Fujita, and Nagatsu T: Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients Neuroscience Letters 165 1994 208 210
5. N.R. Bhat, P. Zhang, J.C. Lee, and 1. Hogan EL: Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures Journal of Neuroscience 18 1998 1633 1641 (Pubitemid 28103071)
6. I.N. Hsieh, A.S. Chang, C.M. Teng, C.C. Chen, and 1. Yang CR: Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-kappaB and JNK/p38 MAPK activation pathways Journal of Biomedical Science 18 2011 18 28
7. E.C. Hirsch, S. Vyas, and Hunot S: Neuroinflammation in Parkinson's disease Parkinsonism Related Disorder 1 18 Suppl. 2012 S210 S212
8. R.B. Maccioni, L.E. Rojo, J.A. Fernandez, and 1. Kuljis RO: The role of neuroimmunomodulation in Alzheimer's disease Annals of the New York Academy of Sciences 1153 2009 240 246
9. L. Acarin, B. Gonzalez, and Castellano B: Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage Stroke 33 2002 2499 2505
10. L. Sanchez de Miguel, S. Casado, J. Farre, M. Garcia-Duran, L.A. Rico, and M. Monton et al. Comparison of in vitro effects of triflusal and acetysalicylic acid on nitric oxide synthesis by human neutrophils European Journal of Pharmacology 343 1998 57 65 (Pubitemid 28161052)
11. M. Coma, L. Sereno, B. Da Rocha-Souto, T.C. Scotton, J. Espana, and M.B. Sanchez et al. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease Neurobiology of Disease 38 2010 482 491
12. S.N. Whitehead, E. Massoni, G. Cheng, V.C. Hachinski, M. Cimino, and W. Balduini et al. Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke Brain Research 1366 2010 246 256
13. Y. Bayon, A. Alonso, and M. Sanchez Crespo 4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4- trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation British Journal of Pharmacology 126 1999 1359 1366 (Pubitemid 29142066)
14. A. Fernandez de Arriba, F. Cavalcanti, A. Miralles, Y. Bayon, A. Alonso, and M. Merlos et al. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid Molecular Pharmacology 55 1999 753 760
15. N.R. Jeon, S. Koppula, B.W. Kim, S.H. Park, H.W. Lee, and Choi DK: MMHD [(S,E)-2-methyl-1-(2-methylthiazol-4-yl) hexa-1 5-dien-ol], a novel synthetic compound derived from epothilone, suppresses nuclear factor-kappaB-mediated cytokine expression in lipopolysaccharide-stimulated BV-2 microglia Journal of Pharmacological Sciences 112 2010 158 166
16. B.W. Kim, S. Koppula, I.S. Kim, H.W. Lim, S.M. Hong, and S.D. Han et al. Anti-neuroinflammatory activity of Kamebakaurin from Isodon japonicus via inhibition of c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells Journal of Pharmacological Sciences 116 2011 296 308
17. V. Bocchini, R. Mazzolla, R. Barluzzi, E. Blasi, P. Sick, and Kettenmann H: An immortalized cell line expresses properties of activated microglial cells Journal of Neuroscience Research 31 1992 616 621
18. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and 1. Tannenbaum SR: Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Analytical Biochemistry 126 1982 131 138 (Pubitemid 13203451)
19. +-induced cytotoxicity in human dopaminergic SH-SY5Y cells Journal of Ethnopharmacology 130 2010 290 298
20. H.M. Ko, S. Koppula, B.W. Kim, I.S. Kim, B.Y. Hwang, and K. Suk et al. Inflexin attenuates proinflammatory responses and nuclear factor-kappaB activation in LPS-treated microglia European Journal of Pharmacology 633 2010 98 106
21. Boje KM: Nitric oxide neurotoxicity in neurodegenerative diseases Frontiers in Bioscience 9 2004 763 776
22. E.J. Kim, K.J. Kwon, J.Y. Park, S.H. Lee, C.H. Moon, and 1. Baik EJ: Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2 Brain Research 941 2002 1 10 (Pubitemid 34603279)
