Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: Determinants of uptake and transcellular translocation of organic cations

British Journal of Pharmacology

Volumn 163, Issue 3, 2011, Pages 546-555

  Konig J ^a   Zolk, O ^a   Singer, K ^a   Hoffmann, C ^a   Fromm, M F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

double transfected cells; drug transport; MATE1; MDCK; metformin; OCT1; OCT2; organic cation transporters

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; MEMBRANE PROTEIN; METFORMIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG UPTAKE; GENETIC TRANSFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; DOGS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; METFORMIN; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; TRANSFECTION;

EID: 79955903884     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01052.x     Document Type: Article

References (33)

1. Alexander SPH, Mathie A, Peters JA, (2009). Guide to Receptors and Channels (GRAC), 4th edition. Br J Pharmacol 158 (Suppl. 1): S1-S254.
2. Bachmakov I, Glaeser H, Fromm MF, König J, (2008). Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1. Diabetes 57: 1463-1469.
3. Bachmakov I, Glaeser H, Endress B, Mörl F, König J, Fromm MF, (2009). Interaction of beta-blockers with the renal uptake transporter OCT2. Diabetes Obes Metab 11: 1080-1083.
4. Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH, (2010). Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenet Genomics 20: 38-44.
5. Cui Y, König J, Keppler D, (2001). Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 60: 934-943. (Pubitemid 33027428)
6. Fromm MF, (2003). Importance of P-glycoprotein for drug disposition in humans. Eur J Clin Invest 33 (Suppl. 2): 6-9.
7. Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y, (2009). Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4. Drug Metab Dispos 37: 2103-2111.
8. Ho RH, Kim RB, (2005). Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther 78: 260-277. (Pubitemid 41254111)
9. Huang S-M, Zhang L, Giacomini KM, (2010). The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA. Clin Pharmacol Ther 87: 32-36.
10. Kindla J, Fromm MF, König J, (2009). In vitro evidence for the role of OATP and OCT uptake transporters in drug-drug interactions. Expert Opin Drug Metab Toxicol 5: 489-500.
11. Kitamura S, Maeda K, Sugiyama Y, (2008). Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans. Naunyn Schmiedebergs Arch Pharmacol 377: 617-628.
12. Koepsell H, Lips K, Volk C, (2007). Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24: 1227-1251. (Pubitemid 46876495)
13. Kopplow K, Letschert K, König J, Walter B, Keppler D, (2005). Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 68: 1031-1038. (Pubitemid 41345794)
14. Letschert K, Komatsu M, Hummel-Eisenbeiss J, Keppler D, (2005). Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2. J Pharmacol Exp Ther 313: 549-556. (Pubitemid 40604153)
15. +/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17: 2127-2135. (Pubitemid 44141902)
16. Matsushima S, Maeda K, Kondo C, Hirano M, Sasaki M, Suzuki H, et al,. (2005). Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther 314: 1059-1067. (Pubitemid 41205969)
17. Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, et al,. (2009). The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine. Drug Metab Dispos 37: 555-559.
18. Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB, (2010). Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2, and single nucleotide polymorphisms. Am J Physiol Renal Physiol 298: F997-F1005.
19. Nies AT, Herrmann E, Brom M, Keppler D, (2008a). Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol 376: 449-461.
20. Nies AT, Schwab M, Keppler D, (2008b). Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. Expert Opin Drug Metab Toxicol 4: 545-568. (Pubitemid 351890738)
21. Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, et al,. (2009). Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50: 1227-1240.
22. Omote H, Hiasa M, Matsumoto T, Otsuka M, Moriyama Y, (2006). The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. Trends Pharmacol Sci 27: 587-593. (Pubitemid 44572392)
23. Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y, (2005). A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A 102: 17923-17928. (Pubitemid 41798478)
24. Sato T, Masuda S, Yonezawa A, Tanihara Y, Katsura T, Inui K, (2008). Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochem Pharmacol 76: 894-903.
25. Tanihara Y, Masuda S, Sato T, Katsura T, Ogawa O, Inui K, (2007). Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol 74: 359-371. (Pubitemid 46890818)
26. +/organic cation antiporters (MATE/SLC47A). Biochem Pharmacol 75: 1689-1696.
27. +/organic cation antiporter MATE1. Am J Physiol Renal Physiol 292: F593-F598. (Pubitemid 46220526)
28. Tsuda M, Terada T, Mizuno T, Katsura T, Shimakura J, Inui K, (2009a). Targeted disruption of the multidrug and toxin extrusion 1 (Mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol 75: 1280-1286.
29. Tsuda M, Terada T, Ueba M, Sato T, Masuda S, Katsura T, et al,. (2009b). Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells. J Pharmacol Exp Ther 329: 185-191.
30. Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y, (2002). Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 302: 510-515. (Pubitemid 34787213)
31. Yokoo S, Yonezawa A, Masuda S, Fukatsu A, Katsura T, Inui K, (2007). Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol 74: 477-487. (Pubitemid 46963232)
32. Zolk O, (2009). Current understanding of the pharmacogenomics of metformin. Clin Pharmacol Ther 86: 595-598.
33. Zolk O, Solbach TF, König J, Fromm MF, (2009). Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. Drug Metab Dispos 37: 1312-1318.