메뉴 건너뛰기




Volumn 7, Issue 10, 2012, Pages

Polymorphisms in the Inflammatory Genes CIITA, CLEC16A and IFNG Influence BMD, Bone Loss and Fracture in Elderly Women

Author keywords

[No Author keywords available]

Indexed keywords

C TYPE LECTIN DOMAIN 16A; GAMMA INTERFERON; LECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84868153915     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047964     Document Type: Article
Times cited : (10)

References (76)
  • 1
    • 0037129560 scopus 로고    scopus 로고
    • Epidemiology and outcomes of osteoporotic fractures
    • Cummings SR, Melton LJ, (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359: 1761-1767.
    • (2002) Lancet , vol.359 , pp. 1761-1767
    • Cummings, S.R.1    Melton, L.J.2
  • 3
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi H, (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7: 292-304.
    • (2007) Nat Rev Immunol , vol.7 , pp. 292-304
    • Takayanagi, H.1
  • 4
    • 33846903357 scopus 로고    scopus 로고
    • Vascular calcification and osteoporosis-from clinical observation towards molecular understanding
    • Hofbauer LC, Brueck CC, Shanahan CM, Schoppet M, Dobnig H, (2007) Vascular calcification and osteoporosis-from clinical observation towards molecular understanding. Osteoporos Int 18: 251-259.
    • (2007) Osteoporos Int , vol.18 , pp. 251-259
    • Hofbauer, L.C.1    Brueck, C.C.2    Shanahan, C.M.3    Schoppet, M.4    Dobnig, H.5
  • 5
    • 33744968928 scopus 로고    scopus 로고
    • Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women
    • Holmberg AH, Johnell O, Nilsson PM, Nilsson J, Berglund G, et al. (2006) Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women. Osteoporos Int 17: 1065-1077.
    • (2006) Osteoporos Int , vol.17 , pp. 1065-1077
    • Holmberg, A.H.1    Johnell, O.2    Nilsson, P.M.3    Nilsson, J.4    Berglund, G.5
  • 7
    • 0022353748 scopus 로고
    • Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta
    • Dewhirst FE, Stashenko PP, Mole JE, Tsurumachi T, (1985) Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta. J Immunol 135: 2562-2568.
    • (1985) J Immunol , vol.135 , pp. 2562-2568
    • Dewhirst, F.E.1    Stashenko, P.P.2    Mole, J.E.3    Tsurumachi, T.4
  • 8
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
    • Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, et al. (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408: 600-605.
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1    Ogasawara, K.2    Hida, S.3    Chiba, T.4    Murata, S.5
  • 9
    • 0036839436 scopus 로고    scopus 로고
    • Modulation of gene expression by the MHC class II transactivator
    • Nagarajan UM, Bushey A, Boss JM, (2002) Modulation of gene expression by the MHC class II transactivator. J Immunol 169: 5078-5088.
    • (2002) J Immunol , vol.169 , pp. 5078-5088
    • Nagarajan, U.M.1    Bushey, A.2    Boss, J.M.3
  • 10
    • 0027490172 scopus 로고
    • Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
    • Steimle V, Otten LA, Zufferey M, Mach B, (1993) Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75: 135-146.
    • (1993) Cell , vol.75 , pp. 135-146
    • Steimle, V.1    Otten, L.A.2    Zufferey, M.3    Mach, B.4
  • 11
    • 0028228832 scopus 로고
    • Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles
    • Allen M, Sandberg-Wollheim M, Sjogren K, Erlich HA, Petterson U, et al. (1994) Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles. Hum Immunol 39: 41-48.
    • (1994) Hum Immunol , vol.39 , pp. 41-48
    • Allen, M.1    Sandberg-Wollheim, M.2    Sjogren, K.3    Erlich, H.A.4    Petterson, U.5
  • 12
    • 0017157626 scopus 로고
    • Mixed lymphocyte cultures in rheumatoid arthritis
    • Stastny P, (1976) Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest 57: 1148-1157.
