A Coarse-Grained Elastic Network Atom Contact Model and Its Use in the Simulation of Protein Dynamics and the Prediction of the Effect of Mutations

PLoS Computational Biology

Volumn 10, Issue 4, 2014, Pages

  Frappier, Vincent ^a   Najmanovich, Rafael J ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMS; COARSE-GRAINED MODELING; ECONOMIC AND SOCIAL EFFECTS; END EFFECTORS; LEARNING SYSTEMS; MOLECULAR DYNAMICS; POTENTIAL ENERGY; PROTEINS;

ANALYSIS METHOD; ATOM CONTACTS; COARSE-GRAINED; CONTACT MODELING; ELASTIC NETWORK MODELS; ELASTIC NETWORKS; MODEL METHOD; NORMAL MODE ANALYSIS; PROTEIN DYNAMICS; PROTEINS STRUCTURES;

FORECASTING;

ARTICLE; ARTIFICIAL NEURAL NETWORK; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CUPSAT; DMUTANT; ELASTIC NETWORK ATOM CONTACT MODEL; ENTROPY; I MUTANT 2.0; INTERMETHOD COMPARISON; MEASUREMENT ACCURACY; MEASUREMENT ERROR; MOLECULAR INTERACTION; MOLECULAR MODEL; POINT MUTATION; POPMUSIC 2.0; PREDICTION; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SUPPORT VECTOR MACHINE; THERMODYNAMICS; CHEMISTRY; CRYSTALLOGRAPHY; ELASTICITY; GENETICS; MUTATION; THEORETICAL MODEL;

PROTEIN;

CRYSTALLOGRAPHY; ELASTICITY; MODELS, THEORETICAL; MUTATION; PROTEINS;

EID: 84901355476     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003569     Document Type: Article

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