Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2- hydroxy-4-trifluoromethylbenzoic acid

Molecular Pharmacology

Volumn 55, Issue 4, 1999, Pages 753-761

  Fernández De Arriba, Alberto ^a   Cavalcanti, Fernando ^a   Miralles, Agustí ^a   Bayón, Yolanda ^b   Alonso, Andrés ^b   Merlos, Manuel ^a   García Rafanell, Julián ^a   Forn, Javier ^a  

^a Laboratorio Uriach   (Spain)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXY 4 (TRIFLUOROMETHYL)BENZOIC ACID; ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2 INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; SALICYLATE SODIUM; SALICYLIC ACID DERIVATIVE; TRIFLUSAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; HUMANS; INFLAMMATION; ISOENZYMES; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MEMBRANE PROTEINS; NF-KAPPA B; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED LEW; SALICYLATES; SALICYLIC ACIDS;

EID: 17144462683     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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