    • (1976) J Clin Invest , vol.57 , pp. 1148-1157
    • Stastny, P.1
  • 13
    • 0034485826 scopus 로고    scopus 로고
    • HLA class II association with rheumatoid arthritis: facts and interpretations
    • Zanelli E, Breedveld FC, de Vries RR, (2000) HLA class II association with rheumatoid arthritis: facts and interpretations. Hum Immunol 61: 1254-1261.
    • (2000) Hum Immunol , vol.61 , pp. 1254-1261
    • Zanelli, E.1    Breedveld, F.C.2    de Vries, R.R.3
  • 14
    • 0024313371 scopus 로고
    • HLA-A, B antigens and alpha 1-antitrypsin phenotypes in nodal generalised osteoarthritis and erosive osteoarthritis
    • Pattrick M, Manhire A, Ward AM, Doherty M, (1989) HLA-A, B antigens and alpha 1-antitrypsin phenotypes in nodal generalised osteoarthritis and erosive osteoarthritis. Ann Rheum Dis 48: 470-475.
    • (1989) Ann Rheum Dis , vol.48 , pp. 470-475
    • Pattrick, M.1    Manhire, A.2    Ward, A.M.3    Doherty, M.4
  • 15
    • 78149408549 scopus 로고    scopus 로고
    • New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study
    • Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino JJ, et al. (2010) New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS One 5: e9723.
    • (2010) PLoS One , vol.5
    • Nakajima, M.1    Takahashi, A.2    Kou, I.3    Rodriguez-Fontenla, C.4    Gomez-Reino, J.J.5
  • 16
    • 70350646912 scopus 로고    scopus 로고
    • Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    • Rivadeneira F, Styrkarsdottir U, Estrada K, Halldorsson BV, Hsu YH, et al. (2009) Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 41: 1199-1206.
    • (2009) Nat Genet , vol.41 , pp. 1199-1206
    • Rivadeneira, F.1    Styrkarsdottir, U.2    Estrada, K.3    Halldorsson, B.V.4    Hsu, Y.H.5
  • 18
    • 78349288821 scopus 로고    scopus 로고
    • Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data
    • Farber CR, (2010) Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data. J Bone Miner Res 25: 2359-2367.
    • (2010) J Bone Miner Res , vol.25 , pp. 2359-2367
    • Farber, C.R.1
  • 19
    • 0038647391 scopus 로고    scopus 로고
    • Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women
    • Chung HW, Seo JS, Hur SE, Kim HL, Kim JY, et al. (2003) Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. J Hum Genet 48: 243-248.
    • (2003) J Hum Genet , vol.48 , pp. 243-248
    • Chung, H.W.1    Seo, J.S.2    Hur, S.E.3    Kim, H.L.4    Kim, J.Y.5
  • 20
    • 0037241338 scopus 로고    scopus 로고
    • Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women
    • Ferrari SL, Ahn-Luong L, Garnero P, Humphries SE, Greenspan SL, (2003) Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. J Clin Endocrinol Metab 88: 255-259.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 255-259
    • Ferrari, S.L.1    Ahn-Luong, L.2    Garnero, P.3    Humphries, S.E.4    Greenspan, S.L.5
  • 21
    • 0035156066 scopus 로고    scopus 로고
    • A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women
    • Ferrari SL, Garnero P, Emond S, Montgomery H, Humphries SE, et al. (2001) A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women. Arthritis Rheum 44: 196-201.
    • (2001) Arthritis Rheum , vol.44 , pp. 196-201
    • Ferrari, S.L.1    Garnero, P.2    Emond, S.3    Montgomery, H.4    Humphries, S.E.5
  • 22
    • 0030857328 scopus 로고    scopus 로고
    • Polymorphisms of the interleukin-6 gene are associated with bone mineral density
    • Murray RE, McGuigan F, Grant SF, Reid DM, Ralston SH, (1997) Polymorphisms of the interleukin-6 gene are associated with bone mineral density. Bone 21: 89-92.
