Synthesis and evaluation of a 5-membered isoiminosugar as glycosidase inhibitor

Tetrahedron Letters

Volumn 39, Issue 32, 1998, Pages 5841-5844

  Godskesen, Michael ^a   Lundt, Inge ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 HYDROXYMETHYLPYRROLIDINE; GLYCOSIDASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

EID: 0032490970     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01157-5     Document Type: Article

References (17)

1. 1. Jespersen, T. M., Dong, W., Sierks, M.R., Skrydstrup, T., Lundt, I., Bols, M. Angew. Chem. 1994, 106, 1858 (Int. Ed. Engl. 1994, 33, 1778); Jespersen, T.M., Bols, M., Sierks, M.R., Skrydstrup, T. Tetrahedron 1994, 50, 13449.
2. 1. Jespersen, T. M., Dong, W., Sierks, M.R., Skrydstrup, T., Lundt, I., Bols, M. Angew. Chem. 1994, 106, 1858 (Int. Ed. Engl. 1994, 33, 1778); Jespersen, T.M., Bols, M., Sierks, M.R., Skrydstrup, T. Tetrahedron 1994, 50, 13449.
3. 1. Jespersen, T. M., Dong, W., Sierks, M.R., Skrydstrup, T., Lundt, I., Bols, M. Angew. Chem. 1994, 106, 1858 (Int. Ed. Engl. 1994, 33, 1778); Jespersen, T.M., Bols, M., Sierks, M.R., Skrydstrup, T. Tetrahedron 1994, 50, 13449.
4. 2. Instead of Isoiminosugar the terms 1-N-Iminosugar (Ichikawa, M., Igarashi, Y., Ichikawa, Y. Tetrahedron Letters 1995, 36, 1767) or 1-Aza-sugar (Bols, M. Accounts Chem. Res. 1998, 31, 1) have been used.
5. 2. Instead of Isoiminosugar the terms 1-N-Iminosugar (Ichikawa, M., Igarashi, Y., Ichikawa, Y. Tetrahedron Letters 1995, 36, 1767) or 1-Aza-sugar (Bols, M. Accounts Chem. Res. 1998, 31, 1) have been used.
6. 3. Ichikawa, Y.; Igarashi, Y. Tetrahedron Lett. 1995, 36, 4585.
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8. 5. Ichikawa, M.; Igarashi, Y.; Ichikawa, Y. Tetrahedron Lett. 1995, 36, 1767.
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16. 3).
17. 2′,3 = 11.5 Hz) and 2.49 (m, H-3).