Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway

Molecules

Volumn 18, Issue 1, 2013, Pages 354-372

  Lee, Meng Shiou ^a   Chao, Jung ^b   Yen, Jiin Cherng ^b   Lin, Li Wei ^c   Tsai, Fan Shiu ^c   Hsieh, Ming Tsuen ^a   Peng, Wen Huang ^a   Cheng, Hao Yuan ^d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d Health Science and Management   (Taiwan)

Author keywords

Apoptosis; Glutamate; Neuroprotection; Schizandrin

Indexed keywords

EID: 84872841568     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18010354     Document Type: Article

References (42)

1. Meldrum, B.; Garthwaite, J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 1990, 9, 379-387.
2. Choi, D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988, 8, 623-634.
3. Hengartner, M.O. The biochemistry of apoptosis. Nature 2000, 407, 770-776.
4. Martin, S.J.; Green, D.R. Protease activation during apoptosis: Death by a thousand cuts- Cell 1995, 82, 349-352.
5. Rao, R.V.; Ellerby, H.M.; Bredesen, D.E. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004, 4, 372-380.
6. Kerr, J.F.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 4, 239-257.
7. Dreyer, E.B.; Zhang, D.; Lipton, S.A. Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death. Neuroreport 1995, 6, 942-944.
8. Hockenbery, D.; Nunez, G.; Milliman, C.R.; Schreiber, D.; Korsmeyer, S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990, 348, 334-336.
9. Green, D.R.; Reed, J.C. Mitochondria and apoptosis. Science 1998, 281, 1309-1312.
10. Saelens, X.; Festjens, N.; Vande Walle, L.; van Gurp, M.; van Loo, G.; Vandenabeele, P. Toxic proteins released from mitochondria in cell death. Oncogene 2004, 23, 2861-2874.
11. Wang, X.; Yang, C.; Chai, J.; Shi, Y.; Xue, D. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science 2002, 298, 1587-1592.
12. Yang, J.; Liu, X.; Bhalla, K.C.; Kim, N.; Ibrado, A.M.; Cai, J.; Peng, T.I.; Jones, D.P.; Wang, X. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 1997, 275, 1129-1132.
13. Mielke, K.; Herdegen, T. JNK and p38 stresskinases - Degenerative effectors of signal-transductioncascades in the nervous system. Prog. Neurobiol. 2000, 1, 45-60.
14. Zhu, X.; Lee, H.G.; Raina, A.K.; Perry, G.; Smith, M.A. The role of mitogen-Activated protein kinase pathways in Alzheimer's disease. Neurosignals 2002, 5, 270-281.
15. Jiang, Q.; Gu, Z.; Zhang, G.; Jing, G. Diphosphorylation and involvement of extracellular signal-regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons. Brain Res. 2000, 857, 71-77.
16. Segura Torres, J.E.; Chaparro-Huerta, V.; Rivera Cervantres, M.C.; Montes-Gonzalez, R.; Flores Soto, M.E.; Beas-Zarate, C. Neuronal cell death due to glutamate excitotocity is mediated by p38 activation in the rat cerebral cortex. Neurosci. Lett. 2006, 403, 233-238.
17. Zhao, Z.Z. An Illustrated Chinese Material Medica in Hong Kong; Chung Hwa Book: Hong Kong, China, 2004.
18. Hsieh, M.T.; Tsai, M.L.; Peng, W.H.; Wu, C.R. Effects of Fructus schizandrae on cycloheximideinduced amnesia in rats. Phytother. Res. 1999, 3, 256-257.
19. Cheng, H.Y.; Hsieh, M.T.; Wu, C.R.; Tsai, F.H.; Lu, T.C.; Hsieh, C.C.; Li, W.C.; Lin, Y.T.; Peng, W.H. Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity. J. Pharmacol. Sci. 2008, 1, 21-31.
20. Ramoa, A.S.; Alkondon, M.; Aracava, Y.; Irons, J.; Lunt, G.G.; Deshpande, S.S.; Wonnacott, S.; Aronstam, R.S.; Albuquerque, E.X. The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels. J. Pharmacol. Exp. Ther. 1990, 1, 71-82.
21. Drian, M.J.; Kamenka, J.M.; Pirat, J.L.; Privat, A. Non-competitive antagonists of N-methyl-Daspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex. J. Neurosci. Res. 1991, 29, 133-138.