    • (1997) Bone , vol.21 , pp. 89-92
    • Murray, R.E.1    McGuigan, F.2    Grant, S.F.3    Reid, D.M.4    Ralston, S.H.5
  • 23
    • 77955985353 scopus 로고    scopus 로고
    • Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women
    • Swanberg M, McGuigan F, Ivaska KK, Gerdhem P, Lerner UH, et al. (2010) Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women. Bone 47: 424-429.
    • (2010) Bone , vol.47 , pp. 424-429
    • Swanberg, M.1    McGuigan, F.2    Ivaska, K.K.3    Gerdhem, P.4    Lerner, U.H.5
  • 24
    • 33744779045 scopus 로고    scopus 로고
    • Estrogen regulation of immune cell bone interactions
    • Weitzmann MN, Pacifici R, (2006) Estrogen regulation of immune cell bone interactions. Ann N Y Acad Sci 1068: 256-274.
    • (2006) Ann N Y Acad Sci , vol.1068 , pp. 256-274
    • Weitzmann, M.N.1    Pacifici, R.2
  • 25
    • 0041836267 scopus 로고    scopus 로고
    • Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator
    • Cenci S, Toraldo G, Weitzmann MN, Roggia C, Gao Y, et al. (2003) Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci U S A 100: 10405-10410.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10405-10410
    • Cenci, S.1    Toraldo, G.2    Weitzmann, M.N.3    Roggia, C.4    Gao, Y.5
  • 26
    • 77953576852 scopus 로고    scopus 로고
    • CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis
    • Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, et al. (2010) CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet 19: 2331-2340.
    • (2010) Hum Mol Genet , vol.19 , pp. 2331-2340
    • Bronson, P.G.1    Caillier, S.2    Ramsay, P.P.3    McCauley, J.L.4    Zuvich, R.L.5
  • 28
    • 77954330568 scopus 로고    scopus 로고
    • Major histocompatibility complex class II transactivator gene polymorphism: associations with Lofgren's syndrome
    • Grunewald J, Idali F, Kockum I, Seddighzadeh M, Nisell M, et al. (2010) Major histocompatibility complex class II transactivator gene polymorphism: associations with Lofgren's syndrome. Tissue Antigens 76: 96-101.
    • (2010) Tissue Antigens , vol.76 , pp. 96-101
    • Grunewald, J.1    Idali, F.2    Kockum, I.3    Seddighzadeh, M.4    Nisell, M.5
  • 29
    • 50149101695 scopus 로고    scopus 로고
    • Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality
    • Lindholm E, Melander O, Almgren P, Berglund G, Agardh CD, et al. (2006) Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. PLoS One 1: e64.
    • (2006) PLoS One , vol.1
    • Lindholm, E.1    Melander, O.2    Almgren, P.3    Berglund, G.4    Agardh, C.D.5
  • 30
  • 31
    • 73449129721 scopus 로고    scopus 로고
    • Chromosomal region 16p13: further evidence of increased predisposition to immune diseases
    • Martinez A, Perdigones N, Cenit MC, Espino L, Varade J, et al. (2010) Chromosomal region 16p13: further evidence of increased predisposition to immune diseases. Ann Rheum Dis 69: 309-311.
    • (2010) Ann Rheum Dis , vol.69 , pp. 309-311
    • Martinez, A.1    Perdigones, N.2    Cenit, M.C.3    Espino, L.4    Varade, J.5
  • 33
    • 20944445879 scopus 로고    scopus 로고
    • MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    • Swanberg M, Lidman O, Padyukov L, Eriksson P, Akesson E, et al. (2005) MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat Genet 37: 486-494.
    • (2005) Nat Genet , vol.37 , pp. 486-494
    • Swanberg, M.1    Lidman, O.2    Padyukov, L.3    Eriksson, P.4    Akesson, E.5
  • 34
    • 67649840704 scopus 로고    scopus 로고
    • Signalling through C-type lectin receptors: shaping immune responses
    • Geijtenbeek TB, Gringhuis SI, (2009) Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol 9: 465-479.
    • (2009) Nat Rev Immunol , vol.9 , pp. 465-479
    • Geijtenbeek, T.B.1    Gringhuis, S.I.2
  • 35
    • 34547621758 scopus 로고    scopus 로고
    • A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    • Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, et al. (2007) A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448: 591-594.
