Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease

Chinese Journal of Natural Medicines

Volumn 12, Issue 4, 2014, Pages 251-258

  Lv, Yan Ni ^a,b   Li, Shao Xia ^b   Zhai, Ke Feng ^b   Kou, Jun Ping ^b   Yu, Bo Yang ^a  

^a China Pharmaceutical University   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cerebrovascular disease; Molecular target; Network pharmacology; NF B signaling pathway; Schisandrin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 8; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA INTERFERON RECEPTOR 1; HYDROGEN PEROXIDE; I KAPPA B KINASE ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; PIGS2 PROTEIN; PLANT MEDICINAL PRODUCT; PROTEIN BCL 2; PROTEIN P50; SCHIZANDRIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR NFKB1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; CYCLOOCTANE DERIVATIVE; HERBACEOUS AGENT; LIGNAN; POLYCYCLIC HYDROCARBON;

ANIMAL CELL; ARTICLE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DATA BASE; DRUG TARGETING; MEDICAL LITERATURE; NONHUMAN; PREDICTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING; ANIMAL; CEREBROVASCULAR DISORDERS; DRUG EFFECTS; GENE REGULATORY NETWORK; GENETICS; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; PC12 CELL LINE;

ANIMALS; CEREBROVASCULAR DISORDERS; CYCLOOCTANES; DRUGS, CHINESE HERBAL; GENE REGULATORY NETWORKS; HUMANS; LIGNANS; MOLECULAR TARGETED THERAPY; PC12 CELLS; POLYCYCLIC COMPOUNDS; PROTEIN INTERACTION MAPS; RATS; SIGNAL TRANSDUCTION;

EID: 84901371289     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60051-0     Document Type: Article

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