In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7330-7336

  Kuriyama, Chinami ^a   Kamiyama, Ogusa ^a   Ikeda, Kyoko ^a   Sanae, Fujiko ^a   Kato, Atsushi ^b   Adachi, Isao ^b   Imahori, Tatsushi ^c   Takahata, Hiroki ^c   Okamoto, Tadashi ^d   Asano, Naoki ^a,d  

^a HOKURIKU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Amylo 1,6 glucosidase; Caco 2; Glycogen phosphorylase; Hepatocytes; Noncompetitive inhibitor; Pharmacological chaperone; Six membered sugar mimics

Indexed keywords

1 DEOXYNOJIRIMYCIN; 1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; 7 O BETA DEXTRO GLUCOPYRANOSYL ALPHA HOMONOJIRIMYCIN; ACARBOSE; ALPHA GLUCOSIDASE; ALPHA HOMONOJIRIMYCIN; DEXTRO ISOFAGOMINE; FAGOMINE; GLUCAN 1,3 BETA GLUCOSIDASE; GLYCOSIDASE INHIBITOR; ISOFAGOMINE; MIGLITOL; UNCLASSIFIED DRUG; VALIOLAMINE; VOGLIBOSE;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; GLUCONEOGENESIS; GLYCOGENOLYSIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL CULTURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT;

ANIMALS; CACO-2 CELLS; CARBOHYDRATE CONFORMATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GAUCHER DISEASE; GLYCOGEN; GLYCOSIDE HYDROLASES; HEPATOCYTES; HUMANS; IMINO SUGARS; LYSOSOMES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA; RATTUS;

EID: 48449092818     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.026     Document Type: Article

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