    • (2007) Nature , vol.448 , pp. 591-594
    • Hakonarson, H.1    Grant, S.F.2    Bradfield, J.P.3    Marchand, L.4    Kim, C.E.5
  • 36
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, et al. (2007) Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 357: 851-862.
    • (2007) N Engl J Med , vol.357 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3    Lander, E.S.4    Daly, M.J.5
  • 37
    • 70349630427 scopus 로고    scopus 로고
    • Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients
    • Marquez A, Varade J, Robledo G, Martinez A, Mendoza JL, et al. (2009) Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients. Eur J Hum Genet 17: 1304-1308.
    • (2009) Eur J Hum Genet , vol.17 , pp. 1304-1308
    • Marquez, A.1    Varade, J.2    Robledo, G.3    Martinez, A.4    Mendoza, J.L.5
  • 38
    • 80051706384 scopus 로고    scopus 로고
    • Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex
    • Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, et al. (2011) Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Hum Mol Genet.
    • (2011) Hum Mol Genet
    • Zuvich, R.L.1    Bush, W.S.2    McCauley, J.L.3    Beecham, A.H.4    de Jager, P.L.5
  • 39
    • 77953715174 scopus 로고    scopus 로고
    • Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus
    • Kim K, Cho SK, Sestak A, Namjou B, Kang C, et al. (2010) Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus. Ann Rheum Dis 69: 1247-1250.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1247-1250
    • Kim, K.1    Cho, S.K.2    Sestak, A.3    Namjou, B.4    Kang, C.5
  • 40
    • 0034946347 scopus 로고    scopus 로고
    • Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy
    • Deguchi K, Kamada M, Irahara M, Maegawa M, Yamamoto S, et al. (2001) Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy. Menopause 8: 266-273.
    • (2001) Menopause , vol.8 , pp. 266-273
    • Deguchi, K.1    Kamada, M.2    Irahara, M.3    Maegawa, M.4    Yamamoto, S.5
  • 41
    • 1542720317 scopus 로고    scopus 로고
    • Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women
    • Gerdhem P, Brandstrom H, Stiger F, Obrant K, Melhus H, et al. (2004) Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women. Calcif Tissue Int 74: 264-269.
    • (2004) Calcif Tissue Int , vol.74 , pp. 264-269
    • Gerdhem, P.1    Brandstrom, H.2    Stiger, F.3    Obrant, K.4    Melhus, H.5
  • 42
    • 34848847248 scopus 로고    scopus 로고
    • Variation in the BMP2 gene: bone mineral density and ultrasound in young adult and elderly women
    • McGuigan FE, Larzenius E, Callreus M, Gerdhem P, Luthman H, et al. (2007) Variation in the BMP2 gene: bone mineral density and ultrasound in young adult and elderly women. Calcif Tissue Int 81: 254-262.
    • (2007) Calcif Tissue Int , vol.81 , pp. 254-262
    • McGuigan, F.E.1    Larzenius, E.2    Callreus, M.3    Gerdhem, P.4    Luthman, H.5
  • 43
    • 0033787711 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production
    • Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV, (2000) A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 61: 863-866.
    • (2000) Hum Immunol , vol.61 , pp. 863-866
    • Pravica, V.1    Perrey, C.2    Stevens, A.3    Lee, J.H.4    Hutchinson, I.V.5
  • 44
    • 78149435367 scopus 로고    scopus 로고
    • Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk
    • Morrison BA, Ucisik-Akkaya E, Flores H, Alaez C, Gorodezky C, et al. (2010) Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk. Autoimmunity 43: 690-697.
    • (2010) Autoimmunity , vol.43 , pp. 690-697
    • Morrison, B.A.1    Ucisik-Akkaya, E.2    Flores, H.3    Alaez, C.4    Gorodezky, C.5
  • 45
    • 77958478634 scopus 로고    scopus 로고
    • Effect of precision on longitudinal follow-up of bone mineral density measurements in elderly women and men
    • Lenora J, Akesson K, Gerdhem P, (2010) Effect of precision on longitudinal follow-up of bone mineral density measurements in elderly women and men. J Clin Densitom 13: 407-412.
