Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells

Biochemical Pharmacology

Volumn 58, Issue 4, 1999, Pages 571-586

  Sharom, Frances J ^a   Yu, Xiaohong ^a   Lu, Peihua ^a   Liu, Ronghua ^a   Chu, Joseph W K ^a   Szabó, Katalin ^b   Müller, Marianna ^b   Hose, Curtis D ^d   Monks, Anne ^d   Váradi, András ^b   Seprôdi, János ^c   Sarkadi, Balázs ^b  

^a UNIVERSITY OF GUELPH   (Canada)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ATPase activity; Azidopine photolabeling; Daunorubicin transport; Drug binding; Drug transport; Fluorescent dye transport; Peptide derivatives; Proteoliposomes

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AZIDOPINE; CALPEPTIN; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; FLUORESCENT DYE; GLYCOPROTEIN P; PACLITAXEL; PEPTIDE DERIVATIVE; REVERSIN 121; REVERSIN 205; RHODAMINE 123; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG BINDING; DRUG TRANSPORT; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEOLIPOSOME;

ADENOSINE TRIPHOSPHATASES; ANIMALS; AZIDES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CHO CELLS; COLCHICINE; CRICETINAE; DAUNORUBICIN; DIHYDROPYRIDINES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLUORESCENT DYES; HUMANS; OLIGOPEPTIDES; P-GLYCOPROTEIN; PEPTIDES; PHOTOAFFINITY LABELS; RHODAMINE 123; TUMOR CELLS, CULTURED;

EID: 0033567425     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00139-2     Document Type: Article

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