22. Kuwana, T.; Mackey, M.R.; Perkins, G.; Ellisman, M.H.; Latterich, M.; Schneiter, R.; Green, D.R; Newmeyer, D.D. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002, 111, 331-342.
23. Saito, M.S.; Korsmeyer, J.; Schlesinger, P.H. BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat. Cell Biol. 2000, 8, 553-555.
24. Korsmeyer, S.J.; Wei, M.C.; Saito, M.; Weiler, S.; Oh, K.J.; Schlesinger, P.H. Pro-Apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 2000, 12, 1166-1173.
25. Van Loo, G.; Saelens, X.; van Gurp, M.; MacFarlane, M.; Martin, S.J.; Vandenabeele, P. The role of mitochondrial factors in apoptosis: A Russian roulette with more than one bullet. Cell Death Differ. 2002, 10, 1031-1042.
26. Beyaert, R.; van Loo, G.; Heyninck, K.; Vandenabeele, P. Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas. Int. Rev. Cytol. 2002, 2149, 225-272.
27. Jiang, Q.; Gu, Z.; Zhang, G. Activation, involvement and nuclear translocation of c-Jun N-terminal protein kinase 1 and 2 in glutamate-induced apoptosis in cultured rat cortical neurons. Brain Res. 2002, 956, 194-201.
28. Kurino, M.; Fukunaga, K.; Ushio, Y.; Miyamoto, E. Activation of mitogen-Activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors. J Neurochem. 1995, 3, 1282-1289.
29. Arendt, T.; Holzer, M.; Grossmann, A.; Zedlick, D.; Bruckner, M.K. Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-Activated protein kinase in Alzheimer's disease. Neuroscience 1995, 1, 5-18.
30. Olney, J.W. Inciting excitotoxic cytocide among central neurons. Adv. Exp. Med. Biol. 1986, 203, 631-645.
31. Raoul, C.; Pettmann, B.; Henderson, C.E. Active killing of neurons during development and following stress: A role for p75(NTR) and Fas- Curr. Opin. Neurobiol. 2000, 1, 111-117.
32. Blatt, N.B.; Glick, G.D. Signaling pathways and effector mechanisms pre-programmed cell death. Bioorg. Med. Chem. 2001, 6, 1371-1384.
33. Zimmermann, K.C.; Bonzon, C.; Green, D.R. The machinery of programmed cell death. Pharmacol. Ther. 2001, 1, 57-70.
34. Behl, C.; Hovey, L., III; Krajewski, S.; Schubert, D.; Reed, J.C. BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. Biochem. Biophys. Res. Commun. 1993. 197, 949-956.
35. Schelman, W.R.; Andres, R.D.; Sipe, K.J.; Kang, E.; Weyhenmeyer, J.A. Glutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line. Brain Res. 2004, 128, 160-169.
36. Susin, S.A.; Lorenzo, H.K.; Zamzami, N.I.; Marzo, B.; Snow, E.G.; Brothers, M.; Mangion, J.; Jacotot, E.; Costantini, P.; Loeffler, M.; et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999, 128, 441-446.
37. Daugas, E.; Susin, S.A.; Zamzami, N.; Ferri, K.F.; Irinopoulou, T.; Larochette, N.; Prevost, M.C.; Leber, B.; Andrews, D.; Penninger, J.; et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. Fed. Proc. 2000, 5, 729-739.
38. Miyashita, T.; Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995, 80, 293-299.
39. Thomenius, M.J.; Distelhorst, C.W. Bcl-2 on the endoplasmic reticulum: Protecting the mitochondria from a distance. J. Cell Sci. 2003, 116, 4493-4499.
40. Owada, K.; Sanjo, N.; Kobayashi, T.; Mizusawa, H.; Muramatsu, H.; Muramatsu, T.; Michikawa, M. Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-Activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons. J. Neurochem. 1999, 5, 2084-2092.
41. Choi, D.W. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci. 1988, 10, 465-469.
42. Chiu, P.Y.; Leung, H.Y.; Siu, A.H.; Poon, M.K.; Ko, K.M. Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemiareperfusion injury in rat hearts. Acta Pharmacol. Sin. 2007, 10, 1559-1565.