    • (2010) J Clin Densitom , vol.13 , pp. 407-412
    • Lenora, J.1    Akesson, K.2    Gerdhem, P.3
  • 46
    • 34548126988 scopus 로고    scopus 로고
    • Prediction of bone loss using biochemical markers of bone turnover
    • Lenora J, Ivaska KK, Obrant KJ, Gerdhem P, (2007) Prediction of bone loss using biochemical markers of bone turnover. Osteoporos Int 18: 1297-1305.
    • (2007) Osteoporos Int , vol.18 , pp. 1297-1305
    • Lenora, J.1    Ivaska, K.K.2    Obrant, K.J.3    Gerdhem, P.4
  • 47
    • 0031942163 scopus 로고    scopus 로고
    • Bone mineral density assessed by quantitative ultrasound and dual energy X-ray absorptiometry. Normative data in Malmo, Sweden
    • Karlsson MK, Obrant KJ, Nilsson BE, Johnell O, (1998) Bone mineral density assessed by quantitative ultrasound and dual energy X-ray absorptiometry. Normative data in Malmo, Sweden. Acta Orthop Scand 69: 189-193.
    • (1998) Acta Orthop Scand , vol.69 , pp. 189-193
    • Karlsson, M.K.1    Obrant, K.J.2    Nilsson, B.E.3    Johnell, O.4
  • 48
    • 38749107021 scopus 로고    scopus 로고
    • Rates of fracture in participants and non-participants in the Osteoporosis Prospective Risk Assessment study
    • Gerdhem P, Akesson K, (2007) Rates of fracture in participants and non-participants in the Osteoporosis Prospective Risk Assessment study. J Bone Joint Surg Br 89: 1627-1631.
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 1627-1631
    • Gerdhem, P.1    Akesson, K.2
  • 49
    • 77953452345 scopus 로고    scopus 로고
    • Bone turnover markers and prediction of fracture: a prospective follow-up study of 1040 elderly women for a mean of 9 years
    • Ivaska KK, Gerdhem P, Vaananen HK, Akesson K, Obrant KJ, (2010) Bone turnover markers and prediction of fracture: a prospective follow-up study of 1040 elderly women for a mean of 9 years. J Bone Miner Res 25: 393-403.
    • (2010) J Bone Miner Res , vol.25 , pp. 393-403
    • Ivaska, K.K.1    Gerdhem, P.2    Vaananen, H.K.3    Akesson, K.4    Obrant, K.J.5
  • 50
    • 47549095521 scopus 로고    scopus 로고
    • Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk
    • Ivaska KK, Lenora J, Gerdhem P, Akesson K, Vaananen HK, et al. (2008) Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk. J Clin Endocrinol Metab 93: 2622-2632.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2622-2632
    • Ivaska, K.K.1    Lenora, J.2    Gerdhem, P.3    Akesson, K.4    Vaananen, H.K.5
  • 51
    • 0034917362 scopus 로고    scopus 로고
    • Clinical evaluation of the Elecsys beta-CrossLaps serum assay, a new assay for degradation products of type I collagen C-tlopeptides
    • Okabe R, Nakatsuka K, Inaba M, Miki T, Naka H, et al. (2001) Clinical evaluation of the Elecsys beta-CrossLaps serum assay, a new assay for degradation products of type I collagen C-tlopeptides. Clin Chem 47: 1410-1414.
    • (2001) Clin Chem , vol.47 , pp. 1410-1414
    • Okabe, R.1    Nakatsuka, K.2    Inaba, M.3    Miki, T.4    Naka, H.5
  • 52
    • 34547210007 scopus 로고    scopus 로고
    • Biochemical Markers of Bone Turnover Part II: Clinical Applications in the Management of Osteoporosis
    • Seibel MJ, (2006) Biochemical Markers of Bone Turnover Part II: Clinical Applications in the Management of Osteoporosis. Clin Biochem Rev 27: 123-138.
