Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles

Biomaterials

Volumn 35, Issue 24, 2014, Pages 6585-6594

  Ren, Hao ^a,c   Han, Min ^b   Zhou, Jing ^a,c   Zheng, Ze Feng ^a   Lu, Ping ^a,c   Wang, Jun Juan ^a,c   Wang, Jia Qiu ^a   Mao, Qi Jiang ^a   Gao, Jian Qing ^b   Ouyang, Hong Wei ^a,c  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine   (China)

Author keywords

Astrocyte; Cell activation; Drug release; Inflammation; Nanoparticle; Spinal surgery

Indexed keywords

CHEMICAL ACTIVATION; COPOLYMERS; DRUG PRODUCTS; MOLECULAR BIOLOGY; NANOPARTICLES; NEURONS; PATIENT REHABILITATION; REPAIR;

ASTROCYTE; CELL ACTIVATION; DRUG RELEASE; INFLAMMATION; SPINAL SURGERY;

SYNTHESIS (CHEMICAL);

AUTACOID; CELL CYCLE PROTEIN; FLAVONOID; FLAVOPIRIDOL; GLIAL FIBRILLARY ACIDIC PROTEIN; LACTIC ACID; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, RAT; NANOPARTICLE; PIPERIDINE DERIVATIVE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL; ANIMAL BEHAVIOR; ASTROCYTE; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CONVALESCENCE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE; WOUND HEALING;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; INFLAMMATION; INFLAMMATION MEDIATORS; LACTIC ACID; MICROTUBULE-ASSOCIATED PROTEINS; NANOPARTICLES; NEURONS; PIPERIDINES; POLYGLYCOLIC ACID; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; WOUND HEALING;

EID: 84901472538     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.04.042     Document Type: Article

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