Highly diastereoselective additions to polyhydroxylated pyrrolidine cyclic imines: Ready elaboration of aza-sugar scaffolds to create diverse carbohydrate-processing enzyme probes

Chemistry - A European Journal

Volumn 9, Issue 14, 2003, Pages 3397-3414

  Chapman, Timothy M ^a   Courtney, Steve ^b   Hay, Phil ^b   Davis, Benjamin G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Oxford GlycoSciences   (United Kingdom)

Author keywords

Asymmetric synthesis; Azasugars; Carbohydrates; Enzyme catalysis; Heterocycles

Indexed keywords

ADDITION REACTIONS; AROMATIC COMPOUNDS; CONFORMATIONS; ENZYME INHIBITION; ENZYMES; NITROGEN COMPOUNDS; REACTION KINETICS; STEREOCHEMISTRY; SUGARS; SYNTHESIS (CHEMICAL);

IMINES;

ORGANOMETALLICS;

ALPHA GALACTOSIDASE INHIBITOR; CARBOHYDRATE DERIVATIVE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; ENZYME; ENZYME INHIBITOR; ERYTHRITOL; HETEROCYCLIC COMPOUND; HYDROXYL GROUP; IMINE; PYRROLIDINE DERIVATIVE; THREITOL; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CHEMICAL REACTION; CONFORMATION; DIASTEREOISOMER; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROPHOBICITY; MACROMOLECULE; RACEMIC MIXTURE;

EID: 0042848476     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200304718     Document Type: Article

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