    • (2006) Clin Biochem Rev , vol.27 , pp. 123-138
    • Seibel, M.J.1
  • 53
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, Donnelly P, (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68: 978-989.
    • (2001) Am J Hum Genet , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 55
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, et al. (2009) A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41: 527-534.
    • (2009) Nat Genet , vol.41 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3    Heo, J.Y.4    Oh, J.H.5
  • 56
    • 79955578829 scopus 로고    scopus 로고
    • Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
    • Duncan EL, Danoy P, Kemp JP, Leo PJ, McCloskey E, et al. (2011) Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet 7: e1001372.
    • (2011) PLoS Genet , vol.7
    • Duncan, E.L.1    Danoy, P.2    Kemp, J.P.3    Leo, P.J.4    McCloskey, E.5
  • 57
    • 76749119927 scopus 로고    scopus 로고
    • Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis
    • Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, et al. (2010) Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet 6: e1000806.
    • (2010) PLoS Genet , vol.6
    • Guo, Y.1    Tan, L.J.2    Lei, S.F.3    Yang, T.L.4    Chen, X.D.5
  • 58
    • 77953523922 scopus 로고    scopus 로고
    • IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study
    • Guo Y, Zhang LS, Yang TL, Tian Q, Xiong DH, et al. (2010) IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. J Bone Miner Res 25: 1042-1048.
    • (2010) J Bone Miner Res , vol.25 , pp. 1042-1048
    • Guo, Y.1    Zhang, L.S.2    Yang, T.L.3    Tian, Q.4    Xiong, D.H.5
  • 59
    • 77954157408 scopus 로고    scopus 로고
    • An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits
    • Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, et al. (2010) An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet 6: e1000977.
    • (2010) PLoS Genet , vol.6
    • Hsu, Y.H.1    Zillikens, M.C.2    Wilson, S.G.3    Farber, C.R.4    Demissie, S.5
  • 60
    • 77954717620 scopus 로고    scopus 로고
    • Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study
    • Karasik D, Hsu YH, Zhou Y, Cupples LA, Kiel DP, et al. (2010) Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. J Bone Miner Res 25: 1555-1563.
    • (2010) J Bone Miner Res , vol.25 , pp. 1555-1563
    • Karasik, D.1    Hsu, Y.H.2    Zhou, Y.3    Cupples, L.A.4    Kiel, D.P.5
  • 61
    • 77951645281 scopus 로고    scopus 로고
    • Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women
    • Koller DL, Ichikawa S, Lai D, Padgett LR, Doheny KF, et al. (2010) Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. J Clin Endocrinol Metab 95: 1802-1809.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1802-1809
    • Koller, D.L.1    Ichikawa, S.2    Lai, D.3    Padgett, L.R.4    Doheny, K.F.5
  • 62
    • 76249108602 scopus 로고    scopus 로고
    • Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies
    • Kung AW, Xiao SM, Cherny S, Li GH, Gao Y, et al. (2010) Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet 86: 229-239.
    • (2010) Am J Hum Genet , vol.86 , pp. 229-239
    • Kung, A.W.1    Xiao, S.M.2    Cherny, S.3    Li, G.H.4    Gao, Y.5
  • 63
    • 78649692094 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone
    • Paternoster L, Lorentzon M, Vandenput L, Karlsson MK, Ljunggren O, et al. (2010) Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone. PLoS Genet 6: e1001217.
    • (2010) PLoS Genet , vol.6
    • Paternoster, L.1    Lorentzon, M.2    Vandenput, L.3    Karlsson, M.K.4    Ljunggren, O.5
  • 65
    • 64549163221 scopus 로고    scopus 로고
    • Common variants in the region around Osterix are associated with bone mineral density and growth in childhood
    • Timpson NJ, Tobias JH, Richards JB, Soranzo N, Duncan EL, et al. (2009) Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet 18: 1510-1517.
    • (2009) Hum Mol Genet , vol.18 , pp. 1510-1517
    • Timpson, N.J.1    Tobias, J.H.2    Richards, J.B.3    Soranzo, N.4    Duncan, E.L.5
  • 66
    • 61849164536 scopus 로고    scopus 로고
    • Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups
    • Xiong DH, Liu XG, Guo YF, Tan LJ, Wang L, et al. (2009) Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet 84: 388-398.
