-
1
-
-
79960771381
-
Transporter-mediated drug-drug interactions
-
F. Muller, and M.F. Fromm Transporter-mediated drug-drug interactions Pharmacogenomics 12 2011 1017 1037
-
(2011)
Pharmacogenomics
, vol.12
, pp. 1017-1037
-
-
Muller, F.1
Fromm, M.F.2
-
2
-
-
0033739725
-
Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
-
H. Suzuki, and Y. Sugiyama Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine Eur J Pharm Sci 12 2000 3 12
-
(2000)
Eur J Pharm Sci
, vol.12
, pp. 3-12
-
-
Suzuki, H.1
Sugiyama, Y.2
-
3
-
-
0033756459
-
Transporter-mediated permeation of drugs across the blood-brain barrier
-
I. Tamai, and A. Tsuji Transporter-mediated permeation of drugs across the blood-brain barrier J Pharm Sci 89 2000 1371 1388
-
(2000)
J Pharm Sci
, vol.89
, pp. 1371-1388
-
-
Tamai, I.1
Tsuji, A.2
-
4
-
-
77954846109
-
Renal clearance in drug discovery and development: Molecular descriptors, drug transporters and disease state
-
B. Feng, J.L. LaPerle, G. Chang, and M.V. Varma Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state Expert Opin Drug Metab Toxicol 6 2010 939 952
-
(2010)
Expert Opin Drug Metab Toxicol
, vol.6
, pp. 939-952
-
-
Feng, B.1
Laperle, J.L.2
Chang, G.3
Varma, M.V.4
-
5
-
-
3542995726
-
The complexities of hepatic drug transport: Current knowledge and emerging concepts
-
P. Chandra, and K.L. Brouwer The complexities of hepatic drug transport: current knowledge and emerging concepts Pharm Res 21 2004 719 735
-
(2004)
Pharm Res
, vol.21
, pp. 719-735
-
-
Chandra, P.1
Brouwer, K.L.2
-
6
-
-
79956326438
-
Transporter-mediated drug uptake and efflux: Important determinants of adverse drug reactions
-
O. Zolk, and M.F. Fromm Transporter-mediated drug uptake and efflux: important determinants of adverse drug reactions Clin Pharmacol Ther 89 2011 798 805
-
(2011)
Clin Pharmacol Ther
, vol.89
, pp. 798-805
-
-
Zolk, O.1
Fromm, M.F.2
-
7
-
-
77649216536
-
Membrane transporters in drug development
-
International Transporter Consortium, K.M. Giacomini, S.M. Huang, D.J. Tweedie, L.Z. Benet, and K.L. Brouwer et al. Membrane transporters in drug development Nat Rev Drug Discov 9 2010 215 236
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 215-236
-
-
Transporter Consortium, I.1
Giacomini, K.M.2
Huang, S.M.3
Tweedie, D.J.4
Benet, L.Z.5
Brouwer, K.L.6
-
9
-
-
79953649285
-
Multidrug resistance ABC transporter structure predictions by homology modeling approaches
-
M. Honorat, P. Falson, R. Terreux, A. Di Pietro, C. Dumontet, and L. Payen Multidrug resistance ABC transporter structure predictions by homology modeling approaches Curr Drug Metab 12 2011 268 277
-
(2011)
Curr Drug Metab
, vol.12
, pp. 268-277
-
-
Honorat, M.1
Falson, P.2
Terreux, R.3
Di Pietro, A.4
Dumontet, C.5
Payen, L.6
-
10
-
-
34548083160
-
ABCG2 (breast cancer resistance protein/mitoxantrone resistance- associated protein) ATPase assay: A useful tool to detect drug-transporter interactions
-
H. Glavinas, E. Kis, A. Pál, R. Kovács, M. Jani, and E. Vági et al. ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions Drug Metab Dispos 35 2007 1533 1542
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1533-1542
-
-
Glavinas, H.1
Kis, E.2
Pál, A.3
Kovács, R.4
Jani, M.5
Vági, E.6
-
11
-
-
0000859372
-
++ by sarcoplasmic reticulum fragments
-
++ by sarcoplasmic reticulum fragments J Biol Chem 239 1964 648 658
-
(1964)
J Biol Chem
, vol.239
, pp. 648-658
-
-
Martonosi, A.1
Feretos, R.2
-
12
-
-
0014939405
-
Inside-out red cell membrane vesicles: Preparation and purification
-
T.L. Steck, R.S. Weinstein, J.H. Straus, and D.F. Wallach Inside-out red cell membrane vesicles: preparation and purification Science 168 1970 255 257
-
(1970)
Science
, vol.168
