Five-membered iminocyclitol α-glucosidase inhibitors: Synthetic, biological screening and in silico studies

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1911-1917

  Guerreiro, Luis R ^a   Carreiro, Elisabete P ^a   Fernandes, Luis ^a   Cardote, Teresa A F ^b   Moreira, Rui ^b   Caldeira, Ana T ^a   Guedes, Rita C ^b   Burke, A J ^a  

^a UNIVERSITY OF ÉVORA   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Glucosidase; (3,4) Dihydroxypyrrolidine; Enantiopure compound; Iminocyclitol; Small molecule inhibitor

Indexed keywords

3,4 DIACETOXYPYRROLIDINIUM 2,2,2 TRIFLUOROACETATE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; N BENZYL 3,4 DIHYDROXYPYRROLIDINE; N BENZYL 3,4 PYRROLIDINEDIOL DIACETATE; PYRROLIDINE 3,4 DIOL; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL;

ALPHA-GLUCOSIDASES; CYCLITOLS; ENZYME INHIBITORS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PYRROLIDINES; SACCHAROMYCES CEREVISIAE;

EID: 84875211152     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.030     Document Type: Article

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