    • (2009) Am J Hum Genet , vol.84 , pp. 388-398
    • Xiong, D.H.1    Liu, X.G.2    Guo, Y.F.3    Tan, L.J.4    Wang, L.5
  • 67
    • 35748963239 scopus 로고    scopus 로고
    • Genome-wide association with bone mass and geometry in the Framingham Heart Study
    • Kiel DP, Demissie S, Dupuis J, Lunetta KL, Murabito JM, et al. (2007) Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet 8Suppl 1: S14.
    • (2007) BMC Med Genet , vol.8
    • Kiel, D.P.1    Demissie, S.2    Dupuis, J.3    Lunetta, K.L.4    Murabito, J.M.5
  • 68
    • 79955788680 scopus 로고    scopus 로고
    • Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese
    • Kou I, Takahashi A, Urano T, Fukui N, Ito H, et al. (2011) Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. PLoS One 6: e19641.
    • (2011) PLoS One , vol.6
    • Kou, I.1    Takahashi, A.2    Urano, T.3    Fukui, N.4    Ito, H.5
  • 69
    • 69949108619 scopus 로고    scopus 로고
    • Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males
    • Liu YZ, Pei YF, Liu JF, Yang F, Guo Y, et al. (2009) Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. PLoS One 4: e6827.
    • (2009) PLoS One , vol.4
    • Liu, Y.Z.1    Pei, Y.F.2    Liu, J.F.3    Yang, F.4    Guo, Y.5
  • 70
    • 43049181624 scopus 로고    scopus 로고
    • Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    • Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, et al. (2008) Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371: 1505-1512.
    • (2008) Lancet , vol.371 , pp. 1505-1512
    • Richards, J.B.1    Rivadeneira, F.2    Inouye, M.3    Pastinen, T.M.4    Soranzo, N.5
  • 72
    • 77953720174 scopus 로고    scopus 로고
    • MHC class II transactivator negatively regulates RANKL-mediated osteoclast differentiation by downregulating NFATc1 and OSCAR
    • Kim JH, Kim K, Youn BU, Jin HM, Kim N, (2010) MHC class II transactivator negatively regulates RANKL-mediated osteoclast differentiation by downregulating NFATc1 and OSCAR. Cell Signal 22: 1341-1349.
    • (2010) Cell Signal , vol.22 , pp. 1341-1349
    • Kim, J.H.1    Kim, K.2    Youn, B.U.3    Jin, H.M.4    Kim, N.5
  • 73
    • 58149400586 scopus 로고    scopus 로고
    • Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese
    • Awata T, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, et al. (2009) Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese. J Clin Endocrinol Metab 94: 231-235.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 231-235
    • Awata, T.1    Kawasaki, E.2    Tanaka, S.3    Ikegami, H.4    Maruyama, T.5
  • 74
    • 66949120294 scopus 로고    scopus 로고
    • Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population
    • Wu X, Zhu X, Wang X, Ma J, Zhu S, et al. (2009) Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population. Clin Endocrinol (Oxf) 71: 46-49.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 46-49
    • Wu, X.1    Zhu, X.2    Wang, X.3    Ma, J.4    Zhu, S.5
  • 75
    • 59149093799 scopus 로고    scopus 로고
    • Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia
    • Zoledziewska M, Costa G, Pitzalis M, Cocco E, Melis C, et al. (2009) Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Genes Immun 10: 15-17.
    • (2009) Genes Immun , vol.10 , pp. 15-17
    • Zoledziewska, M.1    Costa, G.2    Pitzalis, M.3    Cocco, E.4    Melis, C.5
  • 76
    • 67651152724 scopus 로고    scopus 로고
    • Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians
    • Rubio JP, Stankovich J, Field J, Tubridy N, Marriott M, et al. (2008) Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun 9: 624-630.
    • (2008) Genes Immun , vol.9 , pp. 624-630
    • Rubio, J.P.1    Stankovich, J.2    Field, J.3    Tubridy, N.4    Marriott, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.