, pp. 255-257
-
-
Steck, T.L.1
Weinstein, R.S.2
Straus, J.H.3
Wallach, D.F.4
-
13
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
R.L. Juliano, and V. Ling A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants Biochim Biophys Acta 455 1976 152 162
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
14
-
-
0007630205
-
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells
-
M. Horio, M.M. Gottesman, and I. Pastan ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells Proc Natl Acad Sci U S A 85 1988 3580 3584
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 3580-3584
-
-
Horio, M.1
Gottesman, M.M.2
Pastan, I.3
-
15
-
-
0026722467
-
Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase
-
B. Sarkadi, E.M. Price, R.C. Boucher, U.A. Germann, and G.A. Scarborough Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase J Biol Chem 267 1992 4854 4858
-
(1992)
J Biol Chem
, vol.267
, pp. 4854-4858
-
-
Sarkadi, B.1
Price, E.M.2
Boucher, R.C.3
Germann, U.A.4
Scarborough, G.A.5
-
16
-
-
0026768856
-
Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells
-
C.A. Doige, and F.J. Sharom Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells Biochim Biophys Acta 1109 1992 161 171
-
(1992)
Biochim Biophys Acta
, vol.1109
, pp. 161-171
-
-
Doige, C.A.1
Sharom, F.J.2
-
17
-
-
0033567425
-
Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells
-
F.J. Sharom, X. Yu, P. Lu, R. Liu, J.W. Chu, and K. Szabó et al. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells Biochem Pharmacol 58 1999 571 586
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 571-586
-
-
Sharom, F.J.1
Yu, X.2
Lu, P.3
Liu, R.4
Chu, J.W.5
Szabó, K.6
-
18
-
-
0033984873
-
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
-
B. Stieger, K. Fattinger, J. Madon, G.A. Kullak-Ublick, and P.J. Meier Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver Gastroenterology 118 2000 422 430
-
(2000)
Gastroenterology
, vol.118
, pp. 422-430
-
-
Stieger, B.1
Fattinger, K.2
Madon, J.3
Kullak-Ublick, G.A.4
Meier, P.J.5
-
19
-
-
34547189233
-
Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2)
-
G. Williamson, I. Aeberli, L. Miguet, Z. Zhang, M.B. Sanchez, and V. Crespy et al. Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2) Drug Metab Dispos 35 2007 1262 1268
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1262-1268
-
-
Williamson, G.1
Aeberli, I.2
Miguet, L.3
Zhang, Z.4
Sanchez, M.B.5
Crespy, V.6
-
20
-
-
0346732289
-
Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein
-
M.K. Al-Shawi, M.K. Polar, H. Omote, and R.A. Figler Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein J Biol Chem 278 2003 52629 52640
-
(2003)
J Biol Chem
, vol.278
, pp. 52629-52640
-
-
Al-Shawi, M.K.1
Polar, M.K.2
Omote, H.3
Figler, R.A.4
-
21
-
-
33845362976
-
Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs
-
Y. Shirasaka, Y. Onishi, A. Sakurai, H. Nakagawa, T. Ishikawa, and S. Yamashita Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs Biol Pharm Bull 29 2006 2465 2471
-
(2006)
Biol Pharm Bull
, vol.29
, pp. 2465-2471
-
-
Shirasaka, Y.1
Onishi, Y.2
Sakurai, A.3
Nakagawa, H.4
Ishikawa, T.5
Yamashita, S.6
-
23
-
-
48949117167
-
Utilization of membrane vesicle preparations to study drug-ABC transporter interactions
-
H. Glavinas, D. Mehn, M. Jani, B. Oosterhuis, K. Herédi- Szabó, and P. Krajcsi Utilization of membrane vesicle preparations to study drug-ABC transporter interactions Expert Opin Drug Metab Toxicol 4 2008 721 732
-
(2008)
Expert Opin Drug Metab Toxicol
, vol.4
, pp. 721-732
-
-
Glavinas, H.1
Mehn, D.2
Jani, M.3
Oosterhuis, B.4
Herédi-Szabó, K.5
Krajcsi, P.6
-
24
-
-
34248530310
-
