A prospect for pyrrolidine iminosugars as antidiabetic α-glucosidase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10345-10346

  Trapero, Ana ^a   Llebaria, Amadeu ^a  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; IMINOSUGAR; MIGLITOL; PYRROLIDINE DERIVATIVE; VOGLIBOSE;

ALKYLATION; ANTIDIABETIC ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR DOCKING; NOTE; PROTEIN BINDING; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ALPHA-GLUCOSIDASES; ANIMALS; ENZYME INHIBITORS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; IMINO SUGARS; MALE;

EID: 84870991117     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301682r     Document Type: Note

References (5)

1. Standl, E.; Schnell, O. Alpha-Glucosidase Inhibitors 2012-Cardiovascular Considerations and Trial Evaluation Diabetes Vasc. Dis. Res. 2012, 9, 163-169
2. Kato, A.; Hayashi, E.; Miyauchi, S.; Adachi, I.; Imahori, T.; Natori, Y.; Yoshimura, Y.; Nash, R. J.; Shimaoka, H.; Nakagome, I.; Koseki, J.; Hirono, S.; Takahata, H. α-1- C -Butyl-1,4-dideoxy-1,4-imino- l -arabinitol as a Second-Generation Iminosugar-Based Oral α-Glucosidase Inhibitor for Improving Postprandial Hyperglycemia. J. Med. Chem. 2012, DOI: 10.1021/jm301304e.
3. Ogawa, S. Synthetic Studies on Glycosidase Inhibitors Composed of 5a-Carba-Sugars. In Carbohydrate Mimics; Chapleur, Y., Ed.; Wiley-VCH: Weinheim, Germany, 1998; pp 87-106.
4. Winchester, B. G. Iminosugars: From Botanical Curiosities to Licensed Drugs Tetrahedron: Asymmetry 2009, 20, 645-651
5. Compain, P.; Chagnault, V.; Martin, O. R. Tactics and Strategies for the Synthesis of Iminosugar C-Glycosides: A Review Tetrahedron: Asymmetry 2009, 20, 672-711