23. Allan SM: The role of pro- and antiinflammatory cytokines in neurodegeneration Annals of the New York Academy of Sciences 917 2000 84 93
24. H.D. Venters, Q. Tang, Q. Liu, R.W. VanHoy, R. Dantzer, and 1. Kelley KW: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide Proceedings of the National Academy of Sciences of the United States of America 96 1999 9879 9884 (Pubitemid 29398826)
25. J. Da Silva, B. Pierrat, J.L. Mary, and Lesslauer W: Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes Journal of Biological Chemistry 272 1997 28373 28380 (Pubitemid 27517783)
26. L.J. Van Eldik, W.L. Thompson, H. Ralay Ranaivo, H.A. Behanna, and D. Martin Watterson Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches International Review of Neurobiology 82 2007 277 296
27. P.P. Tak, and 1. Firestein GS: NF-kappaB: a key role in inflammatory diseases Journal of Clinical Investigation 107 2001 7 11 (Pubitemid 32047405)
28. K.U. Tufekci, S. Genc, and Genc K: The endotoxin-induced neuroinflammation model of Parkinson's disease Parkinson's Disease 2011 2011 1 25
29. J. Ock, S. Kim, K.Y. Yi, N.J. Kim, H.S. Han, and J.Y. Cho et al. A novel anti-neuroinflammatory pyridylimidazole compound KR-31360 Biochemical Pharmacology 79 2010 596 609
30. S. Aid, and Bosetti F: Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications Biochimie 93 2011 46 51
31. K.F. Beck, W. Eberhardt, S. Frank, A. Huwiler, U.K. Messmer, and H. Muhl et al. Inducible NO synthase: role in cellular signalling Journal of Experimental Biology 202 1999 645 653 (Pubitemid 29184231)
32. M. Hernandez, A.F. de Arriba, M. Merlos, L. Fuentes, M.S. Crespo, and 1. Nieto ML: Effect of 4-trifluoromethyl derivatives of salicylate on nuclear factor kappaB-dependent transcription in human astrocytoma cells British Journal of Pharmacology 132 2001 547 555 (Pubitemid 32142368)
33. T.C. Frank-Cannon, L.T. Alto, F.E. McAlpine, and 1. Tansey MG: Does neuroinflammation fan the flame in neurodegenerative diseases? Molecular Neurodegeneration 4 2009 47 59
34. T.S. Blackwell, and 1. Christman JW: The role of nuclear factor-kappa B in cytokine gene regulation American Journal of Respiratory Cell and Molecular Biology 17 1997 3 9 (Pubitemid 127500814)
35. D. Schmid, M. Gruber, C. Piskaty, F. Woehs, A. Renner, and Z. Nagy et al. Inhibition of NF-kappaB-dependent cytokine and inducible nitric oxide synthesis by the macrocyclic ellagitannin oenothein B in TLR-stimulated RAW 264.7 macrophages Journal of Natural Products 75 2012 870 875
36. V. Ulivi, P. Giannoni, C. Gentili, R. Cancedda, and F. Descalzi p38/NF-kB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes Journal of Cellular Biochemistry 104 2008 1393 1406 (Pubitemid 351961709)
37. J. Ock, S.H. Hong, and Suk K: Identification of KT-15073 as an inhibitor of lipopolysaccharide-induced microglial activation Biological and Pharmaceutical Bulletin 33 2010 461 467
38. S. Hunot, M. Vila, P. Teismann, R.J. Davis, E.C. Hirsch, and S. Przedborski et al. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 101 2004 665 670 (Pubitemid 38084694)
39. A.D. Bachstetter, B. Xing, L. de Almeida, E.R. Dimayuga, D.M. Watterson, and Van Eldik LJ: Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ) Journal of Neuroinflammation 8 2011 79 90
40. M. Valle, M.J. Barbanoj, A. Donner, I. Izquierdo, U. Herranz, and N. Klein et al. Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers European Journal of Clinical Pharmacology 61 2005 103 111 (Pubitemid 40674742)