Cholesterol potentiates ABCG2 activity in a heterologous expression system: Improved in vitro model to study function of human ABCG2
-
A. Pal, D. Mehn, E. Molnár, S. Gedey, P. Mészáros, and T. Nagy et al. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2 J Pharmacol Exp Ther 321 2007 1085 1094
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 1085-1094
-
-
Pal, A.1
Mehn, D.2
Molnár, E.3
Gedey, S.4
Mészáros, P.5
Nagy, T.6
-
25
-
-
70349153908
-
Effect of membrane cholesterol on BSEP/Bsep activity: Species specificity studies for substrates and inhibitors
-
E. Kis, E. Ioja, T. Nagy, L. Szente, K. Herédi-Szabó, and P. Krajcsi Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors Drug Metab Dispos 37 2009 1878 1886
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1878-1886
-
-
Kis, E.1
Ioja, E.2
Nagy, T.3
Szente, L.4
Herédi-Szabó, K.5
Krajcsi, P.6
-
26
-
-
79953793971
-
In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides
-
G.E. Flaten, G. Kottra, W. Stensen, G. Isaksen, R. Karstad, and J.S. Svendsen et al. In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides J Med Chem 54 2011 2422 2432
-
(2011)
J Med Chem
, vol.54
, pp. 2422-2432
-
-
Flaten, G.E.1
Kottra, G.2
Stensen, W.3
Isaksen, G.4
Karstad, R.5
Svendsen, J.S.6
-
27
-
-
33746548445
-
+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
-
+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2 J Am Soc Nephrol 17 2006 2127 2135
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2127-2135
-
-
Masuda, S.1
Terada, T.2
Yonezawa, A.3
Tanihara, Y.4
Kishimoto, K.5
Katsura, T.6
-
28
-
-
79959593077
-
Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes
-
T. De Bruyn, Z.W. Ye, A. Peeters, J. Sahi, M. Baes, and P.F. Augustijns et al. Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes Eur J Pharm Sci 43 2011 297 307
-
(2011)
Eur J Pharm Sci
, vol.43
, pp. 297-307
-
-
De Bruyn, T.1
Ye, Z.W.2
Peeters, A.3
Sahi, J.4
Baes, M.5
Augustijns, P.F.6
-
29
-
-
33645743694
-
The human organic anion transporter 3 (OAT3; SLC22A8): Genetic variation and functional genomics
-
A.R. Erdman, L.M. Mangravite, T.J. Urban, L.L. Lagpacan, R.A. Castro, and M. de la Cruz et al. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics Am J Physiol Renal Physiol 290 2006 F905 F912
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Erdman, A.R.1
Mangravite, L.M.2
Urban, T.J.3
Lagpacan, L.L.4
Castro, R.A.5
De La Cruz, M.6
-
31
-
-
80052147737
-
Proteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo?
-
M. Ogura, M. Ayaori, Y. Terao, T. Hisada, M. Iizuka, and S. Takiguchi et al. Proteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo? Arterioscler Thromb Vasc Biol 31 2011 1980 1987
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. 1980-1987
-
-
Ogura, M.1
Ayaori, M.2
Terao, Y.3
Hisada, T.4
Iizuka, M.5
Takiguchi, S.6
-
32
-
-
0030905160
-
Jejunal permeability: A comparison between the Ussing chamber technique and the single-pass perfusion in humans
-
H. Lennernas, S. Nylander, and A.L. Ungell Jejunal permeability: a comparison between the Ussing chamber technique and the single-pass perfusion in humans Pharm Res 14 1997 667 671
-
(1997)
Pharm Res
, vol.14
, pp. 667-671
-
-
Lennernas, H.1
Nylander, S.2
Ungell, A.L.3
-
33
-
-
48749121103
-
Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions
-
R. Elsby, D.D. Surry, V.N. Smith, and A.J. Gray Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions Xenobiotica 38 7-8 2008 1140 1164
-
(2008)
Xenobiotica
, vol.38
, Issue.78
, pp. 1140-1164
-
-
Elsby, R.1
Surry, D.D.2
Smith, V.N.3
Gray, A.J.4
-
34
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
-
P. Artursson Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells J Pharm Sci 79 6 1990 476 482
-
(1990)
J Pharm Sci
