3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: Inhibition of rat intestinal α-glucosidase

Bioorganic Chemistry

Volumn 54, Issue , 2014, Pages 81-88

  Carreiro, Elisabete P ^a   Louro, Patrícia ^a   Adriano, Gizé ^a   Guedes, Romina A ^a   Vannuchi, Nicholas ^a   Costa, Ana R ^a   Antunes, Célia M M ^a,c   Guedes, Rita C ^b   Burke, A J ^a  

^a UNIVERSITY OF ÉVORA   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

1 Benzyl 3,4 dihydroxypyrrolidine; 1 Benzyl 3 hydroxypyrrolidine; Rat intestinal cells; Small molecule inhibitor; Glucosidase

Indexed keywords

(3,4) DIHYDROXYPYRROLIDINE DERIVATIVE; 3 HYDROXYPYRROLIDINE DERIVATIVE; ALPHA GLUCOSIDASE; IMINOSUGAR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; 3,4-DIHYDROXYPYRROLIDINE; GLYCOSIDASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; IC 50; INTESTINE; LC 50; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; RAT; SYNTHESIS; TOXICITY TESTING; ANIMAL; ARTEMIA; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; ANIMALS; ARTEMIA; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GLYCOSIDE HYDROLASE INHIBITORS; HUMANS; INTESTINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901282250     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.04.007     Document Type: Article

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