, vol.79
, Issue.6
, pp. 476-482
-
-
Artursson, P.1
-
35
-
-
33748887871
-
Caco-2 cell permeability assays to measure drug absorption
-
R.B. van Breemen, and Y. Li Caco-2 cell permeability assays to measure drug absorption Expert Opin Drug Metab Toxicol 1 2 2005 175 185
-
(2005)
Expert Opin Drug Metab Toxicol
, vol.1
, Issue.2
, pp. 175-185
-
-
Van Breemen, R.B.1
Li, Y.2
-
36
-
-
25144494314
-
Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
-
K. Kopplow, K. Letschert, J. König, B. Walter, and D. Keppler Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells Mol Pharmacol 68 4 2005 1031 1038
-
(2005)
Mol Pharmacol
, vol.68
, Issue.4
, pp. 1031-1038
-
-
Kopplow, K.1
Letschert, K.2
König, J.3
Walter, B.4
Keppler, D.5
-
37
-
-
79955903884
-
Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: Determinants of uptake and transcellular translocation of organic cations
-
J. Konig, O. Zolk, K. Singer, C. Hoffmann, and M.F. Fromm Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations Br J Pharmacol 163 3 2011 546 555
-
(2011)
Br J Pharmacol
, vol.163
, Issue.3
, pp. 546-555
-
-
Konig, J.1
Zolk, O.2
Singer, K.3
Hoffmann, C.4
Fromm, M.F.5
-
38
-
-
22944446686
-
Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein
-
S. Matsushima, K. Maeda, C. Kondo, M. Hirano, H. Sasaki, and H. Suzuki et al. Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein J Pharmacol Exp Ther 314 3 2005 1059 1067
-
(2005)
J Pharmacol Exp Ther
, vol.314
, Issue.3
, pp. 1059-1067
-
-
Matsushima, S.1
Maeda, K.2
Kondo, C.3
Hirano, M.4
Sasaki, H.5
Suzuki, H.6
-
39
-
-
0038725719
-
Experimental estimation of the role of P-glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the Caco-2 cell model
-
J.I. Pachot, R.P. Botham, and K.D. Haegele Experimental estimation of the role of P-glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the Caco-2 cell model J Pharm Pharm Sci 6 1 2003 1 12
-
(2003)
J Pharm Pharm Sci
, vol.6
, Issue.1
, pp. 1-12
-
-
Pachot, J.I.1
Botham, R.P.2
Haegele, K.D.3
-
40
-
-
56349138032
-
Several major antiepileptic drugs are substrates for human P-glycoprotein
-
C. Luna-Tortós, M. Fedrowitz, and W. Löscher Several major antiepileptic drugs are substrates for human P-glycoprotein Neuropharmacology 55 8 2008 1364 1375
-
(2008)
Neuropharmacology
, vol.55
, Issue.8
, pp. 1364-1375
-
-
Luna-Tortós, C.1
Fedrowitz, M.2
Löscher, W.3
-
41
-
-
0037666795
-
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
-
N. Zelcer, M.T. Huisman, G. Reid, P. Wielinga, P. Breedveld, and A. Kuil et al. Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2) J Biol Chem 278 26 2003 23538 23544
-
(2003)
J Biol Chem
, vol.278
, Issue.26
, pp. 23538-23544
-
-
Zelcer, N.1
Huisman, M.T.2
Reid, G.3
Wielinga, P.4
Breedveld, P.5
Kuil, A.6
-
42
-
-
72449167919
-
Potentiation of MRP2/Mrp2-mediated estradiol-17beta-glucuronide transport by drugs - A concise review
-
K. Heredi-Szabo, K. Jemnitz, E. Kis, E. Ioja, J. Jánossy, and L. Vereczkey et al. Potentiation of MRP2/Mrp2-mediated estradiol-17beta-glucuronide transport by drugs - a concise review Chem Biodivers 6 11 2009 1970 1974
-
(2009)
Chem Biodivers
, vol.6
, Issue.11
, pp. 1970-1974
-
-
Heredi-Szabo, K.1
Jemnitz, K.2
Kis, E.3
Ioja, E.4
Jánossy, J.5
Vereczkey, L.6
-
43
-
-
59449087893
-
A novel screening strategy to identify ABCB1 substrates and inhibitors
-
O. von Richter, H. Glavinas, P. Krajcsi, S. Liehner, B. Siewert, and K. Zech A novel screening strategy to identify ABCB1 substrates and inhibitors Naunyn Schmiedebergs Arch Pharmacol 379 1 2009 11 26
-
(2009)
Naunyn Schmiedebergs Arch Pharmacol
, vol.379
, Issue.1
, pp. 11-26
-
-
Von Richter, O.1
Glavinas, H.2
Krajcsi, P.3
Liehner, S.4
Siewert, B.5